Numerical analysis of tunnel in rock with basalt fiber reinforced concrete lining subjected to internal blast load

Priyanka Jain,Tanusree Chakraborty 사단법인 한국계산역학회 2018 Computers and Concrete, An International Journal Vol.21 No.4

The present study focuses on the performance of basalt fiber reinforced concrete (BFRC) lining in tunnel situated in sandstone rock when subjected to internal blast loading. The blast analysis of the lined tunnel is carried out using the threedimensional (3-D) nonlinear finite element (FE) method. The stress-strain response of the sandstone rock is simulated using a crushable plasticity model which can simulate the brittle behavior of rock and that of BFRC lining is analyzed using a damaged plasticity model for concrete capturing damage response. The strain rate dependent material properties of BFRC are collected from the literature and that of rock are taken from the authors' previous work using split Hopkinson pressure bar (SHPB). The constitutive model performance is validated through the FE simulation of SHPB test and the comparison of simulation results with the experimental data. Further, blast loading in the tunnel is simulated for 10 kg and 50 kg Trinitrotoluene (TNT) charge weights using the equivalent pressure-time curves obtained through hydrocode simulations. The analysis results are studied for the stress and displacement response of rock and tunnel lining. Blast performance of BFRC lining is compared with that of plain concrete (PC) and steel fiber reinforced concrete (SFRC) lining materials. It is observed that the BFRC lining exhibits almost 65% lesser displacement as compared to PC and 30% lesser displacement as compared to SFRC tunnel linings.

Alcohol associated liver cirrhotics have higher mortality after index hospitalization: Long-term data of 5,138 patients

( Priyanka Jain ),( Saggere Muralikrishna Shasthry ),( Ashok Kumar Choudhury ),( Rakhi Maiwall ),( Guresh Kumar ),( Ankit Bharadwaj ),( Vinod Arora ),( Rajan Vijayaraghavan ),( Ankur Jindal ),( Manoj 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.1

Background/Aims: Liver cirrhosis is an important cause of morbidity and mortality globally. Every episode of decompensation and hospitalization reduces survival. We studied the clinical profile and long-term outcomes comparing alcohol-related cirrhosis (ALC) and non-ALC. Methods: Cirrhosis patients at index hospitalisation (from January 2010 to June 2017), with ≥1 year follow-up were included. Results: Five thousand and one hundred thirty-eight cirrhosis patients (age, 49.8±14.6 years; male, 79.5%; alcohol, 39.5%; Child-A:B:C, 11.7%:41.6%:46.8%) from their index hospitalization were analysed. The median time from diagnosis of cirrhosis to index hospitalization was 2 years (0.2-10). One thousand and seven hundred seven patients (33.2%) died within a year; 1,248 (24.3%) during index hospitalization. 59.5% (2,316/3,890) of the survivors, required at least one readmission, with additional mortality of 19.8% (459/2,316). ALC compared to non-ALC were more often (P<0.001) male (97.7% vs. 67.7%), younger (40-50 group, 36.2% vs. 20.2%; P<0.001) with higher liver related complications at baseline, (P<0.001 for each), sepsis: 20.3% vs. 14.9%; ascites: 82.2% vs. 65.9%; spontaneous bacterial peritonitis: 21.8% vs. 15.7%; hepatic encephalopathy: 41.0% vs. 25.0%; acute variceal bleeding: 32.0% vs. 23.7%; and acute kidney injury 30.5% vs. 19.6%. ALC patients had higher Child-Pugh (10.6±2.0 vs. 9.0±2.3), model for end-stage liver-disease scores (21.49±8.47 vs. 16.85±7.79), and higher mortality (42.3% vs. 27.3%, P<0.001) compared to non-ALC. Conclusions: One-third of cirrhosis patients die in index hospitalization. 60% of the survivors require at least one rehospitalization within a year. ALC patients present with higher morbidity and mortality and at a younger age. (Clin Mol Hepatol 2021;27:175-185)

Primary pulmonary epithelioid inflammatory myofibroblastic sarcoma: a rare entity and a literature review

Priyanka Singh,Aruna Nambirajan,Manish Kumar Gaur,Rahul Raj,Sunil Kumar,Prabhat Singh Malik,Deepali Jain 대한병리학회 2022 Journal of Pathology and Translational Medicine Vol.56 No.4

Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is an aggressive subtype of inflammatory myofibroblastic tumor (IMT) harboring anaplastic lymphoma kinase (<i>ALK</i>) gene fusions and is associated with high risk of local recurrence and poor prognosis. Herein, we present a young, non-smoking male who presented with complaints of cough and dyspnoea and was found to harbor a large right lower lobe lung mass. Biopsy showed a high-grade epithelioid to rhabdoid tumor with ALK and desmin protein expression. The patient initially received 5 cycles of crizotinib and remained stable for 1 year; however, he then developed multiple bony metastases, for which complete surgical resection was performed. Histopathology confirmed the diagnosis of EIMS, with <i>ALK</i> gene rearrangement demonstrated by fluorescence in situ hybridization. Postoperatively, the patient is asymptomatic with stable metastatic disease on crizotinib and has been started on palliative radiotherapy. EIMS is a very rare subtype of IMT that needs to be included in the differential diagnosis of ALKexpressing lung malignancies in young adults.

Effectiveness of online versus in-person structured training program on arterial blood gas, electrolytes, and ventilatory management of critically ill patients

Gaurav Jain,Bhavna Gupta,Priyanka Gupta,Sagarika Panda,Sameer Sharma,Shalinee Rao 대한중환자의학회 2021 Acute and Critical Care Vol.36 No.1

Background: Due to the risk of viral transmission during in-person training, a shift towardonline platforms is imperative in the current pandemic. Therefore, we compared the effectivenessof an in-person interactive course with a structurally similar online course designedto improve cognitive skills among clinical health professionals in arterial blood gas analysis,management of electrolyte imbalances, and approaches to mechanical ventilation in criticallyill patients. Methods: In an observational, outcome assessor-blinded, cohort trial, group A included participantsenrolled prospectively in an online course, while group B included those who tookpart in an in-person course (retrospective arm). The primary objective was comparison ofcognitive skills through a pre and post-test questionnaire. Statistical analysis was performedusing Student t-test. Results: In total, 435 participants were analyzed in group A, while 99 participants were evaluatedin group B. The mean pre-test score was 9.48±2.75 and 10.76±2.42, while the meanpost-test score was 11.94±1.90 (passing rate, 64.6%) and 12.53±1.63 (passing rate, 73.3%)in groups A and B, respectively. Group B scored significantly higher in both pre-test (P=0.001)and post-test evaluations (P=0.004). The improvement in post-test score was significantlygreater (P=0.001) in group A (2.46±2.22) compared to group B (1.77±1.76). The medicalspecialties fared better in group B, while surgical specialties scored higher in group A. Thepre-test vs. post-test scores exhibited a moderate correlation in both groups (P<0.001). Thefeedback survey showed a Likert score >3.5 for most points in both groups. Conclusions: The online teaching module exhibited a significant benefit in terms of participantsensitization and knowledge sharing.

A general Volterra-type integral equation associated with an integral operator involving the product of general class of polynomials and multivarible H-function in the kernel

agarwal,Priyanka Harjule,Rashmi Jain 장전수학회 2017 Proceedings of the Jangjeon mathematical society Vol.20 No.3

In this paper, we solve a general Volterra-type fractional equation associated with an integral operator involving a product of general class of polynomials and the multivariable H-function in its Kernel. We make use of convolution technique to solve the main equation.On account of the general nature of multivariable H-function and general class of polynomials, We can obtain a large number of integral equations involving products of several useful polynomials and special functions as its special cases. For the lack of space, we record here only two such special cases which involve the product of general class of polynomials SM N & Appell's function F3 and a general class of polynomials. The main result derived in this paper also generalizes the results obtained by Gupta et. al.[2] and Jain[3, p. 102-103, eq. (3.5),eq.(3.6)]

Profiling Virulence and Antimicrobial Resistance Markers of Enterovirulent <italic>Escherichia Coli</italic> from Fecal Isolates of Adult Patients with Enteric Infections in West Cameroon

Marbou Wiliane J. T.,Jain Priyanka,Samajpati Sriparna,Halder Gourab,Mukhopadhyay Asish K.,Dutta Shanta,Kuete Victor 질병관리본부 2020 Osong Public Health and Research Persptectives Vol.11 No.4

Objectives This study aimed to identify virulent and antimicrobial resistant genes in fecal E. coli in Mbouda, Cameroon. Methods A total of 599 fecal samples were collected from patients with enteric infections who were ≥ 20 years old. E. coli was isolated on the MacConkey agar and virulent genes were detected by multiplex/simplex PCR. Isolates in which ≥ 1 virulent gene was detected were subjected to antibiotic susceptibility testing. The resulting resistant isolates were subjected to PCR, followed by sequencing for resistant genes detection. Results There were 119 enterovirulent E. coli identified, amongst which 47.05% were atypical enteropathogenic E. coli (EPEC), 36.97% enterotoxigenic E. coli, 10.08% Shiga toxin producing E. coli (STEC) and 5.88% were enteroinvasive E. coli (EIEC). The occurrence of the eae gene (47.06%) was higher compared with CVD432 (33.61%), aaic (13.45%), stx2 (10.08%) and stx1 (0.84%). High resistance rates were noted for ampicillin (94.64% EPEC, 91.67% STEC, 59.09% EAEC, and 57.14% EIEC) and sulfamethoxazole-trimethoprim (100% EPEC and 83.33% STEC, 81.82% EAEC and 71.43% EIEC). sul2 (71.43%), tetB (64.71%), tetA (59.94%) and blaTEM (52.10%) were detected. A double mutation (S83L; D87N) was seen in gyrA and a single mutation (S80I) was observed in parC.