Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

황해 동남 해역의 수괴지표성 요각류 및 모악류의 분포와 수괴특성

박주석,이삼석,강영실,이병돈,허성회 동의대학교 기초과학연구소 1993 基礎科學硏究論文集 Vol.3 No.1

Distribution of indicator species of copepods and chaetognaths were studied as an indicator species of water mass in the southeastern area of the Yellow Sea. Undinula darwini, Lucicutia flavicornis, Pleuromamma gracilis, Euchaeta resselli, Euchaeta plana and Sagitta enflata were found to be reliable indicator species for determining warm water mass. Of these species, E. plana and E. russelli have a weak tolerance on the low temperature. Sagitta crassa was indicator species of neritic waters: Sagitta bedoti was that of mixing waters. Centropages agdominalis represented neritic cold waters. In February U. darwini, L. flavicornis, P. gracilis, E. russelli, E. plana and S. enflata occurred in the western waters of Cheju-Do where warm waters over 14℃ occupied. Centropages abdominalis occurred in the northern area beyond Chindo with water temperature less than 10℃. E. plana, E. russelli and S. bedoti were found at the regions between Cheju-Do and Chindo where the water temperature was 12∼14℃ corresponding to the mixing waters. Based on cluster analysis and T-S diagram in February three different water masses were identified from the south to the north. In August, water masses were analyzed at two different layers, 0∼20m and 20m∼bottom layers, separated by thermocline depth. In 0∼20m layer, E plana and E. russelli were found from the western waters of Cheju-Do to Daehuksando. In 20m∼bottom layer, E. russelli and E. plana occurred at the northwestern waters of Cheju-Do with the water temperature warmer than 12℃. C. abdominalis was found at the northern area beyond Chindo. Based on the cluster analysis and T-S diagram in August three different water masses at 0∼20m and 20m∼bottom layers were identified from the coast to the offshore. C. abdominalis was found at the adjacent water of Chindo at 0∼20m layer and the northern area beyond Chindo at 20m∼bottom layer. This fact suggested that the cold water mass existed at the adjacent waters of Chindo in summer.

특발성 과호산구 증후군 환자의 치료 도중 발생한 간혈종 1례

이영태,김동기,박지훈,김윤정,김기향,박보민,권민정,김애란,이원식,주영돈,손창학 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Idiopathic hypereosinophilic syndrome is characterized by marked elevation of eosinophil count ( >1,500/㎣) in peripheral blood without explaining etiology. It shows tissue involvement in many organs such as liver, G-I tract, myocar dium, lung, skin, kidney and nerve. Some case of hypereosinophilic syndrome with hepatic involvement have been reported, but not much. We have recently experienced a case with idiopathic hypereosinophilic syndrome of a 40 year old man who presented with RUQ pain. By abdominal CT, ill- defined subcapsular hematoma was detected. Liver biopsy showed eosinophilic infiltration within the portal tract and sinusoid. Drain procedure and corticosteroid adminiiatbrought marked improvement of clinical manifestation, hematologic abnormality and radiologic abnormality.

융모성림프구를 보이는 비장변연부 림프종 1예

진한영,손창학,주영돈,박정하,이재익,조영완,이원식 인제대학교 2006 仁濟醫學 Vol.27 No.-

Splenic marginal zone lymphoma is very rare B-cell lymphoma, characterized by an indolent clinical course. Clinical features are moderate-to severe splenomegaly, absolute lymphocytosis, and bone marrow intrasinusoidal infiltration of lymphocyte. We report the case of a 37-year-old male with SMZL. He complained of LUQ pain, who had a massive splenomegaly and moderate lymphocytosis in peripheral blood. Immunophenotyping findings and morphologic findings were consistent with SMZL. He underwent splenectomy and received chemotherapy with cyclophosphamide for eight months. Now, one year later after surgery he has a nearly normal blood count with no treatment.

김치 발효중 생체활성 아민 생성에 관한 연구

서일원,류춘선,이주돈,이영환,변광의 순천향대학교 기초과학연구소 1997 순천향자연과학연구 논문집 Vol.3 No.2

Biogenic amines can be formed and degraded either as the result of endogenous amino acid decarboxylase activity in raw materials or by the growth of decarboxylase-positive microorgannisms under conditions favorable to enzyme activity. Three biogenic amines(Tryptamine, Histamine, Tyramine) were intensively investigated by the HPLC during Kimchi fermentation at 5℃. The patterns of microfloral changes in lactic acid bacterial group, Leuconostoc, Streptococcus and Lactobacillus, were similar to the typical low-temperature fermentation. The population of microbial growth were high after 10 days and gradually decreased. The levels of Tyramine were lowered(10mg/kg) during this mid-periods(8∼16 days) but very high in initial-(15mg/kg) and final-periods (30mg/kg), in which the total acidity ranged between 0.2∼0.35% and 0.4∼0.6%, while the acidity in mid-periods revealed 0.35∼0.4% beginning the initial ripening period. Leuconostoc was highly increased in number in mid-period but slightly declined as the acidity increased, whereas Streptococcus was highly distributed in initial-period and Lactobacillus in final-period. The levels of Tryptamine and Histamine were relatively low throughout the whole fermentation period, but the profile of Tryptamine level was very similar to the case of Tyramine. Histamine was maintained at a certain level after mid-period of fermentation.

가족성 고콜레스테롤혈증 유병자에서 HMG Co-A Reductasen Inhibitor 및 Bile Acid Resin의 투여로 인한 아킬레스건 황색종의 감소

채인호,한기훈,박영배,조주희,김효수,손대원,김철호,오병희,이명묵,최윤식,서정돈,이영우 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.9

삼출성 중이염 환자에서의 혈중 및 아데노이드 면역글로불린 E의 면역혈청학적 연구

장혁순,강성호,유창수,김성현,이병돈,박영진,윤세동,안희영,강주원 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

Otitis media with effusion (OME) is one of the most common disease in children but its pathogenesis is not clear. In particular the role of allergy has revealed conflicting support with widely varing opinions as to its importance. Within recent years, striking biochemical and immunochemical analytic techniques have opened a new approach the study of otitis media with effusion. So we focused on distributions of IgE in adenoid tissue and serum IgE levels. Authors compared the serum IgE and the distribution of IgE in adenoid tissue between the 20 patients underwent tonsillectomy, adenoidectomy and ventilating tube insertion and control group of 11 patients underwent tonsillectomy and adenoidectomy. The results were as follows; 1. In the distribution of IgE in adenoid tissue, there was a significant increase in the group of patients with OME compared to the control group (P<0.01). 2. In the analysis of serum IgE levels, the levels of IgE in the OME patients an control group were higher than normal level, although the level of IgE in the OME patients were less than that of control group, there was no significance P>0.05).

Clinical Significance of p53, P-glycoprotein, and Glutathione S transferase-π in Advanced Non-Small Cell Lung Cancer

Young Don Joo,Chang Hak Sohn 대한암학회 2002 Cancer Research and Treatment Vol.34 No.1

Purpose: A retrospective study was performed o definethe clninical significance of p53, P-glycoprotein (Pgp),and Glutathione S transferase-π (GST-π) immunohistochemical(IHC) expression in advanced non-small celllung cancer (NSCLC).Materials and Methods: We reviewed fifty sevenpatients with advanced NSCLC who had undergonesurgical resection or bronchoscopic biopsy betweenMarch 1997 and March 1999. IHC staining for p53, GST-π,and Pgp was performed using formalin-fixed, paraffinembeddedspecimens of the fifty seven patients.Results: The IHC expression rate was 63% for p53, 28%for Pgp, and 53% for GST-π, respectively. The mediansurvival of the fifty seven patients was 45 weeks and theresponse rate was 38.6% (partial response, 22/57). Thechemotherapy response and median survival of the p53negative group (57% and 61 weeks) were better thanthose demonstrated by the p53 positive group (28%and 21 weeks) (p〈0.05). Additionally, the GST-π negativegroup showed a greater improvement of survival andresponse rate than the positive group (p〈0.05). Pgpexpression status appeared to have no significantdifferential effect on chemotherapy response andsurvival.Conclusion: These results suggest that immunohistochemicalstaining of p53 and GST-π may be useful inpredicting the response to chemotherapy as well assurvival in advanced NSCLC. However, this study islimited by its retrospective nature and the small numbersof tumors studied from a heterogenous group of patients.(Cancer Res Treat. 2002;34:34-40)

Granulocyte colony-stimulating factor-induced immature myeloid cells inhibit acute graft-versus-host disease lethality through an indoleamine dioxygenase-independent mechanism

Joo, Young-Don,Lee, Sun-Mi,Lee, Soo-Woong,Lee, Won-Sik,Lee, Sang-Min,Park, Ji-Kyoung,Choi, Il-Whan,Park, Sae-Gwang,Choi, Inhak,Seo, Su-Kil Blackwell Publishing Ltd 2009 Immunology Vol.128 No.1

<P>Summary</P><P>Granulocyte colony-stimulating factor (G-CSF)-mobilized donor graft tissue used for peripheral blood stem cell transplantation contains a large number of immature myeloid cells that suppress alloreactive donor T cells, resulting in an inhibition of acute graft-versus-host disease (GVHD). However, the molecular mechanism underlying the suppressive function of immature myeloid cells is not fully understood. Here, we investigated whether indoleamine 2,3-dioxygenase (IDO) is related to the suppressive mechanism of G-CSF-induced immature myeloid cells (gMCs). We found that Gr-1<SUP>+</SUP> CD11b<SUP>+</SUP> cells were highly induced in G-CSF-injected donor graft tissue, which is a phenotype of immature myeloid cells, resulting in an inhibition of acute GVHD lethality by suppressing alloreactive donor T-cell expansion. IDO was not detected in primary isolated gMCs; however, this enzyme was markedly induced after treatment with interferon-&ggr; (IFN-&ggr;). This level was significantly higher in IFN-&ggr;-treated gMCs than in bone marrow myeloid cells, which promote alloreactive T-cell responses. We next investigated the functional role of IDO in gMC-mediated inhibition of acute GVHD lethality. We found no changes in gMC-mediated survival or alloreactive donor T-cell suppression when IDO activity was blocked using 1-methyl tryptophan. In addition, there was no difference in gMC-mediated survival rates between recipients transferred with either wild-type gMCs or IDO<SUP>−/−</SUP> gMCs. Taken together, our data suggest that gMC-mediated inhibition of lethal acute GVHD is through an IDO-independent mechanism.</P>

HCC : PO-08 ; The utility of add-on Primovist-MRI for staging workup in very early or early hepatocellular carcinoma on liver dynamic CT

( Young Joo Jin ),( So Yun Nah ),( Jin Woo Lee ),( Jung Il Lee ),( Byung Wook Bang ),( Seok Jeong ),( Kye Sook Kwon ),( Don Haeng Lee ),( Hyung Gil Kim ),( Yong Woon Shin ),( Young Soo Kim ),( Yong Su 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: The usefulness of additional examination of Primovist-enhanced magnetic resonance images (MRI) during initial staging workup in hepatocellular carcinoma (HCC) patients who are candidates for curative treatment with no suspicious intrahepatic HCC lesion by liver dynamic computed tomography (CT) remains to be elucidated. Methods: A consecutive 104 patients who were initially diagnosed as having definite HCC without any suspicious HCC lesions by liver dynamic CT at our institution between December 2009 and May 2012 were enrolled. All of them showed Barcelona Clinic Liver Cancer (BCLC) stages 0 or A. We evaluated whether an additional examination of Primovist- enhanced MRI could affect on BCLC stage, directly comparing to liver dynamic CT. Results: Newly detected intrahepatic abnormal findings on Primovist-enhanced MRI were observed in 41 (39.4%) of the 104 patients. Eighteen (17.3%) patients had truly new HCCs, but 6 patients of initial BCLC stage A remained at this stage despite an increase in tumor number. Of the 104 patients, 31 (29.8%) and 73 (70.2%) had BCLC stages 0 and A HCC before Primovist-enhanced MRI, respectively, and 26 (25.0%), 71 (68.3%), and 7 (6.7%) patients had BCLC stages 0, A, and B HCC after Primovist-enhanced MRI, respectively. In 12 (11.5%) of the 104 patients, BCLC stage changed from 0 to A (5/31, 16.1%) or from A to B (7/73, 9.6%). Conclusions: Primovist-enhanced MRI can provide additional information regarding the detection of new intrahepatic HCC lesions during initial staging workup in patients with BCLC 0 or A stage, but with no suspicious HCC lesion by liver dynamic CT.