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( Hyeon Joo Ham ),( In Jun Yeo ),( Seong Hee Jeon ),( Jun Hyung Lim ),( Sung Sik Yoo ),( Dong Ju Son ),( Sung-su Jang ),( Haksup Lee ),( Seung-jin Shin ),( Sang Bae Han ),( Jae Suk Yun ),( Jin Tae Hon 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.1
Recently, increasing evidence suggests that neuroinflammation may be a critical factor in the development of Parkinson’s disease (PD) in addition to the ratio of acetylcholine/dopamine because dopaminergic neurons are particularly vulnerable to inflammatory attack. In this study, we investigated whether botulinum neurotoxin A (BoNT-A) was effective for the treatment of PD through its anti-neuroinflammatory effects and the modulation of acetylcholine and dopamine release. We found that BoNT-A ameliorated MPTP and 6-OHDA-induced PD progression, reduced acetylcholine release, levels of IL-1β, IL-6 and TNF-α as well as GFAP expression, but enhanced dopamine release and tyrosine hydroxylase expression. These results indicated that BoNT-A had beneficial effects on MPTP or 6-OHDA-induced PD-like behavior impairments via its anti-neuroinflammation properties, recovering dopamine, and reducing acetylcholine release.
Liquid Silicone Rubber/Nano Silicon Carbide함량에 따른 나노콤포지트의 열전도와 부분방전 저항성 특성에 관한 연구
남진우(Jin-Woo Nam),임재현(Jae-Hyeon Lim),손민호(Min-Ho Son),함재진(Jae-Jin Ham),강정현(Jung-Hyeon Kang),유주열(Joo-Yeol Ryu),이보인(Lee Bo In),박재준(Jae-Jun Park),박익준(Park Ik Jun) 대한전기학회 2021 대한전기학회 학술대회 논문집 Vol.2021 No.7
Nano Silicon Carbide was modified with a vinyl group to strengthen the dispersibility and the bonding of the chemical interface between the silicon resin and the SiC surface. The modified nano SiC was charged and dispersed as 0, 1, 3, 5, 7, 9 wt%, and samples were prepared to evaluate partial discharge resistance, thermal conductivity, and (+) HVDC dielectric strength. Thermal conduction, partial discharge resistance, and dielectric breakdown strength were evaluated. The partial discharge resistance was studied continuously for 5kV/720Hz×500 hours with an IEC(B) electrode.
외상 후 스트레스장애로 진단된 화상 환자의 기질 및 성격차원 특성
윤석찬,함병주,변정현,은헌정,손현균,서국희,최인근,Yoon, Suk-Chan,Ham, Byung-Joo,Byun, Jeong-Hyun,Eun, Heon-Jeong,Son, Hyeon-Gyun,Suh, Kuk-Hee,Choi, Ihn-Geun 대한생물정신의학회 2005 생물정신의학 Vol.12 No.2
Objective:The aim of this study was to evaluate the temperament and character profiles of the patients with posttraumatic stress disorder(PTSD) after burn injury. Methods:The study subjects consisted of 23 PTSD patients after burn injury, 24 patients not being diagnosed as PTSD after burn injury(non-PTSD) and 53 healthy controls. The assessment of PTSD was performed using clinician administered PTSD scale. All participants were instructed to complete the Temperament and Character Inventory(TCI), the Beck Depression Inventory and the State and Trait Anxiety Inventory of Spielberger. Results:The PTSD group after burn injury, compared with the non-PTSD group and the normal controls, had the higher novelty seeking and harm avoidance scores. But there were no differences in other dimensions in the TCI among the three groups. Conclusion:The results of this study suggest that the PTSD group after burn injury showed the specific properties of temperament and character compared with the non-PTSD group and the normal group.
카이로프랙틱 처치가 인라인스케이트 선수들의 고관절 가동범위와 기록향상에 미치는 영향
이봉규(Lee, Bong-Kyu),정한석(Jung, Han-Suk),함주현(Ham, Joo-Hyeon),한승혜(Han, Seung-Hye) 한국웰니스학회 2021 한국웰니스학회지 Vol.16 No.4
본 연구는 카이로프랙틱 처치가 인라인스케이트 선수들의 고관절 가동범위와 기록향상에 미치는 영향을 알아보고자 하였다. 연구 대상자들은 대한롤러연맹 소속 18세 이상의 남, 여 인라인스케이트 선수 42명으로 선정하여 카이로프랙틱 집단(21명), 폼롤러 운동 집단(21명)으로 무작위로 배정하였다. 운동프로그램은 주 1회, 5주간, 총 5회 수행하였다. 프로그램 시행 전, 후로 고관절 가동범위와 인라인 트랙 200m 1바퀴 기록을 평가했다. 자료처리는 대응표본 t 검정(paired t-test)과 독립표본 t 검정(independent t-test)을 실시하여 다음과 같은 결과를 도출하였다. 카이로프랙틱 집단에서 고관절 신전, 굴곡, 외전, 내전, 외회전, 내회전 범위에서 통계적으로 유의한 결과를 나타냈으며(p<.05), 폼롤러 운동 집단에서는 고관절 내회전에서만 유의한 결과가 나타났다. 인라인 트랙 200m 1바퀴 기록에서는 카이로프랙틱 집단에서만 유의한 결과가 나타났다(p<.05). 결론적으로 본 연구를 통해 카이로프랙틱 처치가 인라인스케이트 선수들의 고관절 가동범위와 기록향상에 영향을 미치는 가능성을 제시하고 있으며, 향후의 연구에서는 기록향상에 미치는 영향을 정확하게 알아보기 위해 근력 테스트도 추가하여 다양한 대상자와 다양한 처치방법을 카이로프랙틱 처치와 비교하는 연구가 필요할 것으로 사료된다. The purpose of the study was to investigate the effect of chiropractic treatment on hip joint range of motion and record improvement of inline skate players. The subjects of this study were selected as 42 male and female inline skaters aged 18 or older from the Korean Roller Federation and randomly divided into two groups, the chiropractic group(21 skate players), foam roller exercise group(21 skate players). the exercise program was conducted once a week, for 5 weeks, and for a total of 5 times. before and after the program was implemented, measured hip joint range of motion and inline track 200m one lap record. data processing was conducted by Paired t-test, Independent t-test, the results are as follows. in the chiropractic group(p<.05), the results showed statistically significant increase in hip joint extension, flexion, abduction, adduction, external rotation, internal rotation. in the foam roller exercise group, the results showed significant increase only in hip joint internal rotation. in the record of one lap of 200m in the inline track, the result was significantly decreased only In the chiropractic group(p<.05). in conclusion, this study suggests the possibility of chiropractic treatment affecting hip joint range of motion and record improvement of inline skate players. in future studies. it is considered necessary to compare various subjects and various treatment methods with chiropractic treatment by adding strength test to accurately investigate the impact on record improvement.
( Dai Hyun Kim ),( Se Jeong Lee ),( Sung Jin Park ),( Min Seok Ham ),( Ji Hyuck Hong ),( Soo Hong Seo ),( Hyo Hyun Ahn ),( Young Chul Kye ),( Hyeon Soo Kim ),( Im Joo Rhyu ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Myokines could be associated with peripheral inflammation. The impaired skin barrier function triggers abnormal muscle contraction leading to an increased neurosensory response and neurogenic inflammation. Objectives: The aim of this study was to verify that the specific myokine, leukemia inhibitory factor (LIF), could have meaningful roles on aggravation of pruritus in chronic inflammatory skin disorders. Methods: An in vitro coculture model between dorsal root ganglion (DRG) neurons and keratinocytes was adopted for assessment of possible trophic effect. The activation of serial signaling pathways in DRG neurons by LIF and/or nerve growth factor (NGF) were examined. Results: LIF treatment to DRG neurons showed significant neurite outgrowth comparable with NGF. LIF also meaningfully affected axonal growth in coculture models. The LIF induced neurotrophic effects were effectively diminished by TrkA inhibitor, K252a. LIF application resulted in time- and dose-dependent tropomyosin receptor kinase A (TrkA) and Akt phosphorylation in DRG neurons. In addition, TrkA and Akt phosphorylation by LIF in DRG neurons were effectively prohibited with TrkA inhibitor, K252a respectively. Lastly, Akt phosphorylation induced by LIF was also meaningfully restrained by phosphoinositide 3-kinase (PI3K) inhibitor, LY-294002. Conclusion: LIF could cause increased neurite outgrowth and activation of TrkA/PI3K/Akt phosphorylation in DRG neurons.
죽음준비교육이 일반인의 연명치료중단 및 호스피스·완화의료에 대한 인식에 미치는 효과
총배령,이윤주,김수연,김슬기,김시애,김현지,남이,함석영,강경아,Tsung, Pei-Ling,Lee, Yoon Joo,Kim, Su Yeon,Kim, Seul Ki,Kim, Si Ae,Kim, Hyeon Ji,Nam, Yi,Ham, Suk Young,Kang, Kyung Ah 한국호스피스완화의료학회 2015 한국호스피스.완화의료학회지 Vol.18 No.3
목적: 본 연구에서는 일반인을 대상으로 죽음준비교육 프로그램이 연명치료중단 및 호스피스 완화의료에 대한 인식에 미치는 효과를 규명하기 위해 수행되었다. 방법: 본 연구의 죽음준비교육 프로그램은 총 5주에 걸쳐 진행되었으며 연구 대상자는 서울시 소재 일개구청과 대학교의 협력사업으로 진행한 죽음준비교육 참여자로 실험군 35명, 대조군 40명으로 총 75명이었고 사전 사후 측정은 자가 보고식 설문지를 이용하여 자료를 수집하였다. 결과: 죽음준비교육 후 호스피스 완화의료에 대한 인식은 실험군과 대조군에서 유의한 차이를 보이지 않았으나 연명치료중단 인식정도는 실험군이 대조군보다 유의하게 높은 결과를 보였다. 결론: 인간은 의미를 추구하는 존재로서 늘어나는 기대수명에 맞춰 삶의 질을 높이려는 욕구 또한 증가하고 있으며 자신의 삶의 마지막을 결정할 권리가 있는데, 본 연구결과는 인생의 마지막 순간에 자신의 삶을 결정하는 것에 대한 이론적 근거가 되었다고 본다. 또한, 일반인들에게 호스피스 완화의료에 대한 인식에 긍정적으로 영향을 줄 수 있는 죽음준비교육 프로그램 개발과 적절한 교육과정과 기간 및 교육방법에 대한 평가연구가 계속되어야겠다. Purpose: This study was done to analyze how a death preparation education program have the effects on awareness of hospice palliative care and withdrawing life sustaining treatment in older adults. Methods: This study employed a non-equivalent control group design among quasi-experimental designs. The experimental group was comprised with 35 adults and the control group with 40 adults. The death preparation program consisted of five two-hour sessions and was administered once a week for five straight weeks. Data were analyzed by descriptive statistics, t-test, ${\chi}^2$ test, Fisher's exact test, and ANCOVA using SPSS version 18.0. Results: The mean age of the participants was 66.2 years. A significant difference between the experimental and control groups was observed in withdrawing life sustaining treatment (F=3.380, P=0.040). However, no significant difference was found in awareness of hospice palliative care (F=0.163, P=0.850). Conclusion: The study results indicate that death preparation training could positively affect people's awareness of withdrawing life sustaining treatment. More studies should be conducted to explore effects of death preparation education for all ages and help people better understand hospice palliative care.
Go, Younghoon,Jeong, Ji Yun,Jeoung, Nam Ho,Jeon, Jae-Han,Park, Bo-Yoon,Kang, Hyeon-Ji,Ha, Chae-Myeong,Choi, Young-Keun,Lee, Sun Joo,Ham, Hye Jin,Kim, Byung-Gyu,Park, Keun-Gyu,Park, So Young,Lee, Chul- American Diabetes Association 2016 Diabetes Vol.65 No.10
<P>Hepatic steatosis is associated with increased insulin resistance and tricarboxylic acid (TCA) cycle flux, but decreased ketogenesis and pyruvate dehydrogenase complex (PDC) flux. This study examined whether hepatic PDC activation by inhibition of pyruvate dehydrogenase kinase 2 (PDK2) ameliorates these metabolic abnormalities. Wildtype mice fed a high-fat diet exhibited hepatic steatosis, insulin resistance, and increased levels of pyruvate, TCA cycle intermediates, and malonyl-CoA but reduced ketogenesis and PDC activity due to PDK2 induction. Hepatic PDC activation by PDK2 inhibition attenuated hepatic steatosis, improved hepatic insulin sensitivity, reduced hepatic glucose production, increased capacity for beta-oxidation and ketogenesis, and decreased the capacity for lipogenesis. These results were attributed to altered enzymatic capacities and a reduction in TCA anaplerosis that limited the availability of oxaloacetate for the TCA cycle, which promoted ketogenesis. The current study reports that increasing hepatic PDC activity by inhibition of PDK2 ameliorates hepatic steatosis and insulin sensitivity by regulating TCA cycle anaplerosis and ketogenesis. The findings suggest PDK2 is a potential therapeutic target for nonalcoholic fatty liver disease.</P>