한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

Single Median Maxillary Central Incisor(SMMCI) 환아의 증례보고

신윤경,김영재,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2007 大韓小兒齒科學會誌 Vol.34 No.4

Anatomic abnormalities of teeth development include the presence of a single maxillary central incisor at midline instead of two central incisors. The incidence of cases with a single maxillary central incisor is approximately 1 in every 50,000 live births. single median maxillary central incisor(SMMCI) may be a integral manifestation of anyone of a number of syndromes. It has been reported an association with several midline disorders which have varied in severity. A SMMCI has also been reported as an isolated finding. But in some cases, it has been considered as an incomplete expression of autosomal dominant holoprosencephaly. So any patient who appears for treatment with a SMMCI should be referred for a detailed medical examination to exclude other associated systemic abnormalities and for mutation analysis to facilitate correct diagnosis and the provision of appropriate genetic counseling. Early orthodontic treatment is needed to minimalize emotional trauma of child. This case report was about three patients with a SMMCI as isolated finding. The purpose of these case reports was to present cases of single maxillary central incisor not associated with other disorders. Single Median Maxillary Central Incisor(SMMCI)는 상악 중절치 형성부전으로 하나의 상악 중절치가 정중앙에 위치하는 치아 발달의 해부학적 이상을 의미한다. 50,000명 중에 1명 꼴로 발생할 정도로 아주 드물며 각종 증후군 및 정중선 이형성을 보이는 발달장애와 연관되어 나타나는 것으로 보고되고 있다. SMMCI는 다른 이상과 연계되지 않고 독립적으로 나타날 수도 있으나 상염색체 우성유전인 전전뇌증(holoprosencephaly)의 경미한 발현일 가능성이 있으므로 유전자 상담이 필요하다. 또 특징적인 안모 및 구강 상태를 보이므로 환아의 바람직한 신체적,정서적 발달을 위해 조기에 교정적 접근이 필요하다. 본 증례는 다른 이상 소견을 보이지 않는 세 명의 SMMCI 환아의 증례를 보고하는 바 이다.

응급실을 내원한 구강악안면외과 안면골 골절 환자의 변화에 대한 비교 연구

신상훈,성화식,강영훈,황대석,김용덕,김욱규,김종렬,정인교 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.24

Although there have been many clinical studies about the facial trauma in the recent as well as in the past, severity and frequency of facial trauma are reported multifarious. It seemed to be because of variety of social, cultural, and environmental factors, and the view point of investigators. In this study, we investigated about the patients visiting emergency room during recent 4 years(2004-2007), and compared with retrospective study during former 10 years(1992-1996, 1999-2003) in Dept. OMS Pusan National University Hospital. We assessed the cause, type, demographic, etc, and analyzed alterations of facial bone fractures during past 3 periods. The results were as follows. The total number of patients was increased. 429 patients treated for maxillofacial fractures between January 1992 and December 1996, 466 patients treated between January 1992 and December 1996 and 764 patients treated between January 2004 and December 2007. The male-to-female ratio were 4.6:1, 3.9:1, and 4.16:1, respectively. Patient in the age groups of 10-19 years and 20-29 years increased in the latter two periods. Assaults and falls are decreased gradually, but slip down s are increased. Traffic accidents are still major cause of facial trauma. The mandibular fractures showed the highest incidence thorought three periods. Symphysis fractures of mandible was increased and condyle fractures of mandible was drecreased in the third period.

법랑아세포종의 임상병리학적 연구

성일용,류성호,신상훈,김욱규,김종렬,정인교,변기정 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.1

The authors analyzed retrospectively the 60 patients with ameloblastoma who were treated at Department of Oral and Maxillofacial Surgery, Pusan National University Hospital from MArch, 1990 to December, 1995. The results obtained were as follows: There were 26 males (43.3%) and 34 females (56.7%). The peak age of patients was the third decade (41.7%). The majority of cases occurred in the mandible 93.3%, especially in the angle region (91.1%). Eighteen of 60 patients (30.0%) were associated with an impacted tooth, by impacted 3rd molar teeth (16.6%), molar (10.0%), and premolar and canine (3.4%) in order., Fifteen of 60 patients (25%) were associated with an odontogenic cyst, by dentigenous cyst(13.3%), odontogenic keratocyst(8.4%), and radicular cyst(3.3%) in order. Radiographically, there were 32 unilocular types(54.2%) with average age of 24.9±10.8 years, 14 multilocular types(23.7%) with average age of 35.7±17.7 and 13 mixed types(22.0%) with average age of 41.4±15.8. Histopathologically, there were 42 follicular types(70.0%) with average age of 33.7±15.1 years and 18 plexiform types(30.0%) with average age of 26±14.6. Conservertive treatment was performed in the 33 patients(55.0%) and their average age was 25.2±13.9 years and radical treatment in the 27 patients(45.0%) and their average age was 39.3±41.8. Overall recurrence rate was 10%. A consistent correlation between the age of the patient and the radiographic or histologic type of mandibular ameloblastoma was observed. There was a tendency for ameloblastomas of the follicular type to show a multilocular or mixed appearance and for those of the plexiform type to show a unilocular appearance.

이중 셀 구성에 의한 셀룰라 이동통신 시스템의 채널용량 개선

신창윤,우병훈,조성준 한국항공대학교 1994 論文集 Vol.32 No.-

본 논문에서는 셀에서의 용량 증대를 위하여 셀을 내부 셀과 외부 셀로 나누어 구성하는 이중셀을 적용하였을 경우 반송파 대 동일채널간섭비와 채널용량을 산출하고 분석하였다. 이를 위하여 셀룰라 육상이동통신 시트테에서 규칙적인 주파수재사용 패턴 N을 도출하여 무지향성 안테나 사용시와 지향성 안테나 사용시 셀 패턴에 따른 반송파 대 동일채널간섭비를 계산하였다. 이중 셀을 구성하였을 때 내부 셀에 주파수 재사용 패턴 N을 작게하여 내부와 외부 셀의 주파수 재사용 패턴을 다르게 하면 채널용량이 크게 개선되었다. 실제적인 통화품질 기준인 반송파 대 동일채널간섭비가 24dB 이상이 되는 경우 가장 용량면에서 우수한 주파수 재사용 패턴은 N=7인 3 섹터 셀이었고 이중 셀로 구성하였을 경우 내부 셀 패턴이 N=3, 외부 셀 패턴이 N=7인 3 섹터 셀의 경우였다. 이 경우 이중 셀을 구성하지 않은 N=5인 주파수 재사용 패턴과 같은 용량을 가질 수 있었다. 이것은 이중 셀을 상용하므로서 한정된 주파수의 수용 용량을 1.4배 높일 수 있음을 알 수 있다. In this paper, when the dual cell, a cell which is divided into the inner cell and outer cell, is employed to increase the channel capacity, the carrier power to co-channel interference power ratio (C/I) and channel capacity are evaluated and analyzed. For this evaluation, the regular frequency reuse pattern factor N is calculated and them the C/I is calculated according to the cell pattern when the isotropic antenna is used and the directional antenna is used, respectively. In a dual cell, the channel capacity is incrased by making the frequency reuse pattern factor N of inner cell smaller than that of outer cell. In the case of nondual cell, the channel capacity is the largest when the frequency reuse pattern factor N is 7 in the 3 sector cell on the condition of the C/I is over the 24dB of standard call quality. In the case of dual cell, the channel capacity is the largest when the frequency reuse pattern facotr N is 3 for inner cell and N is 7 for outer cell. In this case, the cell has the same capacity as the frequency reuse pattern factor N=5 of nondual cell. This result shows that the channel capacity with dual cell can be incrased in the limited available frequency by 1.4 times more than the capacity with nondual cell.

학교 책무성 평가의 장애요인과 수용조건 탐색

신상명,이재훈 경북대학교 사범대학부속 중등교육연구소 2006 중등교육연구 Vol.54 No.3

스프레드시트 방식의 OLAP 인터페이스를 위한 시트 분할 기법

신성현,이수안,최훈영,김진호,문양세 강원대학교 정보통신연구소 2007 정보통신논문지 Vol.11 No.-

OLAP(Online-Analytical Processing) is widely used to analyze multidimensional data extracted from a huge size of source operational databases and to provide a useful information for business decision making. OLAP tools provide a variety of ways to analyze and to browse data which are not familiar with end users. But spreadsheet tools like MS Excel are very popular in real-world to calculate some statistics from source data and to analyze them. In this research, we implemented a spreadsheet-like tool on the top of relational databases to support OLAP operations and to browse the results of analytical queries. For implementing the tool, we propose a sheet partition function for spreadsheets which partitions a relational table into multiple sheet based on the number of rows or (dimensional) attribute values. This function can enable users to view a physically stored table as a set of spreadsheets like Excel thus users can browse the stored table as if it is spreadsheets. With this spreadsheet-like interface, users will be able to handle multidimensional data stored in relational databases in more user-friendly way.

確率有限要素法을 利用한 Frame 構造物의 信賴性解析

신재철,정원석,한성호,김선훈 忠南大學校 産業技術硏究所 2002 산업기술연구논문집 Vol.17 No.1

In this paper reliability analysis using stochastic finite element method is formulated, and with its result reliability analysis is accomplished. A displacement and member force of frame structure is acquired in SFEMP(Stochastic Finite Element Method Program) using perturbation method, and then DMCSP(Direct Monte Carlo Simulation Program) is used to verify and compare previous results. With the previous two results, approximate reliability analyses of the MFOSM(Mean First Order Second Moment), AFOSM(Advanced First Order Second Moment), and MCS(Monte Carlo Simulation) including a relatively simple limit state function have accomplished and base of a safety estimate could be acquired. Finally, When the reliability analysis of a complicated structure using stochastic finite element method is accomplished, time is efficiently reduced, and the safety of a structure can be easily evaluated. Hence SFEMP may be considered an efficient tool for evaluating the structural safety and reliability of frame structure.

대뇌 기저핵 신경세포 일차배양에서 망간에 의해 유도된 Appoptosis : 형태학적인 소견

신동훈,김상표,정용욱,배재훈,송대규,백원기 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 본 실험은 대뇌기저핵의 신경세포를 배양하여 망간(MnCl₂)을 투여한 후 망간독성에 의한 신경세포의 apoptosis를 형태학적인 소견으로 관찰하였다. 방법 : 배양된 신경세포에 0.01에서 10μM Mnc12를 48시간동안 처리한 후 TUNEL (TdT-mediated dUTP Nick End Labelling)법 및 투과전자현미경학적으로 관찰하였다. 결과 : TUNEL방법을 이용하여 관찰한 결과 TUNEL반응에 갈색으로 양성반응을 나타내는apoptotic 세포의 수가 대조군에 비해 MnCl₂를 투여한 군에서 유의하게 높게 나타났으며(P〈0.05), 투과전자현미경학적 소견상 대조군의 신경세포들은 핵인(nucleolus)이 두드러지게 특징적으로 보이면서 핵막과 세포질내 소기관들이 잘 보존되어 있으며, 세포질내망(ER)과 사립체(mitochondria)를 특히 많이 가지고 있었다. Mnc12를 48시간 동안 처리한 군에서 이질염색질(heterochromatin)이 핵막으로 이동하면서 응집되어 있었으며, 핵내 불규칙한 형태의 염색질이 나타나 분절이 진행되는 소견을 보였고, Apoptosis의 가장 특징적인 초기 소견인 막으로 둘러싸인 반달모양의 핵내염색질의 분절편(fragment-ed chromatin)과 주위의 상대적으로 정상적인 소기관으로 구성된 apoptotic body를 관찰할 수 있었다. 결론 : 신경세포에서 망간에 의해 apoptosis가 유도됨을 형태학적인 방법으로 확인할 수 있었으며 망간에 의한 세포사망양상에 apoptosis가 하나의 기전이 될 수 있을 것이다. Objectives : Manganese is cytotoxic to the central nervous system including basal gan-glia. Its toxic mechanism is related to oxidative stress, mediated by toxic free radicals but is specultives. In the present study , we have investigated to manifest apoptosis in man-ganese-induced cytotoxicity in primary neuronal cell culture of rat basal ganglia. Methods : To detect apoptotic neuronal cells were stained by the terminal deoxynu-cleotide (TdT) -mediated dUTP nick end-labelling (TUNEL) method and apoptotic changesin nuclei of neurons were observed by electron microscopy. Results : We showed that TUNEL immunostain showed brownish signal in the nuclei of apoptotic cells and the proportions of apoptotic cells in Manganese treatment groups were more higher than controls. On transmission electron microscopy, there were chromatine condensation with margination toward nuclear membrane and condensation of cyto-plasm in the treated with luM MnCl²for 48 hours in a basal ganglia neurons. Apoptotic bodies were found and consisted of semilunar-like condensed nuclei with relatively intact cytoplasmic organelles. Conclusions : Apoptosis appears to be one mechanism in the manganese-induced net-ronal cell death. Manganese intoxication is a convenient model for apoptosis study.

지역사회 거주 저소득층 노인의 우울증상 유병률과 관련인자

신희영,이훈,신일선,김재민,김성완,양수진,윤진상 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.5

Objectives : This study aimed to investigate the prevalence and correlates of depressive symptoms in community-dwelling low income elderly. Methods : A community survey of 1,351 low income residents aged 65 or over was conducted in Buk district of Gwangju, Korea. Depressive symptom was evaluated by the Korean Form of the Geriatric Depression Scale (KGDS). Their Sociodemographic factors, the precence of chronic physical illness, and cognitive functions were investigated. Results : The prevalence rate of depressive symptoms was 69.8%. In multiple logistic regression, chronic physical illness (Odds Ratio : 2.68, 95% Confidence Interval : 1.98-3.63), low education (Odds Ratio : 1.84, 95% Confidence Interval : 1.39-2.43), and cognitive impairment (Odds Ratio : 1.61, 95% Confidence Interval : 1.20-2.16) were independently associated with depressive symptoms. Conclusion : Depressive symptoms in community-dwelling low income elderly were very common, particularly related to current chronic physical illnesses. The results of this study can be useful for the development of community-based prevention and management programs for depression. Of elderleg.