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용형순,고성규,Yong, Hyung-Soon,Ko, Seong-Gyu The Society of Internal Korean Medicine 2004 大韓韓方內科學會誌 Vol.25 No.3
Objective : 황금의 유방암세포주에 대한 항암효과 및 기전에 대한 연구는 아직 미흡하며, 특히 에스트로젠리셉터를 가지지않은 유방암세포주인 MDA-MB-231에 대한 효과 및 기전에 대한 연구는 아직 발표된바 없어, 이에 대한 연구가 진행되었다. Methods : 인간 유방암세포주 MDA-MB-231 MTT assay를 이용 성장방해비율을 조사하였으며. FACS analysis를 이용 cell cycle analysis를 시행하였고, Western Blot Analysis 및 Annexin V analysis를 시행하였다. Results : MDA-MB-231에 대한 황금의 IC50는 180 ug/ml 이었으며 최대 세포성장억제효과는 $500{\mu}g/ml$로 한약재중 비교적 강한 세포독성을 보여 주었다. 유세포분석 에서 황금 $500{\mu}g/ml$의 농도를 72시간 투여한 경우 세포사멸(Sub Gl) 분율이 대조군의 1.7%에 비해 21%로 높아 현저한 용량의존적인 세포사멸현상을 보여주었으며, 세포사멸을 보다 명확히 규명할 수 있는 Annexin V analysis에서도 황금 $200{\mu}g/ml$농도일때 48시간에서 17%의 뚜렷한 세포사멸효과를 나타내었다. 한편 세포사멸촉진인자인 Bax, 세포사멸실행단백질인자인 caspase 3의 활성과 PARP의 분할은 세포사멸이 세포주기정지와 더불어 세포사멸의 과정에 p53이 관여함을 알 수 있다. 앞으로의 연구는 p53발현이 다른 세포주와 각 단백질의 억제제를 통해 인과적인 관련성을 즘 더 명확히 할 필요가 있어야 할 것으로 생각되어진다. Conclusion : 유방암의 예후에 있어 호르몬치료에 부적절함으로 인해 예후가 나쁜 에스트로젠리셉터 발현이 없는 유방암에 대해서도 황금이 탁월한 항암효과를 보여주고 있으며, 임상적으로 황금단독, 다른 항암약재와의 배합, 그리고 기존의 항암화학요법이나 방사선요법과의 병용투여를 통한 초기 및 진행된 유방암의 치료에 대한 새로운 접근의 실마리를 제공할 것으로 생각된다.
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뇌졸중환자(腦卒中患者) 96례(例)에 대(對)한 임상적(臨床的) 고찰(考察)
용형순,고성규,Yong, Hyung-Soon,Ko, Seong-Gyu 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.1
This study was done with 96 cases of stroke patients who admitted to Department of the circulatory internal medicine Sang-ji University oriental Hospital from January to December in 1997. The purpose of this paper is to predict prognosis in stroke patient and to estimate change of muscle motor power between admission and discharge day in Sasang Constitution. The results are as follows. 1. Motor function of upper extremities was improved one stage at discharge day compare to admission day and the function of lower extremities had no change in muscle motor power. 2. Especially March and April had high morbidity any other months and the time of onset was most frequent on the morning. 3. They had hypertension as first preceding disease, and the next was stroke. Stroke occurred most frequently in resting, and the next was in sleeping. 4. In Sasang constitution, Taeyum-in(太陰人), 47.9%, was most neumorous, the next was Soyum-in(少陰人), 36.5%, and the third was Soyang-in(少陽人), 15.6%.
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血證에 관한 中醫學 臨床論文 分析(2) : 해혈, 육혈, 뇨혈, 혈정, 안와내출혈
정한수,용형순,부송아,고성규 대한한방성인병학회 2000 韓方成人病學會誌 Vol.6 No.1
Objective : The purpose of this study was to classify the symptoms of hyeal-jeung(血證) and analyze the tend of treatments in the chinese medical journal Method : This study referrenced the chinese medical magazine that has been published in china for two years, 1996-1997 and the data is classified by the kind of disease and is analyzed by the treatment frequency, treatment way, treatment drug, and the rate of recovery from the disease. Result : Of the hemoptysis(咳血), on the principle, recipe and medicine of treatment, clearing away lung-fire(淸肺), clearing away liver-fire(淸肝), and eliminating stasis(化瘀) was used more then hemostatic(止血). The recovery rate of hemoptysis was more efficient in the oriental-western treatment than pure oriental treatment. Of the epistaxis(??血), the overall mean rate of recovery was 96.8%, and purzing intense heat(瀉火), removing heat form the blood(양혈) and reducing fever(淸熱) was uased generally chosen other than the principle of treatment. Of the hematuria, the treatment was regard on the weakness of the spleen and stomach(脾胃具損). Of the bloody semen, the overall mean rate of recovery was 100%. Of bleeding in the eyeball, there was more efficient the oriental-western treatment than pure oriental treatment. Conclusion : Clinically we severally experienced on attack of hyeal-jeung(血證), but we have not much of data or journal related to this symptoms in our country. So, this study try to examine the symptoms of hyeal-jeung(血證) through chinese medical journal, From the above result, it was concluded that oriental medical treatments show efficient effect in treating hemorrhagic disease and it will be required more investigation of clinical examination in hemorrhagic disease in our country.
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뇌졸중(腦卒中) 전조증상(前兆症狀)으로서의 현훈(眩暈)에 대한 설문조사분석(設問調査分析)
고성규,용형순,Ko, Sung-Gyu,Yong, Hyung-Soon 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.1
Objective : This study has been made to analysis of clinical type of vertigo prodromic Cerebral Vascular Disease in stroke patients who admitted to sangji oriental hospital department of circulatoty internal medicine in the period from July. 1999 to October 1999. Methods : A Questionaire was done after explanationin details to patients and agreement of patients. The inquire was done as follows. Sex and age, risk factor of stroke, type of stroke, existence of vertigo last three years before stroke attack, the beginning age of vertigo and period of prevalence, frequency, continuance time of vertigo, predilection season and time, factor of causing vertigo, accompanying symptoms of vertigo, severity of vertigo. Result and Conclusion : The existence of Rotation sense(Rotation group and non-Rotation group) and the type of Stroke is no difference significantly but the Rotation vertigo group and non-Rotation vertigo group is difference significantly in distribution. The sixties in age of vertigo attack, previous vertigo before 3 year Stroke attack, irregular in predilection season of vertigo, have a high frequency significantly in distribution and previous period of vertigo has no significantly difference in distribution. One or two per a month in frequency of vertigo, below 5 minute in continuance time of vertigo, irregular in predilection time of vertigo, stand up and sit down in causing vertigo position have a high frequency significantly in distribution.
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강구형,용형순,정용수,고성규,박경훈,Kang, Gu-Hyeng,Yong, Hyung-Soon,Jung, Yong-Soo,Ko, Seong-Gyu,Park, Kyoung-Hoon 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.2
Cheiro-oral syndrome is characterized by a partial sensory disturbance in one hand and the ipsilateral oral comer. Its lesion is on the sensory track, and it is comparatively small. Most studies are case studies. These studies reported less than 10 cases. We studied two cases. In one, we observed intracranial hemorrhage involving left thalamus, posterior limb of internal capsule about 5cc in brain computed tomographic scan. The case was shown paresthesia of the right hand and ipsilateral comer of the mouth. The patient also complained about disturbing dysstereognosis and disorder of graphaesthesia. In the other case, we observed nodular calcification at the left basal ganglia external capsule in brain computed tomographic scan. The patient also complained about dysesthesia of the right thumb and index finger, fatigue and verbal disturbance. These cases appeared to be typical strokes in the acute phase, but after acute phase, they had dysethesia in the hand and periord for three months.
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소뇌기능이상의 임상양상을 특징으로 보인 뇌교부출혈 환자 1례
이유경,공경환,용형순,고성규,부송아,Lee, You-Kyung,Kong, Kyung-Hwan,Yong, Hyung-Soon,Ko, Seong-Gyu,Bu, Song-Ah 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.5
I experienced a case of a patient with clinical features of cerebellar dysfunction in the intracranial hemorrhage which encroached the basis of lower pontine and all parts of pontine tegmentum. So I report this case with bibliographical inquiry. In addition, I applied the treatment of Oriental medicine to sequelae of intracranial hemorrhage like disorders of eye movement, central dizziness, cerebellar tremor and ataxias but the effect did not meet my expectation. I anticipate more clinical studies and reports on this hereafter.
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