Clinical Significance of Classification of Graves` Disease According to the Characteristics of TSH receptor Antibodies

(Won Bae Kim),(Hyun Kyung Chung),(Young Joo Park),(Do Joon Park),(Hong Kyu Lee),(Bo Youn Cho) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.3

N/A Background:It has been widely accepted that the epitope (s) and/or functional characteristics of thyrotropin receptor antibodies (TSHRAb) from Graves` patients are heterogenous among patients. However, the clinical significance of such heterogeneity has not been systematically evaluatedyet. We were to elucidate and find the clinical significance of heterogeneity for TSH receptor antibodies in Graves` disease. Methods:We measured stimulating TSHRAb (TSAb) activities using CHO-hTSHR cells, FRTL-5 cells and chimeric receptor expressing cells (Mc1+2 and Mc2), specific blocking TSHRAb (TSBAb) activities using Mc2 cells and TBII activities using porcine thyroid membrane in 136 patients with untreated hyperthyroid Graves` disease. Results: Based on various TSHRAb activities from each patient, the patients could be categorized into 7 subgroups by cluster analysis; 1) Group 1 (n=41) was characterized by moderate TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, typical TSAb epitope, rare blocking antibodies and high TBII activities. 2) Group 2 (n=16) was characterized by the presence of blocking TSHRAb in most patients, albeit the other characteristics were the same as those in Group 1. 3) Group 3 (n=19) patients had low TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, seldom had blocking TSHRAb, but they had high TBII activities. 4) Group 4 (n=30) could be categorized as `mild disease` group, as they had low activities in all kinds of TSHRAb assay and had low antim icrosomal antibody activities. 5) Group 5 (n=14) was characterized by moderate TSAb activities with atypical epitope (s), rare blocking TSHRAb and moderate TBII activities. 6) Group 6 (n=10) patients had veryhigh TSAb activities with typical epitopes, seldom blocking TSHRAb and low TBII activities. 7) Group 7 (n=6) was characterized by very high TSAb activities with atypical epitopes and high TBII activities. Pretreatment serum thyroid hormone level was low only in group 4 patients compared to the other 6 groups (p<0.05). The size of goiter was significantly larger in those in group 1 and group 3 (p<0.05) compared to the other 5 groups. The prevalence of clinically significant ophthalmopathy was higher in group 2 patients than the other 6 groups (50%vs.27.5%,p=0.06). Among 6 kinds of TSHRAb activities, only the blocking TSHRAb activity was significantly associated with the presence of ophthalmopathy in multivariate analysis. Conclusion:These results suggest that the differences inepitopes for TSAb or the presence of blocking TSHRAb is not a major factor in determining the degree of thyrotoxicosis in Graves` disease. Although the pathogenic mechanism is not clearyet, we suggest that patients with ophthalmopathy have different TSHRAb repertoire from those without ophthalmopathy in Graves` disease.

양극성 정동장애와 혈청 Inositol-1-phosphatase 활성도 변화

조현주,김영철,우행원,연규월,조기승 대한생물치료정신의학회 1998 생물치료정신의학 Vol.4 No.2

Objects : Several lines of possibilites have been oroposed about the etiology of bipolar attective disorder in biological, genetic and psychosocial aspect. The purpose of this study is to inspect the etiology of bipolar affective disorder in biological aspect by measuring the changes of serum inositol-1-phosphatase activity and investing a causal relationship between clinical symptoms and serum inositol-1-phosphatase activities in patients with bipolar affective disorder. Methods : The subjects were 18 inpatients who met DSM-IV diagnostic criteria for bipolar I affective disorder, manic episode and 15 normal controls. Inositol-1-phosphatase activities were measured in serum by using spectrophotometer. Clinical symptoms of patients were assessed by YMRS at admission day and after 2 weeks lithium treatment. Results : 1) Inositol-1-phosphatase activities of the patients were increased to about 2 times as compared with those of normal controls. And the activity levels were decreased gradually to the normal at 14 days. 2) Young's Mania Rating Scale(YMRS) scores were decreased significantly by lithium treatment. 3) Statistical significance could not be found between the change of YMRS scores and the levels of inositol-1-phosphatase activity. Conclusion : In this study, statistical significance could not be found between clinical improvement and inositol-1-phosphatase activities, but the fact that lithium treatment improve the clinical manifestation shown by YMRS score changes, and reverse the increased inositol-1-phosphatase activities suggests the strong association between pathophysiology of bipolar affective disorders and inositide metabolism.

國·公有地 管理體系에 관한 國際比較

조주현 건국대학교 1997 政治論叢 Vol.32 No.-

住居密度가 住宅價格에 미치는 影響에 관한 硏究

조주현 建國大學校 社會科學硏究所 1998 社會科學論叢 Vol.3 No.-

The major purpose of this paper is to measure the magnitude and significance of the impact of housing density on housing price. In order to pursue this objective, we employ hedonic model using Seoul apartment data. Through regression analysis, we found following facts: 1)Housing density represented by floor area ratio has a significant impact on reduction in housing price. 2)This trend becomes stronger year after year. 3)However, during those years of 1990 and 1992, this trend is less persuasive. 4)The causes of this weak relationship in these years might be downturn of overall housing market and the changes in regulations on housing density, which in turn, lower the level of expectation in capital gains on housing.

Development of a Chest‑Belt‑Type Biosignal‑Monitoring Wearable Platform System

Joo‑Hyeon Lee,Hyun‑Seung Cho,Jin‑Hee Yang,Sang‑Min Kim,Jeong‑Whan Lee,Hwi‑Kuen Kwak,Je‑Wook Chae 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.4

The purpose of this study was to develop a wearable platform system that can detect and acquire a soldier’s biosignals (i.e., heart activity signal, respiration rate, etc.) in a nonrestrained, unconscious manner. These detected biosignals are transmitted to a processing device to analyze and monitor the soldier’s physical status. To achieve this, textile-based heart activity electrodes and a strain gauge sensor for the respiration signal measurement were developed, and their performances in detecting each signal were verifed. These sensors were embedded in a chest belt to design a wearable platform that can simultaneously measure heart activity and respiration signals. The sensor part of the chest belt has a dual layer structure to detect high-quality signals. Stretch fabric was used on the outer layer and a respiration sensor was attached to the belt. On the inside layer, a non-stretch fabric was used as the base fabric and a heart activity-sensing electrode, that is capable of taking measurements using a modifed lead-II heart activity signal induction method, was embroidered onto the fabric. Subjects were asked to wear the chest belt, and a biosignal processor module was attached to verify the system’s performance while simultaneously acquiring the heart activity and respiration signals. More specifcally, it was confrmed that the two signals were detected in a stable. It is expected that the biosignal-monitoring wearable platform system developed in this study will be able to efectively analyze and monitor soldiers’ biosignals.

不動産 開發商圈 推定의 合理化 方案硏究

曺周鉉 建國大學校 社會科學硏究所 1996 社會科學論叢 Vol.1 No.-

The major purpose of this paper is to introduce theories of location and allocation of retail stores in relation to the consumer behavior of store choice. These theories are then applied to various situations of store location. Also, current status of art in estimation of trade area in Korea is presented and analyzed in relation to the advanced theories and techniques. Finally, public regulaions on store location in apartment complexes are critically reviewed. In the theoretical part, we formally specifies the relationship between shopping frequency and hierarchy of goods and stores. This theory can explain most of the competition and location among retail stores. However, this classical theory can not explain the joint purchase behavior nd location of shopping centers. Shopping center attraction model may be an alternative for this situation if certain parameter values are given. On the technical side, three approaches can be adopted depending on the type of stores: Spatial Monopoly, Market Penetration, and Dispersed Market Approach. As the variation of costs and required expertise is wide even in one approach, great care should be given when we apply those techniques in estimation. In the empirical study, we found that many studies in Korea are misusing and/or abusing the techniques and unit data developed in advanced countries. Also found is the underutilization of existing studies that show whole spectrum of variation of market data in Korea. Current regulations on retail locations are also truned out to be irrelevant in view of the structural changes in retail market.

小賣商店의 立地決定模型에 관한 理論的 考察

曺周鉉 건국대학교 행정대학원 1991 建國大學校 行政大學院 硏究論叢 Vol.19 No.-

젠더정치의 “위기” : 섹슈얼리티의 지형 분석을 중심으로

조주현 이화여자대학교 한국여성연구원 2006 여성학논집 Vol.23 No.2

This work tries to analyze and understand the ways in which women’ssexuality has unfolded in Korean society since the mid-1990s focusing on itssexual politics and the new terrain feminist sexual politics, in response, hasstriven to establish in contemporary Korean society. Especially, it will be shownthat the sexual politics that had been previously practiced, based on the identityof "pure heterosexual women suffering defenselessly under male violence," reveals various lacunae in the realms of both heterosexism and sexual violence. Flourishing discourses of fun/pleasure and deeping intersectionality of sexualityin recent Korean society partly reflect these lacunae or more specifically inefficacy and inadequacy of currently dominant sexual politics. The discussion ofeach realm proceeds by focusing on a specific event that occurred or issues anddiscourses thus raised in Korean society recently. These include the lesbianrights movement, cyberporn, the legislation process of the new acts onprostitution, and the Milyang sexual violence case. 이 글은 1990년대 중반 이후 한국사회의 젠더정치의 “위기”를 가져온 여성체험의차이들이 여러 사회체계들의 상호교차에 의해 구성되고 있는 것임을 섹슈얼리티의 지형 분석을 중심으로 드러내려는 것이다. 그동안 젠더정치가 “순결한 이성애여성” 정체성에 근거해 젠더 억압을 중심으로 여성을 결집시킬 수 있었다면, 1990년대 중반 이후의 젠더정치는 그 같은 정체성에 근거한 젠더 체계로 여성들을 결집시킬 수 없을 정도로 젠더, 계급, 섹슈얼리티, 국가정책 체계들의 상호교차를 통해 여성들의 정체성이 재구성되고 있다. 이 연구는 체계들 간의 상호교차성에 주목함으로써 여성체험의 차이들을 배제시키지 않는 여성운동의 공간을 찾아나갈 수 있음을 주장한다.

再開發ㆍ再建築 事業推進上의 問題點과 改善方案에 관한 硏究

曺周鉉 건국대학교 1995 學術誌 Vol.39 No.1

Urban redevelopment and Housing Reconstruction projects become a profitable business in large cities in Korea as large-scale developable land is getting scarce. Those projects are evaluated and compared with each other in terms of housing supply effect change in population and household density, and financial structure. Also major factors that the success of the projects are identified as construction period, reallocation ratio, and the ratio of public land. Major problems in the process of urban housing redevelopment projects are ; 1) vagueness of the designation criteria of redevelopment area, 2) city government's guidelines that conflict with law and ordinance, 3) serious dependency on market force, 4) corruption in the process of contractor selection, 5) illegal trade of housing rights, and 6) adverse effect on tenants' housing status. As for the apartment reconstruction projects, the whole process is controlled only in view of physical aspects. And negligence of maintenance is serious when reconstruction is expected. Several policy directions are recommended as follow : First more extensive public intervention is needed. In particular, technical and financial assistance, comprehensive redevelopment plans, and continuous monitoring systems are urgent. Second, the designation criteria of redevelopment area should include the socio-economic characteristics of residents as well as physical state of housing. Third urban redevelopment and reconstruction policies should be integrated and coordinated with general housing urban, and social welfare policies. Finally, diverse redevelopment methods should be adopted in consideration of the variations in the topography, physical rotate of housing and housing land, and the specific needs of the residents.

土地開發에 있어서 民間活力의 導入

曺周鉉 건국대학교 행정대학원 1993 建國大學校 行政大學院 硏究論叢 Vol.21 No.-