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Pao-Huan Chen(Pao-Huan Chen),Chun-Ming Shih(Chun-Ming Shih),Chi-Kang Chang(Chi-Kang Chang),Chia-Pei Lin(Chia-Pei Lin),Yung-Han Chang(Yung-Han Chang),Hsin-Chien Lee(Hsin-Chien Lee),El-Wui Loh(El-Wui Lo 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2
Objective: Predicting disease relapse and early intervention could reduce symptom severity. We attempted to identify potential indicators that predict the duration to next admission for an acute affective episode in patients with bipolar I disorder. Methods: We mathematically defined the duration to next psychiatric admission and performed single-variate regressions using historical data of 101 patients with bipolar I disorder to screen for potential variables for further multivariate regressions. Results: Age of onset, total psychiatric admissions, length of lithium use, and carbamazepine use during the psychiatric hospitalization contributed to the next psychiatric admission duration positively. The all-in-one found that hyperlipidemia during the psychiatric hospitalization demonstrated a negative contribution to the duration to next psychiatric admission; the last duration to psychiatric admission, lithium and carbamazepine uses during the psychiatric hospitalization, and heart rate on the discharge day positively contributed to the duration to next admission. Conclusion: We identified essential variables that may predict the duration of bipolar I patients’ next psychiatric admission. The correlation of a faster heartbeat and a normal lipid profile in delaying the next onset highlights the importance of managing these parameters when treating bipolar I disorder.
An Improvement Video Search Method for VP-Tree by using a Trigonometric Inequality
Lee, Samuel Sangkon,Shishibori, Masami,Han, Chia Y. Korea Information Processing Society 2013 Journal of information processing systems Vol.9 No.2
This paper presents an approach for improving the use of VP-tree in video indexing and searching. A vantage-point tree or VP-tree is one of the metric space-based indexing methods used in multimedia database searches and data retrieval. Instead of relying on the Euclidean distance as a measure of search space, the proposed approach focuses on the trigonometric inequality for compressing the search range, which thus, improves the search performance. A test result of using 10,000 video files shows that this method reduced the search time by 5-12%, as compared to the existing method that uses the AESA algorithm.
Adverse events of sugammadex that occurred in a Korean population
Han Woong,Lee Jong Min,박동호,Lee Chia An,Jeong Chang Yeong,Yang Hong Seuk 대한마취통증의학회 2022 Anesthesia and pain medicine Vol.17 No.2
Background: With increasing use, the incidence of adverse events associated with sugammadex, a neuromuscular blockade reverser, is increasing. This study aimed to identify and analyze cases of adverse events caused by sugammadex reported in Korean population.Methods: Out of a total of 12 cases detected using various keywords in the Korean Journal of Anesthesia, Anesthesia and Pain Medicine (Seoul), KoreaMed, PubMed, EMBASE, Web of Science, and The Cochrane Library-CENTRAL from 2013 to December 2020, 10 cases directly associated with sugammadex were selected.Results: Adverse events included five cases of anaphylaxis, one case of cardiac arrest, one case of profound bradycardia, one case of negative pressure pulmonary edema, and two cases of incomplete recovery. Three patients had American Society of Anesthesiologists physical status ≥ 3, two had emergency surgery, and two had a history of allergic reaction. Neuromuscular monitoring was applied in nine cases. The average dose of sugammadex was 2.87 mg/kg, and there were six cases in which one full vial was used, regardless of the state of neuromuscular recovery. Sugammadex was administered immediately after surgery in two cases, at train of four (TOF) 0 in four cases, at TOF 3 in one case, and after evaluation of the clinical signs only with no neuromuscular monitoring in one case.Conclusions: Even with neuromuscular monitoring, an excessive dose of sugammadex was observed. Given that adverse events tend to occur within 10 min of administration, continuous monitoring is important even after administration.
Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis
Wu, Chia-Shan,Bongmba, Odelia Y. N.,Yue, Jing,Lee, Jong Han,Lin, Ligen,Saito, Kenji,Pradhan, Geetali,Li, De-Pei,Pan, Hui-Lin,Xu, Allison,Guo, Shaodong,Xu, Yong,Sun, Yuxiang MDPI AG 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.4
<P>Ghrelin, an orexigenic hormone released primarily from the gut, signals the hypothalamus to stimulate growth hormone release, enhance appetite and promote weight gain. The ghrelin receptor, aka Growth Hormone Secretagogue Receptor (GHS-R), is highly expressed in the brain, with highest expression in Agouti-Related Peptide (AgRP) neurons of the hypothalamus. We recently reported that neuron-specific deletion of GHS-R completely prevents diet-induced obesity (DIO) in mice by activating non-shivering thermogenesis. To further decipher the specific neuronal circuits mediating the metabolic effects of GHS-R, we generated AgRP neuron-specific GHS-R knockout mice (<I>AgRP-Cre</I>;<I>Ghsr<SUP>f/f</SUP></I>). Our data showed that GHS-R in AgRP neurons is required for ghrelin’s stimulatory effects on growth hormone secretion, acute food intake and adiposity, but not for long-term total food intake. Importantly, deletion of GHS-R in AgRP neurons attenuated diet-induced obesity (DIO) and enhanced cold-resistance in mice fed high fat diet (HFD). The HFD-fed knockout mice showed increased energy expenditure, and exhibited enhanced thermogenic activation in both brown and subcutaneous fat; this implies that GHS-R suppression in AgRP neurons enhances sympathetic outflow. In summary, our results suggest that AgRP neurons are key site for GHS-R mediated thermogenesis, and demonstrate that GHS-R in AgRP neurons plays crucial roles in governing energy utilization and pathogenesis of DIO.</P>
Laser brazing molybdenum using two titanium base fillers
Lin, Chia-Chen,Lee, Cheng-Han,Shiue, Ren-Kae,Shy, Hsiou-Jeng Techno-Press 2012 Advances in materials research Vol.1 No.3
Brazing Mo using Ti and Ti-15-3 foils has been investigated in the experiment. For traditional furnace brazing, solidification shrinkage voids cannot be completely removed from the joint even the brazing temperature increased to 2013 K and 160 ${\mu}m$ thick Ti foil applied in brazing. Similar results are observed from the joint using Ti-15-3 filler. In contrast, the quality of laser brazed joint is much better than that of furnace brazed joint. A sound joint is achieved after laser brazing. Tensile strengths of 418 and 373 MPa are obtained from laser brazed joints at the power of 800W and travel speed of 5 mm/s using Ti and Ti-15-3 fillers, respectively. All laser brazed joints are fractured at the brazed zone and cleavage dominated fractures are widely observed from their fractographs. The Ti base fillers show potential in laser brazing Mo substrate.
INVESTIGATING THE IMPACT OF PRODUCT PLACEMENT ON BRAND ATTITUDE: A CASE OF MARVEL MOVIES
George C. Shen,Cia-Han Tsai,Rick Lee,Chia Ann Lai 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07
The success of Marvel movies attracts more companies to place their brands in this series of movies, apparel brand like Under Armour or car manufacturer like BMW has largely used the movie as medium of product placement to increase brand equity. To understand how the product placement in the movie affect consumer attitude and purchase intention is in needed. Neer (2004) states that product placement is a type of marketing by creating impression for consumers unconsciously through incorporation into the plot of TV programs, movies and other media. The conceptual model was built based on the Russell’s (2002) tripartite typology of product placement and social comparison theory. We presume brand-self congruity, placement explicitness, plot connection, and attitude toward the plot and role are positively related to brand attitude and purchase intention. The research employed experiment with a 2 (placement explicitness: prominent/subtle) x 2 (plot connection: main character/supporting role) between subject design. The research theme is under the Under Armour because the brand used product placement as the company’s major marketing communication process of move placement. The research result shows that the more the product placement is identifiable in the movies, with frequent usage or appearance in main plot, the better the placement effect is; the preference of consumers on movies, including plot and role attitude, explicitly influences placement effect. If the real self or ideal self of consumers are consistent with brand image, a higher brand attitude and purchase intention will occur. To best of our knowledge, our paper is first one using self-congruity and attitude toward the plot to investigate the outcome of product placement in the movies. The research concludes with implications for promotion strategy to advance brand image and purchase intention by increasing the effectiveness of product placement. Future research suggestions relevant to the product placement issues, marketing communication and brand management are also provided.