황색포도알균에 의한 급성 화농성 천골장골관절염 1예

문수연,신준범,김경엽,김석연,문수영,문송미,이미숙 대한감염학회 2007 감염과 화학요법 Vol.39 No.5

저자들은 특별한 위험 인자 없이 심한 허리 및 왼쪽 둔부 통증으로 내원하여 황색포도알균에 의한 균혈증이 진단된 젊은 여성에서 드문 감염질환인 화농성 천골장골관절염과 엉덩근 및 엉덩허리근 농양이 발생된 예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Pyogenic sacroiliits is a rare disease and the diagnosis is difficult because of unawareness of the disease and nonspecific symptoms and signs mimicking septic hip, iliopsoas muscle abscess and herniation of intervertebral disk. There are some predisposing factors related to the disease like trauma, pregnancy, intravenous drug abuse and infection of other systems such as skin, genitourinary system and heart. Staphylococcus aureus is the most common causative bacteria. Here we describe a case of 27-year-old woman presented with acute onset of back and left buttock pain. Bone scintigraphy revealed increased uptake at left sacroiliac joint and computed tomography of the pelvis showed left sacroiliitis with left iliacus and iliopsoas abscess. There was no history of usual predisposing conditions. S. aureus was grown from blood cultures and the patient improved with 2 weeks of intravenous cefazolin followed by 4 weeks of oral clindamycin treatment.

특허권과 연구개발 회계처리가 경제적 부가가치에 미치는 영향

박미경(Park, Mi-Kyung),김문태(Kim, Moon-Tae) 한국회계정보학회 2021 재무와회계정보저널 Vol.21 No.4

[연구목적]본 연구는 한국거래소 상장기업을 대상으로 특허권 및 연구개발 관련 지출에 대한 자본화 혹은 비용화 회계처리, 그리고 이들의 상호작용이 경제적 부가가치(EVA:Economic Value Added)에 미치는 영향을 규명하고자 한다. [연구방법]본 연구의 대상기간은 2016년부터 2019년까지이며, 특허권이 재무상태표에 표시된 284개 기업을 표본으로 선정하였다. 경제적 부가가치는 세후순영업이익에서 총자본비용액을 차감하여 산출하였으며, 특허권과 연구개발 관련 지출은 재무제표에서 추출하였다. [연구결과]가설검증을 위하여 단변량 상관분석과 다중회귀분석을 실시한 결과, 특허권 보유액이 많을수록 이에 비례하여 경제적 부가가치에 긍정적인 영향을 미치는 것으로 나타났다. 연구개발 활동을 자산으로 회계처리하였을 경우에 경제적 부가가치에 유의한 양(+)의 설명력을 보인 반면, 연구개발 지출을 비용으로 처리하는 회계처리에 대하여 경제적 부가가치에 통계적으로 유의한 설명력을 보이지 않았다. 자본화 연구개발 활동과 특허권의 상호작용 변수는 통계적 유의수준에서 경제적 부가가치에 양(+)의 설명력으로 영향을 미치는 것으로 나타났으나, 비용화 연구개발 활동과 특허권의 상호작용 변수는 경제적 부가가치에 통계적으로 유의한 설명력을 보이지 않았다. [연구의 시사점]본 연구는 특허권과 연구개발 활동이 타인자본비용 및 자기자본에 대한 기회비용을 세후순영업이익에서 차감하여 산출한 경제적 부가가치에 긍정적인 효과를 유도할 수 있다는 결과를 제시하여 선행연구와 차별성이 있다. 이를 심화하여 연구개발 활동의 자산화와 비용화가 회계처리가 특허권과 상호작용되었을 경우에 경제적 부가가치에 미치는 효과가 차별적으로 도출될 수 있다는 결과를 제시한 점에서 의의가 있을 것이다. [Purpose]This study aims to investigate the effects of capitalization or expensing on patent rights and R&D expenditures and their interaction on economic value added (EVA). [Methodology]The study was conducted from 2016 to 2019, and 284 companies whose patents were listed on the financial status. The economic value added was calculated by subtracting the total capital cost from the net operating profit after tax, and the expenditure related to patent rights and R&D was extracted from the financial statements. [Findings]As the results of univariate correlation analysis and multiple regression analysis, it showed that the more the patent holding amount, the more positive the EVA. For the capitalization of R&D activities as assets, it showed a significant positive(+) explanation for economic value added, while there was no statistically significant explanation for EVA for R&D expensing. The interaction variables between capitalization R&D and patent rights were found to have positive (+) influence on EVA at the statistical significance level, but the interaction variables between expensing R&D and patent rights did not show statistically significant influence on EVA. [Implications]This study is meaningful in that it verified the discriminatory effect of accounting choice of R&D expenditures on EVA when it interacts with patent rights, which are the formalized form of intellectual assets. This study is different from previous studies by suggesting that patent rights and R&D expenditures can induce positive effects on EVA. It may be meaningful that the effect of capitalization or expensing of R&D activities on EVA can be differentiated when accounting method is interacted with patent rights.

비만을 동반한 위암 환자에서 두 병을 같이 수술 치료한 경험(증례)

최경현,윤기영,문형환,신연명,서경원,안수미,송윤미,석정희,정경연,이은하 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Obesity is growing problem in Korea. We had a case of bariatric surgery during gastric cancer operation. Patient was 29 year old Korean lady with early gastric cancer located in the lesser curvature side of the middle 1/3 of the stomach. Her body weight was 89 kg, height 163 cm, and thus body mass index was 33.5 kg/m2. Preoperative blood pressure was 130/90 mmHg, hemoglobin 12.9 g/dL, total lymphocyte count 3,280/mL, serum albumin 4.3 g/dL, CEA 1.1 ng/mL, CA 19-9 9.1 ng/mL, and alpha fetoprotein 2 ng/mL. Another associated disease was right thyroid follicular neoplasm. The chest X-ray was normal. After IM injection of 2,500 units of heparin 30 minutes before the induction of general anesthesia, she received curative subtotal gastrectomy and Roux en Y gastrojejunostomy when a malabsorption loop of 120 cm jejunum was incorporated between the Treitz ligament and the end to side jejuno-jejunostmy site at May 29th 2006. Her postoperative course was uneventful except a minor wound seroma and the elevations of serum amylase(up to 4 folds) and lipase(up to 2 folds). She lost her body weight 9 kg in 5th, 21 kg in 7th, and 27 kg in 10th postoperative months to became 61.5 kg. On follow up exams in July 2008, she gained 4 kg to overcome her weakness and fatigue. From the above result, the incorporation of a malabsorption loop during reconstruction phase of gastric cancer operation was a good option for obese gastric cancer patients especially in cases of early gastric cancer.

응급실에 내원한 환자에서 어지럼증의 원인과 임상양상의 분석

문원식,정경운,위준선,문정미,전병조,김용권,소정일,류진호,허탁,민용일 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Background: Recently, The number of patients who have been complaining of the vertigo or dizziness has been increasing due to rapid growth of elderly population and senile disease. The differentiation of dizzy patients is not familiar to most emergency physicians. This study was designed to differentiate true vertigo and to investigate the clinical difference among central vertigo, peripheral vertigo, and other causes of dizziness. Methods: The authors analyzed the cases of 237 dizzy patients who visited the emergency department of Chonnam University Hospital during the recent 2 years. For the base of dizziness, associated past illnesses, severity, nystagmus type, and the causes of central and peripheral vertigo. Results: Female patients were 142(59.9%) and male patients were 95(40.1%). The most common age group was the 6th decade. The origin of dizziness was classified as peripheral cause(25.3%), central cause(32.9%), and others(41.8%). As to nature of the dizziness, the rotatory sense was dominant in peripheral vertigo and the floating sense and blurred vision in central vertigo. Peripheral vertigo was triggered by position change of head and body, and central vertigo by the eye movement. Audiograms I showed that most patients with central vertigo had normal hearing, but 46.7% of thoswith peripheral vertigo had an abnormal hearing disturbance. Nystagmus was more prevalent in peripheral vertigo Conclusion: History taking and physical examination played an important role in the diagnosis of dizzy patients. An important part of the diagnosis of a dizzy patient could be to evaluate the peripheral origin, the central origin and others causes. Because central vertigo may be associated with a significant neurological pathology, spectral radiological studies, including MRI and CT, are mandatory to rule out a devastating brain lesion.

일간 신문의 기사와 광고에 나타난 식품영양정보의 현황 조사 (2002년)

문현경,용미진,장영주 대한영양사협회 2004 대한영양사협회 학술지 Vol.10 No.2

The object of this study is to investigate and analyze the quantity and quality of information on health, food and nutrition reported by newspapers. Six different major domestic daily newspapers(Hankook Ilbo, Donga Ilbo, Chosun Ilbo, Kyunghyang Shinmun, Hankyoreh Shinmun, JoongAng Ilbo), were monitored from 1st of May to 31st of Oct. 2002. The results of monitoring in the newspapers were summarized as follows; 1. The total percentage of the articles on health, food and nutrition was 2.7% and the percentage of the advertisements on health, food and nutrition was 17.5% of total area of the newspaper. The ratio of the number of food and nutrition topic on the total number of health, food and nutrition topic was 35.8% for the articles, was 62.9% for the advertisements. Among advertisements on food and nutrition, the percentage of advertisements on healthy foods was the highest(3,481 or 55.0%). 2. Contents of 340 articIes(26.1%) were reported as suitable information. Contents of 259 articles(l9.9%) were reported as inaccurate information on health, food and nutrition. In the analysis of advertisements, the number of advertisements without sufficient reliable sources was 2,488 cases(23.0%), and with exaggerated contents was 2,268 cases(21.0%). The articles and advertisements should be backed by scientific research or reliable sources and also the opinions of people with expertise in order to report accurate information to the general public. In order to achieve these results, there should be continuing monitoring activity for the newspapers.

여성잡지에 나타난 식품영양정보의 양적·질적 현황 조사 (2002년)

문현경,용미진,장영주 대한영양사협회 2004 대한영양사협회 학술지 Vol.10 No.2

The desire for the healthy life is increasing as a result of rapidly changing social and economic environment in Korea. Because of the need, information on health, food and nutrition are being introduced through the mass media. The object of this study is to investigate and analyze the quantity and quality of information about health, food and nutrition in women's magazines. Six representative domestic monthly magazines(Lady Kyunghyang, Women Donga, Women Chosun, Women JoongAng, Women sense, Jubu Senghwal) were selected for this study. The results of monitoring from June 2002 to September 2002 for the women's magazines were summarized as follows; 1. The percentage of the articles on health, food and nutrition by total area of the women's magazines was 23.1%. There were total 595 articles on health, food and nutrition. Among these, 400 articles(67.2%) were about food and nutrition. 2. The percentage of the advertisements on health, food and nutrition was 35.3% by total area of the woman's magazines. There were 2,353 advertisements on health, food and nutrition. Among these, 1,574(66.9%) advertisements were about food and nutrition. The most frequently advertised advertisements on food and nutrition were about processed foods (527 cases, 33.5%). The second most frequently advertised advertisements were about diet (374 cases, 23.8%). The third one was healthy foods (345 cases, 21.9%). 3. The contents of 215(53.8%) articles (the total number of articles was 400) was suitable. The contents of 89 advertisements(22.3%) did not have accurate information on health, food and nutrition. For the advertisements in women's magazines (the number of total articles was 2,203), the percentage of the advertisements which was not able to capture the feature of the advertisements was 27.9%, insufficiency of reliable sources was to 21.9%, and exaggeration of the contents in the advertisements was 16.0%. Articles and advertisements should be backed by scientific research or reliable sources and also the opinions of people with expertise in order to report accurate information to the general public. In order to achieve these results, there should be continuing monitoring activity for the women's magazines.

Q 열에 의한 감염성 심내막염 2예

문수연,최영실,박미연,이정아,정미경,정혜숙,정두련,송재훈,백경란 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

Q fever is a zoonosis caused by Coxiella burnetii, Presenting as acute and chronic illness and it has been reported worldwide. Acute Q fever is usually asymptomatic or mild and self-limiting, but infective endocarditis is one of the most serious complications of chronic Q fever and can be fatal. Known risk factors for Q fever endocarditis are valvular heart disease, immunocompromised hosts, and pregnancy. There have been some reports on Q fever in Korea but there exists no report on Q fever endocarditis. We have experienced 2 cases of Q fever with underlying valvular heart disease; both Patients came to the hospital for evaluation of prolonged fever. Although Q fever and Q fever endocarditis are rare in Korea, Q fever endocarditis should be considered in the differential diagnosis of patient with infective endocarditis when causative microorganism cannot be identified.

柴胡가 free radical에 의한 脂質過酸化物 生成에 미치는 效果

문진영,최미정,남경수,임종국 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

Antioxidant effects of aqueous Siho extract on lipid peroxidation were determined by TBA value and also by lipid peroxidation value during the autoxidation of Iinoleic acid. Siho extracts exhibited markedly antioxidant aCtivity, which inhibited 99% of linoleic acid peroxidation. And Siho extracts showed 42% scavenging effect on α,α-dlphenyl-β-pjcrylhydrazyl radical, also exhibited a 60-94% inhibitory effect on superoxide generation. Siho extracts dose-dependently protected the cell death induced by tert-butyl hydroperoxide (t-BHP) and significantly increased cell viability In the normal rat liver cell(Ac2F) . These results suggested that Siho might play a protective role in lipid peroxidation by free radicals. Key Words: lipid peroxidation ; Siho extracts; scavenging effect

Helicobacter pylori가 만성위염과 위종양에 미치는 영향에 관한 면역조직화학적 밑 초미세구조적 연구

문경래,정순봉,이미숙,이미자,서재홍,김만우,박찬국 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : Helicobacter pylori (H. pylori) is accepted as a principal cause of chronic gastritis and an important factor in the pathogenesis of peptic ulcer and gastric malignancy. The aim of our studies is to investigate relationships between H. pylori and gastric epithelial cells. Materials ðods : One hundred and eighty one H. pylori positive cases of gastric biopsy specimens were studied immunohistochemically and ultrastructurally. Results : p53 positive staining exhibited foveolar epithelial hyperplasia in 1 out of 32 cases, regeneration in 2 out of 12 cases, incomplete intestinal metaplasia in 5 out of 41 cases, complete intestinal metaplasia in 3 out of 18 cases, chronic ulcer in 1 out of 9 cases, tubular adenoma in 2 out of 14 cases and intestinal type of adenocarcinoma in 16 out of 21 cases. Ultrastructurally, H. pylori was observed to be in direct contact with the microvilli of the target cells and was demolishing the surface microvilli. The organisms were in close contact with the uncoated cell membrance. Penetration into the gastric cells by a few organisms was associated with marked cell damage and ultimately to cell disintegration. Conclusion : Our results suggest that H. pylori plays a role in the pathogenesis of gastric cancer, leading a relatively slow, long lasting process that induces chronic active gastritis, intestinal metaplasia, dysplasia, and adenocarcinoma of intestinal type.

유방암종에서 p53, cyclin D1 및 cathersin D 단백발현의 의의

문경래,김환정,이미자,기근홍,서재홍,양정원,조현진 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives: Breast carcinoma is a heterogenous disease. The prognosis of this carcinoma correlates with various prognostic factors. The aim of this study was to assess the prognostic significance of expression of p53, cyclin Dl and cathepsin D protiens in association with various prognostic factors in invasive breast carcinoma. Materials and Methods: The relationship is presented between expression of p53, cyclin D1 and cathepsin D by immunohistochemistry and various established prognostic factors such as tumor size, histologic grade, lymph node status and extensive intraductal component in 55 cases of invasive breast carcinoma. Results: No significant correlations were observed between expression of p53, cyclin Dl and cathepsin D and tumor size. The expression of p53 correlated with high histologic grade. The expression of p53 and cyclin Dl correlated with lymph node metastasis. Conclusion: These results indicate that expression of p53 and cyclin Dl in invasive ductal carcinoma may be an important prognostic factor, closely related to the high histologic grade and lymph node metastasis.