Molecular subtypes of triple-negative breast cancer: understanding of subtype categories and clinical implication

Yong‑Moon Lee,Man Hwan Oh,Jai‑Hyang Go,Kyudong Han,Song‑Yi Choi 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Triple-negative breast cancer (TNBC) is a heterogeneous entity that encompasses several subtypes with distinct molecular characteristics. The patients with TNBCs show unpredictable response to the chemotherapy, and further there is the lack of effective agents. Thus, many studies have been underway to discover targeted therapy suitable for patients with specific genetic alterations in each molecular subtypes. TNBCs are classified as four major molecular subtypes according to the gene expression patterns. These are luminal androgen receptor (LAR), mesenchymal-like, immunomodulatory (IM), and basal-like types. Conclusion: Here, we discuss the unique molecular features of each subtype as well as promising targets for anti-cancer therapy.

대형유통상업시설 개발을 위한 소비자 선택기준에 관한 연구 -용인/분당 지역 대형백화점을 기준으로-

정문오 ( Moon Oh Jeong ),김재환 ( Jae Hwan Kim ),김용일 ( Yong Il Kim ),이상엽 ( Sang Youb Lee ) 한국부동산분석학회 2009 不動産學硏究 Vol.15 No.3

Today`s distribution market has many structures such as department stores, large discount stores, traditional markets, and internet shopping malls, and the choice variety of the consumers` purchase behavior increased. For this, this study conducted research about consumer choice criteria about department stores among many distribution market structures and consumer satisfaction in Yong-In and Bun-Dang area. The degree of importance about choice criteria for department stores in general was analyzed, and for the degree of importance items, degree of preference about the actual department stores in Yong-In and Bun-Dang area was additionally analyzed. The selection of factors for department store choice criteria was ultimately done by consulting with researchers of the previous studies and distribution specialists, and the survey was conducted from an outside survey institute, and the relative importance was evaluated by AHP method. Also, additional research was conducted on the actual consumer preference of department stores located in Bun-Dang and Yong-In area about each choice criteria item. From the analysis results, the factors that are considered in priority in choosing a department stores and actual preference of department stores were analyzed, and the consumer characteristics and new perception standard were identified.

급성 포름알데히드 가스 흡입에 의한 흰쥐 후각상피의 형태학적 변화

백선용,전재기,문용석,황승영,노환중,고의경,왕수건 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.3

제조업 산업장의 유기용제 노출에 관한 연구

문덕환,김정하,김필자,박명희,황용식,이채관,이창희 한국산업위생학회 2001 한국산업보건학회지 Vol.11 No.3

Objective : For the purpose of preparing the fundamental data and health promotion and control program on organic solvents in air of manufacturing industry. Methods : The author surveyed number of organic solvent components which was used in working site and also determined the organic solvents concentration in air of 927 manufacturing industries and 1,267 working process with gas chromatography(NIOSH manual) for five years from 1995 to 1999. Results : Mean numbers of solvents components by type of industry, working process was number of 12. There were exceeded to TLV of 1,2-dichloroethane in textile manufacturing industry N,N-dimethyl furan in tanning and dressing of leather ; luggage, handbags, saddlery, harness and footwear manufacturing industry and chemical and chemical product manufacturing industry by type of industry. There were exceeded to TLV of 1,2-dichloroethane in handwriting and drawing process, cellosolove in adhesive spreading process, N,N-dimethly furan in production of solvent process and adhesion process by working process. Total exceeded rate to threshold limit values of organic solvents mixture were 12.9% for EI(Exposure index) and 10.0% for Em(Estimation of mixture) by type of industry, 11.3% for EI and 8.2% for Em by type of working process. The highest exceed rate was 36.7% for EI in tanning and dressing of leather ; luggage handbags, saddlery, harness and footwear manufacturing industry and 29.0% for Em in textile manufacturing industry. the highest exceeded rate was 23.1% for EI and 12.5% for Em in adhesive spreading process by working process. Mean values of total subjects by type of industry and type of working process were 0.7±1.8 for EI and 0.7±1.7 for Em respectively. Conclusions : As above results, the author suggest that it makes the environmental control program on 1.2-dichloro-ethane, N,N-dimethyl furan, cellosolve by kind of organic solvent and on textile manufacturing industry, tanning and dressing of leather ; luggage, handbags, saddlery harness and footwear manufacturing industry by type of industry, and on handwriting, drawing process and adhesive spreading process and adhesion process by type of working process.

도금사업장의 작업환경의 유해인자 노출수준에 관한 연구

문덕환,도수영,이채관,황용식,선병관,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objective : For the purpose of preparing the fundamental data and assessing the status of exposure level of chemical substances and physical agents. Methods and Material : Such as noise, two types of dust, four types of metals, seventeen types of organic solvents, and four types of other materials classified by specific chemical substances in 21 metal product plating factories classified by 28 processes. The author determined exposure level on those hazardous materials from Jan. to Dec. 2001. Results : The results were as follows: 1. The exposure level for noise was exceeded to Threshold Limit Value(TLV) in the process of 6 cases of Machining, 5 and 4 cases of pre and post-buffing, and 6 cases of waterdrop-removing, the mean noise level of all of processes was not exceeded to compliance level. 2. The exposure level for dust was not exceeded to TLV at all. 3. The exposure level for Chromium(Cr) was exceeded to TLV in Chromium plating process, metal exposure level including Zinc(Zn), Manganese(Mn), and Lead(Pb) was not exceeded to TLV. 4. The exposure level of toluene in case of organic solvents was exceeded to TLV in 1 case of finishing/cleaning, coating/developing process, respectively. 5. The exposure level of four types of other materials classified by specific chemical substances were not exceeded to TLV. 6. The exposure level for dust and metal including Zn, Mn, and Pb was decreased in comparison with two results of air monitoring performed. There was no difference of the exposure level for Cr, noise, and four types of other materials classified by specific chemical substances, and the exposure level for organic solvents was slightly increased. 7. The exposure level for noise in factories employing more than 21 workers was higher than that for noise in foadtories employing less than 20 workers. The more workers, the lower exposure level in metal including Zn, Mn. The exposure level for Cr was increasing in factories employing more than 51 workers, and the more workers the lower exposure level in organic solvents. Conclusion : According to above results, this study suggests positive work environment managements in processes exceeding exposure limit value as well as continuously consecutive work environment management in processes not exceeding exposure limit value and revealing no chronological difference of exposure level should be needed.

배출수 처리공정의 진단

문용택,최일환 대한상하수도학회 2002 상하수도학회지 Vol.16 No.6

적응 Simplex-Mesh 기술에 기반한 3차원 물체 복원과 자료압축

문성환,강훈,조용군 중앙대학교 생산공학연구소 1999 생산공학연구소 논문집 Vol.8 No.1

대부분의 3차원 물체 복원 기술은 물체를 다수의 평면으로 나누어 물체의 표면을 근사시켜 표현한다. 주어진 분류치를 사용하여 mesh를 초기화시키는 Marching Cubes 알고리듬과 Delaunay Tetrahedrisation이 널리 사용되고 있다. 이와 더불어 deformable 모델은 적은 수의 가정만으로도 다양한 종류의 데이터들에 대한 복원 및 재구성을 할 수 있기 때문에 일반적인 물체 복원에 적합하다. 본 논문에서는 곡면으로 이루어진 물체에 대해서 적응 simplex mesh 기술을 기반으로 3차원 물체를 압축 복원하는 방법을 제시한다. 이 방법은 미리 정해진 mesh 구조를 변형시키고 곡률과 같은 기하학적인 특성들을 다시 설정하면서 본래의 3차원 물체로 접근시킨다. 시뮬레이션을 통해서 높은 압축률로 물체를 복원하고, 물체의 모양을 최적으로 기술하기 위해 정점들이 곡률이 높은 곳으로 집중되는 것을 보인다. Most of the 3D object reconstruction techniques divide the object into multiplane and approximate the surfaces of the object. The Marching Cubes Algorithm which initializes the mesh structure using a given isovalue, and Delaunay Tetrahedrisation are widely used. Deformable models are well-suited for general object reconstruction because they make little assumptions about the shape to recover and they can reconstruct objects from various types of datasets. In this paper, we propose a novel method for reconstruction of 3D objects. This method, for a 3D object composed of curved planes, compresses the 3D object based on the adaptive simplex-mesh technique. It changes the pre-defined mesh structure, so that it may approach to the original object. Also, we redefine the geometric characteristics such as curvatures. As results of simulations, we show reconstruction of the original object with high compression and concentration of vertices towards parts of high curvature in order to optimize the shape description.

물시멘트비 및 단위수량에 따른 고품질 재생잔골재를 사용한 재생콘크리트의 공학적 특성에 관한 실험적 연구

문형재,송민섭,김재환,장종호,김용로,김무한 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The purpose of this study is to investigate and analyze experimentally and positively engineering properties of recycled concrete using high quality recycled fine aggregate according to w/c ratio and unit water contents. And it is intend to present fundamental data for the mix design and the improvement of quality. The results are as follows; According to the increase of W/C ratio, the addition ratio of superplasticizer was reduced, the strength of compressive and tensile showed low and carbonation depth and chloride penetration depth showed high. And according to the increase of unit water contents, the addition ratio of superplasticizer was reduced, the strength of compressive and tensile showed low and carbonation depth and chloride penetration depth showed high.

3차원 물체 복원과 자료 압축을 위한 적응 Simplex-Mesh 기술의 응용

문성환,조용군,강훈 중앙대학교 정보통신연구소 1999 정보통신연구소논문집 Vol.1 No.1

대부분의 3차원 물체 복원 기술은 물체를 다수의 평면으로 나누어 물체의 표면을 근사시켜 표현한다. 주어진 분류치를 사용하여 mesh를 초기화시키는 Marching Cubes 알고리듬과 Delaunay Tetrahedrisation이 널리 사용되고 있다. 이와 더불어 deformable 모델은 적은 수의 가정만으로도 다양한 종류의 데이터들에 대한 복원 및 재구성을 할 수 있기 때문에 일반적인 물체 복원에 적합하다. 현재 deformable 모델이 기반이 된 복원 시스템에 대한 연구가 활발히 진행중이다. 본 논문에서는 곡면으로 이루어진 물체에 대해서 적응 simplex mesh 기술을 바탕으로 3차원 물체를 압축, 복원하는 방법을 제시한다. 이 방법은 미리 정해진 mesh 구조를 변형시키고 곡률과 같은 기하학적인 특성들을 다시 설정하면서 본래의 3차원 물체로 접근시킨다. 시뮬레이션을 통해서 높은 압축률로 물체롤 복원하고, 물체의 모양을 최적으로 기술하기 위해 정점들이 곡률이 높은 곳으로 집중되는 것을 보인다. Most of the 3D object reconstruction techniques divide the object into multiplane and approximate the surfaces of the object. The Marching Cubes Algorithm which initializes the mesh structure using a given isovalue, and Delaunay Tetrahedrisation are widely used. Deformable models are well-suited for general object reconstruction because they make little assumptions about the shape to recover and they can reconstruct objects from various types of datasets. Now, many researchers are studying the reconstruction systems based on a deformable model. In this paper, we propose a novel method for reconstruction of 3D objects. This method, for a 3D object composed of curved planes, compresses the 3D object based on the adaptive simplex-mesh technique. It changes the pre-defined mesh structure, so that it may approach to the original object. Also, we redefine the geometric characteristics such as curvatures. As results of simulations, we show reconstruction of the original object with high compression and concentration of vertices towards parts of high curvature in order to optimize the shape description.

전력계통의 전압붕괴에 관한 연구

한성문,왕용필,정형환,주수원 동아대학교 공과대학 부설 한국자원개발연구소 1995 硏究報告 Vol.19 No.1

This paper analyzed the static voltage collapse phenomenon and the dynamic voltage collapse phenomenon by means of fluctuations of active-reactive power and the fluctuations of active power offered an output from the load bus respectively. The results are summarized as follows 1. In static state, the voltage collapse value can be computed by applying the equilibrium equation of active- reactive power to Jacobian, the bifurcation point can be also found. 2. The voltage collapse broke out by the reactive power loss and it is found that the active power has an effect on the voltage collapse phenomenon. 3. When a disturbance is given to the active power of the infinite bus voltage side, it is showed that a voltage is collpased by change of the load angle and the current in a dynamic fuctuation of the transient internal voltage E'_(q), E'_(d).