실리콘의 TMAH 식각을 사용한 Suspended-type 마이크로 가스센서의 제조

김현호,이상문,임준우,강봉휘,정완영,이덕동 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

In recent years, different types of microfabricated 'suspended-type' structure have been used as freestanding membranes for a variety of micro gas sensors. We examined the silicon etching characteristics of tetramethyl ammonium hydroxide(TMAH). A suspended type micro gas sensor with platinum heater, sensing electrode and temperature sensor using TMAH etching of silicon was fabricated on silicon nitride(1,500Å)/ silicon dioxide (3,000Å)/ silicon nitride(1,500Å) dielectric membrane. It has low thermal conductivity and balanced stress with silicon substrate for the purpose of improving the thermal isolation between heater and silicon substrate. To avoid any chemical or physical damages to gas sensing material during the photolithography or shadow mask process, the tin dioxide film was deposited onto whole surface of device by using maskless electron beam(e-beam) evaporation technology. The power consumption of the fabricated device was about 40mW at the operating temperature of 250°C. In case of adding Pt(2wt.%) or Pd(2wt.%) catalyst, the sensitivity to CO was higher and the sensitivity to C_(4)H_(10) was higher than those to other gases, respectively.

특발성 혈소판감소성 자반증 환자에서 발생된 그레이브스병 1예

김여주,이규택,김상진,김휘준 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

The autoimmune nature of idiopathic thrombocytopenic purpura(ITP) and Graves' disease has been well established. In both disease, circulating immunoglobulins are believed to be involved in the pathogenesis and transplacental transfer of both disease is the ultimate proof of the importance of the humoral mechanism involved. Because of the tendency of autoimmune disease to cluster in the same individual or members of the same family, simultaneous incidence of ITP and Graves' disease is to be expected. However, in clinical practice, it has been described only rare. Therefore, we report here the case of a patient suffering sequentially from ITP and Geaves' disease with the literature.

수혈혈액 신청에 있어서 신중성을 기하기 위한 조사 : 순천향 천안병원의 혈액반환양 및 반환사유분석을 중심으로 Focusing on the Amount of Returned Blood and Causes of Return in Soonchunhyang Chunan Hospital

김휘준,김일호,길윤경 순천향대학교 1994 논문집 Vol.17 No.4

Careful blood requesting is very important to minimize wastage of precious blood. Excessive blood request causes increased return of unused blood and unnecessary loss in the process of return to blood bank. The standards of the American Association of Blood Banks(AABB) require that blood must be maintained continuously between 1 and 10℃ and most transfusion services have adopted a 30 minutes limit on the time that blood can be out of a monitored refrigerator. Many units of blood were discarded because they had been out of blood bank refrigerator for over 30 minutes. We investigated returned and discarded units of blood and causes of them in our hospital for 6 months. The results were obtained as follows 1. Among the total 14223 units issued, 367 units(2.6%) of blood were returned. The returned rate of each blood component: Whole blood(4%), platelet concentrate(3.4%), packed red cell(3.0%), fresh frozen plasma(0.96%). 2. The department of services that accounted for greatest return of blood units was chest surgery(7.2%) and the next order was OB and GYN surgery(3.9%), and neurosurgery(3.3%). 3. The most common causes of returned units of blood was improvement of patient's condition(51.8%) and the next order was expire(21.3), voluntary discharge(18.1%), transfer(3.3%), transfusion reaction(2.5%), fear for AIDS(1.6%) and refusal for therapy(1.4%). 4. When the units of blood were returned on account of the improvement of patient's condition, the range of Hb was 9.1-18.0/dl in the patients of surgery group and 9.1-14.0/dl in internal medicine respectively. Above results suggest that excessive blood request causes increased return of unused blood and unnecessary loss of blood units and that clinicians should request blood out of consideration for various situation including Hb level and patient's condition to minimize wastage of precious blood.

외상환자에서 전신성 염증 반응 증후군 (Systemic Inflammatory Response Syndrome)의 발생과 혈청 TNF-α와의 관계

김현,이강현,임종천,조준휘,오범진,황성오 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.4

Background and purpose: The systemic inflammatory response syndrome(SIRS), as defined recently by critical-care specialists, may result from various etiologies including infection, burn, or trauma. The purpose of this study was to determine whether TNF-αis associated with the development of systemic inflammatory response syndrome caused by multiple trauma. Methods: The study population consisted of 21 patients with multiple trauma presented emergency department within 2 hours after insult were enrolled in this study. Multiple blood samples were serially drawn to measure serum TNF-αlevel on admission, 12 hours, 24 hours, and every day until 5 days after injury. Serum TNF-αwas measured by ELISA ("Sandwich type"). Blood samples of fifteen volunteers were used as a reference value for serum TNF-α. Results: Serum TNF-αlevels of SIRS group were persistently elevated above reference value until 3 days after on admission. Peak serum TNF-αlevel at 12 hours after admission was higher in SIRS group than non-SIRS group(p<0.05). There was no significant correlation between injury severity score and TNF-αlevels on regression analysis, all patients with ISS higher than 16 had SIRS. No one had SIRS among patients with ISS less than 16. Conclusion: The result of this study suggests that persistent elevation of TNF-αand degree of injury severity are associated with the development of systemic inflammatory response syndrome in multiple trauma.

1998-1999년에 임상 검체로부터 분리된 주요 세균의 항생제 내성

김휘준,조성란 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2

Surveillance of antimicrobial resistance can provide information needs for empirical therapy of antimicrobial agents and for control of resistance. To determine the trend of antimicrobial resistance in Soonchunhyang Chunan Hospital, we analyzed in vitro susceptibility and identification data in 1998 and 1999. The results showed that cefoxitin-resistant Escherichia coli and Klebsiella pneumoniae and 3rd-generation cephalosporin-resistant K. pneumoniae, Enterobacter cloacae, and Serratia marcescens were prevalent, that fluoroquinolone-resistant Acinetobacter baumannii had increased, and imipenem-resistant Pseudomonas aeruginosa were prevalent. Oxacillin-resistant Staphylococcus aureus and penicillin-resistant pneumococci were prevalent. An increase of imipenem-resistant P. aeruginosa and vancomycin-resistant Enterococcus faecium is a new obvious threat. To prevent the spread of multi-resistant bacteria and the emergence of new resistance, continuous monitoring of antimicrobial resistance, appropriate use of antibiotics, and control of nosocomial infection are necessary.

Malassezia sympodialis가 동정된 신생아 Malassezia 농포증 1예

김휘준,이무형,안규중 대한의진균학회 2001 대한의진균학회지 Vol.6 No.4

Neonatal Malassezia pustulosis can be defined as pustules on face and neck, age at onset younger than 1 month, isolation of Malassezia by direct microscopy in pustular material, elimination of other causes of neonatal pustuloses, and response to topical ketoconazole therapy. We report a case of neonatal Malassezia pustulosis in a 20-day-old male. Direct microscopic examination on smears for pustules showed forms of Malassezia yeasts and culture yielded Malassezia sympodialis. The lesions were remarkably improved by topical ketoconazole cream for 14 days. [Kor J Med Mycol 6(4): 229-231] Key Words: Neonatal Malassezia pustulosis

다발성골수종의 형태학적 분류 및 임상 소견에 관한 연구

김휘준,이동화,이성희 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1

1984년 1월부터 1992년 12월까지 9년간 순천향대학병원에서 다발성골수종으로 진단된 28명의 환자를 대상으로 임상 검사 소견 및 생존 기간을 분석하고, 골수천자도말에서 형질세포 분화 정도에 따른 형태학적 분류를 하고, 골수생검상 형질세포 침윤 양샹에 따른 분류를 한 후 이와 같은 분류가 임상 경과 및 예후와 어떤 관련이 있는지를 알아 보았다. 1. 골수천자도말에서 형질세포 분화 정도에 따른 분류를 하여 mature형과 immature형을 비교한 결과 진단 당시 임상 및 혈액학적 변수들간에 유의한 차이는 없었다. 2.골수생검상 형질세포 침윤 양상에 따른 분류를 하여 diffuse형과 packed형 을 비교한 결과 진단 당시 임상 및 혈액학적 변수들간에 유의한 차이는 없었다. 3. 위와 같은 분류가 예후 추정인자로서 의의가 있는지를 알아 보기 위해 평균 생존율을 구해 보았으나 유의한 차이는 없었다. 이상과 같은 결과는 본 연구의 증례가 너무 적었고, 처음 진단이 늦었으며 대부분의 환자가 고령이어서 일찍 치료를 포기한 이유로 생각되며, 추후에 더 많은 증례에 대한 연구가 계속되고 환자에 대한 교육을 실시하여 추적 관찰을 계속한다면 위와 같은 분류 방법이 다발성골수종의 예후를 추정하는데,유용한 지표로 사용될 수 있으리라 사료된다. The maturity of myeloma cells in the bone marrow aspirates and the pattern of infiltratin in the biopsy are known to be highly significant in predicting the prognosis. This study was performed to analyse clinical. hematological, and morphological features of the bone marrow smears and biopsy in multiple myeloma at the time of diagnosis and investigate the correlation between clinical and pathologic findings for the evaluation of survival rate. The subjects for the study were 28 cases of multiple myeloma from January 1984 to December 1992 diagnosed at Soonchunhayang University Hospital. There were no statistical differences between clinical parameters and cell types and pattern of infiltrating in the bone marrow. And there were no statistical differences in survival rate depending on the cell types and pattern of infiltration pattern in the bone marrow. Above findings seemed to be resulted from insufficient subjects and failure of complete follow-up study. However, if a cooperative study of the impact of morphological classification in myeloma is performed in the future, morphological classificatin of myeloma could be considered as a prognostic factor.

Unity 3D를 이용한 3D어드벤처 퍼즐 게임

배준휘, 안성옥, 김수균 배재대학교 공학연구소 2016 공학논문집 Vol.18 No.1

This is configured in a 3D adventure puzzle game game , add a story to the fact that can be somewhat boring in the puzzle game , it has given the features that enhance the driving particle size in the game . Map that was produced directly using the 3DS Max uses the Unity 3D engine to produce a dark atmosphere to become the story , was implemented in accordance with the terrain engine and animation in the game . But is not high degree of freedom because the adventure game , since it is possible to know whether or not what to do but rather clearly , It increases even more immersive degree. 3D 어드벤처 퍼즐게임으로 구성된 이 게임은 퍼즐게임에서의 다소 지루할 수 있는 것에 스토리를 추가하여 게임에 몰입도를 높이는 특징을 주고 있다. 3DS Max를 사용하여 직접 제작한 맵은 스토리와 어울리게 어두운 분위기를 연출하고 Unity 3D엔진을 이용해서 지형엔진과 애니메이션을 게임에 맞게 구현하였다. 어드벤처 게임이다 보니 자유도가 높지는 않지만 오히려 뚜렷하게 무엇을 해야 하는지 알 수 있기 때문에 더욱 더 몰입도를 높여준다.

한국인 음주자들의 혈청 Gamma Glutamyl Transferase 활성도에 관한 연구

金輝俊,安智榮,金昌世 순천향대학교 1992 논문집 Vol.15 No.2

The enzyme r-glutamyl transpeptidase(GGT) catalyzes the hydrolysis of r-glutamyl peptides such as glutathione and the transfer of their r-glutamyl moieties to amino acids and peptides. Since GGT was discovered in 1950 by Hanes et al., it has been established as useful supportive liver function test in various hepatobiliary diseases. Since Zein et al. found in 1970 that serum GGt activities were markedly increased in chronic alcoholism, even though both transaminase and alkaline phosphatase(ALP) being normal, a number of studies have shown a elvations of GGT in alcoholism and good correlation between GGT and amount of alcohol intake. Recently, it has been suggested that serum GGT activity may have a value as a sereening test for alcoholism. This study was conducted on 459 male adults who were examined periodically for physical checkup at Chunan hospital of Soonchunhyang University College of Medicine in October, 1991, with structural questionaire about their drinking habits. Among 459 male adults serum GGT was determined in 236 healthy men consisted of 40 teetotalers and 196 drinkers assessed by history taking, physical examination, and liver function test. This study was attempted with following objectives : 1) to investigate a correlation between serum GGT activity and amount of alcohol intake(grams of pure ethanol per week) and between serum GGT activity and duration of alcohol intake by years, and 2) to investigate whether increased serum GGT activity reflects amount of alcohol intake and duration. The result obtained are as follows; 1) The means of serum GOT in 40 teetotalers and 196 healthy drinkers were 24.8±6.0 U/L and 25.1±5.3 U/L, respectively. The means of two groups showed no statistically significant difference at p >0.05. 2) The means of serum GPT in 40 teetotalers and 196 healthy drinkers were 23.7±8.2 U/L and 22.5±7.3 U/L, respectively. The means of two groups showed no statistically significant difference at p>0.05. 3) The means of serum GGT in 40 teetotalers and 196 healthy drinkers were 24.3±7.3 U/L and 38.9±20.3 U/L, respectively. The mean of serum GGT in healthy drinkers is higher than the mean of serum GGT in teetotalers. The means of two groups showed statistically significant difference at p<0.05. 4) In 196 healthy drinkers the increase of serum GGT activity was paralleled with increasing alcohol intake. Means of serum GGT activities of 5 groups classified by amount of alcohol intake showed statistically significant difference at p<0.05. But serum GGT activity was increased only in long-standing frinkers over 20 years according to duration of alcohol intake. 5) The probability of being a heavy drinker was increased with increasing serum GGT activity and presumably increased to 60% at 80U/L or more of serum GGT activity. 6) Serum GGT activity showed statistically significant correlation with amount of alcohol intake(r=0.3237) and weak correlation with duration of alcohol intake(r=1.1971).

심초음파로 결정된 응급 심낭천자술의 천자부위

김성환,황성오,이강현,조준휘,강구현,문중범,이승환,윤정한,최경훈,김영식 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background: The aim of this study was to determine whether the conventional subcostal approach is suitable for emergency pericardiocentesis in patients with cardiac tamponade or impending cardiac tamponade. Methods: This study was a prospective, observational study conducted at the emergency department of a tertiary hospital, Patients who had symptomatic pericardial effusion and who needed emergency pericardiocentesis in the emergency department were included in this study. We measured the epicardium-to-pericardium distance at the subcostal, parasternal, and apical area with two-dimensional echocardiography to determine the appropriate puncture site for pericardiocentesis. An epicardium-to-pericardium distance of more than 1.0 cm was considered as the primary safety factor in determining the Puncture site for pericardiocentesis. The skin-to-pericardium distance was considered as secondary safety factor. Results: Ninety-five consecutive patients(55 males and 40 females; total mean age: 53 year old) with cardiac tamponade or impending cardiac tamponade were enrolled in this study. The puncture site for pericardiocentesis, as determined by echocardiography, was the subcostal area in 43 patients(45%), the apical area in 40 patients(42%), the left parasternal area In 11 patients(12%), and the right parastemal area in one patient(1%). Pericardiocentesis failed in 2 patients(2%) with the subcostal approach and in one patient(1%) with the apical approach. The average epicardium-to-pericardium distance was 31 ±21 mm in patients with the subcostal approach and 21±8 mm in patients with other approaches. There were no differences in the amount of pericardial fluid and in the intraperical pressure among patient groups according to puncture site. There were two procedure related complications: a puncture of the right ventricle with the subcostal approach and a ventricular tachycardia with the apical approach.