A Study of Physiological Activities of the Thermal Treated Eggplant on the Skin

김란,Kim, Ran The Korean Society for Biotechnology and Bioengine 2016 KSBB Journal Vol.17 No.3

The purpose of the present research was to investigate the physiological activities of the thermal treated eggplant on the skin. Five minute of thermal treatment at $100^{\circ}C$ had the highest polyphenol content of eggplant. However, below and over 5 min of thermal treatment time, they did not increase. When water and ethanol extracts were used, the maximum DPPH radical scavenging activities were obtained, 66.3 and 62.8%, respectively. Among various extracts, the acetone extract gave the highest cosmetic activity. Especially, when acetone extract (15.0 mg/mL) was used, the maximum inhibition activities of tyrosinase, elastase, and collagenase were obtained, 83.4, 78.2 and 62.5%, respectively. These results suggest the anti-wrinkle and whitening and effects of acetone extract were excellent. Therefore, it is should be considered as a promising candidate for novel cosmetic agents.

만성 폐쇄성 폐질환자의 자가간호와 자기효능감 및 사회적지지와의 관계

김란이(Kim, Ran-I),용진선(Yong, Jinsun) 한국간호교육학회 2005 한국간호교육학회지 Vol.11 No.2

Keratitis, Ichthyosis, and Deafness(KID) 증후군 1례

김란,이동환,Kim, Lan,Lee, Dong Hwan 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.11

저자들은 어린선과 과각화증의 특징적인 피부 소견과 결막염, 청력 소실로 KID 증후군이 진단된 환자에서 심한 성장 장애와 담즙 정체, 단백뇨가 동반된 1례를 경험하였기에 이를 보고하는 바이다. KID syndrome was named after the initials of the major three symptoms of the disease; keratitis, ichthyosis, and deafness. The syndrome was first introduced by Dr. Burns in 1915 who described one of his patients with those symptoms. In 1981, Dr. Skinner and his colleagues reported 17 patients who had keratitis, ichthyosis, and deafness. They also called the disease KID syndrome for the first time. After that, there have been only 60 cases of KID syndrome reported. KID syndrome may be presented with neurosensory deafness, vascularizing keratitis and such skin disorders as ichthyosis, ichthyosiform skin eruptions, and alopecia. Also, those with KID syndrome may suffer from repetitive infections, dental affections, hypohidrosis, growth delay and hepatic and renal abnormalities. The authors report the first case of KID syndrome in Korea with some references. The patient presented with keratitis, neurosensory deafness, and such characteristic skin disorders as ichthyosis and hyperkeratosis.

패션점포에서 감성마케팅과 비주얼 머천다이징이 소비자태도에 미치는 영향

김란임 ( Ran Im Kim ),이승희 ( Seung Hee Lee ) 한국패션비즈니스학회 2013 패션 비즈니스 Vol.17 No.1

The purpose of this study was to classify consumer`s attitude at fashion store and analyze the relationship between emotional marketing and visual merchandising. Questionnaires were administered to 20-30 young consumers at fashion store in 20-30s who live in Seoul and Daegu. Data were analyzed by using frequency, factor analysis. reliability analysis, correlation analysis, regression analysis, multiple regression analysis, mediated regression analysis, analysis of variance, T-test one way ANOVA. The results are as follows. First, emotional marketing had an effect on positive emotional response at fashion store. Second, visual merchandising had an effect on positive emotional response at fashion store. Third, emotional marketing and visual merchandising had an effect on positive relationship. Forth, positive emotional response had an effect on positive consumer`s attitude. Lastly, emotional marketing and visual merchandising had an effect on positive consumer`s attitude. The result of this study suggests to the fashion business that well managed various emotional response factor, positive emotional experience and desirable visual merchandising are necessary.

Prognostic Significance for Long-Term Outcomes Following Radical Prostatectomy in Men with Prostate Cancer: Evaluation with Prostate Imaging Reporting and Data System Version 2

김란,김찬교,Jung Jae Park,Jae-Hun Kim,Seong Il Seo,Seong Soo Jeon,Hyun Moo Lee 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.2

Objective: To retrospectively determine whether the use of the Prostate Imaging Reporting and Data System (PI-RADS) version 2 (v2) helps predict long-term outcomes for prostate cancer (PCa) patients following radical prostatectomy (RP). Materials and Methods: A total of 166 patients with localized PCa evaluated with multiparametric magnetic resonance imaging (mpMRI) at 3T before RP were enrolled. Three groups were created based on PI-RADS v2 score used to predict clinical outcomes: group A, ≥ 3; group B, ≥ 4; group C, 5. We calculated biochemical recurrence-free survival (RFS) and progressionfree survival (PFS). Cox proportion hazards models were used to identify variables predictive of biochemical recurrence and disease progression. Results: During a median follow-up of 9.1 years, biochemical recurrence occurred in 67 patients (40.4%) and disease progression occurred in 55 patients (33.1%). In all groups, 10-year RFS and 10-year PFS were significantly lower for PI-RADS scores ≥ 3, ≥ 4 and 5 than for score < 3, < 4 and < 5 (p < 0.05), respectively. In multivariate analysis, PI-RADS score ≥ 3 and score 5 were significant independent risk marker for biochemical recurrence (hazard ratio [HR] = 5.58, p = 0.018; HR = 1.75, p = 0.033) and disease progression (HR = 3.99, p = 0.047; HR = 2.31, p = 0.040). Moderate inter-observer agreement was seen for PI-RADS scoring. Conclusion: PI-RADS v2 may be used to predict long-term outcomes following RP in PCa.

스테로이드 충격요법 후 재발된 국소성 분절성 사구체 경화증에서 혈장반출법의 치료 효과

김란,김은미,Kim Lan,Kim Eun-Mi 대한소아신장학회 2003 Childhood kidney diseases Vol.7 No.1

목적 : 국소성 분절성 사구체 경화증은 치료에 잘 반응하지 않고, 장기적 예후가 좋지 않은 것으로 알려져 있다. 저자들은 스테로이드 충격 요법 후 괄목할만한 관해율의 향상을 보였으나 다시 스테로이드 저항성을 보이거나 스테로이드 의존성을 보인 환자 4명을 대상으로 혈장반출법, 스테로이드 충격 요법 및 immunoglobulin 병행치료의 효과를 알아보고자 본 연구를 시행하였다. 대상 및 방법 : 1988년 3월부터 2002년 7월까지 국소성 분절성 사구체 경화증이 확진된 환자중 스테로이드 충격 요법을 시행 후 스테로이드 의존성 혹은 저항성을 보였던 4명의 환자를 대상으로 총 8회의 혈장 반출법을 시행하고 후향적 방법으로 치료 효과를 평가하였다. 결과 : 총 4명의 환자 중 남자는 3명, 여자는 1명이었다. 4명의 환자에서 총 8회의 혈장반출법을 시행하여 모두 관해가 왔으며 이중 두 명의 환자에서 두 번씩의 재발이 있어 각각 2회씩의 혈장 반출법을 다시 시행하여 2명 모두 관해가 왔으나 한 명에서는 이후 2회의 재발이 있어 경구 스테로이드를 투여하여 관해를 보였다. 이들 환자들은 발병 이후 현재까지 3명의 환자에서는 10년 이상, 한 명의 환자는 5개월간 추적 관찰중으로 혈중 크레아티닌과 사구체 여과율은 정상을 유지하고 있다. 결론 : 스테로이드 의존성 또는 저항성 국소성 분절성 사구체 경화증 환자를 대상으로 혈장 반출법, 스테로이드 충격 요법 및 immunoglobulin의 병행 치료는 완전 관해를 이루고, 정상 신장 기능을 유지하는데 효과가 있다고 사료된다. Purpose : Focal segmental glomerulosclerosis(FSGS) is known to have a poor prognosis and a poor response to treatment. We performed a combination therapy of plasmapheresis, steroid pulse and immunoglobulin in 4 patients with relapsed steroid dependent(SD) or steroid resistant(SR) FSGS after steroid pulse therapy. Materials and Methods : 8 cycles of plasmapheresis were performed in 4 patients with biopsy proven FSGS who had relapsed after steroid pulse therapy from March 1988 to July 2002. Clinical findings and treatment courses were reviewed retrospectively. Results : Among the 4 patients, there were 3 males and 1 female. After 8 cycles of plasmapheresis, clinical remissions were obtained. Two of the four patients had two relapses and received 2 more cycles of plasmapheresis which resulted in remissions. One of these patients had two further relapses and was treated with oral steroid resulting in clinical remission. Three patients have maintained normal serum creatinine level and glomerular filtration rates during the follow-up period of 10 years, and the other 1 patient for 5 months. Conclusion : A combination therapy of plasmapheresis, steroid pulse and immunoglobulin led to a complete remission in patients with FSGS who were SD or SR and was effective in maintaining normal renal function.

일반논문 : 중학교 과학과 교육과정(제 6차~2009 개정) 변화에 대한 과학교육전문가, 현직교사 및 예비교사들의 인식 분석

손연아 ( Yeon A Son ),김란이 ( Ran I Kim ),남믿음 ( Mid Eum Nam ),손에녹 ( E Nok Son ),문성채 ( Sung Chae Moon ),김동렬 ( Dong Ryeul Kim ) 인하대학교 교육연구소 2014 교육문화연구 Vol.20 No.4

본 연구의 목적은 중학교 과학과 교육과정의 총론 및 각론을 제 6차부터 2009 개정까지 비교분석하고, 분석 결과를 과학교육전문가, 현직교사와 예비교사들에게 제시하여 이들의 교육과정에 대한 인식을 조사하고 차기 교육과정을 위한 시사점을 도출하는데 있다. 연구 결과는 다음과 같다. 첫째, 총론 부분에 대한 인식 분석 결과, 교육과정 성격이 변화가 거의 없음, 새롭게 추가된 용어에 대한 설명 및 근거 제시 필요, STEAM을 통한 타학문간의 통합성 강조, 탐구활동의 강조 등의 측면에서 바람직한 점과 문제점들을 제안하였다. 둘째, 각론은 ``교육목표``, ``교수학습방법``, ``학습 내용``, ``평가`` 측면에서 과학교육전문가, 현직교사와 예비교사들의 인식을 알아보았다. 우선 각론의 교육목표에 대해서는 총론과 각론의 연계성 부족, 실제 수업에서의 구현 방법에 대한 설명 부족, 일상생활과 연관된 문제해결력 강조 등 3가지 측면에서 논의점을 제시하였다. 각론의 교수학습방법에 대해서는 교수·학습 방법에서 강조하는 활동이 어떤 목표와 연관되는지 설명 부재, 학생중심 수업활동 강조, 통합과 융합 강조, 교사의 수업전문성 필요 등 4가지 측면에서 바람직한 점과 문제점을 제시하였다. 각론의 학습 내용 부분에 대해서는 과학사의 도입 및 적용, 단원 구성, 학습량과 연계성에 대한 문제에 대해서, 그리고 각론의 평가 부분에 대해서는 평가 방법 및 영역의 다양성 강조, 평가의 신뢰도와 타당도, 진로지도와 창의성 평가의 어려움, 자유탐구 평가의 어려움, STEAM에 대한 평가 기준 및 방법의 부재 등 5가지 측면에서 논의점을 제시하였다. The purpose of this study was to comparatively analyze the contents of general and particular theories from the 6th middle school science curriculum to the 2009 revised one and to draw implications for the next curriculum by investigating science education experts and in-service and pre-service teachers` perceptions of the analysis results. The results of this study can be summarized as follows; Firstly, as a result of analyzing their perceptions of general theories, there was hardly change in the character of curriculum, and they found it necessary to explain newly-added terms and give logical reason for them. Besides, they suggested desirable things and problems in the aspect of emphasizing the integration between science and other academic fields through STEAM and emphasizing inquiry activities. Secondly, this study investigated science education experts and teachers` perceptions of particular theories in the aspects of ``educational objective``, ``teaching & learning methods``, ``learning contents`` and ``evaluation``. The educational objectives of particular theories were discussed in such 3 aspects as ``the lack of connectivity between general theories and particular theories``, ``the lack of explanation about how to implement in actual class``, and ``emphasis on the problem-solving ability related to daily lives``. The teaching & learning methods of particular theories were discussed in such 4 aspects as ``the absence of explanation about what goals a certain activity emphasized by teaching & learning methods is connected to``, ``emphasis on student-centered class activities``, ``emphasis on integration and convergence``, and ``need for teachers` class professionalism``. The learning contents of particular theories were discussed in the aspects of ``introduction and application of the history of science``, ``chapter organization`` and ``learning amount and connectivity``. Lastly, for the evaluation of particular theories, this study suggested 5 things to discuss, ``emphasis on the diversity of evaluation methods and domains``, ``reliability and validity of evaluations``, ``future career guidance``, ``difficulty of creative evaluations``, ``difficulty of free inquiry evaluations`` and ``the absence of evaluation standards and methods for STEAM``.

재독 한국인 간호사들의 사회적 지지, 직무만족도 및 소진과의 관계연구

김란(Kim, Ran),김창숙(Kim, Chang Sook),김영재(Kim, Young Jae),박인순(Park, In Soon),박명희(Park, Myung Hee) 한국간호교육학회 2003 한국간호교육학회지 Vol.9 No.2

계면활성제가 모발 염모제의 산성 염료에 미치는 영향

김란(Ran Kim),장미화(Mi Haw Chang) 한국디자인문화학회 2015 한국디자인문화학회지 Vol.21 No.2

국내시장에서 국산제품보다 외국 브랜드 염모제의 판매량이 더 높아 현실적으로 화학적 염모제를 사용할 수밖에 없는 상황이다. 이 상황에서 모발 염모제 제형화시 화학 성분 함유량을 낮게 낮추고, 여러 가지 화학 첨가물을 최소화하는 것이 필요하다. 또한 유해 성분 사용을 금지하고, 염색성을 향상시키는 방법을 연구해서 모발 염모제의 안정성을 높이는 것이 바람직하다고 생각한다. 본 연구는 밀링형 산성 염료 중에서 Disazo계 산성염료인 C.I. Acid Red 114을 선정한 후 모발 염모제인 산성 염모제를 제형화 하려고 한다. 산성 염모제를 제형화 시킬 때 다양한 첨가물이 들어가는데 그 중에서 계면활성제에 대한 효과를 검토하고자 한다. 가장 우선적으로 산성 염료로 모발 염모제 제형화시 사용된 염료의 최대흡수파장 λmax과 구조를 확인하기 위해서 FT-IR분석, UV-Vis 흡수스펙트럼 분석을 해보았다. FT-IR분석에 의해 염료의 구조를 확인 하였으며 용매로는 benzyl alcohol (C6H5CH2OH)를 사용하였다. 계면활성제의 종류에는 양이온 계면활성제, 음이온 계면활성제, 비이온 계면활성제를 첨가하여 모발의 염색성을 검토하였다. 실험 결과 산성 염료에서는 양이온 계면활성제가 염색성이 우수하였다. 또한 양이온 계면활성제를 농도 별로 염색을 실시하여 농도가 0.15%∼0.2% 첨가하였을 때 가장 염색성이 우수함을 알았다. 산성 염료는 염료분자가 커서 모발 깊숙이 침투하지 못하고 모발 표면에 흡착하여 세정 견뢰도가 낮아서 여러 가지 계면활성제를 가지고 세정 견뢰도를 실험한 결과 양이온 계면활성제가 다른 계면활성제 보다 우수하였다. 그 이유는 양이온 계면활성제가 염료와 반응하여 모발의 표면에 염착되어 모발과의 염착력을 증가시키고 모발과 염료간의 이온 결합력을 증가시키기 때문이라고 추측할 수 있다. Because foreign brands hair dyes outsell domestic products in the domestic market. so we cannot help using chemical hair dyes. Therefore, when hair dyes is formulated, it is required that content of chemical composition lower its content and minimize many chemical additives. Also, harmful ingredients are prevented and it is desirable that stability of hair dyes become high through improving dyeing property. In the present study, the milling acid dyes, such as C.I. Acid Red 114 was chosen to approach the appropriate conditions for Acid Dyes. When surfactants was added in the bath, the uptake of C.I. Acid Red 114 was increased dramatically. the surfactant was used as a cationic surfactant, an anionic surfactant, a noninoic surfactant. The chemical structures of dyestuffs were characterized by UV and FT-IR analysis. The maximum absorption wavelength determined by the UV-visible spectrum were 620㎚ for the respective dyestuff of C.I. Acid Red 114. Dyeing is a cationic surfactant was the most effective. As the concentration of cationic surfactant increased from 0.15% up to 0.2% the dye adsorption. Acid dyes low in washing fastness of the dye molecule cursor, as a result of the washing fastness test with a surfactant, the cationic surfactant is a high fastness. The behaviour is explained by the cationic surfactant access to the hair surface in advance of the dye molecules which then improve affinity of the dye molecules in hair surface.

우리춤 체조가 여성노인의 신체적 건강, 자기효능감 및 스트레스에 미치는 영향

김란(Ran Kim),박인순(In-soon Park),박명희(Myung-hee Park) 대한환경위생공학회 2009 대한환경위생공학회지 Vol.24 No.4

The purpose of this study was to identify the effect of Korean traditional dance exercise on physical health (BMI; body mass index, BP; blood pressure, VC; vital capacity, TC; total cholesterol, HDL; high-density lipoprotein, TG; triglyceride), self-efficacy and stress in elderly women. A quasi-experimental research design(one group pretest and posttest) was used for this study. Participants were recruited in a metropolitan city and a total of 43 community dwelling elderly women completed the 12-week Korean traditional dance exercise program. Descriptive statistics and paired t-tests were used in the data analysis by SPSS/WIN 12.0. After the Korean traditional dance exercise program there was a significant difference in BMI, VC, TC, HDL, stress and self-efficacy. There were, however, no significant changes in BP, and TG level after completing this program. This study suggests that Korean traditional dance exercise may be one of the effective nursing interventions for elderly women.