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화영지통탕(和營止痛湯)의 혈관신생억제효과(血管新生抑制效果)에 관한 실험적(實驗的) 연구(硏究)
김인석,박준혁,강희,김성훈,유영법,심범상,최승훈,안규석,Kim, In-Seok,Park, Joon-Hyuck,Kang, Hee,Kim, Sung-Hoon,Yu, Young-Beob,Shim, Bum-Sang,Choi, Seung-Hoon,Ahn, Koo-Seok 대한암한의학회 2001 大韓癌韓醫學會誌 Vol.7 No.1
The purpose of this study is to prove the angiogenesis effects of WhaYoungJiTongTang (hereinafter referred to as the 'WYJTT'). For the study, by utilizing liver cancer cell line; SK-HEP-1, lung cancer cell line: A549, stomach cancer cell line: AGS and bovine capillary endothelial cell: BCE, the effects of the WYJTT on toxicity and proliferation ability of cells and the effects on anti-angiogenesis of bovine capillary endothelial cell and of mice's aorta were studied. 1. Cell viability assay In comparison with the control group, when $100{\mu}g/ml$ of WYJTT was injected, the viability was reduced in SK-Hep-1, $400{\mu}g/ml$ in A549 and $200{\mu}g/ml$ in AGS. 2. Cell proliferation assay In comparison with the control group, when $600{\mu}g/ml$ of WYITT was injected, DNA synthesis was reduced to 35.1% in the SK-Hep-1, 56.0% in A549, and 25.8% in BCE (bovine capillary endothelial cell); and when $400{\mu}g/ml$ was injected, DNA synthesis was reduced to 12.1 in AGS. 3. Tube formation assay In the event that BCE is injected with WYJTT in each of its content gradient, the anti-angiogenesis was effective in amounts of $400{\mu}g/ml$ with 6 hours of the treatment. 4. Aortic ring assay In comparison with the control group, the angiogenesis was restricted to the remarkable degree in amount of $200{\mu}g/ml$: 10% in $400{\mu}g/ml$; and fully inhibited in each of $800{\mu}g/ml$ and $1600{\mu}g/ml$. As a result of the experiments mentioned above, WYJTT showed its anti-angiogenesis effects against cancer cell line.
김인석,김학수,Kim, In Seok,Kim, Hak Soo 한국강구조학회 2008 韓國鋼構造學會 論文集 Vol.20 No.5
최근 장대 건설 구조물에 사용이 증가되고 있는 합성형 구조물에서 나타나고 있는 예기치 못한 일부 균열 현상의 구조적 원인을 분석하기 위하여, 강재복부의 수직보강재, stud 및 dowel bar의 유무, 전단철근의 간격과 콘크리트 강도 등을 실험변수로 하여 4점 재하 휨시험을 통해 강재와 철근콘크리트간의 구조적 합성거동 효과를 분석 하였다. 실험결과, 수직보강재는 강재의 국부좌굴 방지와 파괴시 강재와 콘크리트의 부착파괴를 방지하여 구조적 합성거동에 따른 단면내력(파괴하중)의 증진에 효과적인 것으로 나타났으나, 추가적으로 설치한 stud 및 dowel bar, 콘크리트의 강도와 전단철근량 등은 합성보의 휨거동에 큰 영향을 주지 않는 것으로 나타났다. The composite structures of steel and reinforced concrete, which have been widely used in large-scale concrete structures, werestudied to investigate the cause of unexpected cracks and to verify the composite actions between the two materials. Vertical stiffeners between flanges, studs and dowel bars, stirrups, and concrete strength were chosen as experimental variables in afour-point loading test. The results showed that the vertical stiffener prevented not only the local web buckling, but also bond failures between steel and concrete. It increased the flexural resistance (fracture loads) due to the composite action of two materials, compared withthose of any experimental variable. However, the composite behavior of steel reinforced concrete beam was not affected seriously by additional studs, dowel bars, stirrups, and concrete strength.
수직관에서 2상선회유동이 보이드분포와 압력강하에 미치는 영향
김인석,손병진,신현동,곽기태,Kim, I.S.,Son, B.J.,Shin, H.D.,Kwack, K.T. 대한설비공학회 1989 설비공학 논문집 Vol.1 No.2
This experimental investigation has been conducted to determine the effects of swirling angle and flow patterns on distributions of void fraction, bubble velocity and two-phase pressure drop in a vertical straight tube. Swirling angles of $0^{\circ}$ (non swirling), $30^{\circ}$, and $45^{\circ}$ were tested with air-water two components over a range of superficial air velocities. A transparent lucite tube of 38mm in internal diameter was used for the test section. The void fraction and bubble velocities were measured by means of a optical fiber probe at the upper part of the swirler in the test section. Pressure drops which seem to be closely related with flow patterns and swirling angle were measured by a differential pressure transducer. It is shown that the probability density functions of pressure drop demonstrate peculiar features for both swirling angles and flow patterns, whereas the distributions of void fraction and bubble velocities are parabolic and flat shape in the vicinity of tube center, respectively except bubbly flow in any swirling angle cases, and the void fraction increases with increasing swirling angle around the center of tube.
자매에서 발생하는 Leigh 병 (아급성 괴사성 뇌척수병증)
김준현(Jun Hyeon Kim),김인정(In Jeong Kim),김인석(In Seok Kim),윤원상(Won Sang Yoon),김은영(Eun Young Kim),김성호(Sung Ho Kim),우영종(Young Jong Woo) 대한소아신경학회 1997 대한소아신경학회지 Vol.5 No.1
In two female siblings, growth and developmental retardation, poor sucking, anorexia, floppiness and respiratory difficulty developed around 2 and 4 monthes of age in each, and the respiratory symptoms rapidly aggravated to comatose states and finally into death one month later, On admission at emergency room, severe acidosis and high lactate and pyruvate levels in serum and cerebrospinal fluid were revealed in one. Brain computed tomography and magnetic resonance imaging revealed identical bilateral involvement of putamen in both of the sibs, which made the diagnosis of Leigh disease(subacute necrotizing encephalomyelopathy) possible. There is also a family history of early death in infancy period: an elder sister and a brother of mother died with unknown cause at their 5 and 10 months of age. Mitochondrial enzyme functions could not be assayed.
고통의 의미 -빅터 에밀 프랑클의 로고테라피를 중심으로-
김인석 ( In Suk Kim ) 경희대학교 인문학연구원 2012 인문학연구 Vol.0 No.22
본 논문에 있어서 고통의 의미에 대한 탐구는 빅터 에밀 프랑클의 로고테라피에 기초하였다. 사람들은 살아가면서 여러 가지 크고 작은 고통을 경험한다. 이 고통들로 인하여 사람들은 절망에 빠진다. 프로이트와 아들러는 마음의 고통들의 원인을 심리학적인 측면에서 찾는다. 그리고 이에 대한 극복의 근거를 심리학적인 차원에 둔다. 그런데 프랑클의 로고테라피는 심리학적인-주관적인 사실들 너머 있는 참되고 객관적인 정신학적인(누로지칼)에 속하는 치료자원들을 활성화시켜서 마음의 고통을 유한다. 로고테라피는 심신의 고통을 느끼는 사람들로 하여금 그의 고통에 내재하여 있는 개인적인 삶-의미를 보게 만든다. 고통은 의미를 가지고 있으며, 고통의 의미는 삶의 특별한 태도를 취함으써, 즉 태도 가치를 실현함으로써 발견된다. 이럼으로써 고통받고 있는 사람은 절망을 극복하게 된다. The study of the meaning of pain is based on logotheraphy of Viktor E. Frankl. Our life is severely challenged by pain-experience. The painexperiences makes man fall in the depths of despair. The psychological reductionism of Freud and Adler reduces everything to its earliest psychological origins. The psychological theraphy of Freud and Adler operates in the psychological-subjective dimension. But the very task of logotheraphy is to look beneath the level of psychological-subjective facts to the true-objective(noological) dimensions of meaning of pain. Logotheraphy makes man who feels mental(physical) pain see his personal Life-meaning of pain; pain has a meaning, and the meaning of pain is found in the fulfilling of an specific life-attitude, a attitude-value. A suffuring person can overcome despair.