Positive Association of TEAD1 With Schizophrenia in a Northeast Chinese Han Population

Yang Sun,Lin Wen,Yi-Yang Luo,Wen-Juan Hu,Hui-Wen Ren,Ye Lv,Cong Zhang,Ping Gao,Li-Na Xuan,Guan-Yu Wang,Cheng-Jie Li,Zhi-Xin Xiang,Zhi-Lin Luan 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.12

Objective Schizophrenia is a complex and devastating psychiatric disorder with a strong genetic background. However, much uncertainty still exists about the role of genetic susceptibility in the pathophysiology of schizophrenia. TEA domain transcription factor 1 (TEAD1) is a transcription factor associated with neurodevelopment and has modulating effects on various nervous system diseases. In the current study, we performed a case–control association study in a Northeast Chinese Han population to explore the characteristics of pathogenic <i>TEAD1</i> polymorphisms and potential association with schizophrenia.Methods We recruited a total of 721 schizophrenia patients and 1,195 healthy controls in this study. The 9 single nucleotide polymorphisms (SNPs) in the gene region of <i>TEAD1</i> were selected and genotyped.Results The genetic association analyses showed that five SNPs (rs12289262, rs6485989, rs4415740, rs7113256, and rs1866709) were significantly different between schizophrenia patients and healthy controls in allele or/and genotype frequencies. After Bonferroni correction, the association of three SNPs (rs4415740, rs7113256, and rs1866709) with schizophrenia were still evident. Haplotype analysis revealed that two strong linkage disequilibrium blocks (rs6485989-rs4415740-rs7113256 and rs16911710-rs12364619-rs1866709) were globally associated with schizophrenia. Four haplotypes (C-C-C and T-T-T, rs6485989-rs4415740-rs7113256; G-T-A and G-T-G, rs16911710-rs12364619-rs1866709) were significantly different between schizophrenia patients and healthy controls.Conclusion The current findings indicated that the human <i>TEAD1</i> gene has a genetic association with schizophrenia in the Chinese Han population and may act as a susceptibility gene for schizophrenia.

CT Quantitative Analysis and Its Relationship with Clinical Features for Assessing the Severity of Patients with COVID-19

Sun Dong,Li Xiang,Guo Dajing,Wu Lan,Chen Ting,Fang Zheng,Chen Linli,Zeng Wenbing,Yang Ran 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.7

Objective: To investigate the value of initial CT quantitative analysis of ground-glass opacity (GGO), consolidation, and total lesion volume and its relationship with clinical features for assessing the severity of coronavirus disease 2019 (COVID-19). Materials and Methods: A total of 84 patients with COVID-19 were retrospectively reviewed from January 23, 2020 to February 19, 2020. Patients were divided into two groups: severe group (n = 23) and non-severe group (n = 61). Clinical symptoms, laboratory data, and CT findings on admission were analyzed. CT quantitative parameters, including GGO, consolidation, total lesion score, percentage GGO, and percentage consolidation (both relative to total lesion volume) were calculated. Relationships between the CT findings and laboratory data were estimated. Finally, a discrimination model was established to assess the severity of COVID-19. Results: Patients in the severe group had higher baseline neutrophil percentage, increased high-sensitivity C-reactive protein (hs-CRP) and procalcitonin levels, and lower baseline lymphocyte count and lymphocyte percentage (p < 0.001). The severe group also had higher GGO score (p < 0.001), consolidation score (p < 0.001), total lesion score (p < 0.001), and percentage consolidation (p = 0.002), but had a lower percentage GGO (p = 0.008). These CT quantitative parameters were significantly correlated with laboratory inflammatory marker levels, including neutrophil percentage, lymphocyte count, lymphocyte percentage, hs-CRP level, and procalcitonin level (p < 0.05). The total lesion score demonstrated the best performance when the data cut-off was 8.2%. Furthermore, the area under the curve, sensitivity, and specificity were 93.8% (confidence interval [CI]: 86.8–100%), 91.3% (CI: 69.6–100%), and 91.8% (CI: 23.0–98.4%), respectively. Conclusion: CT quantitative parameters showed strong correlations with laboratory inflammatory markers, suggesting that CT quantitative analysis might be an effective and important method for assessing the severity of COVID-19, and may provide additional guidance for planning clinical treatment strategies.

Centriolin, a centriole-appendage protein, regulates peripheral spindle migration and asymmetric division in mouse meiotic oocytes

Sun, Tian-Yi,Wang, Hai-Yang,Kwon, Jung-Woo,Yuan, Bao,Lee, In-Won,Cui, Xiang-Shun,Kim, Nam-Hyung Landes Bioscience 2017 Cell Cycle Vol.16 No.19

<P>Unlike somatic cells mitosis, germ cell meiosis consists of 2 consecutive rounds of division that segregate homologous chromosomes and sister chromatids, respectively. The meiotic oocyte is characterized by an absence of centrioles and asymmetric division. Centriolin is a relatively novel centriolar protein that functions in mitotic cell cycle progression and cytokinesis. Here, we explored the function of centriolin in meiosis and showed that it is localized to meiotic spindles and concentrated at the spindle poles and midbody during oocyte meiotic maturation. Unexpectedly, knockdown of centriolin in oocytes with either siRNA or Morpholino micro-injection, did not affect meiotic spindle organization, cell cycle progression, or cytokinesis (as indicated by polar body emission), but led to a failure of peripheral meiotic spindle migration, large polar body emission, and 2-cell like oocytes. These data suggest that, unlike in mitotic cells, the centriolar protein centriolin does not regulate cytokinesis, but plays an important role in regulating asymmetric division of meiotic oocytes.</P>

The Optimization Assignment Model of Multi-sensor Resource Management Based on Rough Entropy

Xiang-yang Chen,Sun-yong Wu 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.5

The management of Multi-sensors in information fusion system occupies an important role with the development of modern weapon platform. Therefore, scientific and rational management of limited sensors resources is essential or urgent, and improvement the capability of air defense operations is necessary. According to the management optimization problem in Multi-sensor optimal resource, we analyzed the definition of rough entropy and presented the method of Multi-sensor management based on rough entropy and target threat degree. By calculating rough entropy of the sensors to the target, the maximum information gain access for each sensor on each target, which acts as cost function, taking into account the target threat degree, and using a linear programming optimization assignment multi-sensor to multi-target. In this paper, we adopted maximum information gain optimization criterion in target tracking, then discussed optimization assignment problem about multi-sensor to multi-target. In addition, we are validate the optimized allocation algorithm with the experimental simulations, and case analysis shows that the effectiveness of the method.

LTE-Advanced 상향링크에서 Device-to-Device 통신을 위한 영역 정보 기반 자원 할당 기법

리향(Xiang Li),양모찬(Mochan Yang),손세걸(Sijie Sun),신요안(Yoan Shin) 한국통신학회 2014 한국통신학회 학술대회논문집 Vol.2014 No.6

H2 Metabolism revealed by metagenomic analysis of subglacial sediment from East Antarctica

Zhifeng Yang,Yu Zhang,Yongxin Lv,Wenkai Yan,Xiang Xiao,Bo Sun,Hongmei Ma 한국미생물학회 2019 The journal of microbiology Vol.57 No.12

Subglacial ecosystems harbor diverse chemoautotrophic microbial communities in areas with limited organic carbon, and lithological H2 produced during glacial erosion has been considered an important energy source in these ecosystems. To verify the H2-utilizing potential there and to identify the related energy-converting metabolic mechanisms of these communities, we performed metagenomic analysis on subglacial sediment samples from East Antarctica with and without H2 supplementation. Genes coding for several [NiFe]- hydrogenases were identified in raw sediment and were enriched after H2 incubation. All genes in the dissimilatory nitrate reduction and denitrification pathways were detected in the subglacial community, and the genes coding for these pathways became enriched after H2 was supplied. Similarly, genes transcribing key enzymes in the Calvin cycle were detected in raw sediment and were also enriched. Moreover, key genes involved in H2 oxidization, nitrate reduction, oxidative phosphorylation, and the Calvin cycle were identified within one metagenome-assembled genome belonging to a Polaromonas sp. As suggested by our results, the microbial community in the subglacial environment we investigated consisted of chemoautotrophic populations supported by H2 oxidation. These results further confirm the importance of H2 in the cryosphere.

Across-fault distributions of radon concentrations in soil gas for different tectonic environments

Xiaolong Sun,Pengtao Yang,Yang Xiang,Xueyun Si,Dongying Liu 한국지질과학협의회 2018 Geosciences Journal Vol.22 No.2

The radon concentration in soil gas at the crustal surface is closely related to the development of local fractures. Therefore, the spatial variation in soil-gas radon concentrations across faults differs between fault zones located in different tectonic environments. This study investigates the Beiluntai thrust fault and the Haiyuan strike-slip fault in west China, which are assumed to be typical examples of the different types of faults. Radon concentrations in soil gas were measured at various locations around these faults, and the spatial variation in these concentrations was characterized along fault-perpendicular profiles. For normal fault, our results indicate that concentrations are usually highest at the fault, and decrease gradually away from the fault in either direction. For thrust, however, concentrations increase in the hanging wall approaching the fault, but decrease sharply at the fault. For strike-slip fault with extension across the fault, soil-gas radon concentrations are relatively high at the fault, and decrease gradually with distance from the fault. For strike-slip fault with contraction across the fault, soil-gas radon concentrations are relatively low at the fault, and increase gradually with distance from the fault.

Epigenetic Regulation of miR-129-2 Leads to Overexpression of PDGFRa and FoxP1 in Glioma Cells

Tian, Xiang-Yang,Zhang, Ling,Sun, Lai-Guang,Li, Ming Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

miR-129-2 is frequently downregulated in multiple cancers. However, how it is silenced in cancers remains unclear. Here we investigated the expression profile and potential biological function of miR-129-2 in glioblastoma (GBM), the most common and lethal form of brain tumors in adults. We showed that miR-129-2 is lost in GBM patient specimens and cultured cell lines. miR-129-2 expression could be restored upon treatment with a histone deadetylase inhibitor (trichostatin A) but not a DNA methylation inhibitor (5-Aza-2'-deoxycytidine), and more profound effect was observed with the treatment of these two drugs in combination. Furthermore, forced expression of miR-129-2 repressed the expression of major oncogenic genes such as PDGFRa and Foxp1 in GBMs. Consistently, expression of miR-129-2 significantly inhibits GBM cell proliferation in vitro. These results reveal that miR-129-2 is epigenetically regulated and functions as a tumor suppressor gene in GBMs, suggesting it may serve as a potential therapeutic target for GBM treatment.

Numerical Study on Key Parameters of Magnetorheological Fluid Reciprocating Seal with Four Magnetic Sources

Xiao-long Yang,Fu-xiang Hao,Peng Sun 한국자기학회 2020 Journal of Magnetics Vol.25 No.2

In order to improve the pressure capability of Magnetorheological fluid (MRF) reciprocating seal with four magnetic sources, MRF reciprocating seal structure was designed based on the formula of MRF reciprocating seal. The magnetic field distributons in the sealing gap of MRF reciprocating seals were analyzed by using finite element analysis of magnetic field. The influences of structure parameters such as sealing gap, ratio of permanent magnet height to length, ratio of pole tooth length to width, ratio of slot width to pole tooth width and ratio of pole piece height to the shaft radius on the sealing capabilities were studied. The results were analyzed and discussed. The results show that the pressure capability of MRF seal decreases significantly with the increase of sealing gap. The pressure capability of the MRF seal increases firstly and then decreases with the increase in the ratio of permanent magnet height to its length. The pressure capability of the MRF seal increases firstly and then decreases with the increase in the ratio of pole tooth length to its width. The pressure capability of the MRF seal increases firstly and then decreases with the increase in the ratio of slot width to pole teeth width. The pressure capability of MRF seal decreases with the increase in the ratio of pole piece height to shaft radius.

Speed Sensorless Control of a Bearingless Induction Motor Based on Modified Robust Kalman Filter

Bian Yifan,Yang Zebin,Sun Xiaodong,Wang Xiang 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.3

To enhance the speed identifcation accuracy in speed sensorless control of a bearingless induction motor (BIM), a speed sensorless control strategy based on modifed robust Kalman flter is proposed. Firstly, the suboptimal principle of the H∞ control method is introduced into the extended Kalman flter to construct the robust Kalman flter. Secondly, the rotor fux linkage of the BIM in the α-β coordinate system is discretized, which is used as a reference model and adjustable model in the model reference adaptive system. At the same time, the modifed robust Kalman flter is obtained by combining the robust Kalman flter with the model reference adaptive system. Finally, the simulation and experimental results show that the proposed BIM speed sensorless control system based on modifed robust Kalman flter has higher accuracy of speed identifcation than the extended Kalman flter control under diferent operation conditions of no-load, sudden load, speed change, and motor parameter mismatch. The motor also has a good suspension performance.