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Hou Ming-Feng,Ou-Yang Fu,Li Chung-Liang,Chen Fang-Ming,Chuang Chieh-Han,Kan Jung-Yu,Wu Cheng-Che,Shih Shen-Liang,Shiau Jun-Ping,Kao Li-Chun,Kao Chieh-Ni,Lee Yi-Chen,Moi Sin-Hua,Yeh Yao-Tsung,Cheng Chi 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
In Western countries, breast cancer tends to occur in older postmenopausal women. However, in Asian countries, the proportion of younger premenopausal breast cancer patients is increasing. Increasing evidence suggests that the gut microbiota plays a critical role in breast cancer. However, studies on the gut microbiota in the context of breast cancer have mainly focused on postmenopausal breast cancer. Little is known about the gut microbiota in the context of premenopausal breast cancer. This study aimed to comprehensively explore the gut microbial profiles, diagnostic value, and functional pathways in premenopausal breast cancer patients. Here, we analyzed 267 breast cancer patients with different menopausal statuses and age-matched female controls. The α-diversity was significantly reduced in premenopausal breast cancer patients, and the β-diversity differed significantly between breast cancer patients and controls. By performing multiple analyses and classification, 14 microbial markers were identified in the different menopausal statuses of breast cancer. Bacteroides fragilis was specifically found in young women of premenopausal statuses and Klebsiella pneumoniae in older women of postmenopausal statuses. In addition, menopausal-specific microbial markers could exhibit excellent discriminatory ability in distinguishing breast cancer patients from controls. Finally, the functional pathways differed between breast cancer patients and controls. Our findings provide the first evidence that the gut microbiota in premenopausal breast cancer patients differs from that in postmenopausal breast cancer patients and shed light on menopausal-specific microbial markers for diagnosis and investigation, ultimately providing a noninvasive approach for breast cancer detection and a novel strategy for preventing premenopausal breast cancer.
Yan-Ming Cheng,Cheng Liu,Jing Wu,He-Miao Liu,Il-Kyoo Lee,Jing Niu,조주필,구경완,Min-Woo Lee,우덕근 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.6
This paper mainly focuses on the control strategy for phase-shifting full-bridge soft switching electrolytic silver power supply based on Zero Voltage Switching (ZVS) soft switching technology. Taking into consideration the low performance of traditional PID control for phase-shifting full-bridge soft-switching, this paper introduce a PID improved by Back Propagation (BP) neural network with one single learning rate which is used to calculate weights from the input layer to the hidden layer and weights from the hidden layer to the output layer. After testing, it is found that setting independent learning rate for calculation of weights from the input layer to the hidden layer and weights from the hidden layer to the output layer which will not have an adverse eff ect on the design of the controller. Instead, the learning rate can be set according to the respective characteristics of the weights between the two layers, which is called double learning rate BP neural network PID. The simulation results indicate that compared with the single learning rate BP neural network PID control, the double learning rate BP neural network control has higher response speed, less over-shoot, short time to enter the steady state and strong immunity.
대만 신종교의 문화콘텐츠 고찰 -자제기금회, 유심성교 그리고 일관도의 문화사업을 중심으로-
쩡쯔밍 ( Chih-ming Cheng ),이경원 ( Gyung-won Lee ),이수현 ( Su-hyun Lee ) 한국신종교학회 2018 신종교연구 Vol.39 No.-
문화콘텐츠라는 용어가 한국사회에서 등장한 지는 그리 오래되지 않았다. 특히 종교문화콘텐츠는 오늘날 문화콘텐츠 조사 및 연구에서 빼놓을 수 없는 핵심분야가 되었다. 이에 신종교문화콘텐츠 연구도 그 관심과 다양한 연구가 필요한 상황이다. 그동안 학회에서 논의되어 온 한국 신종교의 문화콘텐츠 연구에 힘입어 그 연구의 외연을 넓히는 차원에서 가까운 외국의 사례를 조사하고 그 특징을 살펴보는 연구를 진행하고자 한다. 본 고는 대만 신종교의 사례를 중심으로 논의하되 특히 그 사회사업의 현황을 개괄하고 문화사업의 영역에서 나타난 문화콘텐츠의 측면을 다루고자 한다. 그 사례가 되는 종교는 자제기금회와 유심성교 그리고 일관도이다. 이 세가지 신종교의 경우 사회적으로 가장 두드러진 현상을 중심으로 문화콘텐츠의 요소들을 고찰해보고자 한다. 자제기금회의 경우 활발한 구호사업을 벌이고 있는 가운데 특히 인문사업의 분야에서 다양한 콘텐츠를 축적하고 있다. 자선인문, 의료인문, 교육인문의 3대분야에서 그 두각을 드러내고 있다. 유심성교는 종교활동 이외에도 예술과 문학을 중시하여 인간 본성의 진선미를 드러내고자 한다. 유심방송국, 출판사, 문화원, 합창단, 역경대학 등의 활동에서 많은 콘텐츠를 축적하고 있다. 일관도의 문화콘텐츠는 사회사업의 역사를 기반으로 탄생하였으며 현대 정보통신문명의 발전과 더불어 다양한 미디어콘텐츠들이 생산되었다. 특히 전국 각지에서 운용하고 있는 일관도 전문 서점에서는 각종 CD, DVD, VCD, 경전해설서, 일관도 교리서 등을 디지털로 제작하여 판매하고 있다. 이처럼 대만 신종교가 보여주는 활발한 사회활동과 문화콘텐츠는 한국 신종교연구자에게도 주목할 만한 일이다. Official use of the word ‘Cultural Contents’ (referring to creative works as a whole in use as digital content) in Korean society is a fairly recent development. ‘Cultural Contents of Religions’ became especially necessary in the field of research on cultural contents today. Furthermore the cultural contents of new religions also need more interest and various research. Encouraged by the results of research in Korean new religious cultural contents, we tried to expand the research area of cultural contents into foreign countries and collect several of their cases. In this paper we will focus on several Taiwanese new religions and introduce their social works in addition to their cultural works constituting their cultural contents. The main cases are Tzuchi, Weixin and Ikuandao. The content will be composed of current prominent records of these new religions in Taiwanese society. In the case of Tzuchi, they are accumulating cultural contents since they have expanded their relief works. They distinguish themselves in the fields of charitable humanity, medical humanity, and educational humanity. Weixin is trying to manifest human nature in truth, goodness, and beauty through taking a serious involvement in art and literature besides religious works. They accumulate cultural contents through the works of Weixin’s own broadcasting organization, publications, Institute of Culture, choral groups, Yijing college. IKuan-Dao cultural contents have been created based on various social works. Further, various media contents accompanying the development of a contemporary IT civilization have been produced. There are also many bookstores that specialize in IKuan-Dao and they sell many items like CD, DVD, VCD, books of scripture interpretation, and text books. All previous facts of energetic Taiwanese new religious movements are worthy of note to Korean researchers.
Meng-Luen Lee,Ming-Yuh Chang,Tung-Ming Chang,Rei-Cheng Yang,Ming-Che Chang,Albert D. Yang 대한의학회 2018 Journal of Korean medical science Vol.33 No.10
Concurrent involvement of bilateral renal and cerebral arteries, usually incurred as stenosis is rare in childhood-onset Takayasu arteritis (c-TA). We report the case of a 14-year-old girl, with c-TA, presenting with transient ischemic attack after endovascular revascularization for renal artery stenosis and cerebrovascular stroke after surgical revascularization for cerebral artery stenosis associated with childhood-onset moyamoya syndrome. We deem th decrease of blood pressure by endovascular revascularization and improvement of cerebral perfusion by surgical revascularization may have jeopardized the cerebral deep watershed zone to cerebral ischemia followed by cerebral hyperperfusion syndrome and caused transient ischemic attack and cerebrovascular stroke in our patient. Revascularization could be a double-edge sword for c-TA patients presenting with concomitant renal artery stenosis and cerebral artery stenosis, and should be performed with caution. Quantitative analysis of cerebral blood flow by brain magnetic resonance imaging and angiography should be performed within 48 hours after surgical revascularization in c-TA.
Chung-Lin Lee,Ying-Hsu Chang,Chung-Yi Liu,Ming-Li Hsieh,Liang-Kang Huang,Yuan-Cheng Chu,Hung-Cheng Kan,Po-Hung Lin,Kai-Jie Yu,Cheng-Keng Chuang,Chun-Te Wu,See-Tong Pang,I-Hung Shao 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.5
Purpose: Metastatic castration-resistant prostate cancer (mCRPC) has a poor prognosis. Abiraterone acetate (AA), enzalutamide, and chemotherapy are first-line treatments for patients with mCRPC. This study examined prognostic factors for AA response in the form of prostate-specific antigen (PSA) kinetics throughout androgen-deprivation therapy (ADT) in chemonaïve patients with mCRPC. Materials and Methods: We retrospectively included data from 34 chemonaïve patients with mCRPC who had received AA at some point between January 2017 and December 2018. We separated patients into two study arms according to the decrease in PSA percentages after use of AA for 3 months. We correlated PSA kinetics parameters with response and compared the two study groups with respect to PSA kinetics. Results: The patients’ median age was 77 years. In the total group of patients, 64% had a response to AA, whereas 35% did not. The ratio of the PSA level at nadir to the level during ADT was significantly higher in the AA-sensitive group (19.78 vs. 1.03, p=0.019). Conclusions: Patients who experienced a dramatic change in PSA level during ADT were more likely to be resistant to AA after progression to mCRPC. Chemotherapy rather than AA might be more suitable as a first-line treatment for these patients.
Lee, Der-Nan,Cheng, Yeong-Hsiang,Chuang, Yu-Shuan,Shive, Jiing-Lin,Lian, Yuh-Ming,Wei, Hen-Wei,Weng, Ching-Feng Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.1
Three experiments were conducted to evaluate the effects of taurine (Tau) supplements on broiler growth performance, serum constituents and antibody production. In Exp. 1, 3 day old chicks received a basal diet supplemented with Tau at 0, 0.10, 0.20, 0.30 or 0.40% for 6 weeks. Although dietary Tau supplementing at 0.30 or 0.40% enhanced feed conversion and reduced feed consumption during 0 to 3 weeks (p<0.05), neither serum total cholesterol or anti-Newcastle disease virus (NDV) titer were affected. In Exp. 2, dietary Tau supplement at 0.25-0.75% enhanced feed conversion of broilers during 0 to 3 weeks, but daily gain and feed consumption were not affected. The 0.75% Tau supplement group displayed lower serum total cholesterol at 6 weeks (p<0.05) comparing with the control group but no difference in anti-NDV titers. In Exp. 3, broilers were treated with dietary Tau of 0 or 0.50% combined with low (0/0%), medium (0.18/0.08%), or high (0.36/0.16%) methionine (Met) levels for 6 weeks (0 to 3/3 to 6 weeks). The addition of Met significantly improved daily gain and feed conversion of broilers during 0 to 3 weeks (p<0.01). Dietary Tau interacted significantly with Met on daily gain and feed consumption. Broiler serum amino acids revealed that Met supplements only increased serum Met level, but only serum Tau level was enhanced as given dietary Tau supplementation. The broilers receiving Tau normalized serum triglycerides level by feeding with the low Met diet and tended to display higher anti-NDV titers (p<0.10). The experimental results suggest that the growth response obtained by Tau supplements results partly from interactions with sulfur amino acids. However, the modulation of the broiler lipid metabolism may be responsible for dietary Tau.
Developing Interaction Specifications for Online-to-offline (O2O) Proximity Commerce Systems
Cheng-Jhe Lin,Chiuhsiang Joe Lin,Tsai-Ting Lee,Jing-Ming Chiu 대한인간공학회 2014 대한인간공학회 학술대회논문집 Vol.2014 No.5
Information technology products such as smart phones, tablet PCs, eBooks and the intelligent-interactive digital signage have evolved and perfectly merged with the service systems to provide user-friendly user-interfaces and innovative service patterns. Online-to-offline (O2O) service model is one of the newest developments in the service systems where users in the physical world can interact with service providers in the cyberspace through various devices. Although traditional HCI studies have provided various research frameworks to describe interfaces and activities involved, there is a lack of interaction specifications which can clearly describe HCI in the realm of O2O service systems. This study developed a formal language that facilitates establishment of HCI specifications for O2O applications in proximity commerce based on interaction styles consisting of 4 inter-action types represented in an interaction diagram. The formal language thus provides a common ground for service provider and service implementer to communicate and develop a concrete prototype effectively.