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안기석,여환욱,이경원,이순보,박종윤 성균관대학교 기초과학연구소 1993 論文集 Vol.44 No.1
Si(111)7×7 위에 Mg을 흡착시켜 표면 구조의 변화를 RHEED(Reflection High Energy electron Diffraction)와 XPS(X-ray Photoelectron Spectroscopy)를 이용하여 연구하였다. RT∼200℃까지의 기판온도에서 증착량의 증가에 따라 표면구조는 7×7에서 diffused 1×1, 그리고 2√3/3×2√3/3-R30° 구조로 변화하였다. 이를 thermal annealing하여 3-Domain 3×1 구조를 관측하였고, 이 결과는 J. Quinn등의 결과와 일치함을 알 수 있다. 또한, 기판온도를 증가시킴에 따라 diffuse 1×1, Single domain 3×1구조(450℃)에 대하여 Mg(KLL)/Si(2p) peak intensity ratio를 증착량 증가에 따라 측정하여 각기 다른 온도에서의 Mg 흡착에 대한 mechanism을 제시하였다. Change of the Si(111)7×7 surface structure upon Mg adsorption was studied by RHEED(Reflection HI호 Energy Electron Diffraction) and XPS(X-ray Photoelectron Spectrocopy). The RHEED patterns of Si(111)7×7 were changed to the diffuse 1×1 and 2√3/3×2√3/3-R30° patterns with increasing the deposition times of Mg at RT. The diffuse 1×1, 3-domain, and single domain 3×1 structures appeared successively at the adsorption temperature of 300, 350 and 450℃, respectively. We could find the relative coverages of these structures by measuring Mg(KLL)/Si2p XPS intensity ratio.
백서 두개골에 형성된 골 결손부 크기에 따른 골 치유과정에 대한 조직학적 연구
윤도철,김경욱,임창준,김종여 단국대학교 치의학연구소 1994 논문집 Vol.6 No.1
The author made calvarial defects of different sizes in rat to study the effect of defect size on healing process. Experimental animals were sacrified at 3 days, 1 week, 2, 4, 6 weeks. The specimens were examed under light microscope with Hematoxlin-Eosin and modified Gomori's trichrome stain, and under fluorescent microscope after glinding the specimens. The results were as follows. 1. 4㎜-diameter calvarial defects healed about 70% after 6 weeks. 2. Lamellated bone trabecules were seen in 6㎜-diameter calvarial defects after 4 weeks, and the small specules of bone and marrows were observed after 6 weeks. 3. 10㎜-diameters calvarial defects healed about 50% and incomplete interconnection of the lamellated bone trabecules were observed after 6 weeks. 4. Under fluorescent microscope, about 4㎜-long bone regeneration could be seen in most of the defects.
난소절제로 유도된 골다공증 백서의 발치창 치유과정에 관한 조직학적 연구
정지순,임창준,김경욱,김종여 단국대학교 치의학연구소 1994 논문집 Vol.6 No.1
As the old aged population is on a rise, osteoporosis become considered as a major systemic disease causing severe impediment. For the purpose of knowing about the healing process of the extraction socket in the osteoporotic rat and for applying the results to modify treatment plan in the dental management of osteoporosis patient following aging and menopausing, the author induced osteoporosis by orariectomy in rats, and histologically observed the healing process of the extraction socket. The results were as follows. 1. In the control group, 2 weeks after surgery active bone formation was found and after six weeks extraction socket was filled with mature lamellated bone to the middle half. 2. In the experimental group active new bone formation was found one week after surgery and the poor trabeculae was observed composed of immature woven bone in the wall of extraction socket to six weeks. 3. In the fluroscent microscopic study the amount of bone formation of the experimental group was increased in 2 weeks than in 4 weeks, and its quantity of the newly formed bone was less than that of the control group.
( Kyung Soo Kim ),( Hyun Ju Oh ),( Ji Woon Kim ),( Yeo Kyung Lee ),( Soo Kyung Kim ),( Seok Won Park ),( Yoo Lee Kim ),( Won Keun Park ),( Yong Wook Cho ) 대한당뇨병학회 2010 Diabetes and Metabolism Journal Vol.34 No.2
Background: The prevalence of type 2 diabetes in young adults and adolescents has increased in the last decade according to the increasing obese population. The aim of this study was to examine the clinical characteristics of patients diagnosed with diabetes mellitus before the age of 40 years as compared with patients diagnosed at older ages. Methods: This was a cross-sectional, retrospective study using data from 350 diabetic patients who were diagnosed with diabetes in an outpatient setting between January 2005 and December 2007. Patients were diagnosed according to the criteria set forth by the American Diabetes Association. We examined the clinical characteristics and laboratory data of the patients through review of medical records and compared the early-onset diabetic patients (<40 years old) and the usual-onset diabetic patients (≥40 years old). Results: The frequency of early-onset diabetes and usual-onset diabetes were 31.1% (n=109) and 68.9% (n=241), respectively. The early-onset diabetic patients more often had a positive family history of diabetes; higher HbA1c, fasting glucose, and postprandial glucose levels; experienced typical symptoms more frequently; had microalbuminuria more frequently; and required insulin therapy as initial treatment more frequently as compared to usual-onset diabetic patients, and these differences were significant. Conversely, hypertension was significantly more common in the usual-onset diabetic patients. Conclusion: It could be concluded that we should control early onset diabetes more strictly to prevent its complication because early onset diabetic patients represented more severe hyperglycemia and had more prevalent microalbuminuria.
( Yeo Kyung Lee ),( Jo Eun Kim ),( Hyun Ju Oh ),( Kyung Sun Park ),( Soo Kyung Kim ),( Seok Won Park ),( Moon Jong Kim ),( Yong Wook Cho1 ) 대한내과학회 2011 The Korean Journal of Internal Medicine Vol.26 No.4
Background/Aims: The proper treatment of subclinical hypothyroidism and the normal range of serum thyroid stimulating hormone (TSH) concentration are intensely debated. However, few reports have investigated TSH concentrations in Asian ethnic groups. Therefore, the present study was designed to define the TSH reference range in a Korean population and to investigate the metabolic significance of TSH concentration. Methods: We enrolled patients who underwent medical examination at the CHA Bundang Medical Center. Anthropometric data were evaluated, and serum TSH, free T4, and lipid profiles were assayed. Results: A total of 7,270 subjects were included. Mean TSH concentration of the study population was 1.82 ± 0.95 mU/L, and we observed a sex-related difference in TSH concentration (male, 1.67 ± 0.87 mU/L; female, 2.02 ± 1.01 mU/L; p < 0.01). When the 2.5 and 97.5 percentiles were calculated, 95% TSH reference limits were 0.52-4.29 mU/L. TSH concentration was higher in elderly subjects, during winter, in postmenopausal women, and in obese males. Moreover, TSH showed significantly positive correlations with serum total cholesterol, triglyceride, and low density lipoprotein cholesterol regardless of sex, age, season, obesity, or menopausal status (all p < 0.01). Finally, TSH concentration was positively related to the prevalence of metabolic syndrome. Conclusions: We demonstrated the association between TSH concentration within the normal reference range and serum lipid levels. TSH concentration varies according to sex, age, season, and body mass index (only in males). Moreover, high normal TSH levels were significantly associated with an increased prevalence of metabolic syndrome, which may be of importance when evaluating subjects with high normal TSH concentration.