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이성원(Sung Won Lee),이영석(Young Sok Lee),한석원(Suk Won Han),한남익(Nam Ik Han),김욱(Wook Kim),원종만(Jong Man Won),장은덕(Eun Deok Chang),이해규(Hae Giu Lee) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.3
Malignant fibrous histiocytoma is the major subset of soft tissue sarcomas which occurs most commonly in the extremities and trunk, but rarely in the visceral organs. This report documents a case of malignant fibrous histiocyoma arising in the omentum in 36 year-old female whose chief complaints were growing non-tender masses. After surgical resection, there are no evidences of recurrencee or metastasis during 4 months follow up period. Electron microscopic study of the tumor showed irregular, spindle-shaped histiocyte with large indented nuclei and prominent nucleoli. The cytoplaem was abundant with microfilament and distended mitochondria. There was no evidence of myofibril in the tumor.
이광우,이해규,김진우,손호영,차봉연,강무일,윤건호,유순집,강성구,김태규,윤형규,최의진,한훈 대한내과학회 1995 대한내과학회지 Vol.48 No.6
Autoimmune polyglandular syndrome encompasses a number of diseases, ranging from unusual endocrine and nonendocrine disorders to the co-occurrence of common organ specific autoimmune disease. Knowledge of these syndrome is important for several respects: given the presence of one disease, certain others become more likely(in relatives as well as in the primary patient); there are similarities in the etiology and genetics of the different diseases; and immunologic treatment of one disease may be applicable to others. We recently experienced type II autoimmune polyglandular syndrome in a twenty-two-year old female patient who had insulin dependent diabetes mellitus associated with diabetic ketoacidosis, Hashimoto's thyroiditis, autoimmune Addison's disease, primary gonadal failure and alopecia totalis. Among the family member, twenty-year-old sister showed primary gonadal failure. Evaluation of the histocompatibility leukocyte anti- gene(HLA) was done in the patient and 4 relatives by two-step polymerase chain reaction(PCR). In HLA typing, the patient showed HLA-Al, B8, DR3, DR4 haplotypes, which had been known to be related with the autoimmune polyglandular syndrome.
김욱,이광우,이해규,손호영,차봉연,윤건호,유순집,강성구,장은덕,최의진,안중현 대한내과학회 1994 대한내과학회지 Vol.46 No.6
Hypercalcemia associated with chronic renal failure is often a matter of clinical problems. Among the many cause of hypercalcemia, tertiary hyperparathyroidism, which is secreting parathyroid hormone autonomously in spite of hypercalcemia, is seldom reported. Sometimes it requires surgical intervention due to not only symptomatic hypercalcemia, but also longlasting asymptomatic hypercalcemia. We recently have experienced a female patient with hypercalcemia in a thirty- seven-year old, who maintains on hemodialysis. She had received kidney from her husband due to chronic renal failure, but it had rejected acutly. She had markedly elevated level of C-terminal parathyroid hormone and radiologic manifestation of adernoma of the parathyroid gland. The bone pathology was consistent with ostitis fibrosa. Subtotal parathyroidectomy showed 1 adenoma and 2 hyperplasia pathologically, afterthen improved clinically and biochemically.
Yeo Ju Kim,Hae Giu Lee,Jeong Mi Park,Yeon Soo Lim,Myung Hee Chung,Mi Sook Sung,Won Jong Yoo,Hyun Wook Lim 대한영상의학회 2007 Korean Journal of Radiology Vol.8 No.4
Objective: To assess the feasibility and safety of polyvinyl alcohol (PVA) embolization adjuvant to transarterial oily chemoembolization (P-TACE) in advanced hepatocellular carcinoma (HCC) with arterioportal shunts (APS). Materials and Methods: Nineteen patients who underwent PVA embolization for APS before a routine chemoembolization (TACE) procedure were retrospectively reviewed. 10 of these 19 patients underwent follow-up TACE or P-TACE after P-TACE (Group A), but nine patients underwent only initial P-TACE because of progression of HCC and/or underlying liver cirrhosis (Group B). Hepatic function tests, APS grades, and portal flow directions were evaluated before and after P-TACE sessions. Complications after procedures and survival days were also evaluated. Results: In group A, APS grade was improved in eight patients and five of six patients with hepatofugal flow showed restored hepatopetal flow postoperatively. No immediate complication was developed in either group. Transient hepatic insufficiency developed in eight (42.1%) of 19 patients after P-TACE, and seven (87.5%) of these eight recovered within two weeks under conservative care. The mean and median survival time all study subjects was 280 days and 162 days. Conclusion: P-TACE is feasible and safe in advanced HCC patients with APS.
Prince, Martin R.,Lee, Hae Giu,Lee, Chang-Hee,Youn, Sung Won,Lee, In Ho,Yoon, Woong,Yang, Benqiang,Wang, Haiping,Wang, Jin,Shih, Tiffany Ting-fang,Huang, Guo-Shu,Lirng, Jiing-Feng,Palkowitsch, Petra Springer Berlin Heidelberg 2017 EUROPEAN RADIOLOGY Vol.27 No.1
<P><B>Objectives</B></P><P>To investigate the safety and tolerability of gadobutrol at the recommended dose in patients requiring contrast-enhanced magnetic resonance imaging/angiography (MRI/MRA) in the routine setting.</P><P><B>Methods</B></P><P>GARDIAN prospectively enrolled 23,708 patients undergoing routine gadobutrol-enhanced MRI/MRA for approved indications at 272 study centres in Europe, Asia, North America, and Africa and monitored for adverse events.</P><P><B>Results</B></P><P>Median gadobutrol dose was 0.11 mmol/kg body weight. The overall incidence of adverse drug reactions (ADRs) was 0.7 % (<I>n</I> = 170 patients), with similar incidences in patients with renal impairment or cardiac disease, from different geographic regions and in different gadobutrol dose groups. Patients at risk for contrast media reaction had an ADR incidence of 2.5 %. Five patients (0.02 %) experienced serious adverse events, four were drug-related. One patient experienced a fatal anaphylactoid shock, assessed to be related to injection of gadobutrol. The contrast quality of gadobutrol-enhanced images was rated by treating physicians as good or excellent in 97 % cases, with similar ratings in all patient subgroups and indications.</P><P><B>Conclusions</B></P><P>The GARDIAN study shows that gadobutrol at the recommended dose is well tolerated across a large, diverse patient population.</P><P><B>Key points</B></P><P>• <I>Gadobutrol at recommended dose shows low rates of adverse drug reactions</I></P><P>• <I>Gadobutrol demonstrates a uniform safety profile across diverse patient groups</I></P><P>• <I>Gadobutrol provides excellent contrast quality in routine practice</I></P>
20대에서 발병한 간세포암 복합 치료에 반응을 보인 진행성 간세포암
이장은 ( Jang Eun Lee ),윤나리 ( Na Ri Yoon ),배시현 ( Si Hyun Bae ),최종영 ( Jong Young Choi ),윤승규 ( Seung Kew Yoon ),김동구 ( Dong Goo Kim ),천호종 ( Ho Jong Chun ),최병길 ( Byung Gil Choi ),이해규 ( Hae Giu Lee ),장홍석 ( Ho 대한간암학회 2009 대한간암학회지 Vol.9 No.-
The prognosis of young patients with hepatocellular carcinoma is remains controversial. Here we report a case of advanced hepatocellular carcinoma in twenty, successfully treated with transarterial chemolipidolization (TACL), systemic chemotherapy, radiation therapy and surgical resection. Previously healthy 28 years old woman was admitted for treatment of hepatocellular carcinoma. Abdominal CT showed a diffuse infiltrative HCC involving both lobes with intrahepatic bile duct invasion and pericardial lymphadenopathy. She was treated TAC with systemic chemotherapy and external beam radiotherapy. 6 months after these treatments, main tumor and the pericardial lymph node were decreased in size. And then extended left lobectomy and systemic chemotherapy were done. The pericardial lymph node was markedly decreased. The patient has been followed for 10 months without evidence of regional tumor recurrence.
대퇴골두 무혈성 괴사에 대한 혈관부착 비골 이식술 후 디지털 감산 혈관조영술 소견
이기행,김윤수,이해규,옥지훈,김배균,김형민,Lee, Kee-Haeng,Kim, Youn-Soo,Lee, Hae-Giu,Ok, Ji-Hoon,Kim, Bae-Kyun,Kim, Hyoung-Min 대한미세수술학회 2004 Archives of reconstructive microsurgery Vol.13 No.2
Purpose : To observe the patency of anastomosis site and the findings of circulation of grafted fibula in osteonecrosis of femoral head treated with vascularized fibular graft by use of digital subtraction angiography. Materials and Methods : 17 cases of 11 patients who underwent vascularized fibula graft for osteonecrosis of femoral head. We performed digital subtraction angiography(DSA) for them at second week postoperatively in 12 cases, at sixth week in 1 case, at sixth month in 2 cases, at twelfth month in 1 case, and eighteenth month in 1 case which had been got DSA at second week before. We observe the patency of pedicle, and the circulation of grafted fibula such as periosteal and intraosseous vessels with time. Results : All cases except one which were thought failure of selective angiogram showed good passage of blood flow through anstomosed pedicle on DSA. We found the differences in appearance of circulation of grafted fibula with time. DSA at 2nd and 6th week postoperatively revealed both of periosteal and intraosseous vessels along the fibula and blood pooling at the tip of fibula. DSA at 6th month showed maintenance of periosteal and intraosseous vessels along the fibula but did not clearly reveal blood pooling at the tip of fibula. The findings of DSA at 12th and 18th month were similar each other. The periosteal vessels were not seen as the grafted fibular bone were incorporated into surrounding femoral bone but intraosseous vessels were still seen. Conclusion : It was thought that DSA could be used for evaluation of the status of pedicle including anastomsed site and vessels of grafted fibula with time. The periosteal vessels of fibula were decreased with time but intraosseous vessels were still seen until 18th month after vascularized fibula graft.
현수 시스템의 케이블 장력 측정을 위한 표준 실험 장치의 개발
최만용 ( Choi Man Yong ),박해원 ( Park Hae Won ),이규 ( Lee Giu ),장선재 ( Jang Sun Jae ),이승석 ( Lee Seung Seok ) 한국구조물진단유지관리공학회 2006 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.10 No.1
현수시스템에서 케이블의 장력은 구조물의 신뢰성을 확인할 수 있는 매우 중요한 요인이다. 본 논문에서는 현수시스템에서 케이블의 정확한 장력 값을 측정하여 그 값의 신뢰성을 확인하고 실제 현수 시스템에 적용할 수 있도록 하기 위해 케이블의 장력을 측정 할 수 있는 표준 실험 장치 개발에 관한 연구를 수행하였다. 표준 실험 장치를 직접 설계 제작하였으며 시험편을 제작 실험을 수행하였다. 실험을 통해 케이블의 장력 값을 측정할 수 있으며 실제 현수시스템에서 케이블 장력측정에 적용 할 수 있는 표준 실험 장치를 개발하고자 하였다. This paper describes a new tension measurement system of suspension cable. The suspension cables play an important role in long-span cable-supported bridges, of which the reliability assessment has today been a major topic all around the world. Tension data of a suspension cable in mechanical design and selection of a cable in the construction of a structure helps an engineer and researcher. However, it is difficult to supply the repeatability and the reliability of measurement result in previous technique-vibration acceleration measurement system, load cell technique. In this paper, the tension measurement system of suspension cable and the specimen design for accurate measurement are proposed and the measurement results are described.
현수 시스템의 케이블 장력 측정을 위한 표준 실험장치의 개발
최만용(Choi Man Yong),박해원(Park Hae Won),이규(Lee Giu),정선재(Jang Sun Jae),이승석(Lee Seung Seok) 한국구조물진단유지관리학회 2006 한국구조물진단학회 학술발표회논문집 Vol.10 No.1
현수시스템에서 케이블의 장력은 구조물의 신뢰성을 확인할 수 있는 매우 중요한 요인이다. 본 논문에서는 현수시스템에서 케이블의 정확한 장력 값을 측정하여 그 값의 신뢰성을 확인하고 실제 현수 시스템에 적용할 수 있도록 하기 위해 케이블의 장력을 측정 할 수 있는 표준 실험장치 개발에 관한 연구를 수행하였다. 표준 실험 장치를 직접 설계 제작하였으며 시험편을 제작 실험을 수행하였다. 실험을 통해 케이블의 장력 값을 측정할 수 있으며 실제 현수시스템에서 케이블 장력측정에 적용 할 수 있는 표준 실험 장치를 개발하고자 하였다. This paper describes a new tension measurement system of suspension cable. The suspension cables play an important role in long-span cable-supported bridges, of which the reliability assessment has today been a major topic all around the world. Tension data of a suspension cable in mechanical design and selection of a cable in the construction of a structure helps an engineer and researcher. However, it is difficult to supply the repeatability and the reliability of measurement result in previous technique-vibration acceleration measurement system, load cell technique. In this paper, the tension measurement system of suspension cable and the specimen design for accurate measurement are proposed and the measurement results are described.