플라즈마 이온주입기에서의 시변환 쉬스 연구

김곤호,김건우,김영우,최영도,김종식,김상진,한승희,홍문표 漢陽大學校 工學技術硏究所 1998 工學技術論文集 Vol.7 No.1

Abstract- In a plasma source ion implantation, the target is successively biased by negative voltage pulses with an intrinsic finite rise time, resulting in the time-dependent sheath formation around the target. Measurement of time-dependent sheath during the pulse rise show the ion matrix sheath development which is in proportion to square root of time and pulse rise rate over plasma density but independent of the ion mass.

로드셀을 이용한 고속 감자 중량계량법

김상철,임종환,김귀식,김성근,양종훈 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

Potatos, together with tangerines, are one of the major agricultural products in Jeju, and the production account for more than 30% of the domestic production. Recently some kinds of sorting machine for potatos are available, but they are not extensively used because their performance is not satisfactory and/or they are very expensive. This paper presents a load based high speed weighting method for sorting the potatos. This method is based on the fact that the linear momentum of a potato is proportional to the mass of it. The usefulness of the method is demonstrated with sets of experiments.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

ser-M 기반 프리미엄 가전 시장의 경영 전략 메커니즘에 관한 연구: LG전자 사례를 중심으로

김태종(Kim Tae-Jong),엄재근(Eom Jae-Gun) 한국경영교육학회 2020 경영교육연구 Vol.35 No.6

[연구목적] 본 연구의 목적은 세계 가전 시장 점유율 1위를 달성한 LG전자 생활 가전사업을 ser-M Framework으로 분석을 하고, 기업의 Global 경쟁력을 확보하기 위한 최적의 메커니즘 사례를 연구하여 시사점을 도출하고자 한다. [연구방법] 연구대상은 Global 가전 기업 중 세계 생활가전 시장 점유율 1위를 달성한 LG전자 생활가전이다. 지금까지의 가전 산업에서 가전 기업의 연구에 대해서 대부분 미시적 관점에서 연구가 되어 왔으나 거시적이고 포괄적인 관점의 연구는 미흡하였다고 여겨진다. 이에 ser-M Framework를 이용한 대표적 가전 기업의 메커니즘을 분석하여 LG 시그니처라는 고가격과 프리미엄 브랜드 전략으로 성공한 메커니즘을 연구해 보고자 한다. [연구결과] 사례 분석 결과, 국내의 기업들은 일반적으로 초기 창업주의 강한 리더십으로 사업을 성장시키는 S-E-R 메커니즘이 대부분 작동하고 있었으나, LG전자 생활가전의 경우 신기술 변화에 따른 제품 고급화 및 프리미엄 브랜드 전략을 통해 성과를 창출하였으며 주체가 환경 분석을 통하여 경영 전략에 탁월한 의사결정으로 인한 메커니즘이 작동하였다. 따라서 첨단기술로 접목된 프리미엄 가전 시장이 성장하는 환경(E)에 적극적으로 대응하고, 기존의 연구개발 조직을 통폐합하여 자원을 재배치함으로써 프리미엄 제품을 개발시키는데 있어 우수 인력을 활용하는 메커니즘이 가장 적절하였다고 할 수 있다. [연구의 시사점] 본 연구는 ser-M 기반의 가전 기업 메커니즘을 연구에 있어 처음으로 가전 기업의 주체(S), 환경(E), 자원(R), 메커니즘(M)을 통합적으로 고찰한 것이 매우 의미가 깊으며, 대표적 가전사업의 사례 연구라는 것에 의의가 있다. [Purpose] The purpose of this study is to analyze LG Electronics’ household appliances business, which has achieved the highest share of the global home appliance market, as a service-M framework, and to derive implications by studying best mechanism cases to secure the company’s global competitiveness. [Methodology] LG Electronics’ household appliances, which have achieved the largest share of the global home appliance market among global home appliance companies, are subject to research. While most of the research in the consumer electronics industry has been done from a microscopic point of view, it is considered insufficient to do so from a macro-and comprehensive point of view. Therefore, we would like to analyze the mechanisms of representative home appliance companies using the server-M framework and study the mechanisms that succeeded with the high price of LG Signature and premium brand strategy. [Findings] As a result of the case analysis, most of the S-E-R mechanisms that grow businesses with strong leadership of early start-ups worked, but LG Electronics’ household appliances generated results through product advancement and premium brand strategies due to new technology changes, and the main body worked through environmental analysis. Therefore, the most appropriate mechanism was to actively respond to the growing environment (E) of the premium home appliance market, and to utilize the best manpower in developing premium products by consolidating existing R&D organizations and relocating resources. [Implications] This study is very meaningful in that the first integrated consideration of the subject (S), environment (E), resource (R), and mechanism (M) of a consumer electronics company is a case study of a representative consumer electronics business.

분자유전학적방법에 의해 확진된 Leber씨 유전성 시신경병증 2예

김응규,김종환,김상진,예종수,김성은,허경,원인건,황정민 대한신경과학회 1998 대한신경과학회지 Vol.16 No.1

조혈모세포이식 환자에서 침습성 진균 감염에 대한 이트라코나졸 액과 플루코나졸 시럽의 예방 효과 : 전향적, 무작위, 비교 임상시험

최수미,이동건,최정현,박선희,엄기성,김유진,김희제,민창기,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2005 감염과 화학요법 Vol.37 No.2

목적 : 조혈모세포이식 환자에서 호중구 감소 기간 동안 이트라코나졸 액(ITZS)과 플루코나졸 시럽(FCZS)의 진균 감염에 대한 예방 효과를 전향적으로 비교해 보고자 하였다. 재료 및 방법 : 2001년 8월부터 2002년 6월까지 가톨릭 조혈모세포이식센터에 입원하여 동종 조혈모세포이식을 받은 만 18세 이상의 환자들을 각각 ITZS와 FCZS군으로 무작위 배정하여 침습성 진균 감염 발생과 약제 관련 부작용을 전향적으로 조사하였다. 결과 : ITZS군에 40명, FCZS군에 38명이 배정되었고, FCZS군 환자의 평균 나이가 더 많았다. 시험 약제 평균투여기간은 ITZS군 16.4일, FCZS군 21.9일로 ITZS군이 더 짧았다. 이는 ITZS군에서 소화기 부작용으로 인한 약제 중단이 더 많았기 때문으로 보인다. 시험 약제 투여 후 총 빌리루빈 수치의 유의한 증가가 관찰되었으나, 약제 관련 부작용은 모든 환자에서 가역적이었다. 호중구감소 기간동안 표재성 진균 감염은 두 군에서 모두 발생하지 않았고, 침습성 진균 감염은 ITZS군 5명(12.5%), FCZS군 8명(21.1%)으로 FCZS군에서 많았으나, 통계학적으로 유의하지 않았고, 사망률에도 유의한 차이는 없었다. 결론 : 침습성 진균 감염에 대한 이트라코나졸 액과플루코라졸 시럽의 예방 효과에 유의한 차이는 없었으나, 앞으로 더 많은 환자를 대상으로 잘 짝지어진 대조군 연구가 필요할 것으로 보인다. 부작용 중 간독성과 관련하여 이식시 투여되는 여러 약제들과의 상호작용에 대한 연구도 필요할 것이다. Background : Though fluconazole is widely used for antifungal prophylaxis, it is ineffective against mould infections including Aspergillus species. Itraconazole has a broader spectrum than fluconazole but the capsule form shows erratic bioavailability in neutropenic patients. In this study, we compared itraconazole oral solution (ITZS) with fluconazole syrup (FCZS) for the prevention of invasive fungal infection (IFI) in allogeneic hematopoietic stem cell transplant recipients. Materials and Methods : Adults receiving allogeneic hematopoietic stem cell transplantation (HSCT) from september 2001 to June 2002, were randomly allocated to either the ITZS group or the FCZS group. We prospectively evaluated the safety and efficacy of each drug. Results : Out of 78 patients (40 patients in the ITZS group and 38 patients in the FCZS group) who were eligible for this study, 37 patients completed the course of prophylaxis without any evidence of IFI. The mean duration of prophylaxis was 16.4 days for the ITZS group and 21.9 days for the FCZS group (P<0.006). Drug-related adverse events occurred in 28 patients (70.0%) and 19 patients (50.0%) in the ITZS group and the FCZS group, respectively. Common adverse events of ITZS were nausea, vomiting, and diarrhea. Drug-related reversible hepatotoxicity occurred in 4 patients in the ITZS group. There was a significant elevation of total bilirubin level in the ITZS group. The incidence of suspected IFI occurred in 5 patients (12.5%) who received ITZS, compared with 8 (21.1%) who received FCZS (P=0.372). There were no proven IFIs or superficial (oral/vaginal) fungal infections in both groups. Overall mortality was not different between the two groups (2.5% in the ITZS group versus 5.3% in the FCZS group, P=0.610). Conclusion : ITZS and FCZS showed similar protection against IFI during pre-engraftment period. Poor tolerability due to gastrointestinal troubles of ITZS might limit its success as prophylactic therapy. Well matched controlled study with large number of patients will be required in the future.

조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

Malachite Green유도체의 합성과 그 항균성에 관한 연구

金浩植,金鍾大,金在根,韓文洙 嶺南大學校附設 基礎科學硏究所 1986 基礎科學硏究 Vol.6 No.-

Malachite Green derivative bearing butyl group was prepared in the form of Leuco base, 4-butyl-4'. 4"-bis(dimethylamino) triphenylmethane, by the condensation reaction of N,N-dimethylaniline with the formyl derivative of butylbenzene, which had been obtained from butylbenzene by chlormethylation followed by oxidation. The butylbenzene was prepared by the alkylation reaction of benzene with n-butyl choride which had been obtained from n-butyl alcohol and zinc chloride. The antimicrobial and antifungal activity of buty-Malachite Green was evaluated in terms of minimum inhibitory concentration by the dilution method. The butyl-Malachite Green showed considerably increasing activity. This activity was stronger than that of hexyl-Malachite Green. This phenomenon suggested that the activities of the alkyl derivatives increase with decrease in the number of carbon in the alkyl group.

매립장 기반암의 산 중화능력

金鐘根 대구산업정보대학 1998 논문집 Vol.12 No.2

The capacity of Landfill Bedrocks to neutralize acid was determined for material from a Landfill in Y-industry co., Ltd, Pohwang. Most Landfill Bedrocks(mostly mudrock) are composed of quartz, feldspar, smectite, carbonate minerals(mostly calcite), kaolinite and illite by XRD mineralogical analysis. Reactions involving injection zone mudrock and acid solutions proceeded at a relatively rapid rate, achieving equilebrium after a few hours. Injection zone mudrock was found to neutralize approximately 1.101×10^(-3) grams H^(+) ions per gram of mudrock. This value is site-specific and is not necessarily representative of other sites.

Probiotics의 최근연구동향

김진욱,정종근,주치언,이재화 신라대학교 자연과학연구소 2005 自然科學論文集 Vol.14 No.-

Probiotics는 "장내균종을 개선시켜 줌으로써 숙주동물에게 유익한 영향을 주는 것", "사람 또는 동물 장내 미생물의 균형을 개선시켜 숙주에 효과를 주는 살아있는 미생물 단독 또는 혼합배양물"이라는 의미의 용어이다. Probiotics의 조건에는 효능성, 안전성, 안정성, 분리성의 4가지 조건을 만족시켜야 하며, 식품의 상품성 향상, 면역증강, 유해효소의 합성 억제, 유당 불내증 개선, 장내 유해균의 증식 억제, 장내 균총의 정상화 등 다양한 효능을 가지고 있다. 이런 다양한 효능을 가진 probiotics는 건강식품 및 의료용의 소재, 화장용 소재, 사료 첨가제, 생 백신 개발 재료, 천연 항균물질 생산 등 다양한 곳에 응용되어 사용이 가능하다. Probiotics are living non-pathogenic micro-organisms, which as food ingredients also beneficially affect host's health. These non-pathogenic micro-organisms may be lactic acid bacteria, such as lactobacilli, lactococci, and bifidobacteria, or yeasts, such as Saccharomyces cerevisiae subspp. boulardii, or bacillus, such as B. subtilis, B. natto, B. licheniformis. Probiotics were originally used to influence both animal and human health through intestinal microbiota alterations. At present, the specific live microbial food ingredients and their effects on human health are studied both within food matrices and as single or mixed culture preparations. Probiotics such as lactobacilli have been reported to effect positively, gastrointestinal disorders such as diarrhoea (rotavirus-associated and antibiotic -associated), inflammatory bowel disease, pouchitis, irritable bowel syndrome, colorectal cancer, lactose absorption, Helicobacter pylori infection and constipation and are increasingly used as a treatment modality. Basic and clinical research should thus be associated to meet the enthusiasm that patients show for a therapeutical approach that they feel to be safer than most drugs currently proposed to them.