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손정일 ( Chong Il Sohn ),김명곤 ( Myeong Kon Kim ),이기창 ( Kee Chang Lee ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),배상철 ( Sang Cheol Bae ),유대현 ( Dae Hyun Yoo ),김성윤 ( Seong Yoon Kim ),정화순 ( Wha Soon Chung ) 대한류마티스학회 1994 대한류마티스학회지 Vol.1 No.1
호산구 증가증의 원인은 기생충 감염, 알레르기, 약제, 교원성 질환, idiopatic hypereosinophilic syndrme 등에서 나타나며 류마티스 관절염에서는 약 10%의 환자에서 호산구 증가증을 보인다고 한다. 류마티스 질환에서 호산구 증가증은 류마티스 관절염, 다발성 동맥염 및 혈관염, 유육종증 둥과 연관되고 idiopathic hypereosinophilc syndrme이나 골수 증식성 질환, 호산구성 백혈병 등과 감별을 요하며 집중적으로 추적 관찰해야 한다. 저자들은 53세 여자 환자에서 지속적이고, 심한 호산구 증가증이 동반된 류마티스 관절염 환자를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Eosinophilia is usually accompanied by parasite infestation, allergic condition, drug, collagen disease, and idiopathic hypereosinophilic syndrome. In about 10 to 40% of rheumatoid arthritis patients, peripheral blood reveals eosinophilia. Of the rheumatic disease, eosinophilia may occur in rheumatoid arthritis, sarcoidosis, polyarteritis nodosa and other vascultis. Patient with eosinophilia must be carefully followed up due to possibility of progression to eosinophilic leukemia or myeloproliferative disease. We experienced a case of rheumatoid arthritis with severe eosinophilia for a period of more than one year in a 53 year-old female patient, eosinophil more than 85% in the peripheral blood, but in spite of careful laboratory study, there was no evidence of parasite infestation, allergic disease and malignant condition that may cause eosinophilia. Therefore we concluded that her severe eosinophilia was associated with rheumatoid arthritis itself, and now she is intensively followed up at the outpatient department. We have to look for any malignant transformation during her clinical course. Marked eosinophilia associated with rheumatoid arthritis is very rare, so we report this case with a review of literatures.
우종신 ( Jong Shin Woo ),김명곤 ( Myeong Kon Kim ) 대한내과학회 2009 대한내과학회지 Vol.76 No.6
Acute coronary syndrome (ACS) represents a broad spectrum of ischemic myocardial events, including unstable angina, non-ST elevation myocardial infarction, and acute ST elevation myocardial infarction, which are associated with high morbidity and mortality. Early diagnosis and risk stratification are essential for initiation of optimal medical and invasive management. Randomized clinical trials over the past decade have revolutionized the care of patients with ACS. Therapeutic measures consist of administration of aggressive antiplatelet, antithrombotic, and antiischemic agents. In addition, patients with high-risk features, notably positive troponin, ST segment changes, and diabetes, benefit from early invasive intervention as compared to conservative strategies. Lifestyle interventions, modification of risk factor profile, and long-term medical treatment are of pivotal importance in reducing the long-term risk of recurrence. (Korean J Med 76:661-676, 2009)
김용숙 ( Yong Sook Kim ),박인규 ( In Kyu Park ),권진숙 ( Jin Sook Kwon ),정명호 ( Myung Ho Jeong ),김명곤 ( Myeong Kon Kim ),안영근 ( Young Keun Ahn ) 한국조직공학과 재생의학회 2009 조직공학과 재생의학 Vol.6 No.1
재생능과 분화능이 뛰어난 줄기세포를 이용한 심혈관질환의 치료효과에 대한 연구는 재생의학 분야에서 활발히 진행되고 있으나, 치료효과를 극대화하기 위하여 적합한 줄기세포의 종류, 이식 방법, 이식 시기 등과 같은 프로토콜의 표준화가 필요하다. 동물모델을 이용한 연구에서 드러난 문제점의 하나가 이식 세포의 생존률과 회귀능이 낮다는 점이다. 이러한 문제점을 극복하고 줄기세포 자체의 장점을 최대화하기 위하여 유전자 도입이나 싸이토카인을 이용한 세포 전처리 등 다양한 방법이 시도되고 있어 향후 더욱 안전하고 효율적인 세포의 최적화가 가능할 것으로 사료된다.
이정균,이재웅,이방헌,김정현,김순길,임헌길,강석민,김명곤 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.2
The population of elderly patients in the Korea with symptomatic coronary artery disease continues to increase. Although coronary artery bypass graft has been shown to prolong life in these patients and to relieve symptoms to a degree similar to that in younger patients. For this reason, percutaneous transluminal coronary angioplasty (PTCA) is a potentially attractive and less invasive alternative to bypass surgery in elderly patients. So our study was done to evaluate the efficacy of percutaneous transluminal coronary angioplasty in elder coronary artery disease patients. Patients were grouped as group1 (age below 49), group 2 (age 50-64) and group3 (age over 65)for the consecutive patients who underwent coronary angiography and PTCA from Sep. 1994 to Mar. 1996. Unstable angina was more frequent and the intervention rate was higher in the elderly patients. The overall initial success rates of percutaneous transluminal coronary angioplasty for the group 1,2 and 3 were 89.2%, 90.7% and 95.1% respectively. We concluded that percutaneous transluminal coronary angioplasty was an effective therapeutic modality for elderly patients.
일란성 쌍생아와 모친에서 가족적으로 발생한 전신적 홍반성 낭창
김태환,정성수,유대현,김성윤,이인홍,이숭환,남승우,박문향,이재영,김명곤,전재범,배상철 대한내과학회 1996 대한내과학회지 Vol.50 No.6
Systemic lupus erythematosus is an autoimmune disease characterized by the production of variety of autoantibodies, especially antinuclear antibodies, with a diverse array of multisystem inflammatory destructions. However, the etiology of lupus has remained elusive. The interpretation of heterogeneity of systemic lupus erythematosus has suggested that different genetic and environmental components might play a role in the development of this disease, The recognition that familial lupus and increased concordance rate in monozygotic twins suggest the possible important role of genetic components. In this paper, we describe a familial systemic lupus erythematosus in monozygotic twins and their mother, with literature review for possible genetic factors that involving pathophysiology of systemic lupus erythematosus.