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홍주현,진계환,박경순,조명찬,박길선,차은종,이태수 충북대학교 의과대학 충북대학교 의학연구소 2003 忠北醫大學術誌 Vol.13 No.2
연구목적: 초소형 정밀 기계 기술로 제작된 2차원 가속도 센서와 916 MH2 단거리 고주파 데이터 통신 기술을 응용하여 인체의 운동상태를 자동으로 감지하고 분류하는 기법을 제안 하고자 하였다. 재료 및 방법: 인체의 신호를 획득하기 위하여 미국 버클리대에서 제작한 무선 센서를 등 산용 조끼의 전면상단에 부착해서, 대상자의 흉골 부위에 위치하도록 하고, 앉은 상태에서 일어서거나 눕거나 하는 동작 및 그 역동작이 일어날 때, 가속도 센서에서 감지되는 4가지 종류의 파형 현화에 해당되는 데이터를 무선센서 네트웍을 통해 획득하였다. 결과: 획득한 신호를 주성분분석(Principal Component Analysis)과 지원벡터머신(Support Vector Machine)을 사용하여, 2차주성분까지를 도표화하고 클러스터링 함으로써, 4개의 영역으로 분할하는 것이 가능함을 말 수 있었다 결론: 소형 센서들이 작동되는 임베디드 컴퓨팅 환경에서 일상생활 중에 발생하는 인체의 4가지 동작을 자동으로 감지하고 분류하는 것이 가능함을 보였다. Purpose: New monitoring and classifying method of human motion contort was pro- posed by using 2-axial MEMS accelerometer and 916 MHz short-range data communica-tion technology. Materials and Methods: The wireless sensor of MICA mote was attached to a woman mountain vest and located close to the subject's sternum. During four types of sub-ject's motion, that is, sit-to-stand, stand-to-sit, sit-to-tying, and tying-to-sit, waveform changes of the accelerometer data were acquired by wireless sensor network. Results: The acquired signal was analyzed by Principal Component Analysis(PCA) and Support Vector Machine(SVM) technique. By clustering the first and second principal components, four regions corresponding to the four types of motion, were clearly segment-ed. Conclusion: Human motion context during daily life could be monitored and classified automatically by using small sensors in embedded computing environment
Cha, Choong-Hwan,Cha, Young Joo,Park, Chan-Jeoung,Kim, Hyun Kyung,Cha, Eun-Jong,Kim, Duck Hee,Honghoon,Jung, Jae-Seol,Kim, Mi-Jung,Jang, Seongsoo,Chi, Hyun-Sook,Lee, Dong Soon Walter de Gruyter 2010 Clinical chemistry and laboratory medicine Vol.48 No.7
<P>The erythrocyte sedimentation rate (ESR) test has been considered to be a simple procedure, not requiring quality control (QC). However, QC is essential for accuracy and precision. We evaluated the TEST 1 ESR system and performed QC procedures using newly developed latex control materials in three hospitals.</P>
Cha, Jae-Eun,Lee, Tae-Ho,Eoh, Jae-Hyuk,Seong, Sung-Hwan,Kim, Seong-O,Kim, Dong-Eok,Kim, Moo-Hwan,Kim, Tae-Woo,Suh, Kyun-Yul Korean Nuclear Society 2009 Nuclear Engineering and Technology Vol.41 No.8
Systematic research has been conducted by KAERI to develop a supercritical carbon dioxide Brayton cycle energy conversion system coupled with a sodium cooled fast reactor. For the development of the supercritical $CO_2$ Brayton cycle ECS, KAERI researched four major fields, separately. For the system development, computer codes were developed to design and analyze the supercritical $CO_2$ Brayton cycle ECS coupled with the KALIMER-600. Computer codes were developed to design and analyze the performance of the major components such as the turbomachinery and the high compactness PCHE heat exchanger. Three dimensional flow analysis was conducted to evaluate their performance. A new configuration for a PCHE heat exchanger was developed by using flow analysis, which showed a very small pressure loss compared with a previous PCHE while maintaining its heat transfer rate. Transient characteristics for the supercritical $CO_2$ Brayton cycle coupled with KALIMER-600 were also analyzed using the developed computer codes. A Na-$CO_2$ pressure boundary failure accident was analyzed with a computer code that included a developed model for the Na-$CO_2$ chemical reaction phenomena. The MMS-LMR code was developed to analyze the system transient and control logic. On the basis of the code, the system behavior was analyzed when a turbine load was changed. This paper contains the current research overview of the supercritical $CO_2$ Brayton cycle coupled to the KALIMER-600 as an alternative energy conversion system.
SOHN, EUN JEONG,SHIN, MIN JEA,EUM, WON SIK,KIM, DAE WON,YONG, JI IN,RYU, EUN JI,PARK, JUNG HWAN,CHO, SU BIN,CHA, HYUN JU,KIM, SANG JIN,YEO, HYEON JI,YEO, EUN JI,CHOI, YEON JOO,IM, SEUNG KWON,KWEON, HA Spandidos Publications 2016 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.38 No.1
<P>Oxidative stress-induced apoptosis is associated with neuronal cell death and ischemia. The NOL3 [nucleolar protein 3 (apoptosis repressor with CARD domain)] protein protects against oxidative stress-induced cell death. However, the protective mechanism responsible for this effect as well as the effects of NOL3 against oxidative stress in ischemia remain unclear. Thus, we examined the protective effects of NOL3 protein on hydrogen peroxide (H2O2)-induced oxidative stress and the mechanism responsible for these effects in hippocampal neuronal HT22 cells and in an animal model of forebrain ischemia using Tat-fused NOL3 protein (Tat-NOL3). Purified Tat-NOL3 protein transduced into the H2O2-exposed HT22 cells and inhibited the production of reactive oxygen species (ROS), DNA fragmentation and reduced mitochondrial membrane potential (Delta(Psi m)). In addition, Tat-NOL3 prevented neuronal cell death through the regulation of apoptotic signaling pathways including Bax, Bcl-2, caspase-2, -3 and -8, PARP and p53. In addition, Tat-NOL3 protein transduced into the animal brains and significantly protected against neuronal cell death in the CA1 region of the hippocampus by regulating the activation of microglia and astrocytes. Taken together, these findings demonstrate that Tat-NOL3 protein protects against oxidative stress-induced neuronal cell death by regulating oxidative stress and by acting as an anti-apoptotic protein. Thus, we suggest that Tat-NOL3 represents a potential therapeutic agent for protection against ischemic brain injury.</P>
Broccoli sprout extracts improve alcoholic gastric ulcers via antioxidative activities
YOUNG-HWAN BAN,YESEUL CHA,HAIYU GUO,JIEUN CHOI,EUN SUK AN,JI YOUNG LEE,NU RY HAN,EUN SU JEON,EUN SANG CHO,DA WOOM SEO,JUNG-MIN YON,TAE-SU KIM,SUNG-PYO LEE,EHN-KYOUNG CHOI,YUN-BAE KIM 한국실험동물학회 2016 한국실험동물학회 학술발표대회 논문집 Vol.2016 No.08
Jeong, Hye-Eun,Lee, Su-Jun,Cha, Eun-Young,Kim, Eun-Young,Kim, Ho-Sook,Song, Young Hwan,Shin, Jae-Gook Molecular Diversity Preservation International (MD 2014 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.15 No.5
<P>There has been a wide range of inter-individual variations in platelet responses to clopidogrel. The variations in response to clopidogrel can be driven by genetic polymorphisms involved in the pathway of absorption, distribution, metabolism, excretion, and the target receptor P2Y12. A set of genetic variants known for causing variations in clopidogrel responses was selected, which included <I>CYP2C19*2</I>, <I>*3</I>, <I>*17</I>, <I>CYP2B6*4</I>, <I>*6</I>, <I>*9</I>, <I>CYP3A4*18</I>, <I>CYP3A5*3</I>, <I>MDR1 2677G</I> > <I>T</I>/<I>A</I>, <I>3435C</I> > <I>T</I>, and <I>P2Y12 H2</I> (<I>742T</I> > <I>C</I>). The simultaneous detection of these 10 variants was developed by using a multiplex PCR and single-base extension (MSSE) methodology. The newly developed genotyping test was confirmed by direct DNA sequencing in the representative positive control samples and validated in an extended set of 100 healthy Korean subjects. Genotyping results from the developed MSSE exhibited a perfect concordance with the direct DNA sequencing data and all of variants tested in 100 healthy Korean subjects were in agreement with Hardy-Weinberg equilibrium (<I>p</I> > 0.05). The present molecular diagnostic studies provide an accurate, convenient, and fast genotyping method for the detection of multiple variants. This would be helpful for researchers, as well as clinicians, to use genetic information toward more personalized medicine of clopidogrel and other antiplatelet drugs in the future.</P>
초임계 이산화탄소 Brayton 에너지 전환계통 예비설계
차재은(Jae-Eun Cha),어재혁(Jae-Hyuk Eoh),이태호(Tae-Ho Lee),성승환(Sung-Hwan Sung),김성오(Seong-O Kim),김태우(Tae-Woo Kim),김동억(Dong-Eok Kim),김무환(Moo-Hwan Kim) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.11
The supercritical CO₂ Brayton cycle energy conversion system is presented as a promising alternative to the present Rankine cycle. The principal advantage of the S-CO₂ gas is a good efficiency at a modest temperature and a compact size of its components. The S-CO₂ Brayton cycle coupled to a SFR also excludes the possibilities of a SWR (Sodium-Water Reaction) which is a major safety-related event, so that the safety of a SFR can be improved. KAERI is conducting a feasibility study for the supercritical carbon dioxide (S-CO₂) Brayton cycle power conversion system coupled to KALIMER(Korea Advanced LIquid MEtal Reactor). The purpose of this research is to develop S-CO₂ Brayton cycle energy conversion systems and evaluate their performance when they are coupled to advanced nuclear reactor concepts of the type under investigation in the Generation Ⅳ Nuclear Energy Systems. This paper contains the research overview of the S-CO₂ Brayton cycle coupled to KALIMER-600 as an alternative energy conversion system.