1,5-Diphenylhydantoins을 위한 새로운 Methyl α-Anilinophenylacetate 유도체의 합성

권순경,최희전,박명숙 德成女子大學校 藥學硏究所 2001 藥學論文誌 Vol.12 No.1

For the development of new COX-2 inhibitor, novel key intermediates (2∼4) synthesized through esterification, bromination and α-substitution from phenylacetic acid. The methyl phenylacetate 2 was synthesized through reflux phenylacetic acid with sulfuric and methanol. The methyl α-bromophenylacetate 3 was produced through radical bromination using N-bromosuccinimide from 2. The optical amination to introduce anilino group was contolled under 80℃ in DME. The bromo intermediate was converted to the final methyl α-anilinophenylacetate 4 through reaction with aniline.

Ethyl 2-Methyl-3-Pyrazinyl-3-oxopropionate의 합성과 케토-엔올 토토머화현상

권순경,박명숙,박해선 德成女子大學校 藥學硏究所 2002 藥學論文誌 Vol.13 No.1

Ethyl 2-methyl-3-pyrazinyl-3-oxopropionate is a key intermediate for the development of new drugs and can be synthesized through Claisen condensation from methyl pyrazine carboxylate and ethyl propionate. Even though in β-diketones esters in general the amount of enol form present at equilibrium is far higher than keto form, this key compound showes that the keto concentration is high. It can be explained because of the electron-releasing effect of α-methyl group.

아동의 인터넷 활동 및 선호에 대한 조사 : 연령과 성 차이를 중심으로 Differences between grades and gender

권민균,최명숙 한국아동교육학회 2004 아동교육 Vol.13 No.2

본 연구는 게임, 채팅, 정보검색 및 학습의 다양한 활동을 제공하는 인터넷에 대한 초등학교 아동의 활등 빈도, 선택양식, 인터넷 활등 선호도를 조사한 연구이다. 초등학교 저학년 하동 334명을 대상으로 인터넷 활동빈도, 활동선택, 인터넷 활동 선호도를 조사하였다. 조사결과 인터넷의 다양한 활동 중 일상생활에서 게임을 선택하는 경우가 가장 빈번하였고 이러한 현상은 2학년보다는 3학년이, 여아보다 남아에게 더 분명하였다. 여가로서의 게임에 대한 선호도는 남아가 여아에 비하여, 3학년이 2학년에 비하여 더 높았으며, 채팅 및 학습·정보검색에 대한 선호도는 학년 간 차이는 없으나 남아가 여아보다 높았다. 그러나 유명 사이트 접속도 및 사이트 인식 능력에서 남녀 차이가 없었다. 아동의 일상에서의 인터넷 활용의 다양화를 위한 시사점을 논의하였다. This study surveyed and analyzed elementary school students' various internet activities, internet preferences and knowledge of popular internet sites for children. The results showed that children tended to choose internet games more frequently among various internet activities and this tendency wass more prevalent with older and male children than younger and females. Internet preferences were stronger with male children than females. However, the usage and knowledge of popular internet sites for children differed with older and younger children. This study discussed the meanings of the differences of internet activities, internet preferences and knowledge of internet sites between grades and gender in terms of children's play environment, accessibility and equity to computer and internet.

Polarimeter를 이용한 Unnatural Amino Acid 유도체의 선광도 측정

박명숙,박해선,권순경 德成女子大學校 藥學硏究所 2001 藥學論文誌 Vol.12 No.1

For the development of new COX-2 inhibitor, novel unnatural amino acids, key intermediates were synthesized through induction an arylsulfonyl group to 1-position, an aralkyl group to 4-position of 4-hydroxy L-proline. The 4-aralkyloxy-1-(4-tosyl)-L-prolines 5a-d were synthesized through N-tosylation, esterification, O-alkyl-(or aryl)ation, base-hydrolysis (deprotection of carboxylic acid) from 4-hydroxy-L-proline. The optical activity of unnatural amino acids were studied how the specific rotation was related with their structure. The optical rotation of unnatural amino acids were determined by polarimeter.

인식형 청소년의 자아개념, 목표관리 및 특성불안 변화를 위한 MBTI 교육프로그램 효과 검증

김명권,심혜숙 한국심리유형학회 2000 심리유형과 인간발달 Vol.7 No.-

본 연구에서는 MBTI의 타당도를 검증하기 위하여 505 명의 피험자를 대상으로 MBTI 실시 결과와 표준화 성격진단검사 결과와의 상관분석 및 일원변량분석을 실시 하였다. 그 결과, MBTI 선호지표 중 E는 안정성, 지배성, 사회성, 남향성, 충동성, 우월성과, I는 사려성, 동조성, 임상척도 전부와, S는 책임성, 동조성과, N은 사려성과, T는 안정성, 지배성, 책임성, 사려성, 남향성과, F는 사회성, 동조성, 충동성, 신경질경향과, J는 책임성, 사려성, 동조성과, P는 사회성, 남향성, 충동성과 유의한 정적 상관을 보였다. 그리고 4 기능유형 중 ST는 책임성, 남향성이, SF는 동조성이, NT는 안정성, 지배성, 사려성, 남향성이, NF는 사회성, 충동성이 타유형에 비해 점수가 유의하게 높았다. 또한 4 기질 중 SP는 충동성, 동조성, 불안경향, 신경질경향이, J는 책임성, 동조성이 타기질에 비해 점수가 유의하게 높았으며 NT와 NF기질은 기능유형과 동일하게 나타났다. This study aimed to develop and evaluate a program focused on helping psychologically vulnerable delinquents with P preferences (perceiving types) to adjust better in the society. When a program was carried on trying to help psychologically vulnerable perceiving types to improve their ineffective adjusting behaviors, a significant short-term positive changes took place to them. Three reliable psychological scales were employed to check how much they have changed in a positive way; Tenesse Selfconcept Scale, Goal-Management Scale and Spielberger's Trait Anxiety Inventory. The affirmative changes were obtained in several subscales of the Tenesse Self-Concept Scale, such as total positive self, self-identity, self-satisfaction, physical self, moral ethical self and personal self. Goal setting and Longrange planning were enhanced on the Goal-Management Scale. Traitanxiety was moderately reduced on the Trait Anxiety Inventory. This result manifested that with the aid of properly designed programs, young people with Perceiving preference would become more satisfied with themselves and thereby come to have better selfconcepts. As they become relatively free from the distressing anxieties, their energy may be more readily available to their goal achievements helping them to live better in the society. But in some subscales, there were no statistically significant differences between two groups, therefore some reformations are needed in the program content and procedure. Several suggestions and cautions in interpreting the experiment results and applying the program in the actual situations were mentioned.

벤젠핵의 선택적 브롬화 반응 : 메틸 2-브롬화 3,4-메틸렌다이옥시 5-메톡시 벤조에이트의 합성을 위한 최적조건 Optimal Condition for Synthesis of Methyl 2-bromo-3,4-methylenedioxy-5-methoxybenzoate

박명숙,권순경 德成女子大學校 藥學硏究所 1999 藥學論文誌 Vol.10 No.1

2-Bromo monosubstituent of 3,4-methylenedioxybenzoic acids was obtained from selective bromination in the presence of bromine in glacial acetic acid. Reaction was sucessfully proceeded through stirring of glacial acetic acid after dropwise over 4 h 100mol% of bromine and acetic acid at room temperature for 18 h. 2-Position rather than 6-position of aromatic nucleus was substituted first during bromination, and thereafter 2,6-disubstituted analogue followed even though steric hindrance.

Cyclooxygenase-2 저해제로서의 benzothiazine 유도체 합성과 항염작용 평가

신혜순,박명숙,권순경 德成女子大學校 藥學硏究所 2000 藥學論文誌 Vol.11 No.1

The antiinflammatory mechanism of NSAIDs is attributed to the reduction of prostaglandin synthesis by the direct inhibition of cyclooxygenase. Inhibition of prostaglandin production in organs such as stomach and kidney can result in gastric lesions, nephrotoxicity and increased bleeding. In this study, newly designed COX-2 inhibitors, synthesized 1,2-benzothiazine derivatives, were screened in vitro for selectivity of COX-1 and COX-2 inhibition properties. Lead compounds in the structure-activity relationship were studied to synthesize new highly selective COX-2 inhibitors. To determine inhibitory effect of COX-2, synthesized 1,2-benzothiazine derivatives were screened with accumulation of prostaglandin by lipopolysaccharide (LPS) in aspirin-treated macrophages and murine macropharge cell. Some of synthesized 1,2-benzothiazine derivatives were shown to be effective as selective COX-2 inhibitory activity. Others exhibited a preferential inhibition of COX-2, although some COX-1 inhibitory activity was still present. As a conclusion, simple monomer derivatives were more active than dimer derivatives. Substitution of halogen (Br, Cl) on the benzothiazine nucleus slightly enhanced inhibition activity.

Production Process of Anthrometry, Comfort, and Ergonomics Based Glove Pattern Design for a Wearable Keyboard

( Myoung Sook Kwon ),( Gi Soo Chung ),( Min Jae Yang ) 한국의류학회 2005 한국의류학회 학술대회논문집 Vol.2005 No.-

A Comparison of Standard Methods for Evaluating the Water Resistance of Shell Fabrics

(Myoung Sook Kwon),(Youn Ja Nam) 복식문화학회 2001 Fashion, industry and education Vol.4 No.3

A Comparison of Standard Methods for Evaluating the Water Resistance of Shell Fabrics

Kwon, Myoung Sook,Nam, Youn Ja The Costume Culture Association 2001 Fashion, industry and education Vol.4 No.3

The water resistance of shell fabrics intended for use in outdoor apparel was measured using three different standard test method, ASTM D 751, hydrostatic resistance, procedure A (Mullen test - with and without a fabric support) and Procedure B (Hydrostatic head test). A database of information on their water resistance performance was created. The data collected with different methods were correlated and the advantages and disadvantages of each method were compared. The Mullen test with a support appears to give higher and more favorable water resistance value on shell fabrics preventing fabrice rupture during the test. The hydrostatic head test gave lower hydrostatic pressure values than those measured on the two Mullen tests. The Mullen test is recommended for testing the water resistance of fabrics that have a relatively high water resistance because the Mullen tester applies a wide range of pressure. The hydrostatic head test is recommended for testing the fabrics that have relatively low water resistance. The area of the fabric sample that is in contact with the water is smaller in the Mullen test, so higher pressure levels can be reached and more samples should probably be tested to get a representative value for each fabric type. Futhermore, the hydrostatic head test was deemed more repeatable than the Mullen tests in this study.