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이강욱,김영건,노흥규,송민호,김호,박은신,유순희,한희정,주원찬,원진호,임규,권오유 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.4
Background: The proinflammatory cytokine, IFN-y has been shown to exert pleiotropic effects in a variety of pathophysiologic conditions in autoimmune thyroid disease. The thyrocyte response to IFN-y is mediated two distinct classes of proteins, Janus kinases(Jakl and Jak2) and Signal Transducers and Activation of Transcription(STATl). The activation of STAT 1 is involved in the regulation of many interferon stimulated genes, such as MHC class II, intercellular adhesion molecules-1(ICAM-1) and MHC class II transactivator(CIITA) after the binding to the GASgFN- pactivated site) of the gene promoters. Recently we found TSH/forskolin inhibits IFN-y stimulated maximal expression of ICAM-1 in FRTL-5 cell. IFN-y action is localized between -175 bp and -97 bp from the start of translation of ICAM-1 gene which contains regulatory elements known to be involved in IFN-y action in other eukaryotic cells, palindromic IFN-y activated site(GAS)(5-TTTCCGGGAAA-3) which could bind STAT1, STAT3, STAT5, STAT6. Furthermore, the addition of TSH and forskolin causes a decrease in ICAM-1 promoter activity and its action was localized in GAS. These findings suggested TSH/cAMP signaling pathways downregulate IFN-y activated Janus kinase-STAT signaling path. We wanted to explore the possible involvement of elevated cAMP in the negative regulation of IFN-y induced STAT1 activation in thyroid cells. Method: We made several 5-deletion constructs of rat ICAM-1 promoter and analyzed the promoter activities by measuring the luciferase activity after tranfection into FRTL-5 cells. The protein/DNA complex was measured by electrophoretic mobility shift analysis using labeled oligonucleotide. We checked the level of total and phosphorylated STATl protein by immunoblot analysis using specific antibodies. Results: Stimulation of IFN-y in FRTL-5 cells resulted in rapid activation of STATl/DNA binding activity, which was apparent after several minute of stimulation, maintains its activity until 48 h. Incubation of cells with TSH result in suppression of IFN-p mediated STAT1/DNA binding activity throughout the time course of activation by IFN-y. Addition of TSH into 5H maintained FRTL-5 cells did not change the total amount of latent STAT1 amount and also not affect IFN-y mediated production of total STAT1 until 4 h. IFN-y(100 U/mL) rapidly induced phosphorylation of STAT1 within 30 min. and maintained its level without significant change until 48 hours. Cells treated with TSH dramatically lowered the level of IFN-y induced production and phosphorylation of STAT1 after 12 h, 24 h, 36 h, and 48 h but TSH had no effect on the level of phosphorylated STATl within 4 h after IFN-y stimulation. The proteasome inhibitor, MG132 and phosphatase inhibitor, sodium orthovanadate did not block the TSH or forskolin mediated downregulation of phosphorylated STAT1. Conclusion: These results indicate a regulatory mechanism which TSH signaling can modulate the prolonged activation of Jak/Stat by IFN-y. We identified one of mechanisms related to TSH mediated negative suppression of the ICAM-1 gene; TSH/cAMP signaling pathways downregulate the cytokine activated Janus kinase-STAT signaling path (J Kor Soc Endocrinol 13:536-553, 1998).
조영석,권기현,이준철,나소영,이효진,홍우정,이유선,김군순,송민호,김영건,노흥규 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2
Prediction of thrapeutic response to radioiodine in Graves' disease is poorly understood. Although thyrotropin binding inhibitor immunoglobulin(TBII) level is a strong index for relapse after antithyroid drug medication, conflicting results are reported regarding its prognostic significance in Graves' disease treated with RAI. This study is dengned to evaluate possible relationship between post-treatment hypothyroidism and TBII in Graves' disease treated with RAI. Fourty two patient with Graves' disease after radioiodine treatment were studied retrospectively. The subject were divided into hypothyroid group and euthyroid or hyperthyroid group. We evaluated the association of hypothyroidism and TBII with radioiodine treatment dose. The mean age of hypothyroid group was 48±11 years and euthyroid or hyperthyroid group was 47±12 years. There was no difference in two groups. And there was no significant difference in post- treatment TBII between two groups(49.9±28.5%, 29.9±14.3%, p-value >0.05). The treatment-dose had no influence on post-treatment thyroid state. Euthyroid or hyperthyroid group was done with 13.6±6.9mCi and hypothyroid group was 17.0±10.4mCi(p-value > 0.05). TBII had no prognostic significance on long-term hypothyrodism in Graves' disease treated with radioiodine. And, treatment-dose had no influence on post-treatment thyroid state.
Characteristics of Waste at Industrial Waste Incineration Facilities
( Heung Min Yoo ),( Sung Jin Cho ),( Jung Hun Kim ),( Jang Su Lee ),( Ki Bae Lee ),( Seung Jae Jung ),( Byung Hyun Han ),( Yong Chil Seo ),( Ki Heon Kim ),( Hae Young Jung ) 한국폐기물자원순환학회(구 한국폐기물학회) 2011 한국폐기물자원순환학회 추계학술발표논문집 Vol.2011 No.-
The Characteristics of Syngas and Melting Slag from the Gasification of Automobile Shredder Residues
( Heung-min Yoo ),( Yong-chil Seo ),( Ha-na Jang ) 한국폐기물자원순환학회(구 한국폐기물학회) 2020 한국폐기물자원순환학회 추계학술발표논문집 Vol.2020 No.-
The gasification of Automobile Shredder Residue (ASR) was performed using fixed-bed reactor for the recovery as energy resources. The capacity of fixed-bed reactor was 1kg/hr and the experimental temperature was 800, 1,000, and 1,200 ℃. The equivalence ratio(ER) was ranged from 0.1 to 0.5. The syngas yield composed of hydrogen and carbon monoxide was ranged from 40% to 86%. The syngas yield from the process increased as the gasification temperature increased. In addition, the melting experiment of char and ash from the gasification process was performed for the recycle as the clay bricks from the melting slag. The pore number of melting slag increased as the gasification temperature increased. The strength of melting slag was higher than that of the standard clay bricks. As the results, the melting slag content and the gasification temperature were optimized as 10 wt % and 1,300℃, respectively.
Gasification and Melting Process for the Recycling of Automobile Shredder Residues
( Heung-min Yoo ),( Sungjin Cho ),( Ki-heon Kim ),( Won-seok Yang ),( Jun-kyung Park ),( Ha-na Jang ),( Yong-chil Seo ) 한국폐기물자원순환학회(구 한국폐기물학회) 2019 ISSE 초록집 Vol.2019 No.-
The gasification of Automobile Shredder Residue (ASR) was performed using fixed-bed reactor for the recovery as energy resources. The capacity of fixed-bed reactor was 1kg/hr and the experimental temperature was 800, 1,000, and 1,200 ℃. The equivalence ratio (ER) was ranged from 0.1 to 0.5. The syngas yield composed of hydrogen and carbon monoxide was ranged from 40% to 86%. The syngas yield from the process increased as the gasification temperature increased. In addition, the melting experiment of char and ash from the gasification process was performed for the recycle as the clay bricks from the melting slag. The pore number of melting slag increased as the gasification temperature increased. The strength of melting slag was higher than that of the standard clay bricks. As the results, the melting slag content and the gasification temperature were optimized as 10 wt % and 1,300 ℃, respectively.
EURO 3에 의한 이륜자동차의 미량유해물질 배출특성평가
유흥민 ( Heung Min Yoo ),손지환 ( Ji Hwan Son ),박규태 ( Gyu Tae Park ),문선희 ( Sun Hee Mun ),윤창완 ( Chang Wan Yun ),김정수 ( Jeong Soo Kim ),이종태 ( Jong Tae Lee ) 한국분무공학회 2015 한국액체미립화학회지 Vol.20 No.4
Recently, the researches for air pollutant control technologies have been performing in Korea, while considering an one of the latest main topics as problems on air pollutant control. However, it is difficult to investigate emission amount of air pollutant by passenger cars, because of lack of the domestic information about mobile source; the number of research institutes are less in the whole. Especially, the informations on registered numbers and emissions of motorcycles are less. Thus, in this study, the analysis that is based on experimental results was conducted for finding out source profiling and emission characteristics on motorcycles exhaust. For these experiments, the domestic motorcycles were chosen and evaluated by EURO III standard. From the result, controlled pollutants (CO, HC, NOx) were met to EURO III, but low displacement motorcycles showed a higher incomplete combustion reaction than that of 250 cc motorcycles. Additionally, uncontrolled pollutants (BTEX and 1,3-butadiene) were decreased with increasing a displacement of motorcycles. However, the emission trend of aldehydes was not followed that of those; the formaldehyde ratio increased upto approximately 33%, with increasing a displacement of motorcycles. In the future, it would be used to support the CAPSS as basic data of Korea.
미립화와 환경 2 : 대기오염기여율 평가를 위한 이동오염원의 이산화탄소 동위원소비 활용방안 연구
유흥민 ( Heung-min Yoo ),이종태 ( Jongtae Lee ),손지환 ( Jihwan Son ),박규태 ( Gyu-tae Park ),문선희 ( Sunhee Mun ),윤창완 ( Changwan Yun ),김정수 ( Jeongsoo Kim ) 한국액체미립화학회 2015 한국액체미립화학회 학술강연회 논문집 Vol.2015 No.-
Most of industrial facilities such as power generations, incinerators and refining facilities, can affect to air pollutant in Korea. Thus, we have to control them for keeping the clean and clear air. Additionally, it is important to find out the source of air pollutant. However, it is difficult to distinguish the mobile sources such as motorcycles and passenger cars from air pollutants sources, exactly. In present study, the analysis of carbon isotope ratio on vehicles was conducted to evaluate on air pollutant effect. For these, the exhaust of motorcycles and passenger cars were analyzed on that of 13C/12C. Furthermore, the carbon isotope ratios of exhaust were compared with fuels which are those of 4 manufacturing companies in Korea.