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김종순(Chong Soon Kim),김은실(Eun Sil Kim),한승수(Seung Soo Han),김희근(Hee Geun Kim),강덕원(Duck Won Kang),송명재(Myung Jae Song),이재용(Jae Yong Lee),정내인(Nae In Jeong),이명선(Myung Soon Kim),서두선(Doo Seon Seo),노승익(Seung Ik 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.1
N/A Recently, there are many considerations and studies on biological effects of radiations in radiation workera, as well as in accidentally or therapeutically irradiated persons. The most practical and reliable method of dosimetry for radiation accidents is the scoring of gross chromosomal aberrations in human lymphocytes (Ydr) as a biological dosimetry. By the way, although usual doses of 131I administered therapeutically for thyroid cancer are ranging from 100 mCi to 200mCi, there are differences of absarbed doses and Ydr, ranging from 0.004 to 0.04, on equally administered 131I due to variations in metabolic characteristics, stage of tumors and physical status of subjects. In this study, We exert to obtain the dose-response relationships of 131I, as a good guide to evaluating acute effects of accidental irradiations and radiation induced leukemia or solid tumor, by in vitro induction of chromosomal aberrations. we studied the relationship between radiation dose <D) and the frequency of chromosomal aberrations (Ydr) obserbed in peripheral lymphocytes that were irradiated in vitro with 'I at doses ranging from 0.05 to 6.00 Gy. By scoring cells with unstable chromosomal aberrations (dicentric chromosomes and ring chromosomes) we obtained this linearquadratic dose response equation Ydr=0.064351 D 0.13143 D+0.045684 This dose-response relationship may be useful for evaluating acute and chronic I induced biological effects.