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증발 표면적 증대를 위한 수적 분리기 특성에 관한 연구
모종근,공태우,이광영,정효민,정한식,서정세 경상대학교 해양산업연구소 2002 해양산업연구소보 Vol.15 No.-
The purpose of this research is to obtain the characteristics of water-vapor separator for improving the evaporative surface. The experimental system is constituted with water vapor generator, vapor storage tank, laser source for visualization and camera for photography. The efficiency of water-vapor separator can be varied by the kinds of the inside materials. Thus, in this report, we introduced the three kinds of materials with wire scrap, wire brush and sponge. As the experimental results, the wire brush was showed the best efficiency with 185 g/hr.
Kwang-Han Kong,Ju Young Jung,Kyo Hwan Koo,Si-Whan Song,Kap-Ho Kim,Zhong Ze Han,Seon-Hwa Lee,Ho-Chul Shin 한국실험동물학회 2010 Laboratory Animal Research Vol.26 No.4
Recent researches on clinically used triazole antifungal reagents are focused on their pharmacokinetic disadvantage which increases the probability of inducing adverse effects in patients. For this point, in the present laboratory, Chemon Inc., has investigated new antifungal reactive compounds, KAF-200522 and its chloride form, KAF-200522 · HCl, which has a modified triazole structure. Pharmacokinetic data were measured with LC-MS/MS in male mice which were orally treated with the above compounds at 10 ㎎/㎏. T<SUB>max</SUB> and t<SUB>½</SUB> of KAF-200522 · HCl were comparable to KAF-200522, but AUC and C<SUB>max</SUB> were 1.4 and 1.6 times higher than those of KAF-200522, respectively. In beagle dogs, AUC and C<SUB>max</SUB> of KAF-200522 · HCl were 2.7 and 1.4 times higher than those of KAF-200522, and t<SUB>½</SUB> was 3.5 times higher than that of KAF-200522. Moreover, in beagle dogs, the oral bioavailability value of KAF-200522 · HCl was revealed as 31.0% to contrast to 6.2% of KAF-200522. In 1-week repeated oral treatment toxicity study of KAF-200522 in male rats, inhibition of body weight gain was observed in 120 ㎎/㎏ treatment group, and loss of body weight was observed in 600 ㎎/㎏ treatment group. In the toxicokinetic study of KAF-200522, no accumulation after the systemic exposure was observed. In conclusion, as to the new antifungal drug development, KAF-200522 · HCl was considered to be advantageous in pharmacokinetic characteristics compared to KAF-200522.
Portomesenteric vein thrombosis after gastric surgery
Han, Ji-Won,Kong, Seong-Ho,Shin, Cheong-il,Min, Seung-Kee,Min, Sang-il,Kim, Tae Han,Yang, Jun-Young,Oh, Seung-young,Suh, Yun-Suhk,Lee, Hyuk-Joon,Yang, Han-Kwang Springer-Verlag 2016 Gastric cancer Vol.19 No.4
<P>Postoperative portomesenteric venous thrombosis (PMVT) is a rare but potentially serious complication of gastric surgery. This study analyzed the incidence, characteristics, risk factors, and outcomes of PMVT following gastric surgery. Medical records of patients who underwent gastric surgery between January 2007 and December 2012 were reviewed retrospectively. The risk factors of PMVT were analyzed by a logistic regression analysis with control group matched 1:4 by age, sex, and cancer stage and by a Poisson regression analysis with unmatched control group. The resolution rate of PMVT in 12 months was compared between the treatment group and the nontreatment group. The total incidence of PMVT after gastric surgery was 0.67 % (31/4611). Most (54.84 %) PMVT cases were detected within 1 month postoperatively. No accompanying deep vein thrombosis (DVT) was noted. Multivariate comparison with 1:4 matched control showed that combined splenectomy, synchronous malignancy, and intra-abdominal complication were independent risk factors. Advanced stage, combined splenectomy, and synchronous malignancy were independent risk factors in Poisson regression analysis using unmatched controls. The resolution rate of PMVT was not different from patients treated with anticoagulation (n = 6) or antiplatelet therapy (n = 1) and were not significantly different with those of the untreated group [85.7 % (6/7) vs. 82.3 % (14/17), p = 0.935] during 1-year follow up. PMVT after gastric surgery was associated with advanced cancer stage, combined splenectomy, and synchronous malignancy, but it was not related to laparoscopy or DVT. Significant differences in the natural course of PMVT were not found between the treatment group and observation group.</P>
A 90-day Repeated-Dosed Toxicity Study of Euphorbiae kansui radix Extract in Fischer 344/N Rats
Zhong-Ze Han,Hu-Song Zhang,Ki-Hyun Gil,Joo-Young Lee,Kwang-Han Kong,Myoung-Kyu Han,Hyun-Ju Yang,Hak-Soo Kim,Do-Hyung Kim,Tae-Hwan Ahn,Jin-Sook Bae,Hyun-Kyu Ko,Jung-Woon Lee,Moon-Soon Kim,Si-Whan Song 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.4
This study was performed to evaluate repeated-dose toxicities of Euphorbiae kansui radix extract in F344/N rats. Euphorbiae kansui radix extract was administered orally to rats at dose levels of 0, 37, 111, 333, 1,000 and 2,000 ㎎/㎏/day. Each group consisted of 10 rats of each gender. The Euphorbiae Kansui, Radix extract was given once a day, 5 times a week, for 90 day repeatedly. This study was conducted in accordance with the Protocol of Korea National Toxicology Program (issued by National Institute of Toxicological Research) and The Standards of Toxicity Study for Medicinal Products (issued by Korea Food and Drug Administration). In the present study, there were no dose-related changes in mortality, clinical signs, body weights, ophthalmoscopy, urine analysis, hematological findings, estrus cycle and sperm examination of all animals treated with Euphorbiae kansui radix extract. There were increases of liver weights in 2,000 ㎎/㎏/day groups of males and in 333, 1,000 and 2,000 ㎎/㎏/day groups of females. There were decreases of alkaline phosphatase levels in 1,000 and 2,000 ㎎/㎏/day groups of both sexes. These results suggest that the oral no-observed-adverse-effect level (NOAEL) of the test item, Euphorbiae kansui radix extract, in rats is 2,000 ㎎/㎏/day in both genders; no-observed-effect level (NOEL) is 1,000 ㎎/㎏/day in male and 111 ㎎/㎏/day in female. The target organs were thought to be liver and thymus.
Kong, Seong-Ho,Lee, Hyuk-Joon,Ahn, Hye Seong,Kim, Jong-Won,Kim, Woo Ho,Lee, Kuhn Uk,Yang, Han-Kwang Lippincott Williams Wilkins, Inc. 2012 Annals of surgery Vol.255 No.1
OBJECTIVE:: The purpose of this study is to analyze the relationship between the number of examined lymph nodes (NexLN) and survival in gastric cancer and to determine whether the metastatic/examined lymph node ratio (LN ratio) system can compensate for the shortcomings of the UICC/AJCC staging. METHODS:: Prospective data of 8949 primary T1-T4a gastric cancer patients who underwent curative surgery were reviewed. The patients were stratified by T-stage and grouped according to NexLN; 1 to 14 exLN denoted the first group and every subsequent 10 LNs thereafter. Numbers of LN and 5-year survival rates were analyzed according to NexLN. “The NR-staging system” was generated using 0.2 and 0.5 as the cut-off values of LN ratio and then compared with UICC/AJCC stages. RESULTS:: The proportion of advanced N-stage increased with NexLN. Survival and the LN ratio were constant regardless of NexLN when combining all N0-N3b patients, however, T2/3 and T4a patients showed an increasing tendency toward survival in N1/2 and N3a as NexLN increased, mainly due to a stage migration effect. The LN ratio system showed better patterns of distribution of the LN stage and survival graph. The power of the differential staging of the LN ratio system was fortified with higher NexLN. CONCLUSION:: The relationship between NexLN and survival is probably affected by stage migration in a high-volume gastric cancer center. The LN ratio system could be a better option to compensate for this effect, and the value of the prognosis prediction in this system increases with a higher NexLN.
Surgical Treatment of Gastric Gastrointestinal Stromal Tumor
Kong, Seong-Ho,Yang, Han-Kwang The Korean Gastric Cancer Association 2013 Journal of gastric cancer Vol.13 No.1
Gastrointestinal stromal tumor is the most common mesenchymal tumor in the gastrointestinal tract and is most frequently developed in the stomach in the form of submucosal tumor. The incidence of gastric gastrointestinal stromal tumor is estimated to be as high as 25% of the population when all small and asymptomatic tumors are included. Because gastric gastrointestinal stromal tumor is not completely distinguished from other submucosal tumors, a surgical excisional biopsy is recommended for tumors >2 cm. The surgical principles of gastrointestinal stromal tumor are composed of an R0 resection with a normal mucosa margin, no systemic lymph node dissection, and avoidance of perforation, which results in peritoneal seeding even in cases with otherwise low risk profiles. Laparoscopic surgery has been indicated for gastrointestinal stromal tumors <5 cm, and the indication for laparoscopic surgery is expanded to larger tumors if the above mentioned surgical principles can be maintained. A simple exogastric resection and various transgastric resection techniques are used for gastrointestinal stromal tumors in favorable locations (the fundus, body, greater curvature side). For a lesion at the gastroesophageal junction in the posterior wall of the stomach, enucleation techniques have been tried preserve the organ's function. Those methods have a theoretical risk of seeding a ruptured tumor, but this risk has not been evaluated by well-designed clinical trials. While some clinical trials are still on-going, neoadjuvant imatinib is suggested when marginally unresectable or multiorgan resection is anticipated to reduce the extent of surgery and the chance of incomplete resection, rupture or bleeding.
Kong, Seong-Ho,Kim, Sung Min,Kim, Dong-Gun,Park, Kee Hong,Suh, Yun-Suhk,Kim, Tae-Han,Kim, Il Jung,Seo, Jeong-Hwa,Lim, Young Jin,Lee, Hyuk-Joon,Yang, Han-Kwang The Korean Gastric Cancer Association 2019 Journal of gastric cancer Vol.19 No.1
Purpose: The perigastric vagus nerve may play an important role in preserving function after gastrectomy, and intraoperative neurophysiologic tests might represent a feasible method of evaluating the vagus nerve. The purpose of this study is to assess the feasibility of neurophysiologic evaluations of the function and viability of perigastric vagus nerve branches during gastrectomy. Materials and Methods: Thirteen patients (1 open total gastrectomy, 1 laparoscopic total gastrectomy, and 11 laparoscopic distal gastrectomy) were prospectively enrolled. The hepatic and celiac branches of the vagus nerve were exposed, and grabbing type stimulation electrodes were applied as follows: 10-30 mA intensity, 4 trains, $1,000{\mu}s/train$, and $5{\times}$frequency. Visible myocontractile movement and electrical signals were monitored via needle probes before and after gastrectomy. Gastrointestinal symptoms were evaluated preoperatively and postoperatively at 3 weeks and 3 months, respectively. Results: Responses were observed after stimulating the celiac branch in 10, 9, 10, and 6 patients in the antrum, pylorus, duodenum, and proximal jejunum, respectively. Ten patients responded to hepatic branch stimulation at the duodenum. After vagus-preserving distal gastrectomy, 2 patients lost responses to the celiac branch at the duodenum and jejunum (1 each), and 1 patient lost response to the hepatic branch at the duodenum. Significant procedure-related complications and meaningful postoperative diarrhea were not observed. Conclusions: Intraoperative neurophysiologic testing seems to be a feasible methodology for monitoring the perigastric vagus nerves. Innervation of the duodenum via the celiac branch and postoperative preservation of the function of the vagus nerves were confirmed in most patients.