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Two Androstane Derivatives from the Cultures of Fungus Marasmiellus ramealis (Bull.) Singer
Ning-Ning Yang,Qing-Yun Ma,Sheng-Zhuo Huang,Hao-Fu Dai,Zhi-Kai Guo,Zhi-Fang Yu,You-Xing Zhao 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.11
A new androstane derivative, 4β-methyl-15-oxa-14β-androstane-7-ene-4α-carboxylic acid (1) and a known one 4β-methyl-15-oxa-14β-androstane-7-ene-4α-hydroxyl (2) were isolated from the EtOAc extract of the cultures of the fungus Marasmiellus ramealis (Bull.) Singer. Their structures were elucidated on the basis of 1D and 2D NMR as well as MS spectroscopic data analysis. The inhibitory activity of two isolates against acetylcholinesterase (AChE) revealed that compound 1 exhibited definitely inhibitory activity.
Ning-Ning Dou,Hao-lin Wang,Shao-Zhen Hu,Zheng-Nan Huang,Jun Zhong,Shi-Ting Li 대한척추신경외과학회 2023 Neurospine Vol.20 No.3
Objective: Although endoscopic drill has the advantages in manipulation and hemostasis, whose low efficiency and blurred vision reduce the efficacy of lumbar endoscopic unilateral laminotomy with bilateral decompression (LE-ULBD). The present study was designed to evaluate the safety and efficacy of full-visualized trephine/osteotome in the LE-ULBD surgery for severe lumbar stenosis. Methods: Fifty-seven severe lumbar stenosis patients who underwent LE-ULBD between January 2020 to January 2023 were enrolled, who were divided into drill and visualized trephine groups. The medical records including demographics, operative duration, intraoperative electrophysiological findings, postoperative hospital stay or hospital stay, postoperative outcomes and complications were retrospectively reviewed and analyzed. Results: A total of 57 patients included 15 in drill and 42 in trephine group were enrolled in the study. There was significant difference in the pre- and postoperative visual analogue scale and Oswestry Disability Index scores in both groups (p < 0.05). The mean operative duration in the trephine group (101.05 ± 12.18 minutes) was shorter than that in the drill group (134.67 ± 9.68 minutes) (p < 0.05). There was no statistical difference between the 2 groups in electrophysiological monitoring, posthospital stays, postoperative outcomes and complications. Abnormal free-electromyography (EMG) were recorded in 2 (13.3%) and 5 patients (11.9%) in the drill and trephine group. Intraoperative somatosensory evoked potential changes occurred in 3 (20%) and 3 patients (7.1%) in the drill and trephine group and all patients recovered immediately when surgery ended. No serious complications and recurrence occurred in all the patients. Conclusion: Full-visualized trephine/osteotome has been approved to be convenient, safe and efficient in our study, which combined with translaminar inside-out technique and EMG monitoring especially free-EMG may offer a new choice in LE-ULBD surgery for lumbar stenosis patients.
Chien-Ning Huang,Chi-Li Lin,Hsin-Hua Li,Sing-Hua Tsou,Chiung-Huei Peng 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.7
Abelmoschus esculentus (Okra) Prevents Insulin Resistance and RestoresNeuron Autophagy by Regulating Dipeptidyl Peptidase-4and Thus Improving Hippocampal Function
Relativistic Quantum Collision Theory for Many-particle Systems
Keh-Ning Huang,Hsiao-Ling Sun,Sheng-Fang Lin,Hao-Tse Shiao,Xin-Zeng Wu 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.41
Starting from the relativistic equation of motion governing quantum collision processes, we shall formulate the relativistic quantum collision theory in an ab-initio manner. Quantum electrodynamic effects are, however, incorporated perturbatively. Because heavy projectiles or ultra-high incident energies are considered, the recoil of the target is also treated. Electron-impact ionization of the uranium ion U^(91+) and proton-impact ionization of hydrogen will be given as examples.
Zhi-Ning Huang,Han Liang,Hong Qiao,Bao-Rui Wang,Ning Qu,Hua Li,Run-Run Zhou,Li-Juan Wang,Shan-Hua Li,Fu-Nan Li 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.12
Guided by bioisosterism and pharmacokinetic parameters, we designed and synthesized a series of novel benzamide derivatives. Preliminary in vitro studies indicated that compounds 10b and 10j show significant inhibitory bioactivity in HepG2 cells (IC50 values of 0.12 and 0.13 μM, respectively). Compounds 10b and 10j induced the expression of HIF-1α protein and downstream target gene p21, and upregulated the expression of cleaved caspase-3 to promote tumor cells apoptosis.
( Ying Huang ),( Chenjie Xu ),( Tao Zeng ),( Zhongming Li ),( Yanzhi Xia ),( Gaojian Tao ),( Tong Zhu ),( Lijuan Lu ),( Jing Li ),( Taiyuan Huang ),( Hongbo Huai ),( Benxiang Ning ),( Chao Ma ),( Xinx 대한통증학회 2021 The Korean Journal of Pain Vol.34 No.2
Background: Postherpetic neuralgia (PHN) is the most common complication of acute herpes zoster. The treatment of PHN remains a challenge for clinical pain management. Despite the effectiveness of anticonvulsants, antidepressants, and lidocaine patches in reducing PHN, many patients still face intractable pain disorders. In this randomized controlled study, we evaluated whether hydromorphone through intravenous patient-controlled analgesia (IV PCA) was effective in relieving PHN. Methods: Patients with PHN were randomly divided into two groups, one group received oral pregabalin with IV normal saline, another group received oral pregabalin with additional IV PCA hydromorphone for two weeks. Efficacy was evaluated at 1, 4, and 12 weeks after the end of the treatments. Results: Two hundred and one patients were followed up for 12 weeks. After treatment, numerical rating scale (NRS) score of patients in the hydromorphone group was significantly lower than that of the control group, and the difference of NRS scores between the two groups was statistically significant at 4 and 12 weeks after treatment. The frequency of breakthrough pain in the hydromorphone group was significantly lower than that in the control group 1 and 4 weeks after treatment. After treatment, the quality of sleep in the hydromorphone group was significantly improved compared with the control group. The most common adverse reactions in the hydromorphone group were dizziness and nausea, with no significant respiratory depression. Conclusions: IV PCA hydromorphone combined with oral pregabalin provides superior pain relief in patients with PHN, which is worthy of clinical application and promotion.
Two Androstane Derivatives from the Cultures of Fungus Marasmiellus ramealis (Bull.) Singer
Yang, Ning-Ning,Ma, Qing-Yun,Huang, Sheng-Zhuo,Dai, Hao-Fu,Guo, Zhi-Kai,Yu, Zhi-Fang,Zhao, You-Xing Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.11
A new androstane derivative, $4{\beta}$-methyl-15-oxa-$14{\beta}$-androstane-7-ene-$4{\alpha}$-carboxylic acid (1) and a known one $4{\beta}$-methyl-15-oxa-$14{\beta}$-androstane-7-ene-$4{\alpha}$-hydroxyl (2) were isolated from the EtOAc extract of the cultures of the fungus Marasmiellus ramealis (Bull.) Singer. Their structures were elucidated on the basis of 1D and 2D NMR as well as MS spectroscopic data analysis. The inhibitory activity of two isolates against acetylcholinesterase (AChE) revealed that compound 1 exhibited definitely inhibitory activity.
Huang, Wei-Yi,Chen, Dong-Hui,Ning, Li,Wang, Li-Wei Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
The gene encoding the Nin one binding (NOB1) protein which plays an essential role in protein degradation has been investigated for possible tumor promoting functions. The present study was focused on NOB1 as a possible therapeutic target for breast cancer treatment. Lentivirus mediated NOB1 siRNA transfection was used to silence the NOB1 gene in two established breast cancer cell lines, MCF-7 and MDA-MB-231, successful transfection being confirmed by fluorescence imaging. NOB1 deletion caused significant decline in cell proliferation was observed in both cell lines as investigated by MTT assay. Furthermore the number and size of the colonies formed were also significantly reduced in the absence of NOB1. Moreover NOB1 gene knockdown arrested the cell cycle and inhibited cell cycle related protein expression. Collectively these results indicate that NOB1 plays an essential role in breast cancer cell proliferation and its gene expression could be a therapeutic target.
An Efficient Reactive Power Regulation based DPC Method for AC/DC Converters
Huang Jingjing,Sun Yuangang,Tong Xiangqian,Li Ning 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6
To eliminate the cyclical fluctuation problems of the reactive power existing in the traditional direct power control (DPC), a novel method is proposed for the threephase voltage source AC/DC converter. It employs two switching tables to select the proper switching states according to the instantaneous reactive power deviations. The design principle of the switching tables is provided to ensure the efficient reactive power regulation. Moreover, it should guarantee the steady characteristic of the converter system. The simulation model established under the MATLAB/Simulink environment and the experiment were presented to compare the characteristics obtained by the proposed strategy with that obtained by the traditional DPC strategy. The results show that the ac current obtained by the proposed strategy has the much lower total harmonic distortion rate (THD), and the fluctuation range of the reactive power has the more than two times reduction.
A remote long-term and high-frequency wind measurement system: design, comparison and field testing
Ning Zhao,Guoqing Huang,Ruili Liu,Liuliu Peng 한국풍공학회 2020 Wind and Structures, An International Journal (WAS Vol.31 No.1
The wind field measurement of severe winds such as hurricanes (or typhoons), thunderstorm downbursts and other gales is important issue in wind engineering community, both for the construction and health monitoring of the wind-sensitive structures. Although several wireless data transmission systems have been available for the wind field measurement, most of them are not specially designed for the wind data measurement in structural wind engineering. Therefore, the field collection is still dominant in the field of structural wind engineering at present, especially for the measurement of the long-term and high-frequency wind speed data. In this study, for remote wind field measurement, a novel wireless long-term and high-frequency wind data acquisition system with the functions such as remote control and data compression is developed. The system structure and the collector are firstly presented. Subsequently, main functions of the collector are introduced. Also novel functions of the system and the comparison with existing systems are presented. Furthermore, the performance of this system is evaluated. In addition to as the wireless transmission for wind data and hardware integration for the collector, the developed system possesses a few novel features, such as the modification of wind data collection parameters by the remote control, the remarkable data compression before the data wireless transmission and monitoring the data collection by the cell phone application. It can be expected that this system would have wide applications in wind, meteorological and other communities.