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방사성폐기물드럼 핵종분석에서 감마선 감쇠보정 방법들의 비교 평가
지영용,유영걸,곽경길,강덕원,김기홍,Ji Young-Yong,Ryu Young-Gerl,Kwak Kyoung-Kil,Kang Duck-Won,Kim Ki-Hong 한국방사성폐기물학회 2006 방사성폐기물학회지 Vol.4 No.3
In the measurement of gamma rays emitted from the nuclide in the radioactive waste drum, to analyze the nuclide concentration accurately, it is necessary to use the proper calibration standards and to correct for the attenuation of the gamma rays. Two drums having a different density were used to analyze the nuclide concentration inside the drum in this study. After carrying out the system calibration, we measured the gamma rays emitted from the standard source inside the model drum with changing the distance between the drum and the detector. The measured values were corrected with the three kinds of gamma attenuation correction methode, as a results, the error was less than 10 % in the low density drum and less than 25 % in the high density drum. The measured activity in the short distance was more accruable than in the long distance. The transmission correction for the mass attenuation showed good results(very Low error) compared to the mean density and the differential peak correction method.
전혈 , 림프구와 백혈구 연층 각각의 방사성 동위원소 체외 조사후 배양을 이용한 생물학적 선량측정
김종호,이동수,최창운,정준기,이명철,고창순,김종순,김희근,강덕원,송명재 ( Jong Ho Kim,Dong Soo Lee,Chang Woon Choi,June Key Chung,Myung Chul Lee,Chang Soon Koh,Chong Soon Kim,Hee Geun Kim,Duck Won Kang,Myung Jae Song ) 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.1
The purpose of this study was to establish mononuclear cell cultures such as lymphocytes or buffy coat for the biological dosimetry of in vitro irradiation of the radionuclide Tc 99m in order to exclude the effect of residual doses seen in the cultures of whole blood. Biological dosimetry of Tc-99m on cultured mononuclear cells at doses ranging from 0.05 to 6.00 Gy, by scoring unstable chromosomal aberrations(Ydr) observed in cultured lymphocytes, were performed using peripheral venous blood of healthy normal person. The results showed that; (1) Jn vitro irradiation of radioisotope in separated lymphocyte or buffy coat showed trace amount af residual doses of isotope after washing. Residual doses of isotopes are increased in proportion tn exposed time and irradiated dose without difference between I-131 anct Tc 99m. (2) We obtained these linear-quadratic dose response equations in lymphocyte and buffy coat culture after in vitro irradiation of Tc-99m, respectively (Ydr = 0,001949 D+ 0,006279B+ 0.000185; Ydr= 0.002531 D 0.003274 D+0.003488). In aonclusion, the linear quadrstic dose response equation from in vitro irradiation of Tc 99m with lymphocyte and buffy coat culture was thought to be useful for assessing Tc 99m indueed biological effects. And mononuclear cell cultures seem to be the most appropriate experimental rnodel for the assessment of biological dosimetry of internal irradiation of radionuclides.
방사성옥소 투여에 따른 말초혈액 림프구 수의 변화 및 염색체이상 빈도의 관찰
김종순(Chong Soon Kim),한승수(Seung Soo Han),김희근(Hee Geun Kim),강덕원(Duck Won Kang),송명재(Myung Jae Song),구천희(Chun Hee Koo),신민호(Min Ho Shin),박영주(Young Ju Park),이정임(Jung Yim Lee),박태용(Tae Yong Park),이재용(Jae Yong 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.3
N/A Background: For biological dosimetry of radiation exposure, both observing hema-tologic change and calculating Ydr by chromgsomal analysis as biological indicators are widely used. However, due to the lack of studies on biological dosimetry of radiation dose absorbed in the body such as in the cases of radioactive iodine therapy, the maximal and safe dose is not well known, nor is the extent to which the body can safely endure radiation exposure. Purpose: To investegate the practical applicability of hematologic changes and Ydr as an indicator for estimating radiation exposure, to patients with thyroid diseases after doses of radioactive iodine. Material and Methods: 5 patients with hyperthyroidism and 35 patients who have had thyroid cancer operation were under treatment with radioactive iodine, changes in number of lymphocytes were tracked and Ydr was calculated for more than 2 months by chromosomal analysis in peripheral lymphocytes. Results: 1) The number of lymphocytes began to decrease 2 weeks after doses of radioactive iodine, and reached the nadir after 6 and 8 weeks, then gradually recovered. 2) The nadir count of lymphocytes was reversely correlated with the administered dosage of radioactive iodine. 3) Ydr was generally stable between 2 and 8 weeks. 4) The maximal value of Ydr was correlated with the administered dosage of radioactive iodine. 5) Ydr value at the 2nd week increased with augmented dosage of radioactive iodine. 6) Ydr value at the 2nd week was correlated with fall of lymphocyte count. Conclusion: Patients must be closely observed, because temporary bone marrow suppression and slight chromosomal aberration can be produced by even generally used dosages of radioactive iodine for diagnosis and therapy. Maximal percent fall of lymphocyte count, Ydr at the 2 week interval and maximal Ydr can be used as the biological predictor of administered dosage of radioactive iodine.
갑상선암 환자에 대한 방사선옥소 치료시 물리적 선량 측정
고창순(Chang Soon Koh),이명철(Myung Chul Lee),김종순(Chong Soon Kim),김희근(Hee Geun Kim),강덕원(Duck Won Kang),송명재(Myung Jae Song),김명선(Myung Seon Kim),정내인(Nae In Jeong),이재용(Jai Yong Lee),김종호(Chong Ho Kim) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.1
N/A Radioactive iodine has been widely used in patients with thyroid cancer combined with surgical treatment. However, due to individual variations in absorption and excretion and uptake by tumor tissue of radioactive iodine, there are differences in therapeutic effect and adverse effects even if the same doses are administrated. So this study compared the therapeutic effect and radiation hazard by measuring internal radiation dose. Of total 27 patients with well differentiated thyroid cancer who had been thyroidectomized, we administered radioactive iodine 100 mCi, 150 mCi, 200 mCi. According to BEL DOSIMETRY PROTOCOL, beta and gamma ray dose were estimated from a polt of the logarithrn of the percent of dose per liter of whole blood versus day, and percent dose retained versus day using semilogarithmic paper, respectivel y. 1) Physical dose to whole blood averaged 56.54+13.02 rad in 100 mCi administered group, 76.83+ 19.97 rad in 150 mCi administered group, 95.08 +- 25.51 rad in 200 mCi administered group and there has been a significant correlation among the groups. 2) Mean percent dose retained 48 hours later was 26.34%. 3) There was no significant correlation of physical dose between absence and presence of metastasis. 4) l7 of 19 patients who has been followed up with TSH and serum throglobulin, Thallium scan were successfully ablated by radioactive iodine. 5) Leukocyte, lymphocyte, neutrophil, platelet counts all declined in 4-6 weeks and most of all were restored 3 months 1ater. 6) There was no significant correlation between physical dosimetry and biologic dosimetry. Generally administered doses of radioactive iodine (100-200 mCi) to patients with thyroid cancer postoperatively had developed transient bone marrow suppression and minimal chromosomal aberration, but they were within safety dose to blood (200 rad). And there has been no significant differences in residual dose 48 hours later between Korean and western people.
김종순(Chong Soon Kim),김은실(Eun Sil Kim),한승수(Seung Soo Han),김희근(Hee Geun Kim),강덕원(Duck Won Kang),송명재(Myung Jae Song),이재용(Jae Yong Lee),정내인(Nae In Jeong),이명선(Myung Soon Kim),서두선(Doo Seon Seo),노승익(Seung Ik 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.1
N/A Recently, there are many considerations and studies on biological effects of radiations in radiation workera, as well as in accidentally or therapeutically irradiated persons. The most practical and reliable method of dosimetry for radiation accidents is the scoring of gross chromosomal aberrations in human lymphocytes (Ydr) as a biological dosimetry. By the way, although usual doses of 131I administered therapeutically for thyroid cancer are ranging from 100 mCi to 200mCi, there are differences of absarbed doses and Ydr, ranging from 0.004 to 0.04, on equally administered 131I due to variations in metabolic characteristics, stage of tumors and physical status of subjects. In this study, We exert to obtain the dose-response relationships of 131I, as a good guide to evaluating acute effects of accidental irradiations and radiation induced leukemia or solid tumor, by in vitro induction of chromosomal aberrations. we studied the relationship between radiation dose <D) and the frequency of chromosomal aberrations (Ydr) obserbed in peripheral lymphocytes that were irradiated in vitro with 'I at doses ranging from 0.05 to 6.00 Gy. By scoring cells with unstable chromosomal aberrations (dicentric chromosomes and ring chromosomes) we obtained this linearquadratic dose response equation Ydr=0.064351 D 0.13143 D+0.045684 This dose-response relationship may be useful for evaluating acute and chronic I induced biological effects.
홍원표,양현수,강 용,강덕원 忠南大學校 産業技術硏究所 1988 산업기술연구논문집 Vol.3 No.1
With the growing need of the country's electrical energy from nuclear power generation, the technical importance on the load following has been widely recognized. The load following is being executed by two modes, Boron Regeneration System(BRS) and Boron Thermal Regeneration System(BTRS). Especially, the function of BTRS is solely relied on the efficient use of Boration/dilution in strongly basic resin bed. Therefore, the most influential factors to be investigated in load following operation is to determine the effect of boron concentration in burn-up reactivity and to find the way how to improve the BTRS in order for reusing all the reactor cooling water contaminated by radioactive wastes. This study is mainly devoted to the following purposes : (1) Evaluation of operation data in nuclear power plant about the relation of burn-up reactivity and boron dilution/ boration in BTRS. (2) Diagnostic suggestion on the solving problems in operation of Demineralizer(exchange resin bed).