각종 간질환 환자에서 혈청 Type IV Collagen 측정

강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),박인서(In Suh Park),문영명(Young Myung Moon),한광협(Kwang Hyub Han),전재윤(Chae Yoon Chon),박찬일(Chan Il Park),박영년(Young Nyun Park),정진이(Jin Yi Chung) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.2

N/A Serum type IV collagen levels determined with one-step sandwich enzyme immunoassay using monoclonal antibodies were compared with histologic changes in the liver biopsy specimens from 95 patients with various liver diseases. Although serum type IV collagen levels were not significantly increased in patients with fatty liver and chronic persistent hepatitis compared to normal controls .serum type IV collagen levels were significantly increased in patients with chronic liver disease such as chronic active hepatitis or liver rirrhosis compared to normal controls and patients with fatty liver and chronic persistent hepatitis. According to the progression of liver disease, serum type IV collager levels wen significantly increased. In addition, all the 31 patients with chronic active hepatitis with early cirrhosis and liver cirrhosis showed elevated serum type IV collagen levels higher than mear plus one standard deviation level of controls. Serurn type. IV collagen levels did not correlate with serum transaminase levels in patients with chronic liver disease, A significant positive correlation was found between the serum type IV collagen level and the degree of fibrosis, piecemeal necrosis and portal and/or periportal inflamniation in patients with chronic active hepatitis. the results suggest that the serum type IV collagen levels correlate well with the degree of hepatir fibrosis. Therefore the measurement. of serum type IV collagen level is relatively simple and useful method to reflect the progress of hepatic fibrosis.

무균성 뇌수막염을 동반한 Ramsay Hunt 증후군 1례

연율이,최성동,정승연,서병규,강진한,Yi, Yeon Yul,Choi, Sung Dong,Jeung, Seung Yeon,Suh, Byung Kyu,Kang, Jin Han 대한소아감염학회 1997 Pediatric Infection and Vaccine Vol.4 No.2

Ramsay Hunt syndrome is a viral associated disease with severe otalgia, vertigo, fever, herpetic eruptions on either side of the external auditory meatus and cavum concha, ipsilateral facial nerve palsy and cochleovestibular dysfunction. This syndrome may be the most common cause of unilateral facial paralysis and involvement of both the vestibular and cochlear branch of 8th cranial nerve. And loss of taste sensation may be developed in same involement site. This syndrome affects adults in most cases, and a samll number of children with herpes zoster oticus have been reported. And concomittantly CNS invlovement of this snydrome is very rare. We experienced a 7 years old aged patient of Ramsay Hunt syndrome who had evidence of aseptic meningitis, and this patient showed well reponses with Acyclovir and symptomatic therapy. So, we report this case with brief review of related literatures.

폐경 전후 여성에서 요추골밀도의 예측인자

최성현 ( Sung Hyun Choi ),황다경 ( Da Kyoung Hwang ),송혜령 ( Hye Ryoung Song ),노해정 ( Hae Jeong Noh ),강진이 ( Jin Yi Kang ),최다혜 ( Da Hye Choi ),최희정 ( Hee Jeong Choi ) 대한폐경학회 2009 대한폐경학회지 Vol.15 No.2

연구목적: 이 연구는 폐경 전, 후 여성에서 요추골밀도의 예측인자를 알아보고, 이들 여성에서 낮은 골밀도 (T-score<-2.0)와 관련 있는 인자들을 조사하였다. 연구재료 및 방법: 건강 증진센터에 내원한 21세 이상의 여성 중 폐경 전 여성 1,367명, 폐경 후 여성 1,107을 대상으로 병력, 생활습관을 조사하고, 검사실검사와 요추골밀도를 측정하였다. 폐경 전 후 여성에서 요추골밀도를 예측하는 인자는 다중회귀분석을, 낮은 골밀도에 영향을 주는 인자는 로지스틱회귀분석을 이용하여 분석하였다. 결과: 폐경 전 여성에서는 요추골밀도는 신장, 체중, 체질량지수, 체지방량, 허리둘레, 수축기혈압, 맥박수, 알칼리포스파타제, 저밀도지방단백, 공복 혈당, 공복 인슐린, 호마지수, 당화 혈색소, 요산 및 호모시스테인 수치와 관련이 있었으며, 폐경 후 여성에서는 나이, 신장, 체중, 체질량지수, 체지방량, 허리둘레, 맥박수, 알칼리포스파타제, 요산 및 호모시스테인 수치와 관련이 있었다. 폐경 전 여성에서는 나이, 체중, 맥박수, 당화혈색소, 호모시스테인이 요추골밀도를 예측하는 인자였고 (R2=0.13), 폐경 후 여성에서는 나이, 체중 및 요산치가 요추골밀도를 예측하는 인자였다(R2=0.14). 낮은 골밀도를 (T-score<-2.0)와 관련이 있는 인자는 폐경 전 여성에서 나이, 체중, 맥박수, 알칼라인포스파타제 및 당화혈색소 등이었고, 폐경 후 여성에서는 나이, 체중, 알칼리포스파타제, 요산치가 낮은 골밀도와 연관이 있었다. 결론: 폐경 전 여성에서는 체중이, 폐경 후 여성에서는 나이가 요추골밀도에 있어 다른 인자들보다 중요도나 예측 정도에 있어 상대적인 영향이 더 컸을 뿐 아니라, 낮은 골밀도와도 관련이 있는 것으로 나타났다. Objectives: The objective was to determine predictors of lumbar spinal bone mineral density (BMD) in pre- and postmenopausal women. Also, we investigated factors that affect low BMD (T-score<-2.0). Methods: We analyzed the data of 2,474 women over the age of 21 who visited the Health Promotion Center. Personal and medical history was collected. Physical examination and laboratory tests were performed. LS BMD was measured using dual-energy X-ray absorptiometry. We evaluated predictors of LS BMD using multiple regression analysis. Logistic regression analysis was used to determine factors affecting low BMD. Results: In premenopausal women, LS BMD was correlated with height, weight, body mass index (BMI), body fat%, waist, systolic blood pressure, pulse rate, alkaline phosphatase (ALP), low density lipoprotein cholesterol, fasting glucose, insulin, HOMA-IR, HbA1C, uric acid, and homocysteine levels. In postmenopausal women, LS BMD was correlated with age, height, weight, BMI, body fat%, waist, pulse rate, ALP, uric acid, and homocysteine levels. Among premenopausal women, age, weight, pulse rate, HbA1C, and homocysteine levels were predictors of LS BMD (R2=0.13) and among postmenopausal women, age, weight, and uric acid levels were predictors (R2=0.14). Factors affecting low BMD were age, weight, pulse rate, ALP, and HbA1C in premenopausal women, and age, weight, ALP, and uric acid in postmenopausal women. Conclusion: In premenopausal women, weight was a major predictor of LS BMD. On the other hand, age was the strongest predictor of LS BMD in postmenopausal women.

내시경직시하 세침흡인세포진검사로 진단된 상부위장관종양

신현승,강진경,박인서,문영명,정재복,박찬일,송시영,정진이,임현이 대한소화기내시경학회 1993 Clinical Endoscopy Vol.13 No.2

The endoscopic fine needle aspiration cytology may add to the diagnostic accuracy of endoscopic biopsy and brush cytology. It is also of particular value in submucosal, infiltrative and ulceronecrotic tumors. Endoscopic fine needle aspiration cytology was done with sclerotherapy needle(23 gauge) in. the 17 patients with submucosal tumor(18 cases), extrinsic compression(2 cases), infiltrative gastric cancer(one case) and cancer of the ampulla of Vater(one case) on the upper gastrointestinal endoscopy. Endoscopic fine needle aspiration cytology established the diagnosis in 6 cases(submucosal tumor of the stomach; 2 cases, submucosal tumor of the duodenum; one case, extrinsic mass of the duodenum; one case, infiltrative cancer of the stomach; one case, and the cancer of ampulla of Vater; one case) of 17 cases. There were negative results for malignancy in 7 cases and material insufficiency in 4 cases. Five cases of the positive results with endoscopic fine needle aspiration cytology were not diagnosed with endoscopic forceps biopsies. There was no complication. We conclude that endoscopic fine needle aspiration cytology is a simple and safe technique and is of particular value in submucosal tumor, extrinsic compression of the upper gastrointestinal tract by tumor, and infiltrative gastric cancer.

자연소실된 원발성 식도 악성 림프종 1예

김원호,강진경,조장환,박인서,문영명,함기백,박찬일,임대순,신용준,임현이 대한소화기내시경학회 1993 Clinical Endoscopy Vol.13 No.2

Gastrointestinal involvement has been reported to occur in about 5 to l0% of patients with lymphoma. The most common gastrointestinal site for a lymphoma is the stomach, followed by the small intestine and ileocecal region. When lymphoma is found in the esap us, generally it is with contiguous involvement of the gastric fundus, the cervical node, secondary to mediastinal lymph node compression, or a late manifestation of advanced desease. Such cases cannot be labeled as primary esophageal lymphoma. A search of the literature reveals that there have been about 20 or more published cases classified as esophageal lymphoma. However, more than ten cases are indistingishable from the case of distal esophageal involvement by gastric lymphoma. In 1935, Chiolero described a case of midesophageal stricture, which at autopsy was consistent with Hodgkin's disease for the first time. Berman reported an authentic case of primary histiocytic lymphoma confined to the lower esophagus. Only six or more cases were reported in literature until the present time. Here, a 30-year-old man with substernal discomfort was shown to have a mass lesion on the esophagus. The mass was proved to be malignant lymphoma on the histologic examination. This may be the first report dealing with spontaneous regression of maligant lymphoma of the esophagus possibly associated with the use of cimetidine.

정기검진자중 추가검사 및 자료를 권고받은 대상자의 순응도

윤경아,강진이,조정진 대한가정의학회 1998 Korean Journal of Family Medicine Vol.19 No.3

중년 남성에서 생활 습관과 생물학적 지표의 변화가 혈중 지질 농도에 미치는 영향

조정진,강훈일,윤영호,강진이 대한가정의학회 2000 Korean Journal of Family Medicine Vol.21 No.6