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( Hye Ri Ahn ),( Geum Ok Baek ),( Moon Gyeong Yoon ),( Chul Won Seo ),( Suna Sung ),( Ju A Son ),( Jung Woo Eun ),( Jae Yeon Cheong ),( Hyo Jung Cho ),( Soon Sun Kim ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Hepatocellular carcinoma (HCC) is the one of the most common cancers and lethal diseases in the world. Wiskott-Aldrich Syndrome Protein Family Member 2 (WAVE2) overexpression overexpression is reported in HCC. However, the regulation mechanism of WAVE2 and its effect on HCC progression is not well-known. We aimed to explore WAVE2 regulation mechanism through methylation study and WAVE2 role on HCC progression through in vitro study. Methods: Methylation status of WAVE2 was determined through profiling of promoter-region DNA methylation in HCC from The Cancer Genome Atlas (TCGA) data. Validation was performed with bisulfite-specific PCR sequencing and methylation-specific PCR analysis in 20 pairs HCC tissues with corresponding non-cancerous tissues. Targeted inactivation of WAVE2 using siRNA was performed in HCC cell lines and cell growth and proliferation were examined. Results: WAVE2 was significantly overexpressed in HCCs compared to non-tumor tissues and associated with poor prognosis in overall survival and disease-free survival of patients in TCGA data. Also, we found inverse correlation between DNA methylation and gene expression of WAVE2, and WAVE2 was significantly hypomethylated in human HCC compared to non-tumor. Targeted inactivation of WAVE2 suppressed cell growth and proliferation of HCC cells, and reduced the metastatic potential of HCC cells by selectively modulating epithelial mesenchymal transition regulatory proteins. Conclusions: We observed that WAVE2 is significantly overexpressed and hypomethylated in HCC. Also, WAVE2 up regulation is associated with poor prognosis in HCC patients. WAVE2 activation might be one of the key mechanisms during liver tumorigenesis and can be a candidate of therapeutic target for HCC.
Identification of electronic structure and structural phases in perovskite crystals
Hye Ri Jung(정혜리),Trang Thi Thu Nguyen,Hye-Jin Jin(진혜진),Bich Phuong Nguyen,Seokhyun Yoon(윤석현),William Jo(조윌렴),Won Seok Woo(우원석),Chang Won Ahn(안창원),Shinuk Cho(조신욱),Ill Won Kim(김일원) 한국신재생에너지학회 2017 한국신재생에너지학회 학술대회논문집 Vol.2017 No.9
Jung, Hye Ri,Kim, Gee Yeong,Nguyen, Bich Phuong,Jin, Hye-Jin,Jo, William,Thu Nguyen, Trang Thi,Yoon, Seokhyun,Woo, Won Seok,Ahn, Chang Won,Cho, Shinuk,Kim, Ill Won American Chemical Society 2017 The Journal of Physical Chemistry Part C Vol.121 No.40
<P>Hybrid lead halide perovskite possesses attractive properties and outstanding performance. The electronic structure of hybrid lead halide perovskite single crystal can be used to comprehend its intrinsic properties. In this study, the crystal structure of CH3NH3PbBr3 perovskite crystal was elucidated by transmission electron microscopy. Phonon modes and CH3NH3+ rocking modes were analyzed. Band gaps of the crystal were obtained by temperature-dependent Raman scattering spectroscopy and photoluminescence measurement. Surface potential measurement for a (001) plane exhibited a work function of the material and other phases of PbBr2 and CH3NH3Br. From experimentally determined values, an electronic structure of CH3NH3PbBr3 was built. It showed a p-type characteristic.</P>
증강현실(Augmented Reality) 기술을 활용한 미술교육 - ARToolKit에 기초한 프로그램 개발을 중심으로 -
안혜리(Hye-Ri Ahn),천두만(Doo-Man Chun),안성훈(Sung-Hoon Ahn) 한국미술교육학회 2005 美術敎育論叢 Vol.19 No.3
최근 가상현실(virtual reality 또는 VR)과 구분되는 개념으로서 다양한 분야에 응용되고 있는 증강현실(augmented reality 또는 AR) 기술에 대한 관심이 국내외 학계에서도 고조되고 있다. 본 논문은 이에 주목하면서 미술교육 분야에 AR 기술이 어떻게 활용될 수 있는지를 분석하였다. AR은 현실 환경을 기반으로 컴퓨터에서 생성한 가상의 정보를 부가함으로써 현실세계에 대한 사용자의 인식을 향상시키는 기술이다. AR은 새로운 교수-학습 매체로서 미술교육에 많은 가능성을 제공할 수 있다. 즉 조각, 공예, 건축 등 3차원의 시각적 정보에 대한 학습자의 인식을 향상시키고 현실환경에 기반하므로 미술학습의 내용을 실생활에 쉽게 적용할 수 있다. 또한 실시간 상호작용이 가능하므로 교사와 학생 모두에게 융통성있고 개별화된 미술교육을 제공할 수 있다. 본 연구에서는 증강현실 개발도구의 하나인 ARToolKit를 이용하여 미술교육용 프로그램을 개발하였다. ARToolKit에 기초한 프로그램의 구성을 제시하고, 이 프로그램을 활용하면 효과적이라고 생각되는 미술교육 사례로서 자연물과 조형물에서 입체 기본형 탐구학습과 입체조형물의 공간에 대한 학습을 소개하였다. Today, the augmented reality or AR as a concept different from virtual reality has been given a great attention. AR is a combination of a real environment and a virtual information that augments a user's perception and performance of the real world. This study has examined how the AR technology can be used in art education. The AR has a tremendous potential as a new teaching and learning technology for art education. For example, it enhances learner's perception of 3-D visual information including sculpture, crafts, and architecture. Also, it is interactive in real time that makes art education authentic and learner-centered. The AR system developed in this research was built on top of ARToolKit, which is an open architecture AR development program. The icons captured by digital camera were identified by the AR program, and pre-designed three-dimensional CAD objects substituted the icons. Then the display device showed overlapped image of the original picture and the CAD model. Using this program, the study suggests cases for learning 3-D typeforms found in nature and art objects and space around them.
Kang, Hye-Ri,Cheong, Woo-Chang,Park, Ji-Eun,Ryu, Seungbo,Cho, Hye-Jeong,Youn, Hyunyee,Ahn, Jin-Hyun,Song, Moon Jung American Society for Microbiology 2014 Journal of virology Vol.88 No.12
<P>Upon viral infection, type I interferons, such as alpha and beta interferon (IFN-α and IFN-β, respectively), are rapidly induced and activate multiple antiviral genes, thereby serving as the first line of host defense. Many DNA and RNA viruses counteract the host interferon system by modulating the production of IFNs. In this study, we report that murine gammaherpesvirus 68 (MHV-68), a double-stranded DNA virus, encodes open reading frame 11 (ORF11), a novel immune modulator, to block IFN-β production. ORF11-deficient recombinant viruses induced more IFN-β production in fibroblast and macrophage cells than the MHV-68 wild type or a marker rescue virus. MHV-68 ORF11 decreased IFN-β promoter activation by various factors, the signaling of which converges on TBK1-IRF3 activation. MHV-68 ORF11 directly interacted with both overexpressed and endogenous TBK1 but not with IRF3. Physical interactions between ORF11 and endogenous TBK1 were further confirmed during virus replication in fibroblasts using a recombinant virus expressing FLAG-ORF11. ORF11 efficiently reduced interaction between TBK1 and IRF3 and subsequently inhibited activation of IRF3, thereby negatively regulating IFN-β production. Our domain-mapping study showed that the central domain of ORF11 was responsible for both TBK1 binding and inhibition of IFN-β induction, while the kinase domain of TBK1 was sufficient for ORF11 binding. Taken together, these results suggest a mechanism underlying inhibition of IFN-β production by a gammaherpesvirus and highlight the importance of TBK1 in DNA virus replication.</P><P><B>IMPORTANCE</B> Gammaherpesviruses are important human pathogens, as they are associated with various kinds of tumors. Upon virus infection, the type I interferon pathway is activated by a series of signaling molecules and stimulates antiviral gene expression. To subvert such interferon antiviral responses, viruses are equipped with multiple factors that can inhibit its critical steps. In this study, we took an unbiased genomic approach using a mutant library of murine gammaherpesvirus 68 to screen a novel viral immune modulator that negatively regulates the type I interferon pathway and identified ORF11 as a strong candidate. ORF11-deficient virus infection produced more interferon than the wild type in both fibroblasts and macrophages. During virus replication, ORF11 directly bound to TBK1, a key regulatory protein in the interferon pathway, and inhibited TBK1-mediated interferon production. Our results highlight a crucial role of TBK1 in controlling DNA virus infection and a viral strategy to curtail host surveillance.</P>
Optical Probing of the Electronic Interaction between Graphene and Hexagonal Boron Nitride
Ahn, Gwanghyun,Kim, Hye Ri,Ko, Taeg Yeoung,Choi, Kyoungjun,Watanabe, Kenji,Taniguchi, Takashi,Hong, Byung Hee,Ryu, Sunmin American Chemical Society 2013 ACS NANO Vol.7 No.2
<P>Even weak van der Waals (vdW) adhesion between two-dimensional solids may perturb their various materials properties owing to their low dimensionality. Although the electronic structure of graphene has been predicted to be modified by the vdW interaction with other materials, its optical characterization has not been successful. In this report, we demonstrate that Raman spectroscopy can be utilized to detect a few percent decrease in the Fermi velocity (<I>v</I><SUB>F</SUB>) of graphene caused by the vdW interaction with underlying hexagonal boron nitride (hBN). Our study also establishes Raman spectroscopic analysis which enables separation of the effects by the vdW interaction from those by mechanical strain or extra charge carriers. The analysis reveals that spectral features of graphene on hBN are mainly affected by change in <I>v</I><SUB>F</SUB> and mechanical strain but not by charge doping, unlike graphene supported on SiO<SUB>2</SUB> substrates. Graphene on hBN was also found to be less susceptible to thermally induced hole doping.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2013/ancac3.2013.7.issue-2/nn305306n/production/images/medium/nn-2012-05306n_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn305306n'>ACS Electronic Supporting Info</A></P>