Applications of Intelligent Radio Technologies in Unlicensed Cellular Networks - A Survey

( Yi-feng Huang ),( Hsiao-hwa Chen ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.7

Demands for high-speed wireless data services grow rapidly. It is a big challenge to increasing the network capacity operating on licensed spectrum resources. Unlicensed spectrum cellular networks have been proposed as a solution in response to severe spectrum shortage. Licensed Assisted Access (LAA) was standardized by 3GPP, aiming to deliver data services through unlicensed 5 GHz spectrum. Furthermore, the 3GPP proposed 5G New Radio-Unlicensed (NR-U) study item. On the other hand, artificial intelligence (AI) has attracted enormous attention to implement 5G and beyond systems, which is known as Intelligent Radio (IR). To tackle the challenges of unlicensed spectrum networks in 4G/5G/B5G systems, a lot of works have been done, focusing on using Machine Learning (ML) to support resource allocation in LTE-LAA/NR-U and Wi-Fi coexistence environments. Generally speaking, ML techniques are used in IR based on statistical models established for solving specific optimization problems. In this paper, we aim to conduct a comprehensive survey on the recent research efforts related to unlicensed cellular networks and IR technologies, which work jointly to implement 5G and beyond wireless networks. Furthermore, we introduce a positioning assisted LTE-LAA system based on the difference in received signal strength (DRSS) to allocate resources among UEs. We will also discuss some open issues and challenges for future research on the IR applications in unlicensed cellular networks.

Mutation of IPO13 causes recessive ocular coloboma, microphthalmia, and cataract

Xiu-Feng Huang,Lue Xiang,Wan Cheng,Fei-Fei Cheng,Kai-Wen He,Bo-Wen Zhang,Si-Si Zheng,Ru-Yi Han,Yi-Han Zheng,Xiao-Tao Xu,Huan-Yun Yu,Wenjuan Zhuang,Yuk Fai Leung,Zi-Bing Jin 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Ocular coloboma is a developmental structural defect of the eye that often occurs as complex ocular anomalies. However, its genetic etiology remains largely unexplored. Here we report the identification of mutation (c.331C>T, p. R111C) in the IPO13 gene in a consanguineous family with ocular coloboma, microphthalmia, and cataract by a combination of whole-exome sequencing and homozygosity mapping. IPO13 encodes an importin-B family protein and has been proven to be associated with the pathogenesis of coloboma and microphthalmia. We found that Ipo13 was expressed in the cornea, sclera, lens, and retina in mice. Additionally, the mRNA expression level of Ipo13 decreased significantly in the patient compared with its expression in a healthy individual. Morpholinooligonucleotide- induced knockdown of ipo13 in zebrafish caused dose-dependent microphthalmia and coloboma, which is highly similar to the ocular phenotypes in the patient. Moreover, both visual motor response and optokinetic response were impaired severely. Notably, these ocular phenotypes in ipo13-deficient zebrafish could be rescued remarkably by full-length ipo13 mRNA, suggesting that the phenotypes observed in zebrafish were due to insufficient ipo13 function. Altogether, our findings demonstrate, for the first time, a new role of IPO13 in eye morphogenesis and that loss of function of IPO13 could lead to ocular coloboma, microphthalmia, and cataract in humans and zebrafish.

공공도서관의 시각장애인 서비스 경험의 개선 방향

황의항(Yi Hang Huang),이립위(Li Wei Li),왕일봉(Yi Feng Wang),김응화(Eung Hwa Kim),정의태(Eui Tay Jung),이선미(Sun Mi Lee) 한국디자인리서치학회 2023 한국디자인리서치 Vol.8 No.4

Public Service Motivation and Perception of Self-efficacy: An Empirical Study in Taiwan

( Irving Yi Feng Huang ),( Wan Ling Huang ) 한국행정학회 2011 한국행정학회 학술발표논문집 Vol.2011 No.-

Causal Relations between Exposome and Stroke: A Mendelian Randomization Study

Hong-Qi Li,Yi-Wei Feng,Yu-Xiang Yang,Xin-Yi Leng,Prof Can Zhang,Shi-Dong Chen,Kevin Kuo,Shu-Yi Huang,Xue-Qing Zhang,Yi Dong,Xiang Han,Xin Cheng,Mei Cui,Lan Tan,Qiang Dong,Jin-Tai Yu 대한뇌졸중학회 2022 Journal of stroke Vol.24 No.2

Background and Purpose To explore the causal relationships of elements of the exposome with ischemic stroke and its subtypes at the omics level and to provide evidence for stroke prevention. Methods We conducted a Mendelian randomization study between exposure and any ischemic stroke (AIS) and its subtypes (large-artery atherosclerotic disease [LAD], cardioembolic stroke [CE], and small vessel disease [SVD]). The exposure dataset was the UK Biobank involving 361,194 subjects, and the outcome dataset was the MEGASTROKE consortium including 52,000 participants. Results We found that higher blood pressure (BP) (systolic BP: odds ratio [OR], 1.02; 95% confidence interval [CI], 1.01 to 1.04; diastolic BP: OR, 1.03; 95% CI, 1.01 to 1.05; pulse pressure: OR, 1.03; 95% CI, 1.00 to 1.06), atrial fibrillation (OR, 1.18; 95% CI, 1.13 to 1.25), and diabetes (OR, 1.13; 95% CI, 1.07 to 1.18) were significantly associated with ischemic stroke. Importantly, higher education (OR, 0.69; 95% CI, 0.60 to 0.79) decreased the risk of ischemic stroke. Higher systolic BP (OR, 1.06; 95% CI, 1.02 to 1.10), pulse pressure (OR, 1.08; 95% CI, 1.02 to 1.14), diabetes (OR, 1.28; 95% CI, 1.13 to 1.45), and coronary artery disease (OR, 1.58; 95% CI, 1.25 to 2.00) could cause LAD. Atrial fibrillation could cause CE (OR, 1.90; 95% CI, 1.71 to 2.11). For SVD, higher systolic BP (OR, 1.04; 95% CI, 1.00 to 1.07), diastolic BP (OR, 1.06; 95% CI, 1.01 to 1.12), and diabetes (OR, 1.22; 95% CI, 1.10 to 1.36) were causal factors. Conclusions The study revealed elements of the exposome causally linked to ischemic stroke and its subtypes, including conventional causal risk factors and novel protective factors such as higher education.

The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells

Chun-Yu Liu,Tzu-Ting Huang,Pei-Yi Chu,Chun-Teng Huang,Chia-Han Lee,Wan-Lun Wang,Ka-Yi Lau,Wen-Chun Tsai,Tzu-I Chao,Jung-Chen Su,Ming-Huang Chen,Chung-Wai Shiau,Ling-Ming Tseng,Kuen-Feng Chen 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In this study, we examined a new molecular mechanism of nintedanib in TNBC. The results demonstrated that nintedanib enhanced TNBC cell apoptosis, which was accompanied by a reduction of p-STAT3 and its downstream proteins. STAT3 overexpression suppressed nintedanib-mediated apoptosis and further increased the activity of purified SHP-1 protein. Moreover, treatment with either a specific inhibitor of SHP-1 or SHP-1-targeted siRNA reduced the apoptotic effects of nintedanib, which validates the role of SHP-1 in nintedanib-mediated apoptosis. Furthermore, nintedanib-induced apoptosis was attenuated in TNBC cells expressing SHP-1 mutants with constantly open conformations, suggesting that the autoinhibitory mechanism of SHP-1 attenuated the effects of nintedanib. Importantly, nintedanib significantly inhibited tumor growth via the SHP-1/p-STAT3 pathway. Clinically, SHP-1 levels were downregulated, whereas p-STAT3 was upregulated in tumor tissues, and SHP-1 transcripts were associated with improved disease-free survival in TNBC patients. Our findings revealed that nintedanib induces TNBC apoptosis by acting as a SHP-1 agonist, suggesting that targeting STAT3 by enhancing SHP-1 expression could be a viable therapeutic strategy against TNBC.

Preliminary Evaluation of the in vitro Efficacy of 1, 2-di (Quinazolin-4-yl) Diselane against SiHa Cervical Cancer Cells

Huang, Yin-Jiu,Zhang, Yu-Yuan,Liu, Gang,Tang, Jie,Hu, Jian-Guo,Feng, Zhen-Zhong,Liu, Fang,Wang, Qi-Yi,Li, Dan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Cervical cancer is one the most common malignancies among females. In recent years, its incidence rate has shown a rising trend in some countries so that development of anticancer drugs for cervical cancer is an urgent priority. In our recent anticancer drug discovery screen, 1, 2-di (quinazolin-4-yl)diselane (LG003) was found to possess wide spectrum anticancer efficacy. In the present work, the in vitro anticancer activity of LG003 was evaluated in the SiHa cervical cancer cell line. Compared with commercial anticancer drugs 10-hydroxycamptothecin, epirubicin hydrochloride, taxol and oxaliplatin, LG003 showed better anticancer activity. Furthermore, inhibition effects were time- and dose-dependent. Morphological observation exhibited LG003 treatment results in apoptosis like shrinking and blebbing, and cell membrane damage. Lactate dehydrogenase release assay revealed that LG003 exerts such effects in SiHa cells through a physiology pathway rather than cytotoxicity, which suggests that title compound LG003 can be a potential candidate agent for cervical cancer.

High-Performance Bottom-Contact Organic Thin-Film Transistors Based on Benzo[<i>d</i>,<i>d</i>′]thieno[3,2-<i>b</i>;4,5-<i>b</i>′]dithiophenes (BTDTs) Derivatives

Huang, Peng-Yi,Chen, Liang-Hsiang,Kim, Choongik,Chang, Hsiu-Chieh,Liang, You-jhih,Feng, Chieh-Yuan,Yeh, Chia-Ming,Ho, Jia-Chong,Lee, Cheng-Chung,Chen, Ming-Chou American Chemical Society 2012 ACS APPLIED MATERIALS & INTERFACES Vol.4 No.12

<P>Three benzo[<I>d</I>,<I>d</I>′]thieno[3,2-<I>b</I>;4,5-<I>b</I>′]dithiophene (<B>BTDT</B>) derivatives, end-functionalized with benzothiophenyl (<B>BT-BTDT</B>; <B>2</B>), benzothieno[3,2-b]thiophenyl (<B>BTT-BTDT</B>; 3), and benzo[<I>d</I>,<I>d</I>′]thieno[3,2-<I>b</I>;4,5-<I>b</I>′]dithiophenyl (<B>BBTDT</B>; <B>4</B>), were prepared for bottom-contact/bottom-gate organic thin-film transistors (OTFTs). An improved one-pot [2 + 1 + 1] synthetic method of <B>BTDT</B> with improved synthetic yield was achieved, which enabled the efficient realization of new <B>BTDT</B>-based semiconductors. All of the <B>BTDT</B> compounds exhibited high performance p-channel characteristics with carrier mobilities as high as 0.34 cm<SUP>2</SUP>/(V s) and a current on/off ratio of 1 × 10<SUP>7</SUP>, as well as enhanced ambient stability. The device characteristics have been correlated with the film morphologies and microstructures of the corresponding compounds.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2012/aamick.2012.4.issue-12/am3022448/production/images/medium/am-2012-022448_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am3022448'>ACS Electronic Supporting Info</A></P>

Image Fusion and Evaluation by using Mapping Satellite-1 Data

Huang, He,Hu, Yafei,Feng, Yi,Zhang, Meng,Song, DongSeob Korean Society of Surveying 2013 한국측량학회지 Vol.31 No.6

China's Mapping Satellite-1, developed by the China Aerospace Science and Technology Corporation (CASC), was launched in three years ago. The data from Mapping Satellite-1 are able to use for efficient surveying and geometric mapping application field. In this paper, we fuse the panchromatic and multispectral images of Changchun area, which are obtained from the Mapping Satellite-1, the one that is the Chinese first transmission-type three-dimensional mapping satellite. The four traditional image fusion methods, which are HPF, Mod.IHS, Panshar and wavelet transform, were used to approach for effectively fusing Mapping Satellite-1 remote sensing data. Subsequently we assess the results with some commonly used methods, which are known a subjective qualitative evaluation and quantitative statistical analysis approach. Consequently, we found that the wavelet transform remote sensing image fusion is the optimal in the degree of distortion, the ability of performance of details and image information availability among four methods. To further understand the optimal methods to fuse Mapping Satellite-1 images, an additional study is necessary.

Task Offloading of Intelligent Building Based on CO–HHO Algorithm in Edge Computing

Yi Lingzhi,Gao Xieyi,Li Zongpin,Feng Xiaodong,Huang Jianxiong,Liu Qiankun 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.6

With the rapid development of intelligent devices, the intelligence of buildings is becoming more and more obvious, which leads to the rapid growth of data generated by building users. The existing network bandwidth is far from enough for the transmission of existing data, which will lead to congestion in the process of data transmission. In this paper, a task offl oading strategy based on edge computing is proposed. The edge server is deployed near the data source, which mainly solves the problems of transmission delay and energy consumption of building users during task offl oading. In this paper, the mathematical model of system delay and energy consumption is established fi rst. In order to better refl ect the quality of the system, the delay and energy consumption are combined into system utility, and then the objective function is established. Since the objective function is a mixed integer nonlinear programming problem, fi nding the optimal solution usually requires exponential time complexity. Therefore, this paper fi rstly uses the Tammer decomposition method to decouple the objective function, and decomposes it into the resource allocation problem of fi xed task offl oading decision and the task offl oad problem of maximizing the objective function. Then the convex optimization (CO) theory is used to greatly reduce the complexity of the objective function and optimize the resource allocation problem. Finally, the task offl oading problem is solved by the improved Harris Hawks Optimization (HHO) . The paper compares various offl oading schemes. The simulation results show that the CO–HHO offl oading strategy based on edge computing proposed in this paper can eff ectively reduce the transmission delay and energy consumption of user tasks in intelligent buildings, and is superior to others in all aspects.