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RISS 인기검색어
- 검색키워드
- 저자 : 이재억 ( Jae Auk Lee ) (검색결과 4 건)
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원인불명의 불임환자에서의 Transforming Growth Factor-β1, β2의 발현
황정혜 ( Jung Hye Hwang ),이재억 ( Jae Auk Lee ),장세진 ( Se Jin Jang ) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.12
Objectives: The purpose of this study was to determine the differences of immunohistochemical localization of TGF-β1 and TGF-β2 in the human endometrium of fertile and infertile patients. Methods: We have studied the expression of TGF-β1 and TGF-β2 in the human endometrium of fertile and infertile patients by immunohistochemical staining method. Results: In the women with unexplained infertility, TGF-β1 and TGF-β2 were not expressed in the epithelial and stromal cells during the whole menstrual phase. But in epithelial cells of the fertile women, TGF-β1 was moderately expressed in the secretory phase and TGF-β2 was moderately expressed in the proliferative and secretory phase. In stromal cells of the fertile women, TGF-β1 and TGF-β2 were not expressed in the proliferative and secretory phase, that are similar to the results of unexplained infertility. There are significant differences in the expression of TGF-β1 and TGF-β2 between infertile and fertile patients, especially in the secretory phase of epithelial cells. Conclusions: These findings suggest that the absence of expression of TGF-β1 and TGF-β2 during the menstrual phase in women with unexplained infertility may have a negative effect on implantation and cell differentiation, and could result in ``incomplete`` embryo-maternal recognition, a possible consequence of which may be implantation failure.
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부인암 환자의 항암화학요법시 발생된 백혈구 감소증에 대한 Granulocyte-Colony Stimulating Factor의 임상 효과
문형,노재숙,조삼현,황윤영,이재억,김경태 대한부인종양 콜포스코피학회 1994 Journal of Gynecologic Oncology Vol.5 No.1
The recent introduction of chemotherapy in the treatment of gynecological malignancies has gained wide acceptance along with prstoperative and prostperative adjuvant therapy and with preradiation and concurrent chemoradiation therapy. But, the side effects of chemotherapy including bleeding and infection due to, bone marrow suppression have reaulted in delayed treatment and a reduction in the chemotherspeutic agent used. Recent efforts overcome this bone marrow suppression have led to development of the various human colony-stimulating factor indluding recombinant granulocyte colony-stimulating factor. The author investigated the clinical benefita and toxicity of G-CSF used during chemotherapy of various gynecological malignancies at the Departent of Obstetrics & Gynecology at Hanyang University between August, 1991 and July, 1992. The results were as follows ; 1. An increase in the number of neutrophils follwings a single injection of G-CSF was noted in 19 out of 21 cases(600~1,000/㎣ before injection, 4,500!12,000/㎣ after injection). The remaining 2 cases showed an increase after3~5 continuous injections. 2. To assess the increase in neutropjils according to the dosage of G-CSF given, 100 and 300㎍/㎡ of G-CSF were injected in each trial of chemotherapy in a single case of ovarian cancer. The results were a 1.5 time increase when injected when injected with 300㎍/㎡ 3. After injecting into a patient with recurrent endometrial cancer who was managed with 15gm of ifosfamide, 50gm of cis-platimun, 50gm of adriamycin and 3gm of mesna following surgery, no evidence of neutropenia could be found after 4days of prophylactic G-CSF injections. 4. Patients with cervix cancer with metastasis to the lung were first treated with GM-CSF in one trial and G-CSF in the nest. Patients treated with GM-CSF for a period of 7 days showed leukocytosis(3,600./㎣) but the number was reduced to 1,400/㎣ after 7 days. On the other hand, patients treated with G-CSF showed an increase of 5,700/㎣ within one day and this figure did not dicrease until 20 days later. 5. The toxic effects of G-CSF inclued one case of severe back pain was esily managed by administration acetaminophen. Ohters were headache, chills, general weakness and redness of the oral mucosa and injection area. Most of the theses symptoms disappeared within 2 days. the G-CSF is effective in neutropenia during chemotherapy thereby decreasing the incidence of treatment delay or dose reduction. It also increases the amount of chemotherapeutic agent administered and its toxicity is more tolerable making a rigid systemic chemotherapeutic regime possible
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