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김계형,김낙현,김문석,김충종,전재현,박완범,장원종,박상원,김익상,오명돈,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.6
Infectious diseases imported from other countries have increased as more and more Koreans are going abroad for various purposes. Tsutsugamushi disease from other endemic area such as Southeast Asia is important, because it can occur in any season and eschar may be absent. We report a case of imported tsutsugamushi disease acquired in the Philippines. A patient presented with fever, headache, and maculopapular skin rash. However, eschar was absent. Polymerase chain reaction (PCR) for 56-kDa gene of Orientia tsutsugamushi using buffy coat was positive. Serum indirect immunofluorescent antibody assay was initially negative but became positive with a titer of 1:320 at follow-up, Sequencing analysis revealed the strain to be 100% identical to the TW73R strain identified in Taiwan. After the patient received doxycycline, body temperature normalized in 12 hours. Tsutsugamushi disease is one of the differential diagnoses that should be included for patients with fever who have recently returned from Southeast Asian countries. PCR for O. tsutsugamushi using patient's buffy coat was useful for early diagnosis.
Ciprofloxacin을 이용한 장티프스의 항균요법 : chloramphenicol 요법과의 비교 및 ciprofloxacin 단기요법
최강원,김성민,오명돈 대한화학요법학회 1990 대한화학요법학회지 Vol.8 No.2
Ciprofloxacin was evaluated with regard to its clinical efficacy by randomized controlled study. Ciprofloxacin was given to 32 patients, and chloramphenicol was given to 34 patients with typhoid fever. In chloramphenicol group, there were 1 clinical failure, 4 relapse and 1 carrier while in ciprofloxacin group there was none of clinical failure, relapse or carrier. Number of days to become afebrile after institution of antibiotic therapy was 5.7 days for chloramphenicol, and 3.6 days for ciprofloxacin. Another group of 18 subjects were given 7day-course of ciprofloxacin. There was no clinical failure, relapse or carrier state in this short-term therapy group.
단주기 구조물의 비탄성 응답제어를 위한 최대응답 계수를 사용한 개선된 마찰감쇠기 설계방법
민경원,이명규,이상현,김형섭 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)
The purpose of this paper is to present a design method for friction damper (FD) for inelastic response control of short period structure. A critical design parameter of FD is maximum friction force (MFF) and previous study evaluated MFF using equivalent damping ratio which is based on the maximum displacement. This procedure, however, gives the overestimated MMF for short period structure. In this study, MFF of FD is evaluated based on RMS displacement response which is obtained by using given maximum response and peak factor. Numerical analysis shows that proposed method provide a reasonable MFF of FD for short period structure.
스테로이드를 투여 받는 환자에서 발생한 Nocardia farcinica 뇌 종양 1예
심성훈,박혜인조,김충종,전재현,김의종,오명돈,김남중,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.5
Nocardiosis occurs mostly in the immunocompromised patients. N. farcinica is known to have resistance to some antibiotics and significant increase in morbidity and mortality in patients requiring long-term treatment. Nocardia farcinica infection, especially brain abscess, has not been reported in Korea. Here, we report a case of N. farcinica brain abscess in a patient receiving steroid treatment. The patient was a 64 year-old male with gouty arthritis, He received steroid for more than two months, because of allopurinol-hypersensitivity syndrome with skin rash. After three months of steroid therapy, he visited other hospital with mild fever and left thigh pain and was diagnosed of intramuscular abscess due to gram positive bacilli. One month later, he visited our hospital with right side weakness and was diagnosed as brain abscess. The causative organism turned out to be N. farcinica, which was confirmed by means of 16S rRNA sequencing. Antibiotics were selected by E-test results and treatment was successful.
Carbosulfan의 피부자극성, 안점막 자극성 및 피부감작성등의 알러지성 효과에 관한 연구
이상훈,이동연,백경진,김태원,정두순,임종환,김명석,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-
Many studies have been published on the human health effects of carbosulfan toxicity. Carbosulfan used as an insecticide can produce an irritating and allergenic effect when acting on the skin. In this study, a sensitization test on albino guinea pigs and intradermal reactivity and occular irritation test on albino rabbits were carried out with carbosulfan. Signs of acute skin inflammation appeared along with the clinical symptom of chronic dermatosis caused by the solution irritating characteristics. Moreover, carbosulfan showed severe eye irritation with conjuctival redness and severe opacity on cornea. Preventive measures should involve workers' obligatory instructions on the noxious impact on human skin and strict observance of industrial safety rules.
알코올리즘 환자에서 뇌교외수초용해증과 연관된 주기교대눈떨림과 주기교대주시편위
강성원,이명제,정주리,김영진,양현덕 원광대학교 의과학연구소 2009 圓光醫科學 Vol.24 No.1
주기교대눈떨림와 주기교대주시편위는 이상안구 운동에서도 흔히 관찰되지 않는다. 이런 안구운동은 뇌교와 소뇌에 병변이 있을 때 나타난다고 보고되고 있다. 50세 남자 환자가 과음을 하고 난 이후 심하게 구토를 하여 입원하였다. 다음날 아침에 의식이 없었으며 주기교대눈떨림과 주기교대주시편위가 관찰되었다. 뇌자기공명영상에서는 뇌교나 소뇌에 병변없는 교뇌외수초용해증에 합당한 소견을 보였다. 저자는 아마도 교뇌외수초용해증이 소뇌와 전정신경핵의 경로중에 GABA 시스템에 이상이 발생하여 주기교대눈떨림과 주기교대 주시편위가 나타났을 것으로 추정한다. Background; Periodic alternating gaze deviation(PAGD) and periodic alternating nystagmus(PAN) are rare forms of abnormal eye movement. Multiple lesions in the cerebellum and brainstem have been reported with PAN and PAGD. Case Report; A 50-year-old man presented with severe vomiting after binge drinking. The next morning he. became vegetative state and showed PAGD and PAN. Brain MRI showed findings compatible with extrapontine myelinolysis(EPM) without any brainstem or cerebellar lesions. Conclusions; We postulate that the disturbed GABAnernic system in the pathway from the cerebellum to vestibular nuclei caused probably by EPM developed PAGD and PAN.
공간분석에 의한 산불발생확률모형 개발 및 위험지도 작성
안상현,이시영,원명수,이명보,신영철 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.4
우리나라는 산불을 효율적으로 방지하기 위하여 기상, 지형, 임상을 중심으로 산불발생위험을 관정말 수 있는 알고리즘 및 관련인자의 DIB구축을 통한 웹기반 산불위험예보시스템을 개발하여 활용 중에 있다. 그러나 우리나라의 경우, 자연적으로 산불이 발생하는 미국, 캐나다와 달리 인위적인 산불이 대부분을 차지하고 있어 우리나라에 적합한 지형 및 연로인자와 산불발생에 관한 기초연구가 지속적으로 필요한 실정이다. 따라서 본 연구는 현재 실용화하고 있는 산불위험예보시스템의 알고리즘 개선을 위한 기포연구로서 산불발생지역에 대한 GIS를 이용한 공간분석과 로지스틱 분석을 이용하띠 산불발생위험지역을 구분할 수 있는 산불발생확률모형을 개발하였다. In order to decrease the area damaged by forest fires and to prevent the occurrence of forest fires, the forest fire danger rating system was developed to estimate forest fire risk by means of weather, topography, and forest type. Forest fires occurrence prediction needs to improve continually. Logistic regression and spatial analysis was used in developing the forest fire occurrence probability model. The forest fire danger index in accordance to the probability of forest fire occurrence was used in the classification of forest fire occurrence risk regions.