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뇌졸중(腦卒中) 전조증상(前兆症狀)으로서의 현훈(眩暈)에 대한 설문조사분석(設問調査分析)
고성규,용형순,Ko, Sung-Gyu,Yong, Hyung-Soon 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.1
Objective : This study has been made to analysis of clinical type of vertigo prodromic Cerebral Vascular Disease in stroke patients who admitted to sangji oriental hospital department of circulatoty internal medicine in the period from July. 1999 to October 1999. Methods : A Questionaire was done after explanationin details to patients and agreement of patients. The inquire was done as follows. Sex and age, risk factor of stroke, type of stroke, existence of vertigo last three years before stroke attack, the beginning age of vertigo and period of prevalence, frequency, continuance time of vertigo, predilection season and time, factor of causing vertigo, accompanying symptoms of vertigo, severity of vertigo. Result and Conclusion : The existence of Rotation sense(Rotation group and non-Rotation group) and the type of Stroke is no difference significantly but the Rotation vertigo group and non-Rotation vertigo group is difference significantly in distribution. The sixties in age of vertigo attack, previous vertigo before 3 year Stroke attack, irregular in predilection season of vertigo, have a high frequency significantly in distribution and previous period of vertigo has no significantly difference in distribution. One or two per a month in frequency of vertigo, below 5 minute in continuance time of vertigo, irregular in predilection time of vertigo, stand up and sit down in causing vertigo position have a high frequency significantly in distribution.
비주얼 씽킹을 활용한‘우리 몸의 구조와 기능’수업이 초등학생의 자기주도학습, 창의적 문제해결력 및 과학적 태도에 미치는 효과
고성규 ( Sung Gyu Ko ),홍승호 ( Seung-ho Hong ) 한국생물교육학회 2021 생물교육 Vol.49 No.4
This study developed a ‘structure and function of our body’ program using visual thinking and applied it to analyze the effect on elementary school students’ selfdirected learning skills, creative problem solving ability and scientific attitude. The results of the program using visual thinking to sixth-grade students are as follows. First, the ‘structure and function of our body’ program using visual thinking is effective in improving the sixth graders’ selfdirected learning skills. In the sub-elements, the experimental group was significantly improved in intrinsic motivation, openness, and autonomy. We inferred that the intrinsic motivation has increased because they worked on learning in an acceptable atmosphere by organizing the contents the topic through drawing activities. In the process of sharing each other's drawing outcomes, they acknowledged each other's opinions and openly accepted others' opinions. And autonomy was improved in the process of learners planning and organizing their own learning. Second, there was no significant difference in understanding, diffusion, criticism, and motivation in the sub-elements, although it had a significant impact on improving the total score of their creative problem solving ability. Third, the program had a significant impact on improving scientific attitude. Cooperation increased in the process of communicating and discussing what they organized on their own. Therefore, the program using visual thinking learning strategies demonstrates that the approach might be effective in improving elementary school students' self-directed learning skills, creative problem solving ability, and scientific attitude.
갈근탕이 고지방 식이 유발 백서 모델에 미치는 항비만 효과
기성훈 ( Sung Hoon Ki ),김호준 ( Ho Jun Kim ),고성규 ( Seong Gyu Ko ),송윤경 ( Yun Kyung Song ) 한방재활의학과학회 2016 한방재활의학과학회지 Vol.26 No.2
Objectives To investigate anti-obesity effects of Galgeun-tang, an herbal formula, in high fat diet induced obese mice model. Methods 24 Male C57Bl/6J mice were randomly assigned to normal group fed with normal research diet (NOR, n=6), high fat diet control group treated with water (HFD, n=6), high fat diet group treated with Orlistat (ORL, n=6, Orlistat 10 mg/kg), and high fat diet group treated with Galgeun-tang (GGT, n=6, Galgeun-tang 700 mg/kg). 12 weeks later, body weight, fat weight, liver weight, blood glucose, total cholesterol, triglyceride, HDL, ALT, AST, obesity related neuropeptides and adipokines, ratio of gut microbiota, and histopathology of liver were evaluated. Results In the GGT group, 1. body weight gain, liver weight gain, and total fat weight gain were significantly less than those in the HFD group. 2. blood glucose level was significantly lower and insulin level was significantly higher than in the HFD group. 3. total cholesterol level and triglyceride (TG) level were significantly lower and high density lipoprotein (HDL) level was significantly higher than in the HFD group. 4. appetite-promoting ARC neuropeptides such as Agrp and Npy were significantly less and appetite-inhibiting ARC neuropeptide, Cart was significantly more than in the HFD group in qRT-PCR analysis. 5. adiponectin level and visfatin level were significantly higher, and resistin level and leptin level was significantly lower than in the HFD group. 6. the relative level of Bacteroidetes was significantly higher, and the relative level of Firmicutes was significantly lower than in the HFD group. 7. the increase of adipose tissue was significantly more inhibited than in the HFD group. Conclusions The present study showed that Glageun-tang exerts anti-obesity effects in that it. 1. inhibited the increase in body weight, liver weight, and total fat weight. 2. decreased the level of TG, and increased the level of HDL. 3. influenced neuropeptides and adipokines that are important in regulating food intake and changes of body weight. 4. modified the beneficial quantitative changes in gut microbiota suppressing the tendency toward obesity. (J Korean Med Rehab 2016;26(2):13-28)
갈근탕이 고지방 식이 유발 비만 쥐에서 비만 관련 유전자 발현에 미치는 영향
예성애 ( Sung Ae Ye ),김호준 ( Ho Jun Kim ),고성규 ( Seong Gyu Ko ),송윤경 ( Yun Kyung Song ) 한방재활의학과학회 2016 한방재활의학과학회지 Vol.26 No.2
Objectives The purpose of this study was to evaluate anti-obesity effect of Galgeuntang (gegentang) and elucidate the effect of it on gene expression related to obesity. Methods The experiments were performed with the use of Diet-Induced Obese mice. They were grouped NC (normal control), HFD (high fat diet control), GGT (Galgeun-tang (gegentang), 700 mg/kg), ORL (Orlistat, 10 mg/kg). GGT was orally administered for 12 weeks. Body weight was measured every week. Real-time PCR was performed to investigate the effect of GGT on gene expression in liver tissue. Results GGT group and ORL group were reduced in body weight compared with HFD. HFD increased PPARγ, SREBP-1, Leptin, aP2, FATP1, FAS gene expression compared with NC. GGT increased FATP1 gene expression. But GGT reduced PPARγ & FAS gene expression in liver tissue of diet-induced obese mice compared with HFD. Conclusions These results suggest that GGT is supposed to have a certain impact on the treatment of obesity. But more study is needed in the future. (J Korean Med Rehab 2016;26(2):1-12)
최근 보건의료분야에서 활발하게 연구되고 있는 "Epigenetics"란 무엇인가? -기본개념 및 기전을 중심으로-
이선동,박성균,고성규,신헌태,김명동,Lee, Sun-Dong,Park, Sung-Kyun,Ko, Seong-Gyu,Shin, Heon-Tae,Kim, Myung-Dong 대한예방한의학회 2010 대한예방한의학회지 Vol.14 No.2
The individual differences in disease development and susceptibility have been researched primarily on the subject of genes, environment or the interaction between genes and the environment respectively. However, there have been limitations in explaining complex diseases, and the differences in health and diseases in monozygotic and dizygotic twins. Fortunately, thanks to active research on the relationship between genes and the environment, and epigenetics, there has been much progress in the understanding of body's reactions and changes. Epigenetics is referred to as a study of gene expression through the interactions of DNA methylation, chromatin's histone and the change of structure in tail, RNA editing without any change in DNA sequence. In this paper, we introduce the basic concepts and mechanisms of epigenetics. The result of the epigenetics is heritable ; can regulate gene expressions ; is reversible ; and has many variable forms depending on cell types. The influences of epigenetics occur throughout life, but it is mainly determined in utero during early pregnancies. Diseases occur or the risk rises if these influences continue after birth until adult life when problems occur in excess/lack of nutrition, environmental plasticity, or already inputted data. Therefore, there is a need for change and innovation, especially in interest and investment in health education for young women near pregnancies and correct treatment of epigenetic-related diseases.
지부자(地膚子)의 신생혈관 및 염증매개 단백질 발현에 미치는 영향
나상혁,신용철,고성규,Na, Sang-Hyuk,Shin, Yong-Cheol,Ko, Seong-Gyu 대한동의생리학회 2006 동의생리병리학회지 Vol.20 No.6
Hypoxia induced angiogenesis and inflammation are essential processes for metastasis and progress of solid tumors. We examined the anti-angiogenic and inflammation related activity of Kochiae Fructus (KF) extract. To investigate the roles of the KF extract, we performed MTS assay, western blots using HaCaT cells and $HepG_2$ cells. The results are as follows. The protein level of $HIF-1{\alpha}$ was reduced when induced by $CoCl_2$ in $HepG_2$ cells treated with KF extract and induced by IGF-11 in HaCaT cells treated with KF extract. KF extract reduced the mRNA level of VEGF in HaCaT cells and KF extract reduced the protein level of iNOS in HaCaT cells. These results suggest that KF extract contributes to the anti-angiogenic and anti-inflammatory activities and also we could assume that KF extract act as antioxidant or anti-inflammatory agents via reduction of $HIF-1{\alpha}$.