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정주화,박대규,김현준 대한생물치료정신의학회 1995 생물치료정신의학 Vol.1 No.1
This article would include a comprehensive review of biological markers in schizophrenia. A marker is measurable variation in structure, function, or performance that is associated with an illness. There are at least two important kinds of markers in psychiatry. The first, state marker is found in at least a subgroup of acutely ill patients. The second kind, the trait marker is genetically controlled, seen during illness, before symptom first appear, and between episodes, and is also prevalent in close relatives. Finding biological markers for schizophrenia have been rendered particularly difficult mainly because of three factors : diagnostic uncertainty ; the possibility that schizophrenia is caused by the concerted action of more than one gene ; unlike other organs, central nervous system has seemed nearly impenetrable to researchers. Recent technological advances has made possible the exploration of numerous aspects of brain function and structure, and has permitted the development of biological measures that could potentially serve as markers of schizophrenia. The search for biological markers has extended through a wide range of disciplines, including psychophysiology, neurochemistry, neuroendocrinology, psychoimmunology, neuropathology, psychiatric genetics, neuropsychology, and brain imaging. However, despite dramatic progress in these research areas, biological markers with sufficient specificity, sensitivity and replicability to be used in clinical evaluation have not yet been identified. Nevertheless, there are several candidates. In this review, we describe characteristics and research methods of putative biological markers, and evaluate both their promise and their limitations, and discuss potential utility in clarifying diagnostic, diagnostic, genetic, therapeutic, and prognostic issues in schizophrenia.
복직근 및 박근 근피판술을 이용한 골반 및 서혜부 연부조직 결손의 재건
이재화,정윤규,김주봉,유대현,황성관,이훈범,김석원 大韓成形外科學會 1997 Archives of Plastic Surgery Vol.24 No.6
Many operations for the reconstruction of the pelvic area have been studied until now. The local muscle flap is often used for the closure of these complex wound. But, these local muscle flaps may not be available for reconstruction due to the factors of infection, radiation, and surgical trauma. Since rectus abdominis muscle and gracilis muscle were introduced, their use has been steadily increased for the reconstruction of soft tissue defect of the pelvic area. Inferiorly based rectus abdominis muscle flap and the gracilis muscle flap have been adopted for well-vascularized soft tissue coverage of the defect of pelvis and groin area. These techniques were utilized in seven patients. Of these patients, rectus abdominis muscle flap was used on four patients and three patients were treated with gracilis muscle flap. Among these, chronic osteomyelitis of pelvic bone has been managed with inferiorly based rectus abdominis muscle flap in three patients. No complication has been found. The mean postoperative follow-up period was 26 months, with a range of 12 to 39 months. In conclusion, these muscles are functionally expandable , and provide adequate tissue volume with sufficient blood supply away from the zone of injury, and readily transposed into the pelvis and groin area through subcutaneous tunnel, and serve as an antibiotic delivery system that aids in the eradication of infection. These findings suggest a reconstructive option for the defect of pelvis and groin, and/or bone infection in this area.
이동수,정강욱,황도연,이형화,김대현,김영성,곽동협 대한내과학회 2003 대한내과학회지 Vol.64 No.1
저자들은 장결핵 중 발생 부위상 드문 곳으로 알려진 직장에 발생한 고림성 결핵을 3예 경험하였기에 문헌고찰과 함께 보고하는 바이다. Isolated rectal tuberculosis commonly involves sigmoid, ascending, or transverse colon. Rectal involvement in tuberculosis is uncommon and poorly characterized. Isolated rectal tuberculosis was defined as focal lesions of rectum in the abscence of demonstrable lesions in the small and large bowel. Diagnosis of rectal tuberculosis was based on characteristic endoscopic appearance of lesions, histopathologic feature of tuberculosis in biopsy material and response to antitubercular therapy. Three patients with isolated rectal tuberculosis were seen at Kwak's hospital. The lesions observed was classified according to macroscopic morphology as follows: ulcerative, hypertrophic and ulcero-hypertrophic. Clinical manifestations were non-specific and consists of rectal bleeding, fever, weight loss, constipation and abdominal pain. One of the three patients had coexisting tuberculous pleurisy. Response to antitubercular chemotherapy was good. (Koeran J Med 64:96-100, 2003)
응급실을 내원한 구강악안면외과 안면골 골절 환자의 변화에 대한 비교 연구
신상훈,성화식,강영훈,황대석,김용덕,김욱규,김종렬,정인교 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.24
Although there have been many clinical studies about the facial trauma in the recent as well as in the past, severity and frequency of facial trauma are reported multifarious. It seemed to be because of variety of social, cultural, and environmental factors, and the view point of investigators. In this study, we investigated about the patients visiting emergency room during recent 4 years(2004-2007), and compared with retrospective study during former 10 years(1992-1996, 1999-2003) in Dept. OMS Pusan National University Hospital. We assessed the cause, type, demographic, etc, and analyzed alterations of facial bone fractures during past 3 periods. The results were as follows. The total number of patients was increased. 429 patients treated for maxillofacial fractures between January 1992 and December 1996, 466 patients treated between January 1992 and December 1996 and 764 patients treated between January 2004 and December 2007. The male-to-female ratio were 4.6:1, 3.9:1, and 4.16:1, respectively. Patient in the age groups of 10-19 years and 20-29 years increased in the latter two periods. Assaults and falls are decreased gradually, but slip down s are increased. Traffic accidents are still major cause of facial trauma. The mandibular fractures showed the highest incidence thorought three periods. Symphysis fractures of mandible was increased and condyle fractures of mandible was drecreased in the third period.