간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

무기안료가 시멘트모르타르의 압축강도와 흡수율에 미치는 영향

송혁,이재용,고성석 한국안전학회 2004 한국안전학회지 Vol.19 No.2

The aim of this study was to investigate the influence of inorganic pigments on the physical properties of cement mortar. For this purpose, the compressive stieugth and absorption test were carried out on cement mortar mixed with inorganic pigments by changing the proportion of cement mortar, water-cement ratio, and ratio of pigment. The result of this study can be summarized as follows: The compressive strength of colored mortar rapidly increased in red and yellow mortar, as the mix ratio of pigment increased. In case of green and black mortar, however, the compressive strength decreased as the mix ratio increased. In case of red and yellow mortar, the absorption of colored mortar increased as the mixing ratio increased, if the mean particle diameter of the pigment is small. In case of green and black mortar, the absorption ratio decreased as the mix ratio increased. After investigating the overall physical properties of colored mortar, it was confirmed that the proper mix ratio of pigment securing the properties of colored mortar was below 6% of the weight of the cement to be used.

Pseudomonas aeruginosa와 Acinetobacter baumannii에 대한 Imipenem, Panipenem 및 Meropenem의 시험관내 항균력 비교

송원근,우흥정,강희정,김재석,박민정,이규만 대한화학요법학회 2002 대한화학요법학회지 Vol.20 No.3

목적 : Pseudomonas aeruginosa와 Acinetobacter baumannii는 중요한 병원감염균으로 알려져 있으며 다약제 내성을 잘 유발한다. 최근 들어 전 세계적으로 carbapenem제에 대한 감수성이 떨어지고 있어 문제가 되고 있다. 이에 저자들은 한국에서 분리된 P. aeruginosa와 A. baumannii를 대상으로 imipenem, panipenem 및 meropenem의 항균력을 비교하고자 하였다. 방법 : 150주의 P.aeruginosa (imipenem 감수성, 62주; imipenem 내성. 88주)와 53주의 A.baumannii (imipenem 감수성, 9주; imipenem 내성 44주)를 대상으로 National Committee for Clinical Laboratory Standards의 기준에 따라 미량액체배지희석법으로 imipenem, panipenem. meropenem에 대한 최소억제농도(MIC)를 측정하였다. 결과 : 총 150주의 P. aeruginsa 균주의 MIC_50/MIC_90은 imipenem, panipenem 및 meropenem이 각각 16/64, 16/64 및 4/32㎍/mL이었다, 53주의 A.baumannii 균중의 MIC_50/MIC_90은 imipenem, panipenem 및 meropenem이 각각 32/64, 32/64 및 16/32 ㎍/mL이었다. 88주의 imipenem 내성 P. aeruginosa 균주 중 33주 (38%)는 감수성 결과를 보였으나 그 반대의 결과를 보인 경우는 없었다. 결과 : MIC 결과 상 imipenem에 내성인 P. aeruginosa와 A. baumannii에 대하여 meropenem이 impenem이나 panipenem보다 좀더 강한 활성이 있음을 알 수 있었다. Background : Pseidomonas aeruginosa and Acinetobacter baumannii are important nosocomial pathogens. Many strains are multi-drug resistant, with decreased susceptibility to carbapenem emerging worldwide. We investigated the in vitro activity of imipenem, panipenem, and meropenem against P. aeruginosa and A. baumannii isolates in Korea. Methods : One hundred and fifty strains of P. aeruginosa (imipenem-susceptible, 62strains; imipenem-resistant, 88 strains) and 53 strains of A baumannii (imipenem-susceptible, 9 strains; imipenem-resistant, 44 strains) were examined. Minimal inhibitory concentration (MIC) testing for imipenem, panipenem, and meropenem was performed using the broth microdilution method as described by the National Committee for Clinical Laboratory Standards. Resilts : The MIC_50/MIC_90 of imipenem, panipenem, and meropenem against the clinical isolates were: 16/64, 16/64, and 4/32 ㎍/mL, respectively, against P. aeruginosa; 32/64, 32/64, and 16/32 ㎍/mL against A. baumannii. 33 (38%) of the 88 strains of impenem-resistant P. aeruginosa were susceptible to meropenem but the reverse was observed in none. Conclusion : The MIC data showed that meropenem was more active than imipenem and panipenem against imipenem-resistant P. aeruginosa and A. baumannii isolates.

소음성 난청 선별검사용 문진표의 유용성

송재석,최병수,원종욱,노재훈 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.4

목적 : 소음 특수건강진단시 문진표의 유용성을 알기 위하여 실시되었다. 방법 : 자료로는 전국을 5대 권역으로 나눈 후 연구에 협조적인 산업보건기관을 대상으로 하여, 소음성 난청이 발생한 사업장과 그 부서에 대하여 정상인 근로자의 검진기록과 작업환경측정 기록 및 문진표를 수집하여 분석하였다. 결 과 : 각각의 문진 항목과 청력이상 여부에 대한 분석결과, 귀에서 소리가 난다고 하는 항목과 최근 작은 소리가 잘 안들린다고 하는 만성 특이적 항목만 청력이상 여부와 관계가 있었고, 급성 항목들은 청력 이상 여부와 통계적 연관성이 없었다. 또한 7개의 설문 항목과 연령 및 근무경력만을 이용하여 청력이상을 판정한다고 하였을 때, 실제 건강진단 결과와 비교하게 되면 민감도, 59 %, 특이도, 88 %로 계산 되었으며, 평균 23 %정도가 잘못 분류되었다. 결 론 : 만성적이고 특이적인 항목을 위주로 한 단순하고도 판별력있는 항목의 개발이 필요하며, 이러한 항목들을 전산화하였을 때, 효과적인 소음성 난청의 선별검사 체계를 구축할 수 있을 것이다. Objectives : This study was performed to investigate the effectiveness of the questionnaire. Methods : Workers'health examination records, work environment record, and questionnaires of selected industries as samples were analysed using logistic regression analysis and discrimination analysis Results'Cases of bearing impairment (Dl+C) as dependent variables, and age, work duration and level of environmental noise as independent variables were selected for multiple unconditional logistic regression analysis. Odds ratio was 4.04 in hearing difficulty, 2.78 in tlnnitus and 1.08 in age. In the second analysis Noise induced hearing loss is selected as dependent variable. The OR in hearing difficulty was 3.67(95 % C.1. : 1.61 8.61), and was 1.09(95 % C.1. : 1.05-1.14) in age. Conditionnal multlple logistic regression analysis was performed. In hearing impairment as dependent variable, the OR of age was 1.02(95 % C.1. : 1.00-1.04) and other variables were not significant. However, NIHL as dependent, the OR of hearing difficulty was 4.57(95 % C.1. : 1.43-14.67). According to multiple logistic regression adopting each items of questionnaire as dependent variable, the only item of hearing difficulty showed significant difference with hearing ability. The discrimination analysis was performed with the class variable of hearing impairment, and discrimination variables of age, work duration, and environment noise level. The sensitivity of 59 %, and specificity of 88 %, and average error count of 23 % were obtained. When the numbers of items answered in questionnaire were assumed as the parameter of judgement for noise induced hearing loss (NIHL), the highest sensitivity and specificity were 33.5% and 49.0% in cases of more than two items answered. Conclusions : The development of items that is simple and discriminative mainly consisted of chronic and specific diseases related items is needed. Computerization for newly developed items might be needed to establish effective surveillance system for NIHL in the future.

여성생식계 상피세포에서 Glutathione S-Transferase 출현도에 관한 면역조직화학적 관찰

송계용,김석중,김미경,박용욱,유재형,박상철 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.2

Both placental form (GST-Pi) and basic form (GST-L) of glutathione S-transferase were studied in the epithelium of normal, tumor and tumor like lesions of female genital system. The results obtained were as follows : 1. Staining reaction of GST-Pi were moderate in normal cytotrophoblasts, mild in syncytiotrophoblasts, strong in corpus luteum, moderate to strong in salpingeal mucosa and in proliferative glands, moderate in secretory glands of indometrium and moderate in superficial squamous epithelium of cervix 2. Staining reaction of GST-L were mild in cytotrophoblasts and in syncytiotrophoblasts, of chorionic villi in corpus luteum, negative in salpingeal mucosa, very weak in proliferative glands, mild in secretory, glands of endometrium and in superficial squamous epithelium of cervix. 3. Staining reaction of GST-L were mild in cytotrophoblast and syncytiotrophoblast of choriocarcinoma, moderate in cytotrophoblasts, mild in syncytiotrophoblasts of hydatidiform mole, negative in mucinous epithelium of cust adenoma, in hyperplastia and adenocarcinoma, and mild in adenocarcinoma of cervix. 4. Staining reaction of GST-L were very weak in cytotrophoblasts and syncytiotrophoblasts of choriocarcinoma and in hydatidiform mole, negative in mucinous epithelium of cust adenoma, very weak in serous eptiethlium, negative to mild in hyperplastic and adenocarcinoma, mild in squamous cell carcinoma and adenocarcinoma of cervix. Therefore, staining reaction and distribution of GST-Pi and L isoengumes were different in normal and neoplastic cell of trophoblasts, salpinx, endometrin and cervix

농어촌 지역의 한방의료 이용 실태에 관한 조사 : 전남 신안군 장산면을 중심으로

宋峰根,黃忠演,文錫哉 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1

The prevalence of disease is affected by cultural factors. Changing cultural and social pattern may modify patterns of disease. Today majority of labor force in rural community is elderly population with a concomitant increase in woman. We investigated prevalence of problems in rural population utilizing oriental medical clinic in Changsan-myon, Shinan-gun, Chunnam. The majority of patients in this area were female and in the 40 to 60s. Muscoskeletal problems had the highest incidence. Low back pain was leading complaints in the muscoskeletal problems and knee pain was the most common complaints in the digestive problems, headache in the neurologic problems. cough in the respiratory problems, hypertension in the circulatory problems, ear problems in the sense organ problems, pruritys in the dermatologic problems, leukorrhea and postmenopausal syndrome in the gynecologic problems, and dysuria and enuresis in the urinary problems. These results suggest that oriental medical physicians have attention to health care and management of the expanding population of elderly and female patients with high incidence of muscoskeietal problems in the rural community.

국내의 Acinetobacter baumannii와 Pseudomonas aeruginosa 임상분리주에 대한 Colistin과 Polymyxin B의 감수성 양상

송원근,이태재,박민정,김한성,김재석,우흥정,이규만 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

배경 : 다약제 내성 Acinetobacter baumannii와 Pseudomonas aeruginosa에 의한 감염의 증가로 인해 기존의 치료제를 대신할 수 있는 colistin이나 polymyxin B와 같은 대체 항균제들이 사용되고 있다. 이에 국내에서 분리된 A. baumannii와 P. aeruginosa에 대한 colistin과 polymyxin B의 감수성 현황을 알아보고자 하였다. 재료 및 방법 : 국내 5개 대학병원에서 분리된 균주 중 ceftazidime과 imipenem의 감수성에 따라 93주의 A. baumannii와 99주의 P. aeruginosa를 선택하였다. 액체배지 미량희석법으로 colistin과 polymyxin B의 감수성을 시험하였다. 결과 : Ceftazidime과 imipenem이 감수성인 균주에서는 기타 β-lactam제, aminoglycoside제 및 ciprofloxacin에 대한 감수성율(각각 58-100%, 50-100%, 75-100%)이 높았으나, ceftazidime 또는 imipenem이 내성인 균주에서는 위의 항균제에 대한 감수성율이(각각 ≤31%, ≤47%, ≤18%)이 낮았다(P<0.05). Colistin과 polymyxin B에 대한 A baumannii (MIC_(50/90), 1/2 ㎍/mL)와 P. aeruginosa(MIC_(50/90), 1/1 ㎍/mL)에의 항균 범위는 거의 유사하였고 두 약제 모두 매우 우수한 항균력을 보였다. A. baumannii에서는 1주(1.1%)가 colistin 내성(MIC, 4 ㎍/ mL)이 었으나 polymyxin B에는 감수성(MIC, 2 ㎍/mL)이었으며 이외의 모든 A. baumannii와 P. aeruginosa는 colistin과 polymyxin B에 감수성(MIC, ≤2 ㎍/mL)이었다. 결론 : 국내에서 colistin과 polymyxin B에 둘 다 내성인 A. baumannii나 P. aeruginosa 감염은 없었다. 따라서polymyxin제를 다약제 내성 A. baumannii나 P. aeruginosa 감염에 대한 대체 항균제로 유용하게 사용할 수 있을 것으로 생각된다. Background : The emergence of multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa has become a major problem. The use of nontraditional agents such as colistin and polymyxin B have been tried. The purpose of this study was to evaluate the colistin and polymyxin B susceptibility of A. baumannii and P. aeruginosa isolates in Korea. Materials and Methods : According to susceptibility of ceftazidime and imipenem, selected 93 isolates of A. baumannii and 99 isolates of P. aeruginosa were collected from 5 university hospitals in Korea. Susceptibility to colistin and polymyxin B was tested using the reference broth microdilution method. Results : The rates of other β-lactams, aminoglycosides, and ciprofloxacin susceptibility were high (58-100%, 50-100%, and 75-100%, respectively) in ceftazidime- and imipenem-susceptible isolates but were low (≤31%, ≤47%, and ≤18%, respectively) in ceftazidime- or imipenem-resistant isolates (P<0.05). Colistin and polymyxin B displayed a nearly identical spectrum of activity, exhibiting excellent potency against A. baumannii (MIC_(50/90), 1/2 ㎍/mL) and P. aeruginosa (MIC_(50/90), 1/1 ㎍/mL). Only one of the A. baumannii isolates was resistant to colistin (MIC, 4 ㎍/mL), but the isolate was susceptible to polymyxin B (MIC, 2 ㎍/mL). Conclusion : In Korea, no A. baumannii and P. aeruginosa isolates were resistant to both colistin and polymyxin B. These data suggested that polymyxins may be alternative drugs for multidrug- resistant A. baumannii and P. aeruginosa isolates.

근골격계 질환 예방을 위한 재생타이어 트레드 버핑작업 개선에 관한 연구

김재열,한재호,이연신,김항우,오성민,송경석 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-

As a part of environmental pollution prevention and resources recycling, the regeneration of waste tire has been largely contributed to national industry. But, the worker has been evaded this regeneration process by reason of the best mischievous process condition among 3D industries.So, the first, the process condition of regeneratingwaste tire was analyzed. The second, the equipment or system was developed for the improvement of working strength and environment. The last, researchers intend to solve these problems

환경변화에 따른 대한스노우보드 협회의 조직전략 분석

한이석,김종필,송재현 龍仁大學校 體育科學硏究所 2002 體育科學硏究論叢 Vol.12 No.1

The Purpose of this project is on the following below. Through analyzing the structure of KSBA, We Would like to prescribe the factor of strength, weakness, opportunity and threat and investigate the environment and strategy of our association on those bases. Also, through onproving snowboarding skills of Korean Boarders and providing information for the popularization of snowboard, we would expect to win medals on snowboarding event at the Asian Game Aomory 2003. To achieve this goal, investigating KSBA with using Thibault et al.(1993) We found out the adequate constructional strategies and got the results. First, we have to have competitive power internationally through the intercommunications between the domestic and several international associations that are related to the snowboarding, and grope for the way to participate various competitions We also should attempt to amateur sports. Second, We should not make limitations on membership just to the professionals and make the standard of KSBA for the non-professional snowboarders to expand the public recreational sports. There Should be a structural tool to test the qualification as a snowboard instructor and We also need an internship program for the sport judge for the better capacity. Through those efforts, We can make a great improvement on the quality of the competition. Third, KSBA should have a good relationship with the member players of PSA Korea to produce a lot more volunteers, and can reduce the burden of finance. Finally we would choose adequate media which is suitable for characteristics of each events in snowboard competition and ensure it as a media sport. Then we have to secure the legal and economic status of our members throughout activation of pro-sports, and we have to show the way to the athletics with increase of sponsorship.

적외선 열화상 카메라를 이용한 Plume 형상에 따른 Nd:YAG 레이저 용접 결함 평가

김재열,유영태,양동조,송경석,노경보 한국비파괴검사학회 2003 학술대회 논문집 Vol.- No.1

In Nd:YAG laser welding, evaluation methods of welding flaw are various. But, the method due to plume shape is difficult to classification of welding flaw. The Nd:YAG laser process it known to have high speed and deep penetration capability to become one of the most advanced welding technologies. At the present time, some methods are studied for measurement of plume shape by using high-speed camera and photo diode. This paper describes the machining characteristics of SM45C carbon steel welding by use of an Nd:YAG laser. In spite of its good mechanical characteristics, SM45C carbon steel has a high carbon contents and suffers a limitation in the industrial application due to the poor welding properties. In this study, plume shape was measured by infrared thermal camera that is non-contact /non-destructive thermal measurement equipment through change of laser generating power, speed, focus. Weld was performed on bead-on method. Measurement results are compared as two equipments. Here, two results are composed of measurement results of plume quantities due to plume shape by infrared thermal camera and inspection results of weld bead include weld flaws by ultrasonic inspector.