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Screening of Antioxidant and AnticancerEffects from Flavonoids
강경아,Rui Zhang,Mei Jing Piao,박소윤,박지니,김주선,강삼식,현진원 대한암예방학회 2006 Journal of cancer prevention Vol.11 No.3
Reactive oxygen species (ROS) such as hydrogen peroxide, superoxide anion, and hydroxyl radical lead to damages of cellular molecules and are a cause of cancer. To find the anticancer compounds that scavenge the ROS, we have screened the antioxidant effect against DPPH radical and H2O2 induced oxidative stress from 39 flavonoids at 10μg/ml. (+)-Catechin and epicatechin at 10μg/ml were found to scavenge DPPH radical and intracellular ROS. We also investigated whether two compounds may show anticancer effect against cancer cells by MTT reduction assay. As a result, epicatechin showed the strongest cytotoxicity to U937 cells among NCI-H460, HeLa, U937, and MCF-7 cells. (Cancer Prev Res 11, 235-239, 2006)
강경아,Kang Kyung Ah 한국아동간호학회 1998 Child Health Nursing Research Vol.4 No.1
Suffering is a human burden that may not be truly avoidable. In order to put that view in perspective we must examine suffering in a form as isolated from self-inflicted behavior as possible. The suffering of a child is one such example. The purpose of this study is to understand the meaning of suffering in the teenager and is to analyze difference of suffering in children and adult. The subjects of this study were 6 childrens (12year-17year) including in-patients and out-patients of a general hospital who were diagnosed as having cancer. The data was collected from October 10, 1996 to April 15, 1997. Qualitative research methods of in-depth interview and participant observation were used for data collection. Data analysis progressed according to the fieldwork phases suggested by the Hybrid Model. According to the results of the study, the meaning of suffering in the teenager can be described as follows : Suffering is an inevitable experience of all human beings. When each child experiences pain and destroying child-adult relationship, suffering in which threaten one's personal integrity is perceived differently among each child depending on their personal inner factors, one's significant others, exterior circumstances and stimuli. Suffering brings severe and unendurable distress which accompany anguish, depression, anxiety and fear. This findings provide data for new insights of suffering. When caring for teenager who experience suffering, nurses need to consider the influence of suffering. Moreover, appropriate nursing interventions aimed at relieving suffering need to be developed.
애니메이션 영화를 활용한 초등영어 교수·학습 모형의 개발 및 적용
강경아,이제영,황치복 대한영어영문학회 2018 영어영문학연구 Vol.44 No.3
The purpose of this study was to investigate the effects of utilizing animation movies for teaching English language to elementary school students on their affective domain. To achieve these goals, 22 5th-grade students have learned English by using animation movie Finding Dory 12 times for a month. The students were given questionnaires for analyzing the effects of the treatment on the learner’s interest, confidence, participation and anxiety before and after the experiment. Paired-sample t-tests were implemented to find out whether the mean differences between two tests are statistically significant. The results indicated that a statistically significant improvement in the students’ interest and confidence. There were, however, no statistically significant differences in participation and anxiety. Based on the results of this study, pedagogical implications and suggestions for further research were discussed.
강경아 한국간호과학회 2001 Journal of Korean Academy of Nursing Vol.31 No.4
Purpose: This study was conducted to detect the correlations and the main factors influencing depression, life satisfaction, burden, defenition of suffering, meaning of life, and suffering. Method: The samples were composed of 160 cancer patients who were or outpatients of four hospitals in Seoul. The reliability of the 6 instruments was tested with Cronbach's alpha which ranged from .62 to .90. The data was analyzed using a SAS program for descriptive statistics, Pearson correlation coefficients, and stepwise multiple regression. Results: The results were as follows: 1. The scores on the suffering scale ranged from 132 to 40 with a mean of 87.3 (SD 17.5). 2. There were significant correlations between all the predictive variables and even the amounts of suffering (r=.27-.84, p〈.05). 3. Stepwise multiple regression analysis showed that depression was the main predictor of suffering, and accounted for 71.6% of the variance. In addition burden accounted for 4.6% of the variance in suffering. The two variables combined to account for 76.2% of the variance in suffering. Conclusion: In conclusion and depression, burden were identified as important variables in explaining the suffering of patients with cancer.
메뉴스토리텔링이 SNS구전의도에 미치는 영향 : 고객만족의 매개효과
강경아,김경자,강혜영 관광경영학회 2021 관광경영연구 Vol.104 No.-
In this study, the interest, uniqueness, and differentiation of menu storytelling in the restaurant market were examined by examining the relationship between the influence of SNS word of mouth intention, and the mediating effect of customer satisfaction between menu storytelling and SNS word of mouth intention, and seeking ways to sustain customer satisfaction. , to encourage small business owners to use menu storytelling for marketing. An empirical analysis was conducted through a questionnaire of 382 copies for customers who visit Gyeongju menu storytelling. It was confirmed that menu storytelling (interestingness, uniqueness, differentiation) had a significant effect on SNS word of mouth intention, and customer satisfaction plays a mediating role between menu storytelling and SNS word of mouth intention. It presents practical implications that a lively word-of-mouth effect can be expected through SNS through the development and composition of menu storytelling that emphasizes interest and differentiation from competitors through customer satisfaction through menu storytelling.
강경아,한상숙,이무형,김연정 경희대학교 동서간호학연구소 2008 동서간호학연구지 Vol.14 No.2
Purpose: To screen candidate oriental herb material for antimelanogenics. Methods: Oriental herbs (n=100) were screened for mushroom tyrosinase inhibitory activity in vitro using the HM3KO human melanin cell line cultured in DMEM supplemented with 10% fetal bovine serum. Cytotoxicity was assessed by a cell viability assay involving 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT), Trypan Blue exclusion, and cell enumeration. Results: Tyrosinase inhibitory effects on 100 oriental herbs was evident. Of these, 11 herbs inhibited tyrosinase activity by 40% without being cytotoxic to HM3KO cells. Three herb varieties significantly decreased melanin synthesis in HM3KO cells. Conclusions: Oriental herb can have antimelanogenic effects indicating their potential for functional therapeutic use in dermatological whitening
임상실습 시 간호학생의 성희롱 인식 정도가 성희롱 대처유형에 미치는 영향
강경아 기초간호학회 2018 Journal of korean biological nursing science Vol.20 No.2
Purpose: The purpose of this study was to investigate the relationship between the awareness of sexual harassment and the coping behavior of recipients of sexual harassment. This study also assesses the factors that influence the coping behavior of nursing students during clinical practice. Methods: For this descriptive study, data were collected from November 15 to December 15, 2017. Participants included 221 nursing students recruited from nursing colleges located in three different areas. Results: 22% of the participants answered that they had experienced sexual harassment. Regarding the type of attacker, the majority of attacker was patient(83.7%). The sexual harassment awareness level was 4.22±0.40, the degree of coping for those who experienced sexual harassment was 2.99±0.38. Among the coping behaviors, mitigation (3.48±0.39) was the highest. The factors influencing the coping behavior of recipients of sexual harassment were sexual harassment awareness (β=0.24, p=.016) and satisfaction with preventive education(β=0.45, p<.001). Conclusion: In order to make a safe clinical practice environment, it is necessary to develop a practical sexual harassment prevention program, as well as a reporting and support system for the nursing students. Such a program will help students clearly recognize the sexual harassment situation and increase their abilities to cope with sexual harassment appropriately.
강경아,장주동 한국아동간호학회 2003 Child Health Nursing Research Vol.9 No.1
Purpose: This study is to investigate the smoking experience and its related factors among adolescence. Method: The subject for this study consisted of 2711 students of middle, high school located in youngam-koon, chonnam. The data were collected by an anonymous questionnaire during the period from March. 1, 2001 to June. 20, 2001. Result: The frequency of cigaret smoker was 8%. The frequency of smoker in the high school was higher than that of smokers at the middle school. The motivation of smoking was curiosity and solicitation by friends, and the level of smoking was on average less than 10 cigarettes a day. The 72.2% of smokers started during the middle school period. Students who smoke had more positive attitude toward smoking than students who don't smoke. There were significant differences in there knowledge about the harmful effect of smoking between nonsmoker and smoker. Most smoking students thought that nonsmoking education is necessary for adolescents, even though they don't want to quit the smoking. The frequency of smoker was different between genders. Conclusion: An understanding of the characteristics of smoking of adolescence may provide guidance for preventive interventions with adolescents.
강경아,정유정,정채영 조선대학교 전자정보통신연구소 1999 電子情報通信硏究所論文誌 Vol.2 No.1
Formerly, various classical filtering method was suggested to reconstruct damaged images, however, it premised the matrix about WSS restricted condition and original reflection, and asked the complexity or calculation. Due to these problems, image restoration method, that uses the neural network model, recently started to be developed, a method that minimizes the energy of neural network as renewing the value of neuron repeatedly was suggested after it basically matched an error function of the image restoration problem with the energy function of neural network model. In order to reconstruct damaged images, many researchs are being alone for using an artificial neural network. In this monographs, using an artificial neural network, another model of neural network, suggests algorithm that can infer the original of this pattern with parts of damaged images and parts of images, and would like to apply to handwritten digits.