척수압박으로 발현된 급성 골수성 백혈병에 동반된 과립구성 육종 1 례

윤상준,김영곤,김희종,박유환,정춘해,김양수,김태균,박영진,전호종 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

저자들은 척수압박으로 하지마비를 보인 환자에서 수술 후에 급성 백혈병에 동반된 과립구성 육종으로 진단된 환자 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Granulocytic sarcoma(GS) is an uncommon tumor composed of immature cells of the granulocytic series. Most case of GS occur in the course of acute leukemia and the blast crisis of chronic leukemia, Rarely, however, it may present before leukemia becomes clinically apparent. It may also occur in patients with myeloproliferative disoders. GS has been reported that it occurs in 3% to 9% of patients with acute myelogenous leukemia(AML) and the incidence of GS is reported to be higher in patients with t(8;21). GS occurs relatively commonly in africa and has been reported to affect 10-25% of black children presenting with AML. This is very rare case of granulocytic sarcoma with AML(FAB M5) presented with spinal cord compression which was supported by decompression laminectomy.

분말충진방법과 가공정도에 따른 Ag/BSCCO 초전도선재의 특성

지봉기,김태우,김정호,김중석,주진호 成均館大學校 科學技術硏究所 1998 論文集 Vol.49 No.1

We evaluated the effects of processing variables on interface irregularity. microstructure. and resultant Jc of BSCCC superconductor tape. For the tapes made by PIT technique. the degree of interface irregularity was varied with powder packing methods and forming process variables. It was observed that the degree of interface irregularity of the tape by CIP method was more reduced. compared to that of the tape by ram method. In addition. the degree of interface irregularity was promoted with decreasing the dimension of tape during forming process. As the dimension of wire/tape were changed from diameter of 3.25mm to thickness of 200㎛ during forming process. Jc value was observed to be increased by 10 times. It was likely that the improvenment of Jc was mainly result from the enhanced texturing of 2223 grain. Microstructural investigation showed the degree of texturing was degraded by the existence of both second phases and interface irregularity. If the interface was flat, larger grain size and better texturing near interface were developed compared to those inside superconducting core, The improvements of microstructure near interface may be result of reaction between Ag and superconductor phase.

단지양 근위축증(Monomelic Amyorophy) 3례 : 증례 보고 Case Report

김기찬,정호중,정상욱,정흥채,조근열 고신대학교 의학부 1999 高神大學校 醫學部 論文集 Vol.14 No.1-2

Monomelic amyotrophy is a rare form of motor neuron disease which is insidious onset in the second and fourth decades, male preponderance, sporadic occurrence, wasting and weakness confined to one limb, and absence of involvement of the cranial nerves, cerebrum, brain, stem, and sensory system. Symptoms and signs often progress for several years before spontaneously arresting. Neurologic findings and electrophysiologic studies are only useful for the diagnosis of monomelic amyotrophy and other laboratory testing are frequently normal or nonspecific. We reported three cases of typical monomelic amyotrophy with review of the articles.

이종 재료 접합부의 응력확대계수

김문기,국정한,유중학,성호현 韓國技術敎育大學校 1996 論文集 Vol.3 No.1

In this study, fracture aspects for dissimilar materials welded by right and left or up and down in symmetry are examined by using Finite Element Method(FEM) in case that holes exist at up and down in symmetry for the center of crack, and the results of this study are as follows ; 1. When the strength(E₁) of a material with a center crack is lower than that (E₂) of the dissimilar material which is welded by right and left in symmetry, the crack propagation rate decreases by about 25%, while it increases by about 20% when the E₁ is higher than E₂. 2. When the E₁ is lower than the E₂ which is welded by up and down in symmetry, the crack propagation rate decreases by about 25% while it increases by about 75% when the E₁ is higher than the E₂. 3. The value of K₁/K?? is constant up to 2.0 in which is the ratio (a/R) between crack length and hole radius, and the value is decreased or increased a little above 2.0. It is regarded that a phenomenon of crack closure is applied according to the welded type of dissimilar material. In addition, It is noticed that retardation effect of crack propagation is changed greatly according to the distributed position of dissimilar material.

상태공간모형추정의 Akaike방법과 Aoki방법의 효율성 비교

김혜중,신호중,김명철 동국대학교 자연과학연구원 1995 자연과학연구 논문집 Vol.15 No.-

Among the several state space model building in time series, we investigate the forecasting ability of the Akaike method of model estimation and Aoki's method. There are important differences between two model estimation. Akaike uses the normalized Hankel matrix to extract state vector, while Aoki's method does not. In order to compare the efficiency of two method, we exploit the Monte Carlo approach for the several simulate multivariate co-related time series model.

Helicobacter pylori 와 대장의 신생물과의 연관성

안중욱,류재현,김광호,박응범 대한대장항문학회 2001 Annals of Coloproctolgy Vol.17 No.3

수지상세포의 방사선 저항성에 대한 연구

김은실,김종순,이명호,범희승,민정준,정환정,김성민,허영준,송호천,이제중 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.3

목적 : 림프구와 비교되는 수지상 세포의 방사선 민감성을 보기 위하여 본 연구를 시행하였다. 대상 및 방법 : 말초혈액에서 분리한 T 림프구에 0 Gy, 10 Gy, 30 Gy의 방사선을 조사하고 4시간 후에 유세포 분석기를 이용하여 선량별 세포고사 빈도를 관찰하였다. 또한 조혈모세포에서 미성숙 및 성숙 수지상 세포를 단계적으로 분리 배양하여 각각 0 Gy, 10 Gy, 30 Gy, 100 Gy의 방사선을 조사하고 4시간, 24시간 그리고 48 시간 후에 선량별 세포고사 빈도를 관찰하였다. 사이토스핀(cytospin)슬라이드에 림프구와 미성숙 및 성숙 수지상세포를 3×104개 씩 분주하고 May Grunwald-Giemsa 염색한 후, 광학 현미경 하에서 각각의 세포군 당 100개의 세포에서 세포 면적당 핵의 면적 비를 측정하였다. 결과 : 림프구에서는 방사선조사 선량별로 세포고사 빈도가 유의하게 증가하였으나, 수지상 세포에서는 그 분화정도나 방사선조사 선량에 따른 세포고사의 빈도차이가 없었다. 또한 수지상 세포는 방사선선량과 관계없이 용량에 의존적으로 강력한 T-세포 자극능을 보였다. 림프구의 세포에 대한 핵의 면적 비는 미성숙 및 성숙 수지상세포의 세포에 대한 핵의 면적 비보다 현저히 큰 반면, 두 가지 수지상세포간에 유의한 차이는 없었다. 결론 : 수지상세포는 그 분화도와 상관없이 림프구에 비하여 방사선 저항성을 나타내었고, 이는 세포의 형태적 차이에 따른 표적의 크기와 관련이 있을 것으로 생각되며, 향후 분자 생물학적인 연구의 기초 자료로 활용할 수 있을 것으로 생각된다. Purpose : To evaluate radiation sensitivity of dendritic cells in comparison with lymphocytes. Materials and methods : T lymphocytes captured from peripheral blood were irradiated by 0 Gy, 10 Gy, 30Gy. Apoptosis was measured by flowcytometry for staining of Annexin V 4 hours after irradiation. Immature and mature dendritic cells processed from blood hematopoietic stern cell were irradiated by 0 Gy, 10 Gy, 30 Gy, 100 Gy respectively and apoptosis was measured by flowcytometry with time difference as 4h, 24h and 48h after irradiation. Morphometric analysis by percent nucleus was measured in three cell groups, also. Results : Lymphocytes showed radiation sensitivity by increasing apoptotic fraction according to radiation dose. However, both mature and immature dendritic cells showed consistent fraction of apoptosis in spite of increasing radiation dose. Percent nucleus ratio is significantly higher in lymphocytes than that of mature or immature dendritic cells. Stimulation of T-cell by dendritic cells was not changed after irradiation. Conclusion : Dendritic cells showed radioresistance which was associated with small size of nucleus in comparison with lymphocytes and this result would be used as a basal data of radio-labelling for the cellular trafficking studies in nuclear medicine fields.

단순남성임균성 요도염에 대한 Clavulanatepotentiated Amoxycillin(CPA)의 치료효과

김성호,김중환,허훈,김영태 한양대학교 의과대학 1987 한양의대 학술지 Vol.7 No.1

At the Venerel Disease Clinic of Choong-Ku Public Health Center in Seoul 103 patients with uncomplicated gonococcal urethritis were allocated randomly into one of 2 treatment regimens and 101 male patients were followed. All 51 patients, including PPNG infections, treated with clavulante-potentiated amoxycillin, 375 mg, PO, t.i.d for 5 days recovered (100%). Two (4%) of 50 patients treated with clavulanate-potentiated amoxycillin, 3.25g, PO plus probvenecid, 1g, PO failed to recover. These cases were 2 of 25 Penicillinase Producing Neisseria gonorrhoeae (PPNG) infections (failure rate of 8%) and all 25 non-PPNG infections recovered (100%). The antibiotics susceptibility pattern of pre-and post-treatment isolates from these cases did not give conclusive evidence of reinfection and the patients denied having has sexual intercourse during the follow up period. The fact that these treatment failure cases showed negative culture on the first follow up (at 24 hours) and positive result on the second follow up at 3rd post treatment day suggests that test of cure culture at 24 hours after treatment is not the optimal time. It is suggested that both of these clavulanate-potentiated amoxycillin regimens have simiarly good effect with minimal side effects in the treatment of gonococcal urethritis and , because of high rate of PPNGs among circulating N.gonorrhoeae, they can be recommended as the first line treatment for gonorrhoea in Korea.

뇌 해마가 제거된 흰쥐의 유두체 및 내후야에서 HPLC에 의한 아미노산 신경전달물질 분석

김종규,신중호 순천향대학교 1991 논문집 Vol.14 No.2

뇌 해마가 glutamic acid, aspartic acid 및 그외 amino acid를 흥분성 신경전달물질로 사용하는지를 알기 위하여 대뇌피질을 거쳐 양쪽 해마를 제거한 흰쥐(해마군, 11마리), 해마를 덮는 대뇌피질 부분만을 제거한 흰쥐(대뇌피질 대조군, 8마리) 및 정상대조군(10마리)을 마련한 다음, HPLC를 이용하여 OPA pre-column 유도체화법으로 유두체와 내후야 조직의 아미노산들을 측정하였다. 1. 유두체 조직의 aspartic acid는 두 대조군보다 해마군에서 유의하게 감소되었으나, 두 대조군 사이에는 이렇다 할 차이가 없었다. glutamic acid는 정상 대조군보다 해마군에서 유의하게 증가되었으며, 대뇌피질 대조군에 비해서는 증가된 경향은 보였으나, 유의성은 없었고, 두 대조군 사이에는 아무런 차이가 없었다. serine, glycine, threnonine 및 alanine은 세무리 사이에서 차이가 없었다. 2. 내후야 조직에서 aspartic acid 및 glutamic acid는 두 대조군보다 해마군에서 모두 유의하게 감소 되었으나, 두 대조군들 사이에는 차이가 없었다. glycine은 해마군이 정상 대조군보다 유의하게 감소되었으나, 대뇌피질 대조군보다는 감소된 경향을 보였을뿐 유의성은 없었고, 두 대조군 사이에서는 아무런 차이가 없었다. alanine은 정상 대조군보다 대뇌피질 대조군에서 유의한 감소를 보였으며, 해마군은 정상 대조군에 비하여 감소 경향만 보였고, 해마군과 대뇌피질 대조군 사이에서는 유의한 차이가 없었다. 그리고 serine 및 threonine은 세 무리 사이에 아무런 차이가 없었다. 이상의 결과들을 종합하건데 아미노산인 aspartic acid와 glutamic acid는 해마, 유두체 및 내후야의 많은 신경섬유들이 흥분성 전달물질로 작용할 것으로 추측되어진다. A study was planned to analyze amino acid in target structure of hippocampectomized rats by HPLC. Twenty nine male rats were divided into 3 groups, of which 11 rats had their hippocampal tissue on both sides removed through an opening in the parieto-occipital cortex (hippocampal group), 8 rats received damage to the parieto-occipital cortex only(cortical control group), and 10 rats served as normal control animals. One week later, the animals were sacrificed by decapitation in the cold room. 2-3mg of tissue was obtained from the mammillary body and entorhinal area in one side of the brain. The tissue samples were homogenized in 200ul of 0.5M perchlocric acid in 1mM EDTA with ground-glass homogenizers. After centrifugation at 3,500 rpm for 15 min, an aliquot of 80ul supernatant was neutralized with 20ul of 2M KHCO₃, and then centrifuged again at 3,500 rpm for 10 min. An aliquots of 20ul was taken and diluted with 350ul of β-mercaptopropionic acid in 10ml of 100mM sodium borate buffer(pH 9.1) and 350ul of OPA solved in ethanol which was diluted with 10ml of 100mM sodium borate buffer(pH 9.1). Then 200ul of the resulting sample was injected with SIL-6B auto injector. LC-9A liquid chromatograph, FLD-6A fluorescence detector, CTO-6A column oven and SCL-6B system controller was employed. We used OPA pre-column derivatization method. Peak areas were automatically integrated and calculated by CR6A chromatopac. 1. In mammillary body, aspartic acid decreased significantly in the hippocampal group than in the normal control group(t test, p<0.05) and the cortical control group(p<0.04), while there were no significant difference between the 2 control groups. Glutamic acid increased significantly in the hippocampal group compared with the value obtained from the normal control group(p<0.03), while the difference between the hippocampal group and cortical control group values and between the 2 control group values were nonsignificant. In serine, glycine, threonine and alanine, the differences among 3 group values were nonsignificant. 2. In entorhinal area, aspartic acid and glutamic acid reduced significantly in the hippocampal group than in the normal control group(p<0.02) and the cortical control group(p<0.04), while no significant difference existed between the 2 control groups. Glycine reduced significantly in the hippocampal group compared with the value obtained from the normal control group(p<0.01). while the difference between the hippocampal group and cortical control group values and between the 2 control group values were nonsignififcant. Alanine increased significantly in the normal control group compared with the value obtained from the cortical control group(p<0.05), while no significant difference existed between the normal control group and the hippocampal group. However, the difference between the hippocampal group and the 2 control group values was nonsignificant. In serine and threonine, the difference was nonsignificant among 3 groups. It is inferred from the above mentioned results that the amino acids aspartic acid and glutamic acid are excitatory transmitter substances used by a large number of neurons in hippocampus, mammillary body and entorhinal area.

경기 종합지수 예측을 위한 시계열모형 비교연구

김재현,신호중 서경대학교 1995 論文集 Vol.23 No.2