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The Colonoscopist's Expertise Affects the Characteristics of Detected Polyps
Da Kyoung Jung,Tae Oh Kim,Mi Seon Kang,Mo Se Kim,Min Sik Kim,Young Soo Moon 대한소화기내시경학회 2016 Clinical Endoscopy Vol.49 No.1
Background/Aims: The influence of the endoscopist on the polyp detection rate (PDR) is underappreciated in clinical practice. Moreover, flat lesions or lesions of the proximal colon are more difficult to detect. Here, we evaluated the differences in the PDR and the characteristics of detected polyps according to the experience of the colonoscopist. Methods: We collected data on 2,549 patients who underwent screening colonoscopy performed by three fellows. The PDR was calculated according to the percentage of patients who had at least one polyp (method A) and according to the percentage of detected lesions (method B). The primary outcome included the change in the PDR, and the secondary outcome included the change in the characteristics of the detected polyps with increasing experience of the colonoscopist. Results: No proportional correlation was found between the PDR and increasing experience in colonoscopy with method A; however, with method B, the PDR increased after 400 colonoscopies (p=0.0209). With method B, the detection rates of small polyps (<5 mm) (p=0.0015) and polyps in proximal sites (p=0.0050) increased after 300 colonoscopies. Conclusions: Our study demonstrated that the quality of a colonoscopy, measured by using the PDR, may increase when performed by experienced fellows.
( Da Eun Kim ),( Hyeri Yang ),( Won Hee Jang ),( Kyoung Mi Jung ),( Miyoung Park ),( Jin Kyu Choi ),( Mi Sook Jung ),( Eun Young Jeon ),( Yong Heo ),( Kyung Wook Yeo ),( Ji Hoon Jo ),( Jung Eun Park ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
In order for a novel test method to be applied for regulatory purposes, its reliability and relevance, I.e., reproducibility and predictive capacity, must be demonstrated, Here, we examine the predictive capacity of a novel non-radioisotopic local lymph node assay, LLNA:BrdU-FCM (5-bromo-2`-deoxyuridine-flow cytome-try), with a cutoff approach and inferential statistics as a prediction model. 22 reference substances in OECDTG429 were tested with a concurrent positive control. Hexylcinnamaldehyde 25%(PC), and the stimulation index(SI) representing the fold increase in lymph node cells over the vehicle control was obtained. The optimal cutoff SI(2.7≤cutoff<3.5), with respect to predictive capacity, was obtained by a receiver operating character-istic curve, which produced 90.9% accuracy for the 22 substances. To address the inter-test variability in respon-siveness, SI values standardized with PC were employed to obtain the optimal percentage cutoff(42.6≤Cutoff<57.3%of PC), which produced 86.4% accuracy. A test subastance may be diagnosed as a sensitizer if a statistically significant increase in Si is elicited. The parametric one-sided t-test and non-parametric Wilcoxon rank-sum test produced 77.3% accuracy. Similarly, a test substance could be defined as a sensitizer if the SI means of the vehicle control, and of the low, middle, and high concentrations were statistically significantly different, which was test-ed using ANOVA or Kruskal-Wallis, with post hoc analysis, Dunnett, or DSCF(Dwass-Steel-Critchlow-Fligner), respectively, depending on the equal variance test, producing 81.8% accuracy. The absolute SI-based cutoff approach produced the best predictive capacity, however the discordant decisions between prediction models need to be examined further.
EBM 기반구축을 위한 귀비탕(歸脾湯) 연구 문헌 분석
김정훈 ( Jung Hoon Kim ),이준경 ( Jun Kyoung Lee ),하혜경 ( Hye Kyoung Ha ),서창섭 ( Chang Seob Seo ),이미영 ( Mi Young Lee ),이호영 ( Ho Young Lee ),정다영 ( Da Young Jung ),이남헌 ( Nam Hun Lee ),이진아 ( Jin Ah Lee ),황대선 ( D 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.3
Objectives: To establish the fundaments for EBM of Traditional Korean Medicine, the papers on Guibi-tang(Guipitang) which were frequently used in medical institutions of Traditional Korean Medicine were analyzed through researching domestic and international literatures. Methods: The papers were classified by the year of publishment, by experimental methods, by laboratory animals used in biological experiment and by the kinds of studies on biological efficacy. Results: Of total 39 papers were registered in domestic journals. Since 1980, publishments of papers have continuously increased. The papers on biological studies were 34 volumes, clinical studies were 5 volumes. Biological studies mainly showed the effects of anti-stress, anti-oxidant, hemostasis, anti-osteoporosis, gastroprotection, reproductive ability, brain cell activity, radioprotection. And clinical studies showed improvements of fearful throbbing, memory and orientation, insomnia, vericose vein, schizophrenia. Conclusions: Guibi-tang(Guipitang) could be used to fortify the spleen, nourish the heart and then control the blood. However biological studies need to be conducted in accordance with clinical study and further clinical studies on randomized controlled trials should be proceeded.
Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics
Bae, Jung-woo,Choi, Chang-ik,Kim, Mi-jeong,Oh, Da-hee,Keum, Seul-ki,Park, Jung-in,Kim, Bo-hye,Bang, Hye-kyoung,Oh, Sung-gon,Kang, Byung-sung,Park, Hyun-joo,Kim, Hae-deun,Ha, Ji-hey,Shin, Hee-jung,Kim, Springer Science and Business Media LLC 2011 Acta pharmacologica Sinica. Vol.32 No.10
Isothermal Crystallization Behavior of PAR/PBT Composite Prepared by Island-in-a-sea Fiber Method
Yong, Da Kyoung,Jeon, Han Yong,Yoo, Jae Jung,Im, Jung Nam,Lee, Seung Goo 한국섬유공학회 2013 FIBERS AND POLYMERS Vol.14 No.12
The PAR fiber reinforced PBT composite was manufactured using the PAR/PBT island-in-a-sea fiber. The isothermal crystallization kinetics of the PAR/PBT composite and the neat PBT resin were investigated in the temperature range of $187-199^{\circ}C$. To calculate the Avrami parameters for analyzing the crystallization behavior, crystallization peaks were measured and analyzed in terms of the crystallization temperature and the inclusion of the PAR fiber. The crystallization rate of the PBT is faster than that of the PAR/PBT composite from the analysis of their relative crystallinity. Consequently, it is considered that the PAR fiber interrupted the crystal nucleation and growth of the PBT matrix. It can be confirmed with the crystallization half time and the crystalline morphologies at the chosen isothermal temperatures.
Da Hee Kang,Hanjoo Jo,Min-Jung Jung,Kyoung Hoon Kim,Young-Seak Lee 한국탄소학회 2018 Carbon Letters Vol.27 No.-
TiO2-doped activated carbon fibers(ACFs) were successfully prepared as capacitive deionization(CDI) electrode materials by facile ultrasonication-assisted process. ACFs were treated with titanium isopropoxide(TTIP) and isopropyl alcohol solutions of different concentrations and then calcinated by ultrasonication without heat-treatment. The results show that a certain amount of anatase TiO2 was present on the ACF surface. The specific capacitance of the TiO2-doped ACF electrode was remarkably improved(by 93.8% at scan rate of 50 mV s-1) over that of the untreated ACF electrode, despite decreases in the specific surface area and total pore volume upon TiO2 doping. From the CDI experiments, the salt adsorption capacity and charge efficiency of the sample with TTIP percent concentration of 15% were found to considerably increase by 71.9 and 57.1%, respectively. These increases are attributed to the improved wettability of the electrode, which increases the number of surface active sites and facilitates salt ion diffusion in the ACF pores. Additionally, the Ti-OH groups of TiO2 act as electrosorption sites, which increases the electrosorption capacity.