Fractional-order L_βC_α Low-Pass Filter Circuit

Zhou, Rui,Zhang, Run-Fan,Chen, Di-Yi The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.4

This paper introduces the fundamentals of the conventional LC low-pass filter circuit in the fractional domain. First, we study the new fundamentals of fractional-order LC low-pass filter circuit including the pure real angular frequency, the pure imaginary angular frequency and the short circuit angular frequency. Moreover, sensitivity analysis of the impedance characteristics and phase characteristics of the LC low-pass filter circuit with respect to the system variables is studied in detail, which shows the greater flexibility of the fractional-order filter circuit in designs. Furthermore, from the filtering property perspective, we systematically investigate the effects of the system variables (LC, frequency f and fractional orders) on the amplitude-frequency characteristics and phase-frequency characteristics. In addition, the detailed analyses of the cut-off frequency and filter factor are presented. Numerical experimental results are presented to verify the theoretical results introduced in this paper.

HLA–DPB1 and DPB2 are genetic loci for systemic sclerosis: A genome-wide association study in Koreans with replication in North Americans

Zhou, Xiaodong,Lee, Jong Eun,Arnett, Frank C.,Xiong, Momiao,Park, Min Young,Yoo, Yeon Kyeong,Shin, Eun Soon,Reveille, John D.,Mayes, Maureen D.,Kim, Jin Hyun,Song, Ran,Choi, Ji Yong,Park, Ji Ah,Lee, Y Wiley Subscription Services, Inc., A Wiley Company 2009 Vol.60 No.12

<B>Objective</B><P>To identify systemic sclerosis (SSc) susceptibility loci via a genome-wide association study.</P><B>Methods</B><P>A genome-wide association study was performed in 137 patients with SSc and 564 controls from Korea using the Affymetrix Human SNP Array 5.0. After fine-mapping studies, the results were replicated in 1,107 SSc patients and 2,747 controls from a US Caucasian population.</P><B>Results</B><P>The single-nucleotide polymorphisms (SNPs) (rs3128930, rs7763822, rs7764491, rs3117230, and rs3128965) of HLA–DPB1 and DPB2 on chromosome 6 formed a distinctive peak with log P values for association with SSc susceptibility (P = 8.16 × 10<SUP>−13</SUP>). Subtyping analysis of HLA–DPB1 showed that DPB1*1301 (P = 7.61 × 10<SUP>−8</SUP>) and DPB1*0901 (P = 2.55 × 10<SUP>−5</SUP>) were the subtypes most susceptible to SSc in Korean subjects. In US Caucasians, 2 pairs of SNPs, rs7763822/rs7764491 and rs3117230/rs3128965, showed strong association with SSc patients who had either circulating anti–DNA topoisomerase I (P = 7.58 × 10<SUP>−17</SUP>/4.84 × 10<SUP>−16</SUP>) or anticentromere autoantibodies (P = 1.12 × 10<SUP>−3</SUP>/3.2 × 10<SUP>−5</SUP>), respectively.</P><B>Conclusion</B><P>The results of our genome-wide association study in Korean subjects indicate that the region of HLA–DPB1 and DPB2 contains the loci most susceptible to SSc in a Korean population. The confirmatory studies in US Caucasians indicate that specific SNPs of HLA–DPB1 and/or DPB2 are strongly associated with US Caucasian patients with SSc who are positive for anti–DNA topoisomerase I or anticentromere autoantibodies.</P>

Increased retinoic acid signaling decreases lung metastasis in salivary adenoid cystic carcinoma by inhibiting the noncanonical Notch1 pathway

Zhou Meng-jiao,Yang Jia-jie,Ma Ting-yao,Feng Ge-xuan,Wang Xue-lian,Wang Li-Yong,Ge Yu-ze,Gao Ran,Hong-liang Liu,Shan Lin,Kong Lu,Chen Xiao-hong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

MYB-NFIB fusion and NOTCH1 mutation are common hallmark genetic events in salivary gland adenoid cystic carcinoma (SACC). However, abnormal expression of MYB and NOTCH1 is also observed in patients without MYB-NFIB fusion and NOTCH1 mutation. Here, we explore in-depth the molecular mechanisms of lung metastasis through single-cell RNA sequencing (scRNA-seq) and exome target capture sequencing in two SACC patients without MYB-NFIB fusion and NOTCH1 mutation. Twenty-five types of cells in primary and metastatic tissues were identified via Seurat clustering and categorized into four main stages ranging from near-normal to cancer-based on the abundance of each cell cluster in normal tissue. In this context, we identified the Notch signaling pathway enrichment in almost all cancer cells; RNA velocity, trajectory, and sub-clustering analyses were performed to deeply investigate cancer progenitor-like cell clusters in primary tumor-associated lung metastases, and signature genes of progenitor-like cells were enriched in the “MYC_TARGETS_V2” gene set. In vitro, we detected the NICD1-MYB-MYC complex by co-immunoprecipitation (Co-IP) and incidentally identified retinoic acid (RA) as an endogenous antagonist of genes in the “MYC_TARGETS_V2” gene set. Following this, we confirmed that all-trans retinoic acid (ATRA) suppresses the lung metastasis of SACC by correcting erroneous cell differentiation mainly caused by aberrant NOTCH1 or MYB expression. Bioinformatic, RNA-seq, and immunohistochemical (IHC) analyses of primary tissues and metastatic lung tissues from patients with SACC suggested that RA system insufficiency partially promotes lung metastasis. These findings imply the value of the RA system in diagnosis and treatment.

A High-efficiency Trim Method for CFD Numerical Calculation of Helicopter Rotors

Zhou Ye,Guo-hua Xu,Yong-jie Shi,Run-ze Xia 한국항공우주학회 2017 International Journal of Aeronautical and Space Sc Vol.18 No.2

In order to resolve the trimming difficulty in rotor CFD calculations, a high-efficiency and improved “delta trim method” is established to compute the blade control settings that are necessary to identify the blade motion. In this method, a simplified model which combines the blade element theory and different inflow models is employed to calculate the control settings according to the target aerodynamic forces, then it is coupled into a CFD solver with unsteady Navier-Stokes equations by the delta methodology, which makes the control settings and aerodynamics calculated and updated in the meantime at every trim cycle. Different from the previous work, the current research combines the inflow model based on prescribed wake theory. Using the method established, the control settings and aerodynamic characteristics of Helishape 7A, AH-1G and Caradonna-Tung rotors are calculated. The influence of different inflow models on trimming calculations is analyzed and the computational efficiency of the current “delta trim method” is compared with that of the “CFD-based trim method”. Furthermore, for the sake of improving the calculation efficiency, a novel acceleration factor method is introduced to accelerate the trimming process. From the numerical cases, it is demonstrated that the current “delta trim method” has higher computational efficiency than “CFD-based trim method” in both hover and forward flight, and up to 70% of the amount of calculation can be saved by current “delta trim method” which turns out to be satisfactory for engineering applications. In addition, the proposed acceleration factor shows a good ability to accelerate the trim procedure, and the prescribed wake inflow model is always of better stability than other simple inflow models whether the acceleration factor is utilized in trimming calculations.

High Char-Yield in AN-AM Copolymer by Acidic Hydrolysis of Homopolyacrylonitrile

Run Cheng,You Zhou,Jing Wang,Yumin Cheng,Seungkon Ryu,Riguang Jin 한국탄소학회 2013 Carbon Letters Vol.14 No.1

Acrylonitrile (AN)-acrylamide (AM) copolymers were prepared by nitric acidic hydrolysis of homopolyacrylonitrile. The acrylamino group increased as a function of hydrolysis time, while crystallinity decreased. Differential scanning calorimetry and a thermal gravimetric analysis indicated that the acylamino introduced by acidic hydrolysis effectively enhanced the cyclization reaction at low temperature due to the change of the cyclization reaction mechanism. Char-yield of AN-AM copolymers also gradually increased with increasing hydrolysis time. The maximum char-yield was 49.48% when hydrolized at 23°C in 65% nitric acid solution for 18 h, which was 30% higher than that of non-acidic hydrolysis of homopolyacrylonitrile. Simulation of the practical process also showed an increase of char yields, where the char yields were 55.43% and 62.60% for homopolyacrylonitrile and copolyacrylonitrile, respectively, with a hydrolysis time of 13 h.

Effect of freezing on electrical properties and quality of thawed chicken breast meat

Ran Wei,Peng Wang,Minyi Han,Tianhao Chen,Xinglian Xu,Guanghong Zhou 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.4

Objective: The objective of this research was to study the electrical properties and quality of frozen-thawed chicken breast meat and to investigate the relationship between these parameters at different times of frozen storage. Methods: Thawed samples of chicken breast muscles were evaluated after being kept in frozen storage at –18°C for different periods of time (1, 2, 3, 4, 5, 6, 7, and 8 months). Results: The results showed that water-holding capacity (WHC) and protein solubility decreased while thiobarbituric acid-reactive substances content increased with increasing storage time. The impedance module of samples decreased during 8-month frozen storage. Pearson correlation coefficients showed that the impedance change ratio (Q value) was significantly (p<0.05) related to pH, color, WHC, lipid oxidation and protein solubility, indicating a good relationship between the electrical properties and qualities of frozen-thawed chicken breast meat. Conclusion: Impedance measurement has a potential to assess the quality of frozen chicken meat combining with quality indices.

The novel gene LRP15 is regulated by DNA methylation and confers increased efficiency of DNA repair of ultraviolet-induced DNA damage

( Zhou Min Xu ),( Wei Ran Gao ),( Qi Mei Jian ),( Chen Jing Lu ) 생화학분자생물학회 2008 BMB Reports Vol.41 No.3

Molecular Cloning, Identification and Characteristics of a Novel Isoform of Carbamyl Phosphate Synthetase 1 in Human Testis

( Ran Huo ),( Hui Zhu ),( Li Lu ),( Lan Lan Ying ),( Min Xu ),( Zhi Yang Xu ),( Jian Min Li ),( Zuo Min Zhou ),( Jia Hao Sha ) 생화학분자생물학회 2005 BMB Reports Vol.38 No.1

A gene coding a novel isoform of carbamyl phosphate synthetase I (CPSI) was cloned from a human testicular library. As shown by cDNA microarray hybridization, this gene was expressed at a higher level in human adult testes than in fetal testes. The full length of its cDNA was 3831 bp, with a 3149 bp open reading frame, encoding a 1050-amino-acid protein. The cDNA sequence was deposited in the GenBank (AY317138). Sequence analysis showed that it was homologous to the human CPS1 gene. The putative protein contained functional domains composing the intact large subunit of carbamoyl phosphate synthetase, thus indicated it has the capability of arginine biosynthesis. A multiple tissue expression profile showed high expression of this gene in human testis, suggesting the novel alternative splicing form of CPS1 may be correlated with human spermatogenesis.

Somatostatin Receptors 3, 4 and 5 Play Important Roles in Gallbladder Cancer

Guo, Run-Sheng,Shi, Pei-Dong,Zhou, Jie,Chen, Yue-Yu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

Expression changes of somatostatin receptor subtypes (SSTRs) including SSTR1, SSTR2, SSTR3, SSTR4 and SSTR5 in the development of gallbladder cancer were assessed with attention to relationships with clinical pathological characteristics. SSTRs in 29 gallbladder cancer and 25 normal gallbladder tissue specimens were examined by immunohistochemical staining. Differences between SSTRs expressions and clinical pathological parameters were analyzed by chi-square test. The five subtypes of SSTR were all expressed in gallbladder cancer tissues and SSTR3 presented the highest expression. SSTR5 expression was increased significantly in gallbladder cancer (P<0.05) compared with that in normal gallbladder tissue. SSTR3 expression in highly and moderately differentiated gallbladder cancer was significantly higher than that in poorly differentiated lesions (P<0.05). SSTR4 expression was lower in gallbladder cancer with lymph node metastasis than that in gallbladder cancer without lymph node metastasis (P<0.05). Therfore, these results indicated that SSRT5, SSTR3 and SSTR4 may play important roles in the formation and development of gallbladder cancer.

Fractional-order L<SUB>β</SUB>C<SUB>α</SUB> Low-Pass Filter Circuit

Rui Zhou,Run-Fan Zhang,Di-Yi Chen 대한전기학회 2015 Journal of Electrical Engineering & Technology Vol.10 No.4

This paper introduces the fundamentals of the conventional LC low-pass filter circuit in the fractional domain. First, we study the new fundamentals of fractional-order LC low-pass filter circuit including the pure real angular frequency, the pure imaginary angular frequency and the short circuit angular frequency. Moreover, sensitivity analysis of the impedance characteristics and phase characteristics of the LC low-pass filter circuit with respect to the system variables is studied in detail, which shows the greater flexibility of the fractional-order filter circuit in designs. Furthermore, from the filtering property perspective, we systematically investigate the effects of the system variables (LC, frequency f and fractional orders) on the amplitude-frequency characteristics and phase-frequency characteristics. In addition, the detailed analyses of the cut-off frequency and filter factor are presented. Numerical experimental results are presented to verify the theoretical results introduced in this paper.