Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofi bers

Jin‑Kyung Jeon,Hyunseon Seo,Jimin Park,Soo Ji Son,Yeong Rim Kim,Eun Shil Kim,Jong Woong Park,Woong‑Gyo Jung,Hojeong Jeon,Yu‑Chan Kim,Hyun‑Kwang Seok,Jae Ho Shin,Myoung‑Ryul Ok 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.4

The excessive initial corrosion rate of Mg is a critical limitation in the clinical application of biodegradable Mg implantsbecause the device loses its fi xation strength before the fractured bone heals. This study suggests a new approach to overcomethis hurdle by accelerating tissue regeneration instead of delaying the implant biodegradation. As angiogenesis is anessential process in early bone regeneration, a Mg implant coated with electrospun nanofi bers containing nitric oxide (NO),which physiologically promotes angiogenesis, is designed. The integrated device enables adjustable amounts of NO to bestored on the NO donor-conjugated nanofi ber coating, stably delivered, and released to the fractured bone tissue near theimplanted sites. An in vitro corrosion test reveals no adverse eff ect of the released NO on the corrosion behavior of the Mgimplant. Simultaneously, the optimal concentration level of NO released from the implant signifi cantly enhances tube networkformation of human umbilical vein endothelial cells without any cytotoxicity problem. This indicates that angiogenesis canbe accelerated by combining NO-releasing nanofi bers with a Mg implant. With its proven feasibility, the proposed approachcould be a novel solution for the initial stability problem of biodegradable Mg implants, leading to successful bone fi xation.

Study on Aging Effect of Adhesion Strength Between Polyimide Film and Copper Layer

Seok‑Bon Koo,Chang‑Myeon Lee,Sang‑Jun Kwon,Jun‑Mi Jeon,Jin‑young Hur,Hong‑Kee Lee 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.1

This paper experimentally confirmed that the adhesion strength of the copper layer formed on the surface of the polyimidefilm by wet plating greatly changes with the aging time. The adhesion strength of the copper layer showed a rapid increasefrom 4 to 10 h after aging had begun and then converged to a value without a significant change. The adhesion enhancementbetween polyimide film and copper layer by aging is due to the interlocking effect caused by the volume expansion of copperoxide (CuO) formed in the polyimide, the increased mobility of copper particles enlarged by the decrease of impuritiesin the copper layer grain boundaries, and the consequent change of the crystal structure of the copper layer leading to theinternal stress reduction. Such adhesion improvement can be confirmed by the progress of the cohesive failure indicatingthe breakdown of the polyimide film.

한국 성인의 요추 및 제1 천추의 형태계측학적 연구

전진욱,최장석 인제대학교 1999 仁濟醫學 Vol.20 No.1S

전산화단층촬영과 자기공명영상은 척추관협착증의 진단과 척추체유합술 및 척추경을 통한 나사못 삽입술 등 척추질환의 진단과 치료에 중요한 정보를 제공하고 있다. 저자들은 요천추의 전산화단층촬영과 자기공명영상 100예씩 총 200예를 대상으로 한국 성인의 제1 요추에서부터 제1 천추까지의 척추체, 척추과, 척추경을 조사하여 척추관협착증의 진단, 척추체유합술에 이식골의 크기와 척추경을 통한 나사못의 길이, 나사못의 굵기와 삽입각도 결정에 기본 자료로 활용하려 하였다. Magnetic resonance image(MRI) and computed tomography(CT) provided information for diagnosis of spinal stenosis, and for interbody fusion and instrumentation of transpedicular screw. The author had reviewed the 200 cases of MRI and CT scanning of spine for the measurement of vertebral body canal and pedicle from first lumbar vertebra to first sacral canal. The results were as follows. 1.Anteroposterior, transverse diameter and height of vertebral body increased steadily from first lumbar vertebrar to first sacral vertebra. 2.The narrowest transverse diameter of pedicle was seen at first lumbar vertebra (9.0mm) and the widest at the first sacral(20.4mm). 3.The widest superoinferior diameter of pedicle was seen at first lumbar vertebra (13.1mm) and the narrowest at third lumbar(11.8mm). Above data could be used in diagnosis of spinal stenosis, in decision of the size of bone graft in interbody fusion and length, diameter and insertion of angle of transpedicular screw.

한국 성인의 요추 및 제1 천추의 형태계측학적 연구

전진욱,최장석 인제대학교 1999 仁濟醫學 Vol.20 No.1

동적 후보영역과 이중 템플릿매칭을 이용한 차량 번호판 추출 및 인식

전진석,이은주 한밭대학교 정보통신전문대학원 2003 정보통신전문대학원 논문집 Vol.1 No.1

본 논문에서는 획득한 차량 영상에서, 차량 번호판의 후보영역을 동적으로 할당하여 번호판을 추출하고, 이중 템플릿 매칭을 이용하여 인식하는 방법을 제안하였다. 차량 번호판은, 이 영역이 다른 영역에 비해 영상의 흑백 변화 밀도가 높다는 것을 근거로, 번호판 후보영역을 투영하여 영상 밀도의 기준 밀도와의 차에 의하여 추출된다. 번호판 영역 추출을 실패하면, 다시 동적으로 가장 가능성이 높은 영역을 번호판 후보영역을 결정하였다. 추출된 번호판 영역에서 영역정보에 의하여 문자와 숫자영역을 분리하고,문자와 숫자의 인식은 분할된 입력 패턴과 표준패턴을 흑화소 정보에 의하여 1차 매칭하고, 유사도가 높은 표준패턴과 다시 백화소 정보에 의하여 2차 매칭하는 이중 템플릿 매칭에 의하여 하였다. In this paper, we proposed method to extract vehicle license plate by assigning dynamically candidate area, and to recognize using double template matching in captured vehicle image. We extracted vehicle license plate using density difference of candidate area and reference, because the image density of candidate area is high than other. If it failed to extract in this process, we determine dynamically candidate area. We recognized characters and numbers on plate by double template matching of input pattern and references. Then it matched black pixels first, and white next.

신 이식 환자의 거대세포 바이러스 감염 임상양상 : Single center experience

전진석 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Purpose : Cytomegalovirus (CMV) infection remains one of frequent prevalent infectious diseases complicating the clinical course of kidney transplant recipients and it may need more accurate diagnostic evaluation. There are several reports on CMV disease in renal transplant recipients from Korea in the period before the development of specific diagnostic procedures. Methods : All case records of 280 renal transplant recipients between 1984 and Jan, 2002 were retrospectively assessed. CMV diagnosis was made by positive pp65 antigenemia, as a newly established diagnostic procedure, in the peripheral blood leukocytes or elevated CMV IgG titer. Results : CMV disease was diagnosed in 8 cases. All patients with CMV disease had one or two episodes of acute rejection and steroid pulse therapy. Pneumonia was documented in 7 patients and one patients was diagnosed as a simple febrile disease. Ganciclovir was administered to all 8 cases. Five cases showed complete remission, but two patients treated with OKT3 died of superimposed infections. Conclusion : The occurrence of CMV is related to intensity of immunosuppression for the treatment of acute rejection and the pp65 antigen test was helpful to make an early diagnosis of CMV infection.

전자장치 냉각을 위한 수직수로에서의 열-사이펀 비등실험

전진석,곽호영 중앙대학교 기술과학연구소 1989 기술과학연구소 논문집 Vol.19 No.-

As a result of continuing efforts to improve the circuit performance, the number of devices in the package such as VLSI and the speed of computation has been considerably increased. In fact, during the past two decades the heat flux at the chip level has increased by more than an order of magnitude. Therefore one of the problems faced by engineers who are designing computers, is how to cool the electronic hardware of the computer. The LSI or VLSI chips must be cooled in a manner that the maximum temperature of device junction dose not exceed 85℃ in order in order to keep the reliability. The method of "air cooling" is enough to cool the components such as tube or transistor because of their relatively low heat generation rate. But it is not enough to cool VLSI with such method. Recently "immersion cooling" is studied to solve that problem by many investigators because heat transfer is more effective than others. This paper describes an experimental study on boiling heat transfer between vertical isoflux plates with asymmetric heating with a dielectric fluid, FC-72. This study found that the channel width is not a significant parameter for immersion cooling with FC-72 and that the heat transfer from the vertical plates is more effective than the horizontal plates. And this study demonstrated the possibility of use of "immersion cooling" between narrow PCB's.

성균관대학교 멀티미디어 원격교육 시스템(배움 한마당) 개발에 관한 연구

김석수,권해문,이상권,김상진,전진호,황대준 成均館大學校 科學技術硏究所 1997 論文集 Vol.48 No.1

We propose SKKU Multimedia Distance Education System for distance education between nature science campus(Suwon) and social science campus(Seoul) in Sung Kyun Kwan University on DooRae (Distributed Object Oriented Multimedia Application Crafting Environment for Collaboration) framework (or platform). We support ONE : N study mode for a group lecture and discussion between two campus, and also we support mediation for floor mode of a group lecture and brain storming for floor mode of discussion. The communication portocol of this system is composed of TCP/IP and UDP, and the network type is composed of WAN(El line)for between the Suwon campus and Seoul campus, ATM LAN for each campus(local site). And, this system supports the application development of the collaborative multimedia environment connected with the various network in the CBM (Computer based Multimedia) based. Also, it does not restrict on space between a teacher(s) and a student(s) into cyberspace which made by network. This system has an interaction, late comer, a question and an answer, multi-session, application sharing and whiteboard which resembles chalkboard. Also, various supplementary functions such as video conference and voice conference for this system are what makes face-to-face education effective. Also it supports real or non-real type. The operation system developed on windows 95.

구미지역 직업성질환 감시체계

김성아,김진석,전혜리,정상재,김상우,이채용,함정오,유재영,최태성,하봉구,조민환,우극현 大韓産業醫學會 2003 대한직업환경의학회지 Vol.15 No.1

목적: 구미지역 내 대학병원이자 특수건강진단·보건관리대행기관의 산업의학전문의, 보건관리대행 간호사, 사업장 간호사를 중심으로 직업성질환감시체계를 구축하여 주요 직업성질환들의 발생현황과 규모를 파악하고자 하였다. 또한 연차적으로 산업, 직업, 업무내용 등에 따른 분포나 원인을 기존 자료원(특수건강진단의 직업병 유소견자와 산재요양승인 되는 직업병자)과 비교하여 분석·기술하고 예방 및 관리를 포함한 보건의료기술개발까지을 포함하는 종합적인 감시체계를 구축하고 운용하고자 하였다. 방법: 구미지역의 산업적 특성에 맞는 직업성질환감시체계를 구축하고 지역 감시체계의 모델을 제시하였다. 6대 감시대상 직업성질환(독성 간염, 직업성천식, 직업성 근골격계질환, 직업성 피부질환, 직업성 암, 수지진동증후군)의 실행적 환례정의, 보고양식 및 보고체계 개발, 분석양식 및 결과 배포 형식을 개발하였으며, 그 유병규모를 파악하고, 감시질환의 분포 및 특성, 관련인자 등을 분석·기술하고자 하였다. 이때, 1년간의 환례분석시 직업병 유소견자 및 직업병 요양자에 대한 자료와 함께 비교 분석하였으며, 노동통계자료를 이용하여 년간 발생률을 추정하였다. 결과: 2001. 1. 1일부터 2002.4.30일까지 총 287건이 보고되었으며, 직업성 근골격계질환 132건(46.0%), 직업성 피부질환 100건(34.8%), 독성간염 34건 (11.8%), 직업성천식 16건 (5.6%), 수지진동증후군 5건 (1.7%) 이었으며 직업성 암은 한건도 보고되지 않았다. 보고경로별로는 보건관리대행에서 33건 (11.5%), 해당 유해인자별로 실시되는 특수검진 외의 각종 건강진단업무 수행 중 발견된 환례에 대한 보고가 206건(71.7%)이었다. 직종별 분류의 결과는 섬유업종사자, 단순노무종사자, 음식업종사자 등이 다수를 차지하였다. 근골격계질환의 경우, 수근관증후군이 42건(33%), 외상과염/내상과염이 39건(30%)로 가장 많았다. 직업성 피부질환은 97건이 접촉성 피부염으로 유기용제류가 59건(59%)으로 가장 많고, 니켈 및 에폭시수지에 의한 알레르기성 접촉성 피부염이 각각 6건과 5건이었다. 독성 간염은 모두 DMF 나 DMAc에 의한 것으로, 근무시작 후부터 간기능이상이 발견되기까지의 근무기간은 대부분이 3개월 이하이며, 1개월 이하인 경우도 10건이나 되었다. 동 기간 중 감시환례에 대해 산재요양 자료와 중복여부를 확인한 결과, 중복되는 것은 하나도 없었다. 특수건강진단에서 직업병유소견자로 판정된 경우는 독성간염에서 3건이 있었으며, 나머지 질환은 중복되는 것은 없었다. 2001도 구미지역의 근로자수와 보고환례건수를 이용하여 연간 발생률을 추정하였다. 근로자 10만 명당 연간 발생률은 상지 근골격계질환은 63.6명, 피부질환 48.2명, 독성 간염 17.9명, 천식 7.7명, 수진진동증후군 2.4명이었다. 참여예상인원은 총 46명이었으며, 실제 참여자수는 21명, 평균참여율은 46%, 실제 참여 1이당 평균 보고건수는 산업의학전문의가 28건으로 가장 많았고, 대행간호사는 45,건, 사업장 간호사는 3.3건이었다. 결론: 지역 감시체계는 기존 통계자료들에서 발견되지 않았던 직업성질환의 발견에 유용한 통계원이며, 특히 지역의 특성과 여건을 고려하여 체계화된 시스템을 구축하여 운용한다면 더 성과가 클 것이다. Objectives: Area-based occupational disease surveillance in Kumi (KODS) was used to collect data on occupational diseases. The data was used to estimate the magnitude of the diseases, to analyze for their characteristics and to find links for their intervention and prevention. Methods: Since January 2001, occupational physicians and nurses in Occupational Health Service (OHS) have reported six major occupational diseases; occuaptional musculoskeletal disorders of the upper extremities (MSDUE), occupational dermatoses, toxic hepatitis, occupational asthma (OA), hand-arm vibration syndrome (HAVS), and occupational cancer. For the respective diseases, a reporting sheet and operational diagnostic criteria were developed by the KODS. An analysis of the KODS data, collected over a certain period, was compared with data from the Korea Labor Workers Corporation (KLWC) and the Specific Health Examination (SHE), and the incidence rates of the diseases estimated. Results: Between Jan 2001 and Apr 2002, 287 cases of the six major occupational disease were reported. Of these, there were 132 (46.0%), 100 (34.8%), 34 (11.8%), 16 (5.6%), and 5 (1.7%), cases of MSDUE, occupational dermatoses, toxic hepatitis, OA, and HAVS, repectively. But, there were no cases of occupational cancer. 33 (11.5%) of the incidence were reported via the OHS, 206 (71.7%) from health checkups, and the other 48(16.8%) from other routes. The synthetic fibers and electronic components manufacturing industries accounted for the greatest number of reported cases. With resport to occupation, the greatest numbers of incidence were reported from the elementary occupations, textile workers, assemblers, and cooks and food services worker, in that order. Of the MSDUE cases, carpal tunnel syndrome and epicondylitis were the two most common diseases. Most of the occupational dermatoses were due to contact dermatitis, with organic solvents (59%), nickel (6%), and epoxy resin (5%) accounting for the majority of these cases. All cases of toxic hepatitis were induced by dimethylformamide or dimethylacetamide, which were reported by a unique monitoring system. During same period, there were no cases claimed by workers to the KLWC, and only three cases from SHE, were identified. Using data from workers' number and surveillance, the annual incidence of MSDUE, dermatoses, hepatitis, OA, and HAVS, per 100,000 workers were 63.6, 48.2, 17.9, 7.7, and 2.4, respectively. Conclusions: These results show that an area-based surveillance system can be very effective for the collection of data on work-related diseases, at least in Kumi.

한국형 우울장애 약물치료 알고리듬 2006 (Ⅲ) : 정신병적 양상을 동반한 주요우울삽화

김원,박원명,서정석,민경준,석정호,전덕인,전현태,이상열,송해철,홍진표,한국형 우울장애 약물치료 알고리듬 2006 연구그룹 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Objectives : Since the publication of Korean Medication Algorithm Project for Major DepressiveDisorder (KMAP-MD) in 2002, there has been a substantial need for a revision due to rapid progress in the pharmacological management of depressive disorder. We revised KMAP-MD 2002 and developed the Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) 2006. Methods : We developed a questionniare for surveying the opinion of experts on pharmacotherapy of depressive disorder. The questionnaire consisted of 4 parts ; 1) treatment of non-psychotic depressive disorder, 2) treatment of psychotic de-pressive disorder, 3) treatment according to clinical subtypes and drugs choice considering adverse effects, and 4) treatment of depressive disorder in women. The questionnaire was completed by the review committee consisting of 101 experienced Korean psychiatrists. It is composed of 22 questions, and each question includes 54 sub-items. We classified the expert opinionto 3 categories (the first-line, the second-line, or the third-line) by χ²-test. Results : For depressive disorder with psychotic features, most reviewers prefer the combination of antidepressant and atypical antipsychotics. Electroconvulsive therapy and the combination of antidepressant and typical antipsychotics were the second-line treatment. Among antidepressants, venlafaxine was the most preferred, and SSRI and mirtazapine followed. Among atypical antipsychotics, quetiapine, risperidone and olanzapine were the most preferred, in this order. In patients who have no response to the first-line treatment, many reviewers recommended switching to another antidepressant or adding another atypical antipsychotics Conclusion : For severe depressive disorder with psychotic features, the combination of antidepressant and atypical antipsy-chotics was preferred for the first-line treatment. These results suggest that the medication strategies of depressive disorder are rapidly changing and reflects the recent studies and clinical experiences.