45歲 以後에 初發한 偏執症候群의 特徵

田珍淑,張煥一,李成柱 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1

The 25 patients, in whom paranoid symptoms had occurred after age 45, and who had been admitted to Kyung Hee University Hospital from May 1979 to June 1984, were compared with 40 paranoid schizophrenics who had fitted to the DSM-Ⅲ diagnostic criteria, to clarify whether such syndrome should be classified to schizophrenia or a separate entity. The results were as following; 1. The male to female ratio was 0.92:1 in late paraphrenics, in contrast with 2.33:1 in control (p>0.05). 2. The age at onset was 53.6±8.0 year in late paraphrenics, in contrast with 28.1±7.6 year in control (p<0.001). 3. Majority of late paraphrenics had been ill for 2 weeks to below 6 months (48.0%), while for above 2 years in control (60.0%) (p<0.0005). 4. The late paraphrenics had been in hospital for 32.1±18.6 days on the average, in contrast with 53.4±31.3 days (p<0.01). 5. At time of admission, majority of late paraphrenics had married (68.0%) (p<0.005), in contrast with being single in control (62.5%) (p<0.0005). But divorced, separated or deceased were more in late paraphrenics (32.0%) than control (p<0.05). 6. The numbers of children of late paraphrenics were 3.8±2.0, and of control 0.8±1.4 (p<0.001). 7. Upon socioesonomic classes, majority of both patients belonged to middle class (p>0.5), and control (42.5%) belonged to lower class more than late paraphrenics (20.0%) (p>0.05). 8. The control had been admitted more frequently (2.9±2.1 times) than late paraphrenics (1.4±0.9 times) (p<0.01). 9. Both patients had schizophrenic family members most of all (each other 12.0% and 7.5%) (p>0.5), the late paraphrenics had somewhat more paranoid disorder (8.0%) than control (2.5%) (p>0.3). 10. Majority of late paraphrenics had paranoid personality trait (80.0%) (p<0.0005), in contrast with schizoid one in control (55.0%) (p<0.025). 11. Precipitating factors were present in 92.0% of late paraphrenics and 60.0% of control (p<0.01). Among the contents, family problem was most predominant (56.0%) (p<0.0005) in late paraphrenics and marital and financial problems (each other 28.0%) (p<0.05) in next order, while work (30.0%) and interpersonal problem (17.5%) were more prominent in control (p>0.5). 12. Among the contents of delusions, majority of both patients had persecutory ones (80.0%) (p>0.5) and idea of reference (each other 40.0% and 62.5%) (p>0.05). Otherwise, late paraphrenics had infidelity (36.0%) and hypochondriacal (32.0%) ones (p>0.05), while delusion of being controlled (55.0%) (p<0.01) and other Schneiderian ones (30.0%) were more common in control (p<0.05). In addition, affective symptoms (72.0%) (p<0.05) and cognitive difecit (40.0%) (p<0.0005) were more common in late paraphrenics, while hallucination (60.0%) (p>0.3) and loosening of association (67.5%) (p>0.05) in control. 13. The responses to physical treatment mainly composed of antipsychotics were fair (each other 92.0% and 100.0%) (p>0.05). Otherwise, late paraphrenics administered antidepressants (24.0%) more than the control (p<0.01), while electroconvulsive therapy was used more in control (20.0%) (p>0.1). 14. Most of the clinical diagnoses at discharge were established as paranoid disorder (56.0%) and in next order, paranoid schizophrenia (20.0%). Based on the above results, we concluded that late paraphrenia should be classified to paranoid disorder rather than atypical psychosis in addition to the agreement with the validity of separating this syndrome from schizophrenia in DSM-Ⅲ.

주의력결핍 과잉행동장애 아동의 지적수준에 따른 정신병리와 실행기능의 차이

천은진,서완석,이종범,김진성,구본훈,송창진,성형모,배준용,배대석 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.4

To investigate psychopathoIogy and executive functions of attention deficit hyperactivity disorder (ADHD) children according to intelligence level, this study included 197 ADHD children who visited the outpatient department of neuropsychiatry of YeungNam University Medical Center, from July 2000 to June 2002. The children were divided into groups based on their intelligence levels. They were compared by the Personality Inventory for Children (PIC), Conncers' Continuous Performence Test (CPT), and Wisconsin Card Sorting Test (WCST). There were significant differences in PIC, on the subscales of verbal development, socialization and autism. In the CPT, there was no significant difference. In the WCST, there were significant differences in the total number of errors, the number of perseverative errors, the number of completed categories and the number of trials needed to complete the first category. Considering these results, the intelligence level of ADHD children is related to their disabilities and behavioral symptoms.Executive functions such as abstract thinking, categorization, working memory and flexibility had significant relationship to the intelligence levels of ADHD children. Therefore, the intelligence level of children with ADHD influences the higher executive functions of regulating attention and information processing rather than attentional functions and capacity alone.

Borrmann 4형으로 진단된 진행성 위암환자의 임상적 검토

천영국,김영태,홍수진,김진오,조주영,이문성,심찬섭 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Background/Aim: It is difficult to dignosis of Borrmann type 4 gastric cancer at the early stage, because of its special morphology. Most of the cases have been detected at the advanced stage with poor survival rate. We reviewed patients with advanced gastric cancer, to define clinicopathologic characteristics of Borrmann type 4 gastric cancer comparing other types of gastric cancer. Methods: 1033 patients with advanced gastric cancer were divided into two groups, consisting of 50 patients with Borrmann type 4 gastric cancer, and the remaining 983 patients with all other types of gastric cancer, which were then compared clinicopatologically. Results: The proportion of Borrmann type 4 gastric cancer to advanced gastric cancer was 4.48%(50/1,033). The patients with Borrmann type 4 gastric cancer to advanced gastric cancer was 4.48%(50/1,033). The patients with Borrmann type 4 gastric cancer were composed 20 males and 30 males and revealed the highest frequency 3rd decade (24.0%) in age (range 26-78). In giant folds group (n=27), the number of poorly differentiated cell type, lymph node metastasis, peritoneal seeding were 20 (74.1%), 17 (63,0%), 12 (44.4%). In non-giant folds group (n=23), the number of poorly differentiated type, lymph node metastasis, peritoneal seeding were 17 (73.9%), 15 (65.2%), 6 (26.1%). Rate of tumor invasion in serosa and beyound serosa was 88.9% in giant fold group, 63.0% in non-giant fold group. Surgery was performed in only 32% as a modality of treatment (vs. 82.5%). Characteristics findings of Borrmann type 4 gastric cancer in EUS showed a thickening of the third (submucosa) and fourth (muscularis propria) layers in 72% of 50 patients, and a well preserved five-layered gastric wall structure in 33 patients. Conclusions: We concluded that Borrmann type 4 gastric cancer was diagnosed more in females, as a more advanced disease, early detection was needed. And endoscopic ultrasonography is useful for diagnosis of Borrmann type 4 gastric cancer in the cases of suspicious results of gastroscopy.

백서 뇌의 정상 노화와 병적 노화 과정의 조직학적 차이 및 약물효과

전진숙,한호성,장희경,길영기,김순옥 대한생물치료정신의학회 1997 생물치료정신의학 Vol.3 No.1

Objectives : Besides of malnutrition and neurotoxic effect of alcohol on the prefrontal cortex or subcortical structures, premature aging may be involved in alcohol-induced cognitive disorders. The aims of this study were to evaluate the effect of alcohol on short-term memory function and histology, and to identify the drug responses and an association with aging process to understand a biological mechanism underlying alcoholic dementia. Methods: In experiment 1, T-maze tests were done in 5 aged controls and 5 atropine-treated rats. In experiment 2, T-maze tests were repeated on every week for a month in 5 normal adult and 5 ethanol-treated rats. In experiment 3, T-maze tests were repeated on every week for a month in seven groups of 5 ethanol-treated rats injected with normal saline, fluoxetine, bromocriptine, bethacholine, nimodipine, clonidine and ketamine. After completion of behavioral tests rats were sacrificed by the intracardiac perfusion with phosphate buffered 10% formaldehyde solution, and the brain specimen was stained with hematoxylin-eosin to count cells in prefrontal cortex and hippocampus. Results: 1) Cell numbers of hippocampus(CA1, CA3 and dentate gyrus) and prefrontal cortex were reduced in ethanol-treated rats(P<0.05) without significant changes on T-maze tests. 2)Cell numbers of hippocampus(CA1, CA3 and dentate gyrus) and prefrontal cortex were recovered by bethacholine(P<0.05), while those of hippocampus raised by bromocriptine and clonidine(P<0.05 respectively). There were no significant changes on T-maze tests. 3) Cell numbers of prefrontal cortex in ethanol-treated rats were correlated with those of atropine-treated(r=0.977,P<0.001), and of normal aged(r=0.448, P<0.05) rats. Conclusions : Alcohol-induced memory disorder might be mainly related with cholinergic system as well as adrenergic or dopaminergic ones. Pathological aging process could be involved in a mechanism underlying alcoholic dementia.

모체 Thyroxine 투여가 태아알코올효과를 가진 흰쥐 대뇌겉질 및 해마에서 NPY함유 신경세포의 생후 발달에 미치는 영향

김복,박상기,박영란,김종중,문정석,김주수,문영민,현영식,천관영,정윤영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Background and Objectives: Maternal alcohol abuse is considered to be one of the most prominent cause of neurobiological malformations in the postnatal and adult life of the offspring. In this study, we investigated the effects of maternal alcohol drinking on the postnatal development of NPY-containing neuron, and, the influence of thyroxine treatment on the cerebral cortex and hippocampus of pups of alcohol abused mother. Materials and Method: Time-pregnant rats were divided into three groups. Alcohol-fed group A received 35 calories of liquid alcohol diet daily from gestation day 6; control pair-fed group B was fed a liquid diet in dextrin replaced alcohol isocalorically: alcohol + T4 group C received 35 calories liquid alcohol diet and exogenous thyroxine subcutaneously. Results: Group C showed prominent NPY immunoreactivity in the cerebral cortex compared to group A and B at P7. In group C, NPY-containing neurons were widely distributed in the all layers of cerebral cortex after P14. Besides, numerical decrease of NPY-containing neuron as age increases was not found in group C. However, the decrease of NPY-containing neuron was clearly observed in group A compared to group C after P14. In hippocampus, group Band C were appeared similar patterns after P7. Additionally, in group C, NPY immunoreactivity was prominently appeared in CA2 and CA3 at P14 as compared to group B. Conclusions: The present results showed the increase of intensity and number of NPY-containing neurons in cerebral cortex and hippocampus of pups of exogenous T₄ supplemented alcohol-exposed dams as compared to control pair-fed and alcohol-exposed pups at P7. It presumably suggest that NPY-containing neurons might be regulated by the early postnatal growth stimulatory effect of the exogenously supplemented T₄. Therefore, the increase of NPY synthesis caused by maternal administration of exogenous thyroxine may ameliorate fetal alcohol effect, one of the ill effects as a result of the dysthyroid state following maternal alcohol abuse.

Mn-Ce 복합 산화물에 의한 톨루엔 촉매 산화

천태진,최성우,이창섭 한국환경과학회 2005 한국환경과학회지 Vol.14 No.4

Activity of manganese oxide supported on γ-Al₂O₃ was increased when cerium was added. Also, cerium-added manganese oxide on v-Al₂O₃ was more effective in oxidation of toluene than that without cerium. XRD result, it was observed that MnO₂+CeO₂ crystalline phases were present in the samples. For the used catalyst, a prominent feature has increased by XPS. TPRITPO profiles of cerium-added manganese oxide on γ-Al₂O₃ changed significantly increased at a lower temperature. The activity of 18.2 wt% Mn+10.0 wt% Ce/γ-Al₂O₃ increased at a lower temperature. The cerium added on the manganese catalysts has effects on the oxidation of toluene.

Mn이 첨가된 V₂O_(5)/TiO₂ 촉매상에서 질소산화물의 저온 SCR 특성

천태진,최상기,최성우 한국환경과학회 2004 한국환경과학회지 Vol.13 No.6

V₂O_(5)/TiO₂ catalysts promoted with Mn were prepared and tested for selective catalytic reduction of NOx in NH3. The effects of promoter content, degree of catalyst loading were investigated for NOx activity while changing temperatures, mole ratio, space velocity and O₂ concentration. Among the various V₂O_(5) catalysts having different metal loadings, V₂O_(5)(l wt.%) catalyst showed the highest activity(98%) under wide temperature range of 200-250 C. When the V₂O_(5) catalyst was further modified with 5 wt.% Mn as a promoter, the highest activity(90-47%) was obtained over the low temperature windows of 100-2000. From Mn-V₂O_(5)/TiO₂, it was found that by addition of 5 wt.% Mn on V₂O_(5)/TiO₂ catalyst, reduction activity of catalyst was improved, which resulted in the increase of catalytic activity and NOx reduction. According to the results, NOx removal decreased for 10%, but the reaction temperature down to 100℃.

退行期 偏執症 患者의 自害에 依한 舌 部分切斷 1例

田珍淑,李成主,張煥一 大韓神經精神醫學會 1984 신경정신의학 Vol.23 No.4

A 51 year-old male patient was admitted to Neuropsychiatric ward of Kyunghee University Hospital from April 2 to May 28 in 1984, because he amputed his tongue for himself with a tool under the psychotic state. He has been a heavy drinker with paranoid personality make-up, and lost his father when he was 10 year-old, and separated from his mother at eighteen. Recently, he lost his job and frequently troubled with his spouse, and separated from his son. Psychodynamically, guilt, separation anxiety, lowered self-esteem induced by loss of social role function which led social isolation, and using of rigid adaptation to the stressful life events were remarkable features.

食餌 脂肪質의 不飽化/飽化脂肪酸 比率이 흰쥐의 血淸 脂質組成에 미치는 影響

崔鎭浩,金一星,金在一,朴泉洙,尹泰憲,吳成基 한국노화학회 1992 한국노화학회지 Vol.2 No.1

食餌 脂肪質의 不飽化/飽化脂肪酸 比率이 흰쥐의 肝臟 細胞膜의 脂質組成에 미치는 影響

崔鎭浩,金一星,金在一,朴泉洙,尹泰憲,吳成基 한국노화학회 1992 한국노화학회지 Vol.2 No.1