TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway

Yu Hai-Fan,Zheng Lian-Wen,Yang Zhan-Qing,Wang Yu-Si,Wang Ting-Ting,Yue Zhan-Peng,Guo Bin 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

TAZ, as a crucial effector of Hippo pathway, is required for spermatogenesis and fertilization, but little is known regarding its physiological function in uterine decidualization. In this study, we showed that TAZ was localized in the decidua, where it promoted stromal cell proliferation followed by accelerated G1/S phase transition via Ccnd3 and Cdk4 and induced the expression or activity of stromal differentiation markers Prl8a2, Prl3c1 and ALP, indicating the importance of TAZ in decidualization. Knockdown of TAZ impeded HB-EGF induction of stromal cell proliferation and differentiation. Under oxidative stress, TAZ protected stromal differentiation against oxidative damage by reducing intracellular ROS and enhancing cellular antioxidant capacity dependent on the Nrf2/ARE/Foxo1 pathway. TAZ strengthened the transcriptional activity of Nrf2 which directly bound to the antioxidant response element (ARE) of Foxo1 promoter region. Additionally, silencing TAZ caused accumulation of intracellular ROS through heightening NOX activity whose blockade by APO reversed the disruption in stromal differentiation. Further analysis revealed that TAZ might restore mitochondrial function, as indicated by the increase in ATP level, mtDNA copy number and mitochondrial membrane potential with the reduction in mitochondrial superoxide. Additionally, TAZ modulated the activities of mitochondrial respiratory chain complexes I and III whose suppression by ROT and AA resulted in the inability of TAZ to defend against oxidative damage to stromal differentiation. Moreover, TAZ prevented stromal cell apoptosis by upregulating Bcl2 expression and inhibiting Casp3 activity and Bax expression. In summary, TAZ might mediate HB-EGF function in uterine decidualization through Ccnd3 and ameliorate oxidative damage to stromal cell differentiation via Nrf2/ARE/Foxo1 pathway.

A Fast Kernel Regression Framework for Video Super-Resolution

( Wen-sen Yu ),( Ming-hui Wang ),( Hua-wen Chang ),( Shu-qing Chen ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.1

A series of kernel regression (KR) algorithms, such as the classic kernel regression (CKR), the 2- and 3-D steering kernel regression (SKR), have been proposed for image and video super-resolution. In existing KR frameworks, a single algorithm is usually adopted and applied for a whole image/video, regardless of region characteristics. However, their performances and computational efficiencies can differ in regions of different characteristics. To take full advantage of the KR algorithms and avoid their disadvantage, this paper proposes a kernel regression framework for video super-resolution. In this framework, each video frame is first analyzed and divided into three types of regions: flat, non-flat-stationary, and non-flat-moving regions. Then different KR algorithm is selected according to the region type. The CKR and 2-D SKR algorithms are applied to flat and non-flat-stationary regions, respectively. For non-flat-moving regions, this paper proposes a similarity-assisted steering kernel regression (SASKR) algorithm, which can give better performance and higher computational efficiency than the 3-D SKR algorithm. Experimental results demonstrate that the computational efficiency of the proposed framework is greatly improved without apparent degradation in performance.

Regulatory Mechanisms of Annexin-Induced Chemotherapy Resistance in Cisplatin Resistant Lung Adenocarcinoma

Wang, Chao,Xiao, Qian,Li, Yu-Wen,Zhao, Chao,Jia, Na,Li, Rui-Li,Cao, Shan-Shan,Cui, Jia,Wang, Lu,Wu, Yin,Wen, Ai-Dong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Adenocarcinoma of lung has high incidence and a poor prognosis, woith chemotherapy as the main therapeutic tool, most commonly with cisplatin. However, chemotherapy resistance develops in the majority of patients during clinic treatment. Mechanisms of resistance are complex and still unclear. Although annexin play important roles in various tumor resistance mechanisms, their actions in cisplatin-resistant lung adenocarcinoma remain unclear. Preliminary studies by our group found that in cisplatin-resistant lung cancer A549 cells and lung adenocarcinoma tissues, both mRNA and protein expression of annexins A1, A2 and A3 is increased. Using a library of annexin A1, A2 and A3 targeting combined molecules already established by ourselves we found that specific targeting decreased cisplatin-resistance. Taken together, the underlined effects of annexins A1, A2 and A3 on drug resistance and suggest molecular mechanisms in cisplatin-resistant A549 cells both in vivo and in vitro. Furthermore, the study points to improved research on occurrence and development of lung adenocarcinoma, with provision of effective targets and programmes for lung adenocarcinoma therapy in the clinic.

Role of Grain Refinement Mechanism on Microstructure and Performance in AZ31B Alloy During Interactive Alternating Forward Extrusion (AFE) Process

Yu Wang,Feng Li,Ye Wang,Qiang Chen,Xue Wen Li,Wen Bin Fang 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.4

In this study, interactive alternate forward extrusion (AFE) experiments with varying number of extrusion passes of AZ31magnesium alloy were carried out. The evolution of microstructure, and texture and their effects on the mechanical propertieswere studied. The results show that with the increase of loading passes, the grains are significantly refined, and thedynamic recrystallisation (DRX) structure is uniformly distributed in the product, which is the main reason for the increasein microhardness, compressive strength and failure strain. Further, slip and twinning induced DRX behaviour are consideredto be the main deformation methods in the early stage of deformation. Whereas continuous DRX is considered to be the maindeformation methods for the change in grain morphology in the later stage. During the extrusion process, the deflection angleof the base pole decreases. Finally, the fibre texture is formed; the texture strength is significantly reduced because of theeffect of recrystallisation. The AZ31 magnesium alloy interactive AFE process is discussed with respect to the technologicalexperiment and the microstructure deformation, thus providing a vital scientific basis for further application.

A Comparative Study of Camouflage Printing Color Matching Based on Monitor and Paper Card

Yu-wen Wang,Qing-zhu Yi,Yi Ding,Guang-xin Wu,Jing-bin Zhang,Ni Wang 한국섬유공학회 2021 Fibers and polymers Vol.22 No.4

To improve the accuracy of color reproduction for camouflage printing, a new color matching method, namedmonitor-paper-fabric, was proposed by importing color management into textiles, which matched the printing pastesaccording to the color of the paper card printed by the ink-jet printer after color management. Not like the traditional colormatching method, it matched the printing pastes according to the color from computer monitor after color correction. Twocolor matching methods were analyzed by comparing the color difference. It was found that the “monitor-paper-fabric” colormatching method could be considered as a convenient and feasible color matching method. Most color differences betweenthe monitor and the fabric in the camouflage pattern were reduced to lower than 4, except for color blocks 5 and 6. Inaddition, the color differences of six color blocks between the paper and the fabric were all less than 3.5, and were lower thanthose between the monitor and the fabric. The color consistency between the paper and the fabric was better than thatbetween the monitor and the fabric.

Ballistic transport in 5.1 nm monolayer boron phosphide transistors for high-performance applications

Wang Yu,Chen Wen,Jing Sicheng,Pan Jinghua,Wang Danni,Ma Zelong,Bian Baoan 한국물리학회 2023 Current Applied Physics Vol.52 No.-

Boron Phosphide is reported to be a semiconductor material with anisotropy, tunable bandgap, and high carrier mobility. We study the performance of 5.1 nm metal–oxide–semiconductor field-effect transistors (MOSFETs) based on boron phosphide using quantum transport simulation. The calculated results show that the on-state current can fulfill the requirements of the International Semiconductor Technology Roadmap (ITRS) for high-performance (HP) devices at the optimal doping concentration, but the gate control capability is not ideal. Furthermore, it is found that the gate control capability and on-state current can be significantly improved with the length being 1 nm by using the underlap (UL) structure. We also study the performance of boron phosphide MOSFET with different gate lengths (5–8 nm), and the results suggest that the shorter the gate length, the worse the gate control capability. Interestingly, the p-type boron phosphide MOSFET always outperforms the n-type MOSFET. This work will provide a new reference for the development of two-dimensional (2D) semiconductor devices.

Identification of a Novel Human Lysophosphatidic Acid Acyltransferase, LPAAT-theta, Which Activates mTOR Pathway

( Wen Wen Tang ),( Jian Yuan ),( Xin Ya Chen ),( Xiu Ting Gu ),( Kun Tian Luo ),( Jie Li ),( Bo Wan ),( Ying Li Wang ),( Long Yu ) 생화학분자생물학회 2006 BMB Reports Vol.39 No.5

Measurement of neutron cross sections and resonance parameters of ¹⁶⁹Tm below 100 eV

Wen-Ming, Wang,Xia, Li,Zhi-Xiang, Zhao,Zu-Ying, Zhou,Hong-Wei, Yu,Hai-Cheng, Wu,Yi-Xiang, Wei,Wang, T. F.,Kim, G. N.,Lee, M. W.,Kim, K. S.,Cho, M. H.,Ko, I. S.,Namkung, W. science press 2010 Chinese physics. C Vol.34 No.2

<P>The neutron total cross-sections of thulium (<SUP>169</SUP>Tm) were measured in the neutron energy region from 0.01 eV to 100 eV by using the time-of-flight method at the Pohang Neutron Facility, which consists of an electron linac, a water-cooled tantalum target with a water moderator, and a 12 m time of flight path. Two thulium plates with different thicknesses were used for the neutron transmission measurement. The background level was determined by using a notch-filter of Co, In, and Cd sheets. The present measurement was compared with the previous ones, and a new set of resonance parameters of <SUP>169</SUP>Tm isotope was obtained from the transmission rate by using the SAMMY code, with a comparison with the recommended parameters by Mughabghab.</P>

Hollow-structured Pd/TiO2 as a dual functional photocatalyst for methyl orange oxidation and selective reduction of nitrate into nitrogen

Wen-Min Wang,Shi-Jer Tseng,Yu-Shuan Huang,Qian-Yuan Wu,Wen-Long Wang,Jerry J. Wu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.119 No.-

Nitrate pollution in wastewater has posed a threat to human health and the environment. Photocatalyticreduction is a promising technology to remove nitrate due to its high adaptability, low cost, and high efficiency. However, there is a great challenge to design photocatalyst with high nitrate reduction and highselectivity of nitrogen (N2) yield. In this study, a novel hollow-structured Pd/TiO2 (PHT1) photocatalyst issynthesized with large specific surface area (SBET) and pore volume, strong UV adsorption, high reductionpotential than nitrate to nitrite, high charge transfer rate, and low electron-hole recombination rate. PHT1 exhibits a superior photocatalytic activity on the removal of methyl orange and nitrate. In addition,PHT1 exhibits high N2 selectivity (>95 %). A lower pH can promote the reduction of nitrate and the selectivityof N2 by PHT1. Electrons (e-) and CO2– are the main active species for nitrate reduction with OH asauxiliary radicals. Three main pathways for nitrate reduction are proposed: i) the reaction with formicacid under acidic conditions; ii) the reduction by electrons and the loaded Pd of photocatalyst to captureelectrons to inhibit electron-hole recombination; iii) the reduction by CO2 – generated from formic acidoxidation by OH.

Bridge modal identification based on frequency variation caused by a parked vehicle

Wen-Yu He,Wei-Xin Ren,Quan Wang,Zuo-Cai Wang 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.84 No.3

Modal parameters are the main dynamic characteristics of bridge. This study aims to propose an innovative route to estimate the modal parameters for bridges by using a parked vehicle in which mode shapes with high accuracy and spatial resolution are identified by frequency measurement. Based on the theory of dynamic modification and modal identification, the mathematical formulation between the parked mass induced frequency variation and the modal parameters of a bridge is derived. Then this mathematical formulation is extended to a parked vehicle-bridge system. The arithmetic and processes for estimating the modal parameters based on the identified frequency variation of the vehicle-bridge systems when the vehicle locates at sequentially arranged positions are presented. Finally the proposed method is applied to several simulated bridges of different types. The results indicate that it can estimate the modal parameters with high accuracy and efficiency.