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Association between Pax8-PPARγ1 Rearrangement and Follicular Thyroid Cancer: a Meta-Analysis
Li, Hang-Yu,Xie, Zhi-Hao,Xu, Cong-Hui,Pu, Mei-Ling,Chen, Zi-Yan,Yu, Miao,Wang, Heng-Shu,Zhou, Chen-Ming,Pu, Chao-Yu,Liu, Wei Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9
Background: Pax8 and peroxisome proliferator-activated receptor gamma 1 gene (Pax8-$PPAR{\gamma}1$) are important factors in tumors. Several studies have suggested that follicular thyroid cancer may arise from Pax8- $PPAR{\gamma}1$ rearrangement. In order to have a better understanding of the association between Pax8-$PPAR{\gamma}1$ rearrangement and follicular thyroid cancer, we conducted the presenmt meta-analysis. Materials and Methods: The information was extracted from PubMed, EMBASE and Web of Science. Statistic analysis was performed with Stata12.0 software. Odds ratios (ORs) were calculated using a fixed-effects model. We also performed heterogeneity and publication bias analyses. Results: Nine studies including 198 follicular thyroid cancer patients and 268 controls were considered eligible. The frequency of Pax8-$PPAR{\gamma}1$ rearrangement was significantly higher in the follicular thyroid cancer group than in the control group, with a pooled OR of 6.63 (95%CI=3.50-12.7). In addition, through subgroup analysis, the OR between Pax8-$PPAR{\gamma}1$ rearrangement and follicular thyroid cancer was 6.04 (95%CI = 3.18-11.5) when using benign tumor tissues as controls. The OR for the method subgroup was 9.99 (95% CI =4.86-20.5) in the RT-PCR. Conclusions: The final results demonstrated that Pax8-$PPAR{\gamma}1$ rearrangement has significant association with follicular thyroid cancer.
Flow performance of cryomodules in C-ADS InjectorⅡ
Yu-Qin WAN,Yan-Ning HAN,Jun-Hui Zhang,Chao Li 한국초전도저온학회 2022 한국초전도저온공학회논문지 Vol.24 No.3
Two β=0.10 cryomodules are required for the China Accelerator Driven Subcritical System (C-ADS) injector II accelerator. Flow design is of great importance in the performance of cryomodules, including thermal design, flow distribution, pressure dropand so on. This paper will study convection heat transfer of helium and relation among the pipe diameter, mass flow rate andReynolds number. Furthermore, the influence of flow geometries on pressure drop and flow distribution will also be done. It wasfound that the theoretical flow distribution were in good agreement with the experimental data.
Ginsenoside Rb1 Inhibits Cell Activation and Liver Fibrosis in Rat Hepatic Stellate Cells
Yu-Ting Lo,Ya-Hui Tsai,Shu-Ju Wu,Jiun-Rong Chen,C.-J. Chao 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.10
Chronic hepatitis/cirrhosis is the eighth leading cause of death in Taiwan. Excess accumulated extracellular matrix produced by activated hepatic stellate cells (HSCs) is the major cause of liver fibrosis. Ginsenoside Rb1, the most active compound purified from ginseng, has been considered to be hepatoprotective. This study investigated the effects of ginsenoside Rb1 (98.8% purity) on activation, proliferation, and profibrotic factors in rat HSC-T6 cells under H₂O₂oxidative stress. Rat HSC-T6 cells were activated by 10 nM H₂O₂and then incubated with different concentrations of ginsenoside Rb1 (5, 10, 20, 40, and 80 μg/mL) for 24 hours. Medium containing 0.08% dimethyl sulfoxide or 5 mM N-acetyl-l-cysteine was used as a negative or positive control, respectively. The results showed that ginsenoside Rb1 at 5–40 μg/mL significantly reduced α-smooth muscle actin levels and at 5–80 μg/mL inhibited cell proliferation in HSC-T6 cells after induction with H₂O₂(P<.05). Collagen secreted by HSC-T6 cells was decreased by ginsenoside Rb1 at 5–80 μg/mL (P<.05). Protein expression of transforming growth factor-β1 (TGF-β1), matrix metalloproteinase (MMP)-2, and tissue inhibitor of metalloproteinase (TIMP)-1 was suppressed by ginsenoside Rb1 at 10–80 μg/mL (P<.05). In addition, mRNA expression of type I and III collagen, TGF-β1, and TIMP-1 was inhibited by ginsenoside Rb1 (10 and 80 μg/mL) (P<.05). Therefore, ginsenoside Rb1 exerted an antifibrotic effect on HSCs by inhibiting activation, proliferation, and expression of collagen, TGF-β1, MMP-2, and TIMP-1.
Event-Triggered Media Stream Bandwidth Adjustment in IoT-Based Home Networks
Chao-Yu Hsu,Chin-Lin Hu,Kun-Sheng Huang,Yung-Hui Chen,Jiun-Long Huang 한국통신학회 2020 한국통신학회 APNOMS Vol.2020 No.09
As the coming maturity of Internet of Things, many home-networked devices with various sensors are deployed in residential environments. It is important to accommodate many devices that compete for bandwidth allocation to transmit data inwards and outwards through a certain home network domain. This paper proposes a novel mechanism which can adjust media stream qualities and transmission bandwidth allocations to different devices. This mechanism is agile against dynamic changes of data workload and finite network resources between inside and outside of a home network. Practical demonstration exhibits that the effects are able to maintain differentiated media transfer services in IoT-based home networks.
Activated carbon supported VN, Mo2N, and W2N as catalysts for acetylene hydrochlorination
Hui Dai,Mingyuan Zhu,Haiyang Zhang,Feng Yu,Chao Wang,Bin Dai 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.50 No.-
The development of green catalysts for the calcium carbide acetylene method synthesis of vinyl chloridemonomer (VCM), is essential material to industrial polyvinyl chloride production. The original catalystHgCl2 easy to volatile during the reaction lead to environmental pollution. Here we present threedifferent transition metal nitride load into activated carbon (AC): VN/AC, Mo2N/AC, and W2N/AC as novelcatalysts. W2N/AC and Mo2N/AC was a relatively stable catalyst to compared with VN/AC. All of themVCM selectivity can maintain 98%. More HCl ratio for Mo2N/AC lead its acetylene conversion reach 80%. The former two catalysts are promising candidates for acetylene hydrochlorination.
Comparative Study of Two Common In Vitro Models for the Pancreatic Islet with MIN6
Chao Xinxin,Zhao Furong,Hu Jiawei,Yu Yanrong,Xie Renjian,Zhong Jianing,Huang Miao,Zeng Tai,Yang Hui,Luo Dan,Peng Weijie 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.1
BACKGROUND: Islet transplantation is currently considered the most promising method for treating insulin-dependent diabetes. The two most-studied artificial islets are alginate-encapsulated b cells or b cell spheroids. As three-dimensional (3D) models, both artificial islets have better insulin secretory functions and transplantation efficiencies than cells in twodimensional (2D) monolayer culture. However, the effects of these two methods have not been compared yet. Therefore, in this study, cells from the mouse islet b cell line Min6 were constructed as scaffold-free spheroids or alginate-encapsulated dispersed cells. METHODS: MIN6 cell spheroids were prepared by using Agarose-base microwell arrays. The insulin secretion level was determined by mouse insulin ELISA kit, and the gene and protein expression status of the MIN6 were performed by Quantitative polymerase chain reaction and immunoblot, respectively. RESULTS: Both 3D cultures effectively promoted the proliferation and glucose-stimulated insulin release (GSIS) of MIN6 cells compared to 2D adherent cells. Furthermore, 1% alginate-encapsulated MIN6 cells demonstrated more significant effects than the spheroids. In general, three pancreatic genes were expressed at higher levels in response to the 3D culture than to the 2D culture, and pancreatic/duodenal homeobox-1 (PDX1) expression was higher in the cells encapsulated in 1% alginate than that in the spheroids. A western blot analysis showed that 1% alginate-encapsulated MIN6 cells activated the phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (AKT)/forkhead transcription factor FKHR (FoxO1) pathway more than the spheroids, 0.5% alginate-, or 2% alginate-encapsulated cells did. The 3D MIN6 culture, therefore, showed improved effects compared to the 2D culture, and the 1% alginate-encapsulated MIN6 cells exhibited better effects than the spheroids. The upregulation of PDX1 expression through the activation of the PI3K/AKT/FoxO1 pathway may mediate the improved cell proliferation and GSIS in 1% alginate-encapsulated MIN6 cells. CONCLUSION: This study may contribute to the construction of in vitro culture systems for pancreatic islets to meet clinical requirements.
Chao Wang,Jian-Hui Wang,Shu-Sheng Gu,Xiao Wang,Yu-Xian Zhang 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.3
The elongation of steel-strips in annealing furnace is an important factor that affects the position ofwelding line and safety of air-knife since there is no extra space to install welding line detector in field conditions. Therefore, predicting the elongation of steel-strips in the annealing process is important to fulfill the requirementsof eliminating security risks and improving economic performance. In this paper, we propose a deep architecturescalled I-ELM/MLCSA autoencoders with the concept of stacked generalization philosophy to solve large and complexdata mining problems. The comparison results of the case studies indicate that D-ELMs-AE/MLCSA is apromising prediction algorithm and can be employed for steel-strips elongation predictions with excellent performance.
Yu-Lan Zhu,Shuai Shao,Kui-Rong Ma,Xue-Ling Tang,Li Cao,Hui-Chao Zhao 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.4
Two metal compounds, [Co(phen)2(H2O)2]·2H2SIP·2H2O 1 and [Ni(phen)3]·2H2SIP·3H2O 2, have been obtained by incorporating 1,10-phenanthroline (phen) and 5-sulfoisophthalic acid monosodium salt (NaH2SIP) ligands under hydrothermal conditions. Meanwhile, the two compounds were characterized by element analysis, IR, XRD, TG-DTA and single-crystal X-ray diffraction. Both 1 and 2 present 3D supramolecular structures via O–H···O hydrogen bond interactions. Luminescent properties for 1 and 2 were also studied. The compound 1 has two fluorescence emission peaks centered at 398 nm attributed to the intraligand emission from the SIP ligand and at 438 nm assigned to the combined interaction of intraligand π*-π transitions of the phen ligand and ligand-to-metal-charge-transfer (LMCT) transitions (λex = 233 nm). The compound 2 shows one emission band centered at 423 nm with a shoulder peak at 434 nm which may be originated from the intraligand π*-π transitions of the phen ligand (λex = 266 nm).