Mevatron 67 선형 가속기에서의 6MV X선 측정

조문준 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

The dosimetric measurements of the 6MV X-ray from a Siemens Mevatron 67 linear accelerator have been made. Percent depth dose, beam profile, wedge profile, wedge factor and output factor are presented.

방사선치료 조사영역 내에 발생한 설암 환자에서 입체조형방사선치료 경험 : 증례보고

조문준,장지영,김기환,김병국,송창준,김준상,김재성 충남대학교 암연구소 2003 암연구소 업적집 Vol.3 No.-

Objectives : We report an interim result of conformal radiotherapy in a patient with early stage cancer at the base of the tongue, which developed in a previously irradiated area. Materials and Methods : A 64-year-old male patient was diagnosed with T4NOMO supraglottic cancer. He received 72Gy of radiation therapy from 21 November 1988 to 24 February 1989. He had local failure and underwent a salvage total laryngectomy on 28 August 1989. Subsequently, he did well. In early 1999, he suffered from throat pain. He had a 2.5cm ulcerative mass at the base of his tongue, in the area that had been irradiated previously. Biopsy showed squamous cell carcinoma. After workup, he was diagnosed with base of tongue cancer with T2NOMO. Surgery was not feasible because the morbidity was not acceptable. Since it was difficult to re-irradiate the area with a curable dose using conventional 2D radiation therapy with an acceptable morbidity, we decided to try conformal radiotherapy. We used 7 static beam ports with field sizes from 7×6.4 to 8×8㎠, using 6 and 10MV photons. The fractionation regimen was 1.8Gy, 5 times per week. He received 64.8Gy in 36 fractions from 9 April 1999 to 1 June 1999. Results : In the 21 months since radiotherapy, the patient has not experienced any acute or chronic complications, such as xerostomia. He experienced relief of pain shortly after the start of radiotherapy, showed a complete response, and is still doing well. Conclusion : Conformal radiotherapy can be used to treat cancer that develops within a previously irradiated field, with curative intent.

진행암 환자에서 Cisplatin 병용화학요법 시 Ondansetron의 오심 구토 조절 효과

조문준,윤환중,전의건,길준영,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Ondansetron is a novel agent that selectively binds to the 5-hydroxytryptamine_3 receptor, and has been reported to have a prominent effect in the prevention of anti-neoplastic agent induced nausea and vomiting. Twenty solid tumor patients who were scheduled to receive cisplatin containing combination chemotherapy participated in a prospectively open-labeled study to evaluate the antiernetic efficacy and safety of ondansetron. The male to female ratio was 11 : 9 and median age was 49(16-70). The sites of primary neoplasms and number of patients were as following : head and neck 4, metastatic carcinoma of unknown primary site 3, stomach 3, osteosarcoma 2, ovary 2, esophagus 1, melanoma 1, penile 1, bladder 1, cervix 1, and extragonadal germ cell 1. Ondansetron was given as an 8mg loading dose IV before chemotherapy followed by 8mg IV every 8 hours until 24 hours after chemotherapy completion. Complete or major control(0 to 2 emetic episodes) of emesis was achieved in 17 of 20 patients(85%;complete 50%, major 35%) receiving ondansetron during the first 24hrs of chemotherapy. During the period of day 2 through clay 5 of chemotherapy, 14 of 20(75%) patients had complete or major control of emesis(complete 35%, major 35%). No severe side reactions were recorded in ondansetron treated patients, while mild to moderate headache was noted in 20% of patients. These results show that ondansetron is effective in the control of cisplatin induced nausea and emesis, and can be administered safely with minimal side effects.

폐암의 방사선 치료에 있어 전산화 단층 촬영을 이용한 치료계획에 관한 연구

조문준 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

To evaluate the usefulness of computerized tomography planning in lung cancer, dosimetric comparative study was done between conventional treatment plan and plan based on CT images. Dose distribution was compared between AP PA parallel opposing ports with posterior spinal cord block and AP PA parallel opposing ports with oblique ports based on CT images. CT plan was superior to conventional treatment plan.

IIIB 병기 비소세포 폐암의 방사선치료 성적

조문준,박승호,김재성,김선영 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

To evaluate the effect of radiation therapy in nonsmall cell lung cancer stage IIIB, we analyzed the 23 patients diagnosed NSCLC IIIB and treated curatively with radiation therapy between September 1989 and March 1993 at the department of therapeutic radiology, Chungnam National University Hospital, retrospectively. The actuarial 1 year survival rate was 39.2%, 2 year survival rate was 2.3%, and median survival time was 10 months. The difference of survival rates by performance status, response to radiotherapy, T stage, N stage, tumor size, age, pathologic cell type, combination with chemotherapy was not statistically significant. To increase the survival time and rate of the patients with NSCLC IIIB, further study for adequate radiation fractionation and dose, combination with chemoherapy and surgery will be needed.

방사선치료 조사영역 내에 발생한 설암 환자에서 입체조형방사선치료 경험 : 증례보고

조문준,장지영,김기환,김병국,송창준,김준상,김재성 충남대학교 암공동연구소 2003 암공동연구소 업적집 Vol.3 No.

Objectives : We report an interim result of conformal radiotherapy in a patient with early stage cancer at the base of the tongue, which developed in a previously irradiated area. Materials and Methods : A 64-year-old male patient was diagnosed with T4NOMO supraglottic cancer. He received 72Gy of radiation therapy from 21 November 1988 to 24 February 1989. He had local failure and underwent a salvage total laryngectomy on 28 August 1989. Subsequently, he did well. In early 1999, he suffered from throat pain. He had a 2.5cm ulcerative mass at the base of his tongue, in the area that had been irradiated previously. Biopsy showed squamous cell carcinoma. After workup, he was diagnosed with base of tongue cancer with T2NOMO. Surgery was not feasible because the morbidity was not acceptable. Since it was difficult to re-irradiate the area with a curable dose using conventional 2D radiation therapy with an acceptable morbidity, we decided to try conformal radiotherapy. We used 7 static beam ports with field sizes from 7×6.4 to 8×8㎠, using 6 and 10MV photons. The fractionation regimen was 1.8Gy, 5 times per week. He received 64.8Gy in 36 fractions from 9 April 1999 to 1 June 1999. Results : In the 21 months since radiotherapy, the patient has not experienced any acute or chronic complications, such as xerostomia. He experienced relief of pain shortly after the start of radiotherapy, showed a complete response, and is still doing well. Conclusion : Conformal radiotherapy can be used to treat cancer that develops within a previously irradiated field, with curative intent.

골전이암의 방사선 치료

조문준 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

To assess the effectiveness of palliative radiotherapy in the management of metastatic bone disease, 35 patients were retrospectively analyzed. Pain relief was obtained in 83% with excellent response in 56%. The most frequent primary tumor was lung cancer and followed by breast cancer, hepatoma and lymphoma. Spine, pelvis, upper and lower extremity were frequent metastatic site.

간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

윌름종양의 치료에 대한 임상적 고찰

김재성,조문준,박경덕,설종구 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Wilms' tumor is the paradigm for multimodal treatment of a pediatric malignant solid tumor. Developments in surgical techniques and postoperative care, recognition of the sensitivity of Wilms' tumor to irradiation, and the availability of several active chemotherapeutic agents led to a dramatic change in the prognosis for most patients with this once uniformly lethal malignancy. This article presents four cases of Wilms' tumor managed at Chungnam National University Hospital and reviews current treatment recommendations for patients with Wilms' tumor, based upon the results of the National Wilms' Tumor Studies.

자궁내막암의 방사선치료 성적

김재성,김준상,조문준,박승호,노흥태,남상륜 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.1

Purpose : To evaluate survival rate, treatment failure pattern and complication of endometrial carcinoma patients treated with radiation therapy Materials and Methods : From November 1989 through March 1995, twenty two patients with endometrial carcinoma were treated with radiation therapy at Chungnam National University Hospital. According to the 1988 FIGO staging system, four patients had stage I A disease, 6 stage I B, 4 stage I C, 1 stage Ⅱ A, 6 stage Ⅲ A, and 1 stage Ⅲ B. Radiation therapy was given preoperatively to 2 patients, postoperatively to 19 patients, and curatively to one patient considered to be inoperable due to valvular heart disease. Twelve patients were treated with external radiation therapy alone by conventional technique (180-200 cGy/fraction), and 6 patients with external radiotherapy plus high dose rate intracavitary radiotherapy (HDR ICR), and 4 patients with HDR ICR alone. Results : All patients were followed up for 9 to 71 months (median 21 months). The overall 5 year survival rate of all patients was 68.9%. The 5 year survival rates of stage I , Ⅱ , and Ⅲ were 87.5%, 100%, and 41.6%, respectively. Relapse rate was 9.1% (2/22), and treatment failure occurred as a distant metastasis only without local failure. Early mild complication rate was 31.8% (7/22), and late complication rate 9.1% (2/22), including one radiation colitis and one vulvar ulcer. Conclusion : Adjuvant pelvic radiation thereapy is an effective local treatment modality to prevent local relapse in patients with endometrial carcinoma not accompanying severe late complications.