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- 저자 : ( Jong Seol Park ) (검색결과 361 건)
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박호추,정설미,문덕환,이종태,김대환,김정호,최재일,황용식,이용희,이채언 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.1
In order to evaluate the status of cold exposure and its health hazards of workers at cold storage workplaces and to provide basic data for effective health care, the author measured core temperature and also observed clinical symptoms and signs, past and present history, and general health examination data on 99 cold exposed workers for exposure group and 96 non-exposed workers for control group working at 2 food refrigerating companies in Pusan area from January 6, 1998 to February 24, 1998. The results were as follows: 1. There was statistically significant difference in water intake between the exposure and control group and increased urine volume, urine frequency in exposure group without statistically significant difference. 2. Past and present illness in exposure group were hypertension (18.2%), hepatopathy (8.1%), gastro-intestinal disease(7.1%), arthritis (4.0%), intervertebral disc herniation(4.0%), and so on, and hypertension, arthritis was statistically significant difference compared to control group. 3. Symptoms in exposure group were fatigue(89.9%), headache (64.6%). drowsy(63.6%), neck stiffness(59.6%), excessive food intake(59.6%). general weakness(58.6%), hunger(58.6%), numbness(54.5%), and so on, and there was statistically significant difference between the exposure and control group except fatigue, drowsy. 4. As results of clinical test abnormality rate of the systolic, diastolic blood pressure and electrocardiogram were significantly higher in exposed group than control. 5. Core temperature in exposure group was statistically significantly lower than control group and the highest statistically significant inverse correlation with the working hours and working frequency of daily mean cold storage. As above results, the author suggested that the further studies should be conducted to evaluate the health status of workers about chronic health effects in cold workplaces and to establish effective health care methods for them.
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사람의 비후성 반흔에서 면역조직화학기법에 의한 형질전환인자 알파와 표피성장인자 발현의 차이에 관한 면역조직화학적 연구
박영란,김현곤,김종중,문정석,송준섭,설경수,정윤영 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2
Background and Objectives: Transforming growth factor-α (TGF-α) and epidermal growth factor (EGF) are polypeptides which interact with the epidermal growth factor receptor (EGFR) to produce their biological effects. The aim of the present investigation was to elucidate the immunolocalization of TGF-α and EGF in normal human skin, hypertrophic scar with skin graft on soft tissue defect, and postburn hypertrophic scar without graft. Methods: The data presented in this paper focused attention on differences of expression between two kinds of hypertrophic scars in relation to skin graft using immunohistochemistry. Formalin-fixed and paraffin-embedded tissues from 3 normal skin tissues, 3 hypertrophic scars after skin graft and 8 postburn hypertrophic scars without graft were immunolabelled with antibodies directed against TGF-α and EGF. Results: In normal epidermis of skin, strong TGF-α immunoreactivity (IR) was observed in all epidermal layers except the stratum (S.) basale, whereas EGF was immunopositive in a few cells over all epidermal layers. The staining for TGF-α was found in cell membrane, and EGF was seen either diffuse cytoplasmic or peripheral part of cells in normal epidermis. In hypertrophic scar after six months postoperation, TGF-α IR was observed in the upper part of S. spinosum and S. corneum, whereas EGF was diffusely expressed in the S. spinosum, also its intensity was slightly increased compared to normal skin. In hypertrophic scar without skin graft, very strong expression of EGF was detected in the S. spinosum and S. corneum, and intensity of EGF was increased when compared to normal skin and postoperative hypertrophic scar. EGF and TGF-α coexisted in the cells of S. spinosum in normal skin as well as hypertrophic scars. Double-labeled cells were increased in postburn hypertrophic scar compared to normal skin and postoperative hypertrophic scar. In addition, intensity of EGF and TGF-α double IR was the strongest in postburn hypertrophic scar. Conclusion: These results indicate that EGF may have a more complex regulatory role not only in the early stages of wound healing but also in hypertrophic scar.
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加味鷄血藤湯이 Glutamate receptor와 Free radical 및 뇌손상 보호에 미치는 영향
안종석,김동희,김윤식,이용구,박종오,남궁욱,설인찬 대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.3
This study was investigated to prove the effect of GMGHT on the gultamate receptor, free radical and brain damage in rats sujected to Brain Ischemia The results were as follows ; 1. GMGHT showed significant inhibitory effect of GMGHT on LDH release induced by NMDA, AMPA, and kinate. 2. GMGHT showed significant inhibitory effect of GMGHT on LDH release induced by BSO and Fe^2+. 3. GMGHT decreased coma duration time in a infatal dose of KCN and showed 30% of survival rate in a fatal dose. 4. GMGHT decreased ischemic area and edema incited by the MCA blood flow block. 5. GMGHT showed improvement of forelimb test after MCA occulusion in neurological exemination. 6. GMGHT showed no significant change after MCA occulusion in pathological observation as normal group. These results indicate that GMGHT can be used in the brain damage sujected to Brain Ischemia. Further study will be needed about the functional mechanism and etc.
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맹출성 복잡치아종 : 증례보고 A Case Report
오유향,박종휘,박헌동,설재헌,이병채 조선대학교 구강생물학연구소 2003 口腔生物學硏究 Vol.27 No.1
Odontomas, hamartomas of odontogenic origin, are composed of all the structures that make up teeth The WHO distinguishes odontoma into two types. The complex odontoma is defined as "a malformation in which all the dental tissues are represented. individual tissues being mainly well-formed but occurring in a more or less disorderly Pattern." The compound odomtoma is defined as "a malformation in which all the dental tissues are represented in a more orderly pattern than in the complex odontoma so that the lesion consists of many tooth-like structures. Most of these structures do not resemble morphologically the teeth of normal dentition, but in each one enamel, dentin, cementum and pulp are arranged as in the normal tooth." Although these tumora occur frequently and constitute 22% of all odontogenic tumors, reports on erupted odontomas are very rare. Erupted odontoma are defined as tumors that it occurs a calcified mass may be defected on the alveolar ridge. The final diagnosis should be confirmed by biopsy. The treatment of choice is complete surgical excision, similarly to intraosseous odontoma and it does nat tend to recur. The histopathological report confirmed the diagnosis of complex odontoma. This report presents a case of 8-year-old girl with the calcified mass within the operculum covered the central fossa of the mandibular left fkrst molar. And it was diagnosed as erupted complex odontoma by excisional biopsy.
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소아에서의 Nd : YAG Laser를 이용한 치은착색제거술 YAG Laser in children
모경희,박헌동,박종휘,김효석,정현구,설재헌,이병채 조선대학교 구강생물학연구소 2003 口腔生物學硏究 Vol.27 No.1
Melanin is normally found in the skin of all people, and normal pigmentation of the intraoral tissues is a relative frequent finding. Gingival hyperpigmentation may cause esthetic problems and embarrassment, especially in patients with a gummy smile. Melanin pigmentation is related to etiologic factor such as hormon, systemic factor, drug, smoking and gingival inflamation. Depigmentation procedure can be Performed by gingival epithelium removing procedure, gingivectomy, free gingival graft, laser therapy, dry ice, Vitamin C and phenol-alcohol method. We could obtain favorable esthetic results by procedures such as Nd: YAG laser. The Nd:YAG laser was set at 4 watt, 50mJ, 80 pulse per second. The procedures were performed with contact mode in all pigmented areas by using a handpiece with a 320㎛ diameter fiber optic. Ablation of the gingival hyperpigmented gingiva appeared healthy, pink, and firm. No recurrence of hyperpigmentation had been found in 6 months of follow-up.
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( Jong Seol Park ),( Yong Sung Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
The symptoms of tortuosity of thoracic aorta are variable from asymptomatic feature to dysphagia, GERD symptom, nausea and vomiting. Some cases were reported that intervention or surgical approach was performed due to progression to aortic aneurysm or dissection. Here we report a case of tortuosity of thoracic aorta mimicking lung mass Case Presentation: 83-year-old female presented to our hospital with epigastric discomfort and nausea for 1 month. Her past medical history included hypertension and osteoarthritis. The vital sign at presentation included a blood pressure 140/80mmHg, pulse 68 beats per minute, respiration 14 breaths per minute and body temperature 36. 4`c. Atrial Premature Beat was checked in EKG. On chemical examination of the blood, the CBC,liver function test,BUN and electrolyte were normal. Esophagoduodenoscopy showed GERD LA class M, erosive gastritis, hiatal hernia and compressed esophagus from outside. Lateral chest x-ray showed 5*4cm sized mass like lesion in left lower lung fi eld with the round shape and sharp in margin. So chest CT was performed. It revealed that lower thoraic aorta was tortuous and crossed from left to right above the left diaphragm. After treatment with PPI and GI motility medication, her symptoms gradually decreased and the patient has been followed up in out patient department. Conclusion: Most common cause of aortic disease mimicking lung mass on chest x-ray is aortic aneurysm. However tortuosity of thoracic aorta mimicking lung mass was reported rarely. Like this case, Chest CT can be beneficial for the differential diagnosis with malignancy or other lung lesion. In young age, Loeys-Dietz syndromeor Arterial Tortuosity Syndrome should be considered. In conclusion, this disease can be presented with variable manifestation. Because of the possibility of progression to aortic aneurysm, dissection or compression of adjacent organ, close observation should be performed.
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Park, Seol-Hoon,Ryu, Jin-Sook,Oh, Seung-Jun,Park, Seung-Il,Kim, Yong-Hee,Jung, Hoon-Yong,Lee, Gin-Hyug,Song, Ho-Jun,Kim, Jong-Hoon,Song, Ho-Young,Cho, Kyoung-Ja,Kim, Sung-Bae The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.1
Purpose : The aim of this study was to determine whether $^{18}F$-fluorothymidine (FLT) PET is feasible for the early prediction of tumor response to induction chemotherapy followed by concurrent chemoradiotherapy in patients with esophageal cancer. Methods : This study was prospectively performed as a collateral study of "randomized phase II study of preoperative concurrent chemoradiotherapy with or without induction chemotherapy with S-1/oxaliplatin in patients with resectable esophageal cancer". $^{18}F$-FLT positron emission tomography (PET) images were obtained before and after two cycles of induction chemotherapy, and the percent change of maximum standardized uptake value (SUVmax) was calculated. All patients underwent esophagography, gastrofiberoscopy, endoscopic ultrasonography (EUS), computed tomography (CT) and $^{18}F$-fluorodeoxyglucose (FDG) PET at baseline and 3-4 weeks after completion of concurrent chemoradiotherapy. Final tumor response was determined by both clinical and pathologic tumor responses after surgery. Results : The 13 patients for induction chemotherapy group were enrolled until interim analysis. In a primary tumor visual analysis, the tumor detection rates of baseline $^{18}F$-FLT and $^{18}F$-FDG PET were 85% and 100%, respectively. The tumor uptakes on $^{18}F$-FLT PET were lower than those of $^{18}F$-FDG PET. Among nine patients who completed second $^{18}F$-FLT PET, eight patients were responders and one patient was a non-responder in the assessment of final tumor response. The percent change of SUVmax in responders ranged from 41.2% to 79.2% (median 57.1%), whereas it was 10.2% in one non-responder. Conclusion : The percent change of tumor uptake in $^{18}F$-FLT PET after induction chemotherapy might be feasible for early prediction of tumor response after induction chemotherapy and concurrent chemoradiotherapy in patients with esophageal cancer.
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Jong-Seol Park,Tae-Gon Park,Jin-Seok Park 대한금속·재료학회 2021 ELECTRONIC MATERIALS LETTERS Vol.17 No.3
In this study, we present a new and simple method that utilizes post-processing such as thermal treatment and mechanicalcompression to manufacture a grid patterned silver nanowire (AgNW) fl exible transparent electrode with low sheet resistance,high transmittance, and high fl exibility. The eff ects of thermal treatment and mechanical compression on the structural,optical, and electrical properties of AgNW deposited by bar coating have been analyzed as a function of temperature andpressure. It was discovered that there is a critical thermal treatment temperature (T c ) that determined the abrupt change—decreasing, then rapidly increasing—in the sheet resistance of AgNW. When additional pressure was applied during thermaltreatment, T c was lowered. The cohesion between AgNW wires was improved by thermal treatment below T c , and furtherstrengthened when pressure was applied simultaneously with heat. However, when thermal treatment was performed aboveT c , the unique wire structure of AgNW collapsed. It has also been found that heat treatment and mechanical compressionimprove the fl exibility of AgNW.
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