한국인의 정상적인 노화에 의한 성별 연령별 순음청력에 의한 기준청력

김성희,신종헌,여창기,한영경,이중기,장순석,Kim Sung Hee,Shin Jong Heon,Yeo Chang Ki,Han Young Kyung,Lee Jung Ki,Jarng Soon Suck 한국음향학회 2005 韓國音響學會誌 Vol.24 No.6

이과적인 질환이나, 소음에 의한 청력소실이 없는 경우에도 노화에 의한 청력의 변화에 대해서는 잘 알려진 사실이다. 노인들의 청력에 대한보고는 있었지만, 한국인의 노화에 의한 청력변화에 관한 보고는 드물고, 남녀의 차이에 대한 연구는 제한적이며, 아직도 이견이 있다. 최근 조선대학교에서 개발한 청력검사결과 관리 프로그램 (ARCISM)을 이용하여 한국인의 노화성 난청에 대한 기준 청력범위를 구하고자 연구를 시도하였다. 일 년여 동안 대구파티마병원 건강검진센터에 방문한 환자 중 문진에 응한 1603명의 청력검사결과를 소음에 노출된 경우나 기타 이과적인 질환을 배제한 후, 노화에 따른 청력의 변화에 대해 20대에서 80대까지의 청력도를 구하였다. 나이에 의한 주파수 대역별 청력역치의 상승을 통계학적으로 유의하였으며. 고주파수로 갈수록 그 정도가 심하였다. 특히 4kHz와 8kHz에서 남자에 있어서 여자보다 통계적으로 유의하게 청력소실이 더 크게 나타났다. 개발한 프로그램의 운용으로 방대한 청각검사자료를 이용하여 쉽게 노화에 따른 청력 변화에 대해 기준청력범위를 구할 수 있었고, 향후 노화성 난청의 재활이나 한국형 보청기 개발에 기초자료로 활용될 것으로 생각된다. Declining auditory performance with advanced age is a well known and common problem that is becoming more Prevalent due to the increasing number of elderly people in our society. We introduce a novel ARCISM (Audiogram Result Computer Input. Save & Management software) data management program which enables the assessment of the risk of past history of hearing impairment on the basis of known risk factors. This study investigates the reference levels of pure tone hearing threshold of normal aging in Korean and the difference between fenders. The subjects were carefully selected by questionnaire and absence of any history of otologic infection, noise exposure. and ototoxic drug among 1603 subjects. who visited Health Promotion Center in Daegu Fatima Hospital for one year. The results show (1) hearing sensitivity declines with age. (2) higher frequency shows steeper slope of hearing declines than lower frequency. and (3) there were more hearing loss at 4 and 8 kHz in men than in women. Due to the ARCISM program. it was possible to manage huge data of hearing results and to obtain the reference level of a9e-related hearing declines. Furthermore, we expect that the results of this study can be the fundamental data for hearing rehabilitation for the elderly and for developing suitable hearing aids for Korean.

가사노동의 기계화 : 도입과정과 배경

김성희(Sung Hee Kim),이기영(Ki Young Lee) 가정과삶의질학회 1997 가정과삶의질연구 Vol.15 No.3

가정기기가 가사노동 수행과정에 미치는 효과

金聖姬(Sung Hee Kim),李基榮(Ki Young Lee) 가정과삶의질학회 1997 가정과삶의질연구 Vol.15 No.1

과학기술이 가사노동수행양식에 미친 영향 - 가사노동의 기계화를 중심으로 -

이기영,김성희 ( Ki Young Lee,Sung Hee Kim ) 대한가정학회 1995 Human Ecology Research(HER) Vol.33 No.1

Association of Leisure Time Physical Activity and Metabolic Syndrome over 40 Years

Mi-Young Park,김성희,조윤정,Rae-Ho Chung,Ki-Tae Lee 대한가정의학회 2014 Korean Journal of Family Medicine Vol.35 No.2

Background: This study aimed to investigate the relationship between leisure time physical activities (LTPA) and metabolic syndrome (MS).Methods: Five thousand seven hundred and thirty two adults 40 years old or older were enrolled in the study from April 2009 to December 2010. National Cholesterol Education Program’s Adult Treatment Panel III was used for the criteria of MS, and Minnesota Leisure Time Physical Activity Questionnaire was used to measure LTPA. After adjusted covariates (age, hypertension, smoking, drinking, education level, household income level, work time physical activities, and menopause for females), the relationship between LTPA and MS was analyzed using logistic regression analysis.Results: The prevalence of MS was 22.8% in men, and 14.1% in women. Average LTPA was 1,498 kcal/wk in men, and 1,308 kcal/wk in women. After adjustment for covariates, the odds ratios of middle and low LTPA compared with high LTPA were 1.06 (0.87–1.34), 1.54 (1.08–1.75), for women, this same association was not seen in men. The prevalence of MS was 22.8% in men and 14.1% in women, and their LTPA burned 1,498 and 1,308 kcal/wk, respectively. When the odds ratio of MS for the high LTPA group was set at 1.0, the odds ratio of MS was 1.06 (0.87–1.34) in the middle LTPA group and 1.54 (1.08–1.75) in the low LTPA group in women, which showed that the MS risk increased when the LTPA was lower. This same association was not seen in men.Conclusion: LTPA was independently associated with metabolic syndrome, but only for women.

발작성 심실상성빈맥의 12 유도 심전도를 이용한 감별진단과 ST - T 파 분석의 의의

이승욱(Seung Uk Lee),조정관(Jeong Gwan Cho),류제영(Jay young Rhew),김계훈(Kye Hoon Kim),김원(won Kim),김성희(Seong Hee Kim),김준우(Jun Woo Kim),조장현(Jang Hyun Cho),안영근(Young Keun Ahn),김원영(Won Young Kim),조상기(Sang Ki Cho),정 대한내과학회 1998 대한내과학회지 Vol.55 No.2

N/A Objects: Accurate differential diagnosis of paroxysmal supraventricular tachycardia (PSVT) has become more important after introduction of curative catheter ablation technique into clinical practice. It has been reported that ST-T changes during supraventricular tachycardia are frequent, but its association is different according to the type of PSVT and the location of the AV bypass tracts. Therefore, this study was performed to evaluate the significance of ST-T changes in addition to classic ECG parameters in differentiating AV nodal reentrant tachycardia (AVNRT) and AV reentrant tachycardia (AVRT), and predicting the location of the AV bypass tracts. Methods: One hundred thirty patients presenting with narrow-QRS complex (<120 msec) regular tachycardia in whom the mechanism of the tachycardia was later confirmed as AVNRT or AVRT by electrophysiologic study (EPS) with successful catheter ablation were included in this study. Tachycardia cycle length, visible P wave, pseudo r` wave in Vl, pseudo s wave in the inferior leads, QRS altemation, ST segments depression, and T wave inversion were evaluated in the ECGs recorded during spontaneous episodes of the PSVT and compared between patients with AVNRT (n=54) and AVRT (n=76). Results: Tachycardia cycle lengths were not different between AVNRT and AVRT (355.8 ± 50.6 msec vs. 341.9 ± 51.4 msec). P wave during the tachycardia was significantly more frequently seen in AVRT than AVNRT, (72,4% vs, 9.3%, p<0.0001). However, pseudo r` wave and pseudo s wave were significantly more frequent in AVNRT than AVBT (59.3% vs. 7.9%, 33.3% vs. 1.3%, respectively, p<0,0001). QRS alternation was significantly more frequent in AVRT than AVNRT (342% vs. 11.1%, p<0.05). ST segment depression ≥1 mm was observed in 27.8% of AVNBT and 79.9% of AVBT (p<0.001). T wave inversion was more frequent in AVRT than AVNRT (30.3% vs. 7.4%, p<0.01). ST depression ≥2mm was observed in 76.9% of the left posterior pathways, 28.1% of the left anterolateral pathways, 66.7% of the right posterior pathways, and 1.1% of the right anterior pathways. Sensitivity, specificity, and positive predictive value in differentiating AVRT from AVNRT with visible p wave were 72%, 91%, and 92%, respectively : 78%, 72%, and 80%, respectively with ST segment depression ≥1 mm, and 30%, 93%, and 85%, respectively with T wave inversion. In differentiating AVNRT from AVRT, Sensitivity, Specificity, and positive predictive value of pseudo r' wave and pseudo s wave were 59%, 92%, 84%, respectively and 33%, 99%, 94%, respectively. Sensitivity, specificity, and positive predictive value in distinguishing posterior location from anterior location of the pathways were 74%, 76%, and 72%, respectively with ST segment depression (≥2mm) and 46%, 83%, and 70%, respectively with T wave inversion. Conculsions : ST Segment depression during PSVT can be used complementally to the classic ECG parameters in the differential diagnosis of PSVT and predicting the location of the AV bypass tracts.

pT2 담낭암 환자의 임상양상 및 장기생존에 영향을 미치는 예후인자

강신용(Shin Yong Kang),이선기(Seon Ki Lee),김종렬(Jong Yeol Kim),황윤진(Yoon Jin Hwang),김동선(Dong Sun Kim),김성희(Sung Hee Kim),김상걸(Sang Geol Kim),윤영국(Young Guk Yeun) 한국간담췌외과학회 2008 한국간담췌외과학회지 Vol.12 No.3

Purpose: The prognosis of gallbladder carcinoma is unfavorable, and the depth of invasion, the T-factor, is the most important prognostic factor. T2 tumors are not easily diagnosed preoperatively, and they have unpredictable behavior. In this study, we reviewed the clinicopathologic features of pT2 gallbladder carcinoma and identified prognostic factors. Methods: We enrolled 64 pT2 gallbladder carcinoma patients who underwent surgery in Kyungpook National University Hospital between January 1992 and July 2006. The clinicopathologic features were retrospectively reviewed, and univariate and multivariate analyses were performed using the Kaplan-Meyer method and Cox regression hazard model to identify factors influencing long-term survival. Results: Twenty-one patients (32.8%) were asymptomatic, with seven tumors (10.9%) found incidentally. The gallbladder body was the most commonly involved site (45.3%, 29/64). Although CA19-9 was not sensitive, it was helpful for predicting recurrence. The 5-year diseasespecific survival rate in R0 resection was 75.9%, whereas no patients in the R1 or R2 resection groups survived more than 18 months.횼one of the clinicopathologic factors was prognostic. The unfavorable prognostic effect associated with lymph node involvement highlights the importance of complete lymph node dissection. Partial liver resection favorably affected survival, but not to a statistically significant degree. Conclusion: Absence of symptoms and specific imaging findings in patients with considerable pT2 gallbladder carcinoma warrants high disease suspicion, and every effort should be taken to achieve R0 resection with extensive lymph node dissection, since it may improve long-term survival in pT2 carcinoma patients.

DNA 교차오염 방지기능이 있는 single-tube nested reverse transcription-polymerase chain reaction을 이용한 돼지생식기호흡기증후군바이러스 유전형 감별진단

정필수 ( Pil Soo Jeong ),박수진 ( Su Jin Park ),김은미 ( Eun Mi Kim ),박지영 ( Ji Young Park ),박유리 ( Yu Ri Park ),강대영 ( Dae Young Kang ),차현욱 ( Hyun Ouk Cha ),이경기 ( Kyoung Ki Lee ),김성희 ( Seong Hee Kim ),박최규 ( Choi 한국가축위생학회 2016 韓國家畜衛生學會誌 Vol.39 No.2

In the study, we developed and evaluated a uracil N-glycosylase (UNG)-supplemented single-tube nested reverse transcription-polymerase chain reaction (UsnRT-PCR) assay that can carried out first-round RT-PCR and second-round nested PCR in a reaction tube without reaction tube opening and can simultaneously detect EU- and NA-PRRSV. The UsnRT-PCR confirmed to have a preventing ability of mis-amplification by contamination of pre-amplified PRRSV DNA from previous UsnRT-PCR. Primer specificities were evaluated with RNAs extracted from 8 viral strains and our results revealed that the primers had a high specificity for both genotypes of PRRSV. The sensitivity of the UsnRT-PCR was 0.1 TCID50/0.1 mL for EU- or NA-PRRSV, respectively, which is comparable to that of previously reported real time RT-PCR (RRT-PCR). Clinical evaluation on 110 field samples (60 sera and 50 lung tissues) by the UsnRT-PCR and the RRT-PCR showed that detection rates of the UsnRT-PCR was 70% (77/110), and was relatively higher than that of the RRT-PCR (69.1%, 76/110). The percent positive or negative agreement of the UsnRT-PCR compared to RRT-PCR was 96.1% (73/76) or 90.9% (30/33), showing that the test results of both assays may be different for some clinical samples. Therefore, it is recommend that diagnostic laboratory workers use the two diagnostic assays for the correct diagnosis for the relevant samples in the swine disease diagnostic laboratories. In conclusion, the UsnRT-PCR assay can be applied for the rapid, and reliable diagnosis of PRRSV without concerns about preamplified DNA carryover contamination that can occurred in PCR process in the swine disease diagnostic laboratories.

DNA 교차 오염 방지 기능을 가진 돼지 인플루엔자바이러스 감별진단용 one-step multiplex RT-PCR 진단법

김희정 ( Hee Jung Kim ),김은미 ( Eun Mi Kim ),신연경 ( Yeun Kyung Shin ),송재영 ( Jae Young Song ),김성희 ( Seong Hee Kim ),이경기 ( Kyoung Ki Lee ),이명헌 ( Myoung Heon Lee ),김영화 ( Young Hwa Kim ),박준철 ( Jun Cheol Park ) 한국동물위생학회 2014 韓國家畜衛生學會誌 Vol.37 No.4

In this study, we developed a cost and time saving one-step multiplex RT-PCR for the simultaneous detection and differentiation of swine influenza viruses (SIV) and 2009 pandemic influenza H1N1 virus (pH1N1). The one-step multiplex RT-PCR using four sets of primer was confirmed to be capable of detection of all SIV subtypes and differential diagnosis of major SIV subtype H1, H3 and pH1N1 on individual or mixed viral culture samples. The sensitivity of the multiplex RT-PCR was determined to be at least 2-6 HA/25 μL of the presented SIVs, providing sufficient efficacy for a routine SIV monitoring in diagnostic laboratories. In addition, compared with the conventional RT-PCR methods that cannot avoid the carryover DNA contamination, the developed RT-PCR applied with the uracil DNA glycosylase (UNG) system was proven to prevent a false positive reaction by carryover contamination of the pre-amplified DNA. In conclusion, the one-step RT-PCR with UNG system could be applicable to detect and differentiate of SIV from the viral cultures without worry of carryover DNA contamination in clinical laboratories.

중년 여성에서 당대사에 따른 내장지방 및 대퇴부 지방면적의 변화

이종호,윤지영,김병구,박기문,김성희,이현철,허갑범 대한비만학회 1996 The Korean journal of obesity Vol.5 No.1

Visceral fat accmulation, adjusted for age and overail degree of obesity, is a significant correlate of glucose tolerance and constitutes an independent risk factor for the development of NIDDM. However, feimoral fat has been suggested to buffer or ameliorate the adverse effects of abdominal adipose tissue. The purpose of this study was to evaluate contributions of regional adipose!I.ssue to serum glucoise-insulin homeostasis in 56 subjects with normal glucose tolerace(NGT), 21 IGT and 44 N1DDM patients. Associations between regional fat distribution and serum lipid and hormonal concentrntions were also analyzed. Anthtopometric parameters, fasting serum levels of iipids, sex hormone-binding globulm(SHBG), testosterone, and growth horrnone were measured. An oral glucose tolerance test(OGTT), and computed tamography measurements at umbilicus and thigh midway between the patella and pubis were performed. Normal weight(wt) subjects were divided into 2 groups; NGT and tong term NIDDM and overwt obese subjects into 4 groups; NGT, IGT, newly-onset NIDDM and long-term NIDDM. Visceral fat per kg body wt was higher in overwt-obese control than normal wt controt and higher in long-terrn NIDDM patients than controls. The progression from normal to glucose iotolerance and NIDDM was associated with a decrease in femoral fat and an increase in glucose and free fatty acid areas during OGTT. Insulin response area was the highest in IGT group and the lowest ie normal wt subjects with NIDDM. Serum triglyceride level was high in overwt-obese subjects with long-term NIDDM. Serum levels of SHBG growth hormone were lower in overwt- obese contral than norrnal wt controt. IGT snd NJDDM patients showed a decrease m serum levels of SHBG and growth honnone compared with the normal wt control. In this study, NIDDM patients showed visceral fat accumuiation and decreased fernora1 fat. This abnormal fat distribution in diabetic female subjects may be related to endocrine perturbations, including decmased growth harmone, hyperandrogenicity and low insulin secretion. These changes in fat distribution and hormones in NIDDM patients may cause dyslipidemia and a further increase in the levels of blood glucose and free fatty acid.