Predicting postoperative total calcium requirements after parathyroidectomy in secondary hyperparathyroidism

( Byung Heon Kang ),( Soon Young Hwang ),( Jeong Yeop Kim ),( Yu Ah Hong ),( Mi Yeon Jung ),( Eun Ah Lee ),( Ji Eun Lee3 ),( Jae Bok Lee ),( Gang Jee Ko ),( Heui Jung Pyo ),( Young Joo Kwon ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.6

Background/Aims: To prevent hypocalcemia after parathyroidectomy (PTX), parenteral calcium is required in addition to oral calcitriol and calcium. After switching to oral calcium, patients can be discharged from the hospital. The aim of this study was to analyze the clinical characteristics and outcomes of PTX performed at a single Korean center and to investigate the associated laboratory factors used to analyze the total amount of postoperative calcium required. Methods: We enrolled 91 hemodialysis patients undergoing PTX from November 2003 to December 2011. We collected clinical and laboratory data preoperatively, 12 and 48 hours postoperatively, at discharge, and 3 and 6 months postoperatively. Results: In total, 59 patients underwent PTX with autotransplantation (AT), 6 underwent total PTX without AT, 11 underwent subtotal PTX, and 15 underwent limited PTX. Total PTX without AT showed the lowest recurrence rate. At all postoperative time points, the mean levels of serum calcium, phosphorus, and intact parathyroid hormone (iPTH) decreased significantly, compared with preoperative levels; however, alkaline phosphatase (ALP) increased significantly from 48 hours postoperatively to discharge (p < 0.001). On multiple linear regression analysis, the total amount of injected calcium during hospitalization showed a significant correlation with preoperative ALP (p < 0.001), preoperative iPTH (p = 0.037), and Δphosphorus at 48 hours (p < 0.001). We developed an equation for estimating the total calcium requirement after PTX. Conclusions: Preoperative ALP, preoperative iPTH, and Δphosphorus at 48 hours may be significant factors in estimating the postoperative calcium requirement. The formula for postoperative calcium requirement after PTX may help to predict the duration of postoperative hospitalization.

일부 한국인의 혈청 ceruloplasmin 정상 참고치 설정 및 질환별 비교 : Comparison of Its Level among Various Diseases

이동수,박애자,박정덕,장임원,홍연표 중앙대학교 의과대학 의과학연구소 1999 中央醫大誌 Vol.24 No.1

Ceruloplasmin has been investigated as one of the useful biologic index for early diagnosis of atherolsclerosis. However, there was no normal reference value taking into account the confounders in Korea. This study was performed to estimate the normal reference values and present the confounders of ceruloplasmin. Also we compared of serum ceruloplasmin levels among normal reference group and three abnormal groups: 475 healthy subjects, 53 liver dysfunctions, 72 positive test of chronic inflammatory diseases, and 89 hypercholesterolemias. Mean serum ceruloplasmin level of healthy subjects were 41.6±7.6㎎/㎗ in males and 42.1±7.2㎎/㎗ in females, respectively. It was tend to increase of ceruloplasmin by age in both sexes. However, the statistical difference was not found by age group between both sexes. Statistically significant correlations were found between serum ceruloplasmin and age, body mass index(BMI), white blood cell(WBC) and triglyceride(TG) in males and age, BMI, WBC and total cholestrol(TG) in females. After adjustment for age, BMI,WBC and TG in males and age, BMI, WBC and TG in females, significant elevations of serum ceruloplasmin were found in liver dysfunction(p=0.0077) and positive test of chonic inflammatory disease(p=0.0217) in males and in oisitive test of chronic inflammatory disease(p=0.0023) and hypercholestolemia(p=0.0124) in females relative to healthy reference subjects. There is no statistical difference among liver dysfunction, postive test of chronic inflammatory disease, and hypercholesterolemia.

카드뮴폭로후 고환, 신장 및 간장내 카드뮴축적량과 조직손상의 변화

이영구,박정덕,최병선,홍연표,장임원 大韓産業醫學會 1994 대한직업환경의학회지 Vol.6 No.1

To assess the changes of cadmium deposit and histopathologic finding of testis, liver and kidney, different dose of cadmium (Cd) was administerd into male Sprague-Dawley rat(purchased from KIST, Korea Institute of Science and technology) by single intravenous injection. At 12, 24, 48, 168 and 672 hours after Cd injection, tissue cadmium concentration and histopathological change were examined. Cd exposed group showed lesser weight gain than the control. Renal Cd content tended to increase in time-dependent pattern, while hepatic and testicular Cd content tended to decrease. Mean of renal Cd content to hepatic Cd content (Cd K/Cd L) also progressively increased. These results suggest that Cd might be gradually transported to kidney from other organs. In testis and liver, degenerative changes appeared relatively in acute phase. These changes became more pronounced in testis, while less prominent in liver. In kidney, swelling of proximal tubluar cells and thickening of glomerular basement membrane appeared relatively later and these changes were progressively aggravated.

유방확대술 후 실리콘 삽입물 파열의 치험례

이정엽,홍인표,심영기,이세일 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.1

Silicone prosthesis is well known as relatively acceptable material since Cronin had introduced at 1963. But it can't be a perfect material due to complications such as capsular contracture, prosthesis rupture. We experienced wto cases of prosthesis rupture with siliconoma of breast and the one was identified with history of closed capsulotomy and the other without trauma history. With review of the reported cases, we should consider followings 1. Silicone gel prosthesis can be ruptured with closed capsulotomy or without trauma history. 2. Ruptured prosthesis and silicone gel must be removed for prevention of progressive complications as soon as possible prosthesis rupture is noted.

유전자 검색을 위한 DNA 칩 제작용 microarrayer의 개발

이현동,김기대,김찬수,임용표,박정규 충남대학교 농업과학연구소 2003 농업과학연구 Vol.30 No.1

외국의 경우 게놈 연구 및 바이오 산업에 DNA 칩을 제작할 수 있는 로봇 시스템을 싼 가격에 사용하고 있으나 우리나라의 경우 자동화 시스템을 비싼 가격에 외국에서 도입하여 사용하기 때문에 바이오 산업 및 연구 분야에서의 생산비를 높이게 돼 국내외적으로 생명공학의 경쟁력을 저하시키는 원인이 된다. 따라서, 본 연구에서는 유전체 연구에 필수적인 DNA 칩 제작을 위한 연구용 pin 타입 microarrayer를 개발하였으며, 그 구체적인 연구결과는 다음과 같다. 1. 본 연구에서는 DNA칩 제작을 위한 연구용 pin 타입 microarrayer를 개발하였으며 3축 직교좌표형 로봇 본체 DNA를 묻혀 silylated 슬라이드에 점착하는 DNA 점착 헤드, 칩 및 웰 플레이트 고정부, 핀을 세척 및 건조하는 세척 및 건조장치 등으로 시스템을 구성하였다. 2. DNA 점착 헤드는 DNA 점착시 제도용 펜촉을 사용하도록 설계, 제작하였으며, 슬라이드에 DNA를 점착할 때는 핀이 일정한 힘으로 슬라이드를 누르며 점착할 수 있도록 자석의 반발력을 이용하였다. 3. DNA 점착 헤드 핀의 세척을 위하여 증류수 분사 및 진동 브러쉬를 이용하였으며 세척실험 결과, 핀을 1㎜/s로 이동시키며 브러쉬를 통과하도록 하는 방법이 세척효과가 높은 것으로 나타났으며, 핀 건조실험결과는 8.5㎏/㎤의 압축공기를 30초 동안 핀에 분사하였을 때 핀이 건조되는 것으로 나타났다. 4. 본 로봇 시스템을 이용하여 DNA를 12장의 슬라이드에 모두 점착시키기 위하여 웰 플레이트에서 핀이 DNA를 묻히는 실험을 실시한 결과, 10초 이상 핀에 DNA를 묻혔을 때 슬라이드 12장을 모두 찍는 것으로 나타났으며, 슬라이드에 핀이 1초간 접촉할 때의 DNA 스팟의 크기는 평균 280㎛가 되는 것으로 나타났다. 최소 점 간격을 0.32㎜로 설정한 후 DNA를 점착해 본 결과 최대 8,100여 점의 DNA 스팟을 한 슬라이드에 점착할 수 있는 것으로 나타났다. 5. 본 로봇 시스템은 12장의 동일 DNA 칩을 생성하기 위해 핀의 세척, 건조, DNA를 묻히는 과정 및 DNA 점착 등의 한 과정을 2분 50초 동안 수행할 수 있는 것으로 나타났다. This study exploits the robot system which is necessary in gene study, bio-technology industry. As well, it can achieve the job of DNA chip manufacturing whose use rate has been increased recently. The robot consists of DNA spotting device for spotting DNA on the silylated slide and well plate, bed for fixing well-plate, washing & drying device of washing and drying the pin part of DNA spotting device, distillation-water vessel, and discharge vessel of wash water. We made the term of sticking DNA to the pin on well plate to be 15 seconds. The spot size of DNA was set to be 0.28㎜ on the average by bringing the slide into contact with pin for 1 second. At this rate, if DNA is spotted in the minimum space possible of about 0.32㎜, it can stick about 8,100 DNA spots on the well plate. Analyzing the procedure: Movement starts. Pin washes, dries, and smears DNA on the well plate. Spots DNA onto 12 chips takes 2 minutes and 50 seconds.

형질변형성장인자가 손상골 재생능에 미치는 영향에 과한 실험적 연구

이병도,황의환,이상래,홍정표 慶熙大學校 齒科大學 1995 慶熙齒大論文集 Vol.17 No.2

The purpose of this study was to observe the effect of TGF-81, which promotes differentiation and proliferation of osteoblasts, on bone regeneration. Experimental bone defects that measured 3 mm in diameter were created on the mandibles of guinea pig by removal of bone with the use of trephine burs. In one side of mandibular body, the experimental groups, bone defects were grafted with Biogran(Orthovita Co., U.S.A.) and TGF 131(R&D System Co., U.S.A.). In the remaining side of the mandiblar body, the control groups, bone defects were grafted with only Biogran. Guinea pigs in the control and experimental groups were serially terminated by fours on the 3 days, the 1 week, the 2 weeks, the 3 weeks, and the 4 weeks after experiment, and both sides of the mandibular bodies were removed and fixed with 10% neutral formalin. They were decalcified and embedded in paraffin as using the usual method. The specimen sectioned and stained with hematoxylin and eosin. Also, they were radiographed with a soft X-ray apparatus. The Obtained results.=were as follows; 1. Hemorrhagic condition, observed in the granulation tissues, disappeared on the 1 week after experiment in both groups, and more prominent in the experimental group. The granulation tissues of the experimental group had larger number of cells than those of the control group. 2. Osteoblastic differentiation in the margin of grafted material and adjacent bone was observed on the 1 week after experiment in both groups. Also, bone formation was observed in immature form on the 1 week after experiment, and more prominent in the experimental group. 3. In the polarizing microscopic examination, bone matrix was very loose on the 1 week after experiment, but increase in density with time, and more prominent in the experimental group. 4. In the microradiographic examination, newly formed bone was observed in the experimental group on the 2 weeks after experiment, and this was observed earlier than in the control group. Newly formed bone was increased with time and defected area was markedly decreased on the 4 weeks after experiment.

정신과 치료 집단내 정신증상의 인식 차이에 대한 조사

이강표,남정현 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4

Purpose : The authers investigated how each subgroup of psychiatrists, nurses and aides which consist of mental health workers in the hospital setting cognize the mental symptoms and which symtoms are seriously viewed by each subgroup in order to clarify the viewpoint of each subgroup in understanding the patients. Methods : The subjects of study consist of thirty psychiatrists, thirty nurses and thirty aides. the subjects rated mental symptoms after observing the videotape of patient's case which the authers had made, using the Hopkins Pschiatric Rating Scale. Result : As the duration of service increased, the concordance rate of doctor group increased and that of nurse group also overall increased, but the concordance rate of subgroup after the period of seven years was not constitent. The concordance rate of aide group was relatively lower than those of other groups, however, the concordance rate in subgroup above five-year-period decreased. The doctor group took high cognizance of symptoms related to thought disorder and the nurse group highly cognized psychotic symptoms and symptoms related to anxiety and thus showed a trait which shared with characteristics of doctors and aides. On the other hand the aide group took high cognizance of symptoms related to management of ward-life of patients in comparison with other groups and rated overall pathologic state low. Conclusion : The results suggested that the nurse group needs continuous and effective professional training in order to solve problems caused by long-term service. The aide group had little knowledge and concept about mental disorder and the results suggested that the aide group lacked the consistent viewpoint to cognize the patient and thus the educational training system which is appropriate for the group characteristics needed is urgently.

정신보건심판위원회 퇴원명령 대상자 추적조사

이명수,홍진표,고정아,오정하 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.1

Objectives The purpose of this study was to examine the current situation and the limitations of the Mental Health Review Board and to identify the effectiveness of the community linkage for discharged patients. Methods The data was collected from the 116 patients who were discharged from August 2005 to July 2007 by the order of the Mental Health Review Board. The survey was conducted by telephone with using a structured questionnaire. Results 51 patients (44.0%) were able to be referred to community mental health services when they discharged. The readmission rate was 50.9% and the mean duration to the first readmission was 51.73 days (S.D.=103.5). The mean duration to the first readmission was significantly longer for the group that was referred to community services and that had a negative correlation with the stability of health security. The outpatient maintenance rate and the current admission status were also significantly different between the group that was referred to community services and the group that was not referred. Conclusion The activities of the mental health review board have definite limitations in Korea such as the high rate of immediate readmissions after the discharge orders. A hospital-community integrated service system could be one possible solution to improve the maintenance of mental health patients in the community and to prevent their readmission.

여성 청년층의 학교에서 직업세계로의 이행 실태 분석

이정표 한국직업능력개발원 2004 직업능력개발연구 Vol.7 No.1

The purpose of this paper were to analyse school-to-work transition process of Korean female youth by educational background. To accomplish this purpose, various theoretical approaches about school-to-work transition were examined and supplemented survey results of economically active young population conducting by Korea National Statistical Office in 2003 were analyzed. Generally, Korean youth have difficulties in the school-to-work transition according to the results. Female youth, also, have more difficulties and obstacles in the transition and they have differentiated transition pathways by educational background. It is important to make safety nets for female youth not entry into colleges and actively support to make their transitions work effectively. Young people at risk in terms of sex and educational background need to be given priority in policy and programmes of youth unemployment. 이 글은 우리 나라 청년층이 겪는 학교에서 직업세계로의 이행경로가 성별, 학력별로 어떻게 차별화되고 있는가를 분석하는 데 목적이 있다. 청년층의 이행 실태를 보다 분석적으로 접근하기 위하여 학교에서 직업세계로의 이행에 대한 이론적인 접근을 시도하고, 구체적인 실태 분석을 위하여 통계청에서 2003년 5월에 실시한 '경제활동인구 청년층 부가조사' 자료를 활용하였다. 청년층 부가조사 결과를 통해서 우리 나라 청년층의 학교에서 직업세계로의 이행은 전반적으로 원활하게 이루어지지 않는 것으로 나타났다. 특히 여성 청년층은 남성들에 비해 이행 경로에 있어서 더욱 어려움을 겪고 있으며, 학력 수준에 따라 차별적인 이행 경로를 거치는 것으로 나타났다. 여성 청년층의 학교에서 직업세계로의 이행을 성공적으로 지원하기 위해서는 기본적으로 여성 청년층이 남성들에 비해 가질 수 있는 제도적 장애요인을 제거해주는 것과 동시에, 대학 미진학 여성에 대한 제도적 지원이 적극 강구될 필요가 있다.

증령에 따른 측두하악관절내 탄력섬유의 분포에 관한 연구

이진표,홍정표 慶熙大學校 齒科大學 1993 慶熙齒大論文集 Vol.15 No.1

Observation of elastic fiber's change of mouse TMJ due to several round factor, principily external stimulations, their influence on the TMJ structure's change and the analize of the consecutive evolution of the disease is most important. So, the author believe that the factor of TMJ feature is the elastic feature's change and it's the principal factor of the TmJ disease. For observation of the increase and disposition of elastic fiber that to regulate the elastic feature of tissue and allow it existence. For this propose, observation with histologic methods on 20 mouse ICR of 3 days, 1 week, 2 weeks, 3 weeks and 4 weeks, the results were as follows; 1. In the early stage, the condyle of TMJ is originated from cartilage mass, and it's calcification is endochondral. 2. In the early stage, the disc is relatively thin and immature, but in the later stage the fiber is dense and the disposition is most functional. 3. Observation of the early stage, the elastic fiber is a thin fiber that to across anteroposterior direction, but in the later stage elastic fiber are developed, the disposition that in the early stage was perpendicullar to articular surface, now is parallel. 4. The elastic fiber was observated most clearly in the retrodiscal tissue. 5. In conclusion, the elastic fiber is observed like a thin fiber 1 week from born, but the fiber to increase the weight and it dispose functionally, and 4 week from born, it can realize the normal function.