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The Effect of LIF on Prolactin Production in vitro Decidualizing Human Endometrial Stromal Cells
구미경 ( Mi Kyung Koo ),( Jung Hye Hwang ),( Hee Sun Kwon ),( Jung Han Lee ),( Seung Ryong Kim ),( Moon Il Park ),( Sung Ro Chung ),( Hyung Moon ),( Youn Young Hwang ),( Il Kyu Park ) 대한산부인과학회 2002 대한산부인과학회 학술대회 Vol.88 No.-
상피성 난소암 환자에서 복수 내 p53 자가 항체의 임상적 의의
구미경(Mi Kyung Koo),김경태(Kyung Tai Kim),황윤영(Youn Yeung Hwang),구인상(In Sang Ku),강정권(Jung Kweon Kang),이영미(Young Me Lee),조삼현(Sam Hyun Cho) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.3
N/A Objectives: A study was to assess the prognostic significance of ascitic anti-p53 autoantibodies in patients with advanced ovarian carcinoma. Methods: Retrospective study was peformed in 43 ovarian carcinoma patients who presented with a significant amount of ascites at the Department of Obstetrics and Gynecology in Hanyang University Hospital between 1991 to 2000. p53 autoantibodies were determined by highly specific enzyme-linked immunosorbant assay (p53-Autoantibody ELISA plus , CAT#QI A53, A CN Bioscience Company , Boston). The 'positive' and 'egative' group were categorized on the basis of the presence of anti-p53 autoantibodies. The clinicopathologic characteristics, disease free survival and overall survival rate in each groups were compared. Statistical analysis was performed by χ2 and independent sample t-test Result: Ascitic anti-p53 autoantibodies were found in 16%(7/43)of the study patients. The positive rates were revealed as follows: serous 15%(2/13), mucinous 11%(2/17),undifferentiated,42%(3/7)in histologic type ;stage I/II5%(1/21), III/IV/IV27%(6/16); grade I/II 12%(3/26), III 24%(4/17).There was no correlation between clinicopathologic characteristics and the presence of ascitic anti-p53 autoantibodies except the stage of disease. The overall survival rate revealed no significant statistical meaning (20.0 vs 35.7 months,p=0.492).In contrast, disease free survival rate was decreased in positive group.(10.0 vs 24.7 months, p=0.032).A significance association was observed between presence of ascitic anti-p53 autoantibody and response to chemotherapy. Ascitic anti-p53 autoantibodies were detected in only 3 (16%)of 18 patients who achieved pathological partial and complete response, but it was detected in 3 (75%)of 4 patients who did not respond to chemotherapy (p=0.046). Conclusion: The presence of p53 autoantibodies in ascites is tend to be associated with advanced stage and poorly differentiated group. A significant correlation was observed between presence of ascitic p53 autoantibodies and decrease in disease free survival rate suggesting that it is related to poor prognosis. Moreover, presence of ascitic p53 autoantibodies was also related to chemoresistance. But since this study is retrospective and based on very limited case, further study is warranted to be performed prospectively and based on larger number of study group.
구미경 ( Mi Kyung Koo ),김현희 ( Hyun Hee Kim ),조삼현 ( Sam Hyun Cho ),김승룡 ( Seung Ryong Kim ),조수현 ( Su Hyun Jo ),김경태 ( Kyung Tae Kim ),문형 ( Hyung Moon ),황윤영 ( Yoon Yoong Hwang ),김경헌 ( Kyung Hyun Kim ),유중배 ( 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.3
N/A Objective : Our purpose was to determine the effect of epidural analgesia on the first phase of labor and mode of delivery of nulliparous women. Methods : We studied 170 nulliparous women at near-term who underwent spontaneous and induced labor at the Department of Obstetrics and Gynecology, Hanyang University Hospital from January 1999 to May 2000 prospectively. Eighty women who were received epidural analgesia for pain relief were compared to ninety women as control group. Cesarean delivery was performed when indicated. Results : The demographic characteristics of the two groups were similar with respect to age, height, weight, gestational weeks, and gravida. The two groups had the same cervical dilatation at the time of analgesia. There were no statistically significant difference between two groups. The length of the first phase of labor was same between two groups(558.4±50.4 min. vs 452.1±46.7 min.). There were statistically significant differences in the instrument delivery and cesarean section rate between two groups(43 vs. 32, 8 vs. 16 respectively). Conclusion : Epidural analgesia provides safe and effective intrapartum pain control and may be administered without undesirable effects on the first phase of labor and delivery.
추시개복술상 양성으로 확인된 난소암에서 항암화학요법 후 발생된 난소부전에서의 정상분만
구미경(Mi Kyung Koo),조삼현(Sam Hyun Cho),조수현(Su Hyun Jo),김승룡(Seung Ryong Kim),문형(Hyung Moon),황윤영(Yoon Yoong Hwang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4
We report a successful pregnancy in a woman who at the age of 31years received chemotherapy for mucinous cystadenocarcinoma of the right ovary. She was treated with multiple chemotherapy including cis-platinum, cyclophosphamide, adriamycin, and oral melphalan. She had microscopic residual cancer at the opposite ovary at second-look laparotomy. She developed secondary amenorrhea with symptoms of menopause after commencing treatment which persisted on its completion. Biochemical investigations were consistent with ovarian failure, which was assumed to be chemotherapy-induced. She was given hormonal replacement therapy with a conjugated equine estrogen/medroxyprogesterone acetate combination, resulting in regular withdrawal bleeding. The patient conceived 5 years after completing chemotherapy and gave birth a normal infant at term.
선행 제왕절개술 후의 질식 분만 - 10 년간의 연구 -
나영정(Young Jeong Na),구미경(Mi Kyung Koo),박문일(Moon Il Park),김경태(Kyung Tai Kim),정성로(Sung Ro Chung),황윤영(Youn Yeung Hwang),문형(Hyung Moon),이유경(Yoo Kyoug Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.3
N/A Objective: Recently, enormous amount of the studies about trial of labor after cesarean section has been reported to decrease the rate of cesarean section. This study focused on analyzing multiple variables and results to acknowledge the safety and complications of VBAC (vaginal birth after cesarean section). Methods & materials: This study was performed based on 97 pregnant women who were tried vaginal delivery after cesarean section at Hanyang University Hospital from January 1990 to December 1999.The age of mother, gestational age, estimated fetal body weight by ultrasonography, neonatal body weight, cervical dilatation, cervical effacement, Bishop score, the number of previous vaginal delivery, complications of mother, and complications of fetus were analyzed between successful group (82 patients)and failure group (15patients)with trial of labor. Student T-test and Chi-square test were used for statistical analysis. Results: In the 97 cases with trial of labor after cesarean, the success rate was 84.5%and failure rate was 15.5%. The estimated fetal body weight by ultrasonography, cervical dilatation and effacement, Bishop score, Apgar score had notable differences between successful group and failure group, while the other factors had not. There was no maternal death or uterine rupture in the cases of trial of labor. Conclusion: Trial of labor after cesarean section is relatively safe method of delivery if it is performed under strict indication. It could be suggested that VBAC has relatively little complication in both mother and fetus. The studies with large populations and performed by multi-centers will be needed for the evaluating safety of VBAC and developing safe protocols to decrease the risk of complications.
제왕절개술 후 발생한 T3 Thyrotoxicosis 1 예
성영모(Young Mo Sung),윤상순(Sang Soon Yoon),구미경(Mi Kyung Koo),황정혜(Jung Hye Hwang),박문일(Moon Il Park),정성노(Sung Ro Chung),황윤영(Youn Yeung Hwang),문형(Hyung Moon),이재웅(Jae Ung Lee),안유헌(You Hern Ahn) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.10
Thyroid storm (thyrotoxicosis) is rarely encountered during pregnancy or the puerperium, even in untreated women and characterized by hypertension, hyperthermia, and multiple systems involvement. Much more common is heart failure, apparently caused by the long-term myocardial effects of thyroid hormone and intensified by other pregnancy complications that include severe preeclampsia, infection, anemia, or combinations of these. Prompt diagnosis and treatment of thyroid storm are essential in reducing morbidity and mortality of a patient from this disorder. We experienced a case of triiodothyroxine induced thyroid storm (T3 thyrotoxicosis) developed after Cesarean section. This case highlights both physicians should be aware of the symptoms and risk factors and reversing of heart failure successfully by reducing cardiac workload is important through immediate medical treatment-adequate hydration, thermoregulation, and control of hypertension, infection and anemia et al.
한동익 ( Dong Ik Han ),구인상 ( In Sang Ku ),김성희 ( Seong Hee Kim ),구미경 ( Mi Kyung Koo ),황정혜 ( Jeong Hyae Hwang ),박문일 ( Moon Il Park ),정성로 ( Sung Ro Chung ),차경준 ( Kyung Joon Cha ),박영선 ( Young Sun Park ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.12
목적 : 성별 (sex)에 따른 태아의 차이는 고대로부터 현재에 이르기까지 많은 관심의 대상이 되어왔다. 본 연구는 선형 (linear) 및 비선형적인 (non-linear)분석 방법을 이용하여 태아심박동 (FHR)과 신생아 예후와 관련된 제 변수 등을 분석해 봄으로써 성별에 따른 태아의 행동습성의 차이를 알아보고자 시도되었다. 연구 방법 : 분만 전, 30~42주 사이에 nonstress test (NST)를 시행한 정상산모 중 분만후 태아의 성별을 Objective : The differences between two fetal sexes have been a matter of great concern from ancient times to present day. This study was initiated to research the varying fetal behaviors which would differ according to the fetal sex. Methods : With every
제대탈출증 발생 후 마취과와 소아과 의사가 없는 상황에서 수면마취를 이용한 응급제왕절개술로 성공한 태아 생존
정소은 ( So Eun Jung ),조수훈 ( Soo Hun Cho ),박선영 ( Seon Young Park ),구미경 ( Mi Kyung Koo ),이윤영 ( Yoon Young Lee ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.6
Umbilical cord prolapse is a rare obstetric emergency that requires an expeditious delivery for fetal survival. This serious obstetrical emergency is unfamiliar to many physicians although it represents an acute emergency with high mortality. We have experienced a woman with umbilical cord prolapse and prolonged fetal heart rate deceleration who underwent an emergent cesarean section under use of propofol and the neonate survived with resuscitation when there were no anesthesiologist and pediatrician. There were no adverse outcomes on the woman and neonate.
Holomorphic maps between compact almost Kaehler manifolds
Park, Joon-Sik,Koo, Mi-Kyung 釜山外國語大學校 1999 外大論叢 Vol.19 No.5
기하학의 변분문제를 이용한 연구로서, 긴밀캐라다양체간의 정칙사상과 조화사상과의 관련성 및 더 나아가 완비케라다양체간의 정칙사상과 조화사상간의 관련성에 관하여 연구한 결과 holomorhpic energy와 anti-holomorphic energy의 차가 음이 아닐 때 holomorphic이기 위한 필요충분조건은 anti-holomorphic임을 증명할 수 있었다.