척수압박으로 발현된 급성 골수성 백혈병에 동반된 과립구성 육종 1 례

윤상준,김영곤,김희종,박유환,정춘해,김양수,김태균,박영진,전호종 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

저자들은 척수압박으로 하지마비를 보인 환자에서 수술 후에 급성 백혈병에 동반된 과립구성 육종으로 진단된 환자 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Granulocytic sarcoma(GS) is an uncommon tumor composed of immature cells of the granulocytic series. Most case of GS occur in the course of acute leukemia and the blast crisis of chronic leukemia, Rarely, however, it may present before leukemia becomes clinically apparent. It may also occur in patients with myeloproliferative disoders. GS has been reported that it occurs in 3% to 9% of patients with acute myelogenous leukemia(AML) and the incidence of GS is reported to be higher in patients with t(8;21). GS occurs relatively commonly in africa and has been reported to affect 10-25% of black children presenting with AML. This is very rare case of granulocytic sarcoma with AML(FAB M5) presented with spinal cord compression which was supported by decompression laminectomy.

광 가입자용 송수신기 패키지 대역폭 향상에 관한 연구

김영해,이상훈 三陟大學校 産業科學技術硏究所 2003 産業科學技術硏究論文集 Vol.8 No.2

We propose the optimum TO-can package design in LAW application optical transceiver modules to improve 3dB-bandwidth. The frequency response of TO-38 package is measured and compared to simulation where the 3dB-bandwidth was 3.5GHz. For a higher operating bandwidth (>l5GHz). the new optimized physical geometries of TO-can package such as bonding-wire, lead and material was suggested. The optimal result of simulation shows that TO-can package can be used at a higher bit rate optical module of 10Gbps.

준비운동의 형태와 휴식이 체력요인에 미치는 영향

김영구,김해성 한국스포츠리서치 2001 한국 스포츠 리서치 Vol.12 No.4

The purpose of this syudy was to investigate the effect of rest levels and preexercise types on the ruselts of measurement of physical fitness. The subjects were 60 males who were belonging to I university in Inchon and were divide into 6 gropes which were classfied in accordance with 6 rest and preexercise conditions randomly. The rest levels were two level which were just after exercise and 5 minute arter exercise, the preexercise types were jogging and juvenile gymnastic. The tested items were back muscle strength in strength, body flexion in flexibility, sidestep test and whole body reaction time in agility, and surgent jump in power. All data were analyzed by two - way ANOVA in each tested item. The conclusion were as following ; 1. The preexercise types and rest levels were not significantly effected on the results of strength test in physical fitness. 2. The preexercise types and levels were not significantly effected on the results of agility test in physical fitness. 3. The preexercise types and levels were significantly effected on the results of flexbility test in physical fitness. 4. The preexercise types and rest levels were not significantly effected on the results of power test in physical fitness.

침적형 고정생물막 반응기에서 유기물질 및 질소제거 특성 비교

김영오,남해욱,이종현,박태주 부산대학교 환경문제연구소 1999 環境硏究報 Vol.17 No.1

The two processes of R-1 process(anaerobic/anoxic/aerobic reactor) and R-2 process(anoxic/aerobic reactor) were investigated into the operating strategy of the four kinds of HRTs(4, 6, 8, and 10hr) using the raw sewage in Janglim WWTP The sewage contained various refractory wastewaters such as, leachate, industrial wastewater, pigment wastewater. The purpose of this study was find out to the optimal process that was enhanced to remove not only organic compounds, but also nitrogen and phosphorus, when the influent was used to the refractory sewage. As the range of COD^cr, loading rate during operating days was from 0.66kg/m^3/day to 1.63kg/m^3/day, the effluent concentration was 52.0 ~77.0mg/L in R-1 process and 59.0~81 0mg/L in R-2 process, respectively. Increasing the NH_4^+-N loading rate from 126.5g/m^3/day to 326.3g/m^3/day, the removed loading rates were 116.5~196.4g/m^3/day of R-1 process, and 117.7~191.6g/m^3/day of R-2 process, respectively. The removals of organics and NH_4^+-N of R-1 process were slightly higher than those of R-2 process, but the differences were almost negligible. The phosphorus removal efficiency was 50. 5~34.0% of R-1 process and 40.5 ~25.5% of R-2 process, respectively. The difference of the phosphorus removal efficiency was considered because of the effect of phosphorus release in anaerobic reactor and phosphorus uptake in aerobic reactor by facultative bacteria as well as higher COD_cr,/TP ratio in anoxic reactor of R-1 process by 40% by-pass. Hence, the results of this study showed that R-1 process with by-pass was more suitable for nutrient treatment than R-2 process. The submerged fixed-biofilm packed with SAC media could be applicable for the refractory wastewater treatment.

가스저장탱크에서 가스저장량의 퍼지 제어 방식

이해영,추준욱,김교형 嶺南大學校 工業技術硏究所 1998 工業技術硏究所論文集 Vol.26 No.2

This paper suggests a fuzzy control algorithm which manipulates the quantity of gas in a gas storage tank to a given reference value. Fuzzy control rules proposed in this paper are divided into two groups. The first is to treat the quantity of gas in a gas storage tank, and the second is to manipulate the quantity in pipe which is utilized in moving gas from gas source to a gas storage tank. Fuzzy control rules to treat two control problems mentioned above are designed independently by investigating several special points having inherent features for given assumed possible response characteristics in the sense of common-sense and engineer's technical knowledge. In order to observe the validity of fuzzy control algorithm for manipulating the quantity of gas in a gas storage tank suggested in this paper, computer simulations are done for three cases, which the quantity of generated gas and the required quantity in load have time-varying patterns. Computer simulation results show that fuzzy control rules designed in this paper are well operated for every case.

혼합 가스 열량의 지능적 제어 기법

이해영,전재영,김교형 嶺南大學校 工業技術硏究所 1998 工業技術硏究所論文集 Vol.26 No.2

This paper presents a fuzzy control algorithm which manipulates the calorie of a mixed gas generated by combining two kinds of gases to a specified target value. A suggested fuzzy control algorithm is functionally divided into two groups. The first is a feedback control function which eliminates error between the target value and output value of a mixed gas calorie by analyzing a measured output value of a mixed gas calorie. The second is a predictive or feed forward control function which reduces anticipated such calorie error by investigating variation patterns of quantity and calorie of a gas to be mixed. In order to show the validity of proposed in this paper, computer simulations are performed for three cases with the features of varying quantity and calorie. Computer simulation results show that mixed gas calorie is well controlled for each case.

단일 지수함수형 패턴 제어기에 의한 스테핑 모터의 병렬제어

성원기,김영해 三陟大學校 1997 論文集 Vol.30 No.1

Parallel control of stepping motors by one's exponential pattern control system is described. In this system, two's stepping motors are accelerated in self-driving region on frequency-torque characteristics and two's motors in maximum rating speed. Maximum period of speed-variation range is 2×10-5[sec]. This system enables us to do the independent position and velocity control more economically than the trapezoid wave control system. By experiment, the results is verified.

중합효소연쇄반응을 이용한 도말양성 폐결핵 환자에서의 결핵균 DNA 검출방법에 관한 연구

이종진,김애경,조해정,한표성,홍석철,김주옥,김선영 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

Polymerase chain reaction (PCR) is the most sensitive and rapid method for the diagnosis of M.tuberculosis infection. Many reports have shown different methods for mycobacterial DNA extraction, but revealed many differences in simplicity and time-consumption. We studied which method was the best among 7 different ones for DNA extraction from 32 smear-positive sputa, using PCR of targeting 123bp DNA fragment of IS6110. The methods were the following : SDS-Microwave oven method, NaOH Lysis method, Triton X-100, Proteinase K method, Lysis buffer method. SDS-Proteinase K method, Bead Beater method, and Bead Beater/CTAB method. The amplification products were identified by electrophoresis on ethidium bromide-stained agarose gels, and confirmed by restriction enzyme, Southern blot hybridization, and DNA sequencing. All 32 cases were positive (100%) by the 7 different methods. It took 1 hour or more to detect DNA in SDS-Microwave oven method, NaOH Lysis method, and Bead beater/CTAB method. It took 2 hours or less in the others. SDS-Proteinase K method and Bead Beater/CTAB method were simpler and more convinient than the others. These results suggest that SDS-Proteinase K method and Bead Beater/CTAB method might be better than the others for the extraction of mycobacterial DNA in terms of simplicity and time-consumption, although all the methods were sensitive.

Urinary phthalate metabolites over the first 15months of life and risk assessment – CHECK cohort study

Kim, Sunmi,Lee, Jangwoo,Park, Jeongim,Kim, Hai-Joong,Cho, Geum Joon,Kim, Gun-Ha,Eun, So-Hee,Lee, Jeong Jae,Choi, Gyuyeon,Suh, Eunsook,Choi, Sooran,Kim, Sungjoo,Kim, Sung Koo,Kim, Young Don,Kim, Su You Elsevier 2017 The Science of the total environment Vol.607 No.-

<P><B>Abstract</B></P> <P>Phthalates are important group of endocrine disruptors. Infants and young children are susceptible to phthalate exposure. However, information on the phthalate exposure during the early stages of life is very limited. This study was conducted to understand the temporal trend of exposure to major phthalates among infants of Korea during the first 15months after birth, and to estimate associated risks. A total of 286 urine samples were collected from 171 children at 3, 9, 12, or 15months of age, with 77 children sampled for two or more times. Four phthalates, i.e., di(2-ethylhexyl) phthalate (DEHP), di-isobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP), and diethyl phthalate (DEP) were chosen, and their major metabolites were analyzed in the urine. The DEHP metabolites were detected in 100% of the urine samples at relatively higher levels compared to those reported in other countries. The levels of mono-ethyl phthalate (MEP) were generally lower. Urinary concentrations of most phthalate metabolites, especially DEHP metabolites, increased as children grew older. Intra-class correlation coefficients (ICCs) calculated for DEHP metabolites over time were high (0.7–0.8), suggesting persistence of consistent exposure sources during this sensitive period of life. Hazard quotient (HQ) and hazard index (HI) were calculated from daily intake estimates divided by recommended toxicity thresholds. Among the study population, 4, 16, and 26% of the children showed HI >1 at 9, 12, and 15months of age, respectively. DEHP exposure explained most of the risk estimates. Considering vulnerability of young children to endocrine disruption, efforts to identify sources of exposure and to develop appropriate mitigation options are warranted.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Multiple urines were collected at 3, 9, 12, or 15months of age from 171 children. </LI> <LI> High intra-individual correlation and age-dependent increase were observed. </LI> <LI> Up to 26% of children showed hazard index >1 by exposure to target phthalates. </LI> <LI> Estimated risks are mostly due to the exposure to DEHP and DnBP. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Association between maternal exposure to major phthalates, heavy metals, and persistent organic pollutants, and the neurodevelopmental performances of their children at 1 to 2years of age- CHECK cohort study

Kim, Sunmi,Eom, Soyong,Kim, Hai-Joong,Lee, Jeong Jae,Choi, Gyuyeon,Choi, Sooran,Kim, Sungjoo,Kim, Su Young,Cho, Geumjoon,Kim, Young Don,Suh, Eunsook,Kim, Sung Koo,Kim, Seunghyo,Kim, Gun-Ha,Moon, Hyo-B Elsevier 2018 Science of the Total Environment Vol.624 No.-

<P><B>Abstract</B></P> <P>Exposure of the developing fetus and infants to toxic substances can cause serious lifelong health consequences. Several chemicals have been associated with adverse neurodevelopmental disorders in the early life stages of humans. However, most epidemiological studies have focused on a limited number of chemicals, and hence may exclude important chemicals from consideration or result in conclusions built on associations by chance. In the present study, we investigated the chemical exposure profile of the women, and associated these with the early neurodevelopmental performance of their offspring at 13–24months of age. The chemicals assessed include four phthalates, bisphenol A, three heavy metals, 19 polychlorinated biphenyls (PCBs), 19 organochlorine pesticides, and 19 polybrominated diphenyl ethers, which were measured from urine, whole blood, serum, and/or breastmilk of the pregnant or lactating women. For neurodevelopmental performance, the Bayley Scales of Infant Development-II (BSID-II), Social Maturity Scale (SMS), and Child Behavior Checklist (CBCL) were measured from a total of 140 toddlers. Among the measured chemicals, monoethyl phthalate (MEP) in maternal urine was significantly associated with early mental, psychomotor, and social development. In addition, breast milk di-ethylhexyl phthalate (DEHP) metabolite and blood lead concentrations were inversely associated with mental and psychomotor development indices, respectively. Maternal blood PCB153, heavy metals, and urinary MEP levels were also higher among the children with behavioral problems, as indicated by the CBCL range. Taken together, maternal exposure to several EDCs such as PCBs and DEHP was associated with adverse neurodevelopmental performances among the children aged 1–2years. Confirmation of these association in larger populations, as well as longer-term consequences of such exposure warrant further investigation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Prenatal Hg, Pb, BPA, or DEP exposures were associated with neurodevelopmental delay. </LI> <LI> DEHP exposure through lactation showed negative association with mental index. </LI> <LI> Prenatal Hg, DEP, or PCB exposures showed positive associations on CBCL scores. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>