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A 90-day Repeated-Dosed Toxicity Study of Euphorbiae kansui radix Extract in Fischer 344/N Rats
Zhong-Ze Han,Hu-Song Zhang,Ki-Hyun Gil,Joo-Young Lee,Kwang-Han Kong,Myoung-Kyu Han,Hyun-Ju Yang,Hak-Soo Kim,Do-Hyung Kim,Tae-Hwan Ahn,Jin-Sook Bae,Hyun-Kyu Ko,Jung-Woon Lee,Moon-Soon Kim,Si-Whan Song 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.4
This study was performed to evaluate repeated-dose toxicities of Euphorbiae kansui radix extract in F344/N rats. Euphorbiae kansui radix extract was administered orally to rats at dose levels of 0, 37, 111, 333, 1,000 and 2,000 ㎎/㎏/day. Each group consisted of 10 rats of each gender. The Euphorbiae Kansui, Radix extract was given once a day, 5 times a week, for 90 day repeatedly. This study was conducted in accordance with the Protocol of Korea National Toxicology Program (issued by National Institute of Toxicological Research) and The Standards of Toxicity Study for Medicinal Products (issued by Korea Food and Drug Administration). In the present study, there were no dose-related changes in mortality, clinical signs, body weights, ophthalmoscopy, urine analysis, hematological findings, estrus cycle and sperm examination of all animals treated with Euphorbiae kansui radix extract. There were increases of liver weights in 2,000 ㎎/㎏/day groups of males and in 333, 1,000 and 2,000 ㎎/㎏/day groups of females. There were decreases of alkaline phosphatase levels in 1,000 and 2,000 ㎎/㎏/day groups of both sexes. These results suggest that the oral no-observed-adverse-effect level (NOAEL) of the test item, Euphorbiae kansui radix extract, in rats is 2,000 ㎎/㎏/day in both genders; no-observed-effect level (NOEL) is 1,000 ㎎/㎏/day in male and 111 ㎎/㎏/day in female. The target organs were thought to be liver and thymus.
Han, Jin,Kim, Yong Sook,Lim, Min-Young,Kim, Han Young,Kong, Saerom,Kang, Mikyung,Choo, Yeon Woong,Jun, Ju Hee,Ryu, Seungmi,Jeong, Hye-yun,Park, Jooyeon,Jeong, Gun-Jae,Lee, Jong-Chan,Eom, Gwang Hyeon,A American Chemical Society 2018 ACS NANO Vol.12 No.2
<P>Development of localized inflammatory environments by M1 macrophages in the cardiac infarction region exacerbates heart failure after myocardial infarction (MI). Therefore, the regulation of inflammation by M1 macrophages and their timely polarization toward regenerative M2 macrophages suggest an immunotherapy. Particularly, controlling cellular generation of reactive oxygen species (ROS), which cause M1 differentiation, and developing M2 macrophage phenotypes in macrophages propose a therapeutic approach. Previously, stem or dendritic cells were used in MI for their anti-inflammatory and cardioprotective potentials and showed inflammation modulation and M2 macrophage progression for cardiac repair. However, cell-based therapeutics are limited due to invasive cell isolation, time-consuming cell expansion, labor-intensive and costly <I>ex vivo</I> cell manipulation, and low grafting efficiency. Here, we report that graphene oxide (GO) can serve as an antioxidant and attenuate inflammation and inflammatory polarization of macrophages <I>via</I> reduction in intracellular ROS. In addition, GO functions as a carrier for interleukin-4 plasmid DNA (IL-4 pDNA) that propagates M2 macrophages. We synthesized a macrophage-targeting/polarizing GO complex (MGC) and demonstrated that MGC decreased ROS in immune-stimulated macrophages. Furthermore, DNA-functionalized MGC (MGC/IL-4 pDNA) polarized M1 to M2 macrophages and enhanced the secretion of cardiac repair-favorable cytokines. Accordingly, injection of MGC/IL-4 pDNA into mouse MI models attenuated inflammation, elicited early polarization toward M2 macrophages, mitigated fibrosis, and improved heart function. Taken together, the present study highlights a biological application of GO in timely modulation of the immune environment in MI for cardiac repair. Current therapy using off-the-shelf material GO may overcome the shortcomings of cell therapies for MI.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2018/ancac3.2018.12.issue-2/acsnano.7b09107/production/images/medium/nn-2017-09107t_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn7b09107'>ACS Electronic Supporting Info</A></P>
A case of en coup de sabre treated with hyaluronic acid filler
( Sook Hyun Kong ),( Hana Jung ),( Junyoung Seong ),( Seok Hyun Han ),( Hoseok Suh ),( Yusung Choi ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
En coup de sabre is a rare form of localized scleroderma that presents as a linear, atrophic depression affecting the frontoparietal aspect of the face and scalp. Atrophy of en coup de sabre is a significant cosmetic problem for the patient. Surgical excision, autologous fat or bone grafting, and placement of synthetic tissue inserts have been performed with varing degrees of success. Recently, dermal filler treatments offer an attractive option as they are much less invasive and possess high efficacy in volumization compared to the aforementioned techniques.A 45-old-woman presented with 9-year history of asymptomatic linear vertical atrophic depression on right forehead extending from the glabella to the frontal part of the scalp. Associated alopecia was also noted. Intralesional injection of triamcinolone acetate 2.5mg/ml was tried during 6 months, but did not make any changes. Therefore, the patient was injected with 1ml of hyaluronic acid intradermally to correct the depression. The injections were well tolerated, and the patient did not experience any adverse effects. The patient expressed great satisfaction with the result. Herein, we report a case of en coup de sabre in which hyaluronic acid filler was successfully used to correct the atrophic defect.
Cytological Features That Differentiate Follicular Neoplasm from Mimicking Lesions
Han, Kanghee,Ha, Hwa-Jeong,Kong, Joon Seog,Kim, Jung-Soon,Myung, Jae Kyung,Koh, Jae Soo,Park, Sunhoo,Shin, Myung-Soon,Song, Woo-Tack,Seol, Hye Sil,Lee, Seung-Sook 대한병리학회 2018 Journal of Pathology and Translational Medicine Vol.52 No.2
<P><B>Background</B></P><P>It is difficult to correctly diagnose follicular neoplasms (FNs) on fine-needle aspiration cytology (FNAC) because it shares many cytological features with other mimicking lesions. The aim of this study was to identify the cytological features that differentiate FNs from mimicking lesions. </P><P><B>Methods</B></P><P>We included the cytological slides from 116 cases of thyroid FN diagnosed on FNAC, and included their subsequent histological diagnoses. We evaluated the cytological architectural pattern and nuclear features of the lesions according to their histological groups. </P><P><B>Results</B></P><P>The final histological diagnoses of the 116 cases varied, and included 51 FNs (44%), 47 papillary thyroid carcinomas (40%) including follicular variant, and seventeen cellular nodular hyperplasias (15%). Regardless of the final histological diagnosis, microfollicular pattern was observed in most cases. On the other hand, trabecular pattern was identified in 34% of FNs, but not in any other lesions. Additionally, elongated nuclei and ground glass chromatin were found in only some papillary thyroid carcinomas. </P><P><B>Conclusions</B></P><P>This study shows that the trabecular pattern is a representative cytological feature of FNs that can be used to distinguish FNs from mimicking lesions. In addition, nuclear shape and chromatin pattern can be used to further confirm the diagnosis of FNs from mimicking lesions through FNAC.</P>
A case of lichen amyloidosis treated with Jessner`s solution and salicylic acid occlusion therapy
( Sook Hyun Kong ),( Hana Jung ),( Junyoung Seong ),( Seokhyun Han ),( Hoseok Suh ),( Yusung Choi ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Lichen amyloidosis is a subtype of primary localized cutaneous amyloidosis and is characterized bycircumscribed, highly pruritic, hyperkeratotic, and hyperpigmented papules occurring typically over the shins, ouster aspects of upper arms, and on the upper back. Histologically, amyloid deposits which are thought to be composed of degenerated keratin peptides are observed in the papillary dermis. Treatment of the majority of cases is unsatisfactory. A 47-year-old woman with diabetes presented with 1-year history of localized lichenified erythematous to yellowish papules on her both lower legs. Histopathologic examination revealed amyloid deposits within the dermal papillae. The patient was diagnosed with macular amyloidosis and treated with systemic steroid. But we have to stop using steroid because of hyperglycemic effect. Also she denied intralesional injection of triamcinolone acetate because of pain. Then, we decided to treat with topical Jessner``s solution and salicylic acid occlusion therapy. 2 months after the treatment, the response was good. Jessner``s solution has a keratolytic effect, resulting in specific destruction of the epidermal layer and further regeneration of normal tissue, thus decreasing amyloid aggregation and skin hyperpigmentation. We propose topical Jessner``s solution and salicylic acid occlusion therapy as an option of treatment for lichen amyloidosis.
In-Sook Ahn,Myoung-Sool Do,Bong-Hyuk Choi,Chang-Suk Kong,Su-Ok Kim,Min-Soo Han,Kun-Young Park 한국식품영양과학회 2006 Preventive Nutrition and Food Science Vol.11 No.1
In order to improve the antiobesity effect of Kochujang, 1% of sea tangle powder, alginic acid extract, and fucoidan extract were added to Kochujang. Sea tangle powder-added Kochujang decreased leptin secretion by only 12% compared to Kochujang, whereas alginic acid or fucoidan-added Kochujang significantly decreased leptin secretion by more than 60% in 3T3-L1 adipocytes. Fucoidan, one of the active components of sea tangle, decreased leptin secretion by 56%, 60%, and 60% compared to the control in the concentrations of 1 μM, 2.5 μM, and 5 μM, respectively. To see the effect of fucoidan on TG formation during adipocyte differentiation, 3T3-L1 cells were treated with 1 μM and 5 μM concentrations of fucoidan during adipocyte differentiation (from “day 0” to “day 6”). Oil red O staining showed fucoidan decreased the amount of TG droplets and 5 μM fucoidan potently inhibited TG formation. To see the effect of fucoidan on lipolysis, differentiated 3T3-L1 adipocytes were treated with fucoidan. The secretion of glycerol, which is used to measure lipolytic activity, was increased by 21%, 37%, and 53% compared to the control in the concentrations of 1 μM, 2.5 μM, and 5 μM, respectively. Oil red O staining showed fucoidan decreased TG amount at 1 μM and 5 μM concentrations. These results suggest that fucoidan decreases leptin secretion and TG accumulation by inhibition of adipocyte differentiation and induction of lipolysis. Since fucoidan is reported to have various biological activities in addition to an anti-adipogenic effect, it seems valuable to develop fucoidan-added Kochujang as a multi-functional Kochujang.
Correlation between severity of atopic dermatitis and sleep quality in children and adults
( Byeol Han ),( Tae Seok Kong ),( Young Chae Lee ),( Tae Young Han ),( June Hyunkyung Lee ),( Sook Ja Son ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: The symptoms of atopic dermatitis(AD) can limit a patient’s physical and psychosocial development as well as lower their overall quality of life(QOL), includingsleep quality. Objectives: To evaluate the relationships between clinical disease severity, QOL and sleep quality in children and adults with AD. Methods: 50 adult AD patients and 50 child AD patients were included. The SCORAD was examined to evaluate the severity of AD. Children’s Sleep Habits Questionnaire (CSHQ) and the Children’s Dermatology Life Quality Index(CDLQI) were used to evaluate QOL and sleep disturbance in children. Pittsburgh Sleep Quality Index (PSQI) and Dermatology Life Quality Index(DLQI) wereused in adults. Results: The SCORAD and CSHQ score, the SCORAD and CDLQI score and the CSHQ and CDLQI score demonstrated significant correlations. The SCORAD and PSQI score showed no significant correlation. However, there were significant correlations between the SCORAD and DLQI score and the PSQI and DLQI score. Conclusion: Increasing severity of AD affects sleep quality in children. In adults, even though the total score of thesleep questionnaire is not associated, two components of them are associated with the severity of AD. There is a significant correlation between sleep quality and QOL in both children and adults. Therefore, we suggest that evaluating the sleep quality as well as clinical severity of the disease is necessary.