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김동천 ( Dong Cheon Kim ),조준 ( Joon Cho ),조요한 ( Yo Han Cho ),노홍기 ( Hong Gee Roh ),임소덕 ( So Dug Lim ),고영초 ( Young Cho Koh ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2009 대한뇌종양학회지 Vol.8 No.2
Malignant fibrous histiocytoma(MFH) is a soft tissue sarcoma arising from the extremities and retroperitoneum in older adults. Primary intracranial MFH is extremely rare. A 29-year-old woman presented with headache showing three large masses on brain magnetic resonance image(MRI). She had undergone extended total gastrectomy with splenectomy under the diagnosis of advanced gastric cancer three years previously. Systemic positron extension tomography(PET) computed tomography(CT) scan on routine follow-up study before the first brain surgery revealed no hot spots. Three masses were totally removed at a single session. The pathology was confirmed to be typical MFH. Two months after the first brain surgery, she underwent tonsillectomy due to a rapidly growing tonsillar mass and the pathology was found out to be MFH. Postoperative neck CT with angiography for the evaluation of hypotension showed no significant finding. Except for the tonsillar mass, she had been symptom free during 10 months after the first brain surgery. Between 11th and 18th months postoperatively, multiple intracranial recurrences including metastatic lesions of the mediastinum and the spine were noticed. She died of pneumonia 20 months after the first brain surgery during salvage chemotherapy. We report a rare case of primary MFH of the brain with a past medical history of advanced gastric cancer.
산지별 더덕 추출물의 폐암 및 난소암에 대한 항암 효능
조영락 ( Young Rak Cho ),김수현 ( Soo Hyeon Kim ),윤현재 ( Hyun Jae Yoon ),홍삼열 ( Sam Yeol Hong ),고희영 ( Hee Young Ko ),박은희 ( Eun Hee Park ),김명동 ( Myoung Dong Kim ),서동완 ( Dong Wan Seo ) 한국산업식품공학회 2011 산업 식품공학 Vol.15 No.1
Codonopsis lanceolata L. (Campanulaceae) has long been used in traditional Korean medicine to treat bronchitis, cough, and inflammatory diseases, however, the efficacy of anti-tumor activities remains to be defined. In this study the effects of Codonopsis lanceolata (C. lanceolata) on proliferation, migration and adhesion in lung (A549, H1299) and ovarian cancer (SKOV-3) cells were investigated. To assess and compare the pharmacological effects and production places of C. lanceolata, the ethanolic extracts of C. lanceolata from different places in Korea (Hongseong, Yecheon, Yeongwol, Yanggu, Gangjin, and Hoengseong) were prepared. The extract from Hoengseong county did have only marginal anti-proliferative activity in all the cell lines tested, however, other extracts had little or no effect on cell proliferation. The extracts from Hongseong, Gangjin or Hoengseong county had partial anti-migratory activity in lung cancer cells, but not in ovarian cancer cells. In addition, the extract from Hoengseong county had partial anti-adhesive activity in ovarian cancer cells, however, other extracts did not affect cell adhesion in both lung and ovarian cancer cells. Taken together, these findings provide the first description of anti-tumor efficacy of C. lanceolata from different production places in Korea, and suggest that C. lanceolata from Hoengseong county may have therapeutic potential in lung and ovarian cancers.
유전체필름을 이용한 평행판검출기의 납 차폐물 두께변화에 대한 반응
김용은,조문준,김준상,오영기,김진기,신교철,김정기,정동혁,김기환,Kim Yong-Eun,Cho Moon-June,Kim Jun-Sang,Oh Young-Kee,Kim Jhin-Kee,Shin Kyo-Chul,Kim Jeung-Kee,Jeong Dong-Hyeok,Kim Ki-Hwan 한국의학물리학회 2006 의학물리 Vol.17 No.1
본 연구에서는 납 차폐물의 두께변화에 대한 반응을 알아보기 위하여 크롬으로 코팅된 전극을 사용한 FEP 유전체필름과, 그들 사이에 PTFE 유전체 필름을 삽입한 형태의 평행판 검출기를 제작하였다. 측정조건은 선원-팬텀표면 간의 거리 100 Cm, 조사면 크기 10x10 cm, 그리고 팬텀의 표면으로부터 깊이 5 cm 되는 지점과 10 cm 되는 지점에 유전체필름을 이용한 제작검출기와 Farmer형 전리함을 설치하고 6 MV, 10 MV X-선을 조사하였다. 차폐물은 조사면을 충분히 포함하도록 제작하여 측정순서에 따라 차례대로 Tray 위에 놓아서 두께변화에 대한 감쇄효과를 확인하고 두 검출기 간의 반응함수를 알고자 하였다. 차폐효과에 대한 두 검출기 간의 반응함수는 선량에 대하여 지수적으로 감소함을 확인할 수 있었다. 제작검출기와 비교검출기로 측정한 선형감쇄계수 ${\mu}(cm^{-1})$는 6 MV X-선으로 조사한 경 우 0.1414, 0.541이 었고, 10 MV X-선으로 조사한 경우 각각 0.1368, 0.5279로서 납 차폐물의 두께 변화에 의한 선형감쇄계수가 감소하는 경향을 확인할 수 있었으며 계산된 반응함수로부터 제작검출기는 전리함에 비해 상대적으로 매우 크게 반응하고 있음을 알 수 있었다. 제작검출기에서 측정한 선량값(R)과 전리함에서 측정한 선량값($D_r$) 간의 반응함수를 최적화 과정을 통하여 계산하였다. 이들 반응함수의 최적화 상수 값들은 고 에너지 X-선 크기에 비교적 무관한 경향을 보였다. 제작 검출기와 비교검출기 간의 최적화된 반응함수를 계산한 결과 6 MV X-선의 경우 1%, 10 MV X-선의 경우 4% 이내의 범위 내에서 측정된 선량이 일치함으로써 상대 선량계로서의 가능성을 확인하였다. A parallel plate detector containing PTFE films in FEP film for relative dosimetry was designed to measure the response of detectors to S and 10 MV X-rays from a medical linear accelerator through different thicknesses of lead. The dielectric materials were 100 m thick. The set-up conditions for measurements with this detector were as follows: SSD=100 cm the test detector was at a depth of 5 cm and the reference chamber was at a depth of 10 cm from the phantom surface for 6 and 10 MV X-rays. Lead blocks were designed to cover the irradiated field. They were added to the tray to increase thickness sequentially. We found that the detector response decreased exponentially with the thickness of lead added. The linear attenuation coefficients of the test detector and reference chamber were 0.1414 and 0.541, respectively, for 6 MV X-rays and 0.1358 and 0.5279 for 10 MV X-rays. The test detector response was greater than that of the reference chamber. The response function was calculated from the measured values of the test detector and reference chamber using optimization. These optimized constants for the detector response function were independent of theenergy. As a result of optimizing the response function between detectors, the use of a relative dosimeter was validated, because the response of the test detector was 1% for 6 MV X-rays and 4% for 10 MV X-rays.
Polyesters Syntheses via Palladium Catalyzed Carbonylative Polycondensation Reaction
김영조 ( Young Cho Kim ),유동성 ( Dong Seong Ryu ),김진일 ( Jin Il Kim ) 한국공업화학회 1991 한국공업화학회 연구논문 초록집 Vol.1991 No.0
Novel Polyesters were succesfully synthesized by palladium catalyzed carbonylative polycondensation of xylene dibromides and various diols with carbon monoxide. The effects of reaction variables, such as catalysts, bases, solvents, carbon monoxide pressure, and reaction temperature, were discussed in detail for the reaction of p-dibromoxylene and 2, 2-bis(4-hydroxyphenyl)propane with carbon monoxide. The polyesters were characterized by IR, elemental analysis, GPC, DSC, TGA, and polarizing microscope.