Original Article : A Comparison of Posterior Lamellar Keratoplasty Modalities: DLEK vs. DSEK

( Chan Hui Yi ),( Dong Hoon Lee ),( Eui Sang Chung ),( Tae Young Chung ) 대한안과학회 2010 Korean Journal of Ophthalmology Vol.24 No.4

Purpose: To compare clinical outcomes after deep lamellar endothelial keratoplasty (DLEK) with Descemet stripping endothelial keratoplasty (DSEK) performed as initial cases by a single surgeon. Methods: Sixteen patients with corneal endothelial were enrolled. Eight patients (8 eyes) underwent DLEK and 8 patients (8 eyes) DSEK. We measured uncorrected visual acuity, best corrected visual acuity (BCVA), manifest refraction, corneal endothelial count, interface opacity via Schiempflug imaging, and contrast sensitivity, as well as tracked postoperative complications over the first postoperative year. Results: Primary graft failure occurred in two DLEK cases and one DSEK case, all of which were excluded for further analysis. The average 12-month postoperative BCVA was 20/70 in the DLEK group and 20/50 in the DSEK group, with the difference not statistically significant. No significant differences were identified between the 2 groups in terms of mean spherical equivalent and refractive astigmatism, although individuals in the DSEK group tended toward hyperopia. The average endothelial cell count at postoperative month 12 was 1849±494 in the DLEK group and 1643±417 cells/mm2 in the DSEK group, representing cell losses of 26.2% and 31.9%, respectively. No significant differences in endothelial cell count or endothelial cell loss were observed between groups. Early postoperative donor disc dislocation occurred in two eyes after DLEK and one eye after DSEK. Interface opacities and contrast sensitivities were similarly not significantly different between groups. Conclusions: No significant differences in any assessed clinical outcome were observed between individuals undergoing DLEK and DSEK, when performed as initial cases by a single surgeon.

Studies on the Production of Neutralizing Epitopes of Porcine Reproductive and Respiratory Syndrome Virus by Transgenic Plant

Hui-Ting Chan,Yi-Yin Do,Pung-Ling Huang 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Two-wave Mixing Interferometer for Broadband Vibration Measurements

Chan-Hsiao Ho,Ju-Yi Lee,Hseuh-Ching Shih,Yung-Hui Liu,Lung-Hen Chow 한국소음진동공학회 2003 한국소음진동공학회 국제학술대회논문집 Vol.2003 No.8

옥천대 중부와 경기육괴 중서부에 분포하는 트라이아스기-쥬라기 화강암류의 저어콘 조직과 포화온도

조희제(Hui Je Jo),김남훈(Namhoon Kim),박찬수(Chan-Soo Park),이기욱(Keewook Yi),정창식(Chang-sik Cheong) 한국암석학회 2013 한국암석학회 학술발표회 논문집 Vol.2013 No.5

Exploring Chemotherapy-Induced Toxicities through Multivariate Projection of Risk Factors

Kevin Yi-Lwern Yap,Xiu Hui Low,Alexandre Chan 한국독성학회 2012 Toxicological Research Vol.28 No.2

Many risk factors exist for chemotherapy-induced nausea and vomiting (CINV). This study utilized a multivariate projection technique to identify which risk factors were predictive of CINV in clinical practice. A single-centre, prospective, observational study was conducted from January 2007~July 2010 in Singapore. Patients were on highly (HECs) and moderately emetogenic chemotherapies with/without radiotherapy. Patient demographics and CINV risk factors were documented. Daily recording of CINV events was done using a standardized diary. Principal component (PC) analysis was performed to identify which risk factors could differentiate patients with and without CINV. A total of 710 patients were recruited. Majority were females (67%) and Chinese (84%). Five risk factors were potential CINV predictors: histories of alcohol drinking, chemotherapy-induced nausea, chemotherapy-induced vomiting, fatigue and gender. Period (ex-/current drinkers) and frequency of drinking (social/chronic drinkers) differentiated the CINV endpoints in patients on HECs and anthracycline-based, and XELOX regimens, respectively. Fatigue interference and severity were predictive of CINV in anthracycline-based populations, while the former was predictive in HEC and XELOX populations. PC analysis is a potential technique in analyzing clinical population data, and can provide clinicians with an insight as to what predictors to look out for in the clinical assessment of CINV. We hope that our results will increase the awareness among clinician-scientists regarding the usefulness of this technique in the analysis of clinical data, so that appropriate preventive measures can be taken to improve patients" quality of life.

Exploring Chemotherapy-Induced Toxicities through Multivariate Projection of Risk Factors: Prediction of Nausea and Vomiting

Yap, Kevin Yi-Lwern,Low, Xiu Hui,Chan, Alexandre Korean Society of ToxicologyKorea Environmental Mu 2012 Toxicological Research Vol.28 No.2

Many risk factors exist for chemotherapy-induced nausea and vomiting (CINV). This study utilized a multivariate projection technique to identify which risk factors were predictive of CINV in clinical practice. A single-centre, prospective, observational study was conducted from January 2007~July 2010 in Singapore. Patients were on highly (HECs) and moderately emetogenic chemotherapies with/without radiotherapy. Patient demographics and CINV risk factors were documented. Daily recording of CINV events was done using a standardized diary. Principal component (PC) analysis was performed to identify which risk factors could differentiate patients with and without CINV. A total of 710 patients were recruited. Majority were females (67%) and Chinese (84%). Five risk factors were potential CINV predictors: histories of alcohol drinking, chemotherapy-induced nausea, chemotherapy-induced vomiting, fatigue and gender. Period (ex-/current drinkers) and frequency of drinking (social/chronic drinkers) differentiated the CINV endpoints in patients on HECs and anthracycline-based, and XELOX regimens, respectively. Fatigue interference and severity were predictive of CINV in anthracycline-based populations, while the former was predictive in HEC and XELOX populations. PC analysis is a potential technique in analyzing clinical population data, and can provide clinicians with an insight as to what predictors to look out for in the clinical assessment of CINV. We hope that our results will increase the awareness among clinician-scientists regarding the usefulness of this technique in the analysis of clinical data, so that appropriate preventive measures can be taken to improve patients' quality of life.

Role-Balance Based Multi-Secret Images Sharing using Boolean Operations

( Chi-shiang Chan ),( Yung-chen Chou ),( Yi-hui Chen ),( Yuan-yu Tsai ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.5

In 2011, Chen and Wu proposed their method of sharing n secret images to n+1 shadow images through the concept of a Boolean-based Visual Secret Sharing (VSS) method. However, the shadow images produced by this method are not equally important. If the participant who owns an important shadow image does not want to cooperate with other participants, most secret images can not be reconstructed. In the proposed method, the relationship between the shadows images and secret images are designed in a circular way mostly. Each shadow image only relates to two secret images. This means that if one participant refuses to cooperate with other participants, there are only two secret images which can not be reconstructed. Moreover, our proposed method only needs to produce n shadow images and n secret images can be shared to them.

논문 : 디자인학과 공학 간의 PBL기반 융합교육 사례 -준비과정, 수업운영, 결과물 그리고 성과를 중심으로-

이상선 ( Sang Sun Yi ),김미희 ( Mi Hui Kim ),김상훈 ( Sang Hoon Kim ),김수찬 ( Soo Chan Kim ),박재희 ( Jae Hee Park ),이경석 ( Kyung Seog Lee ) 디자인융복합학회 2014 디자인융복합연구 Vol.13 No.2

본 연구는 연구자가 소속한 대학에서 2013학년도 2학기에 시행한 융합수업에 대한 보고이다. 본 융합수업은 연구자가 소속한 대학에 재직 중인 6명의 교수자가 중심이 되어, 44명의 3학년 학부생을 대상으로 실시하였다. 교수자와 수강생의 전공은, 디자인, 컴퓨터공학, 인간공학, 의공학, 전자공학, 미디어문예창작학으로 다양했다. 본 연구는 학부에서 이루어지는 교과목 차원의 융합교육에 대하여, 사전연구와 시사점, 준비과정, 교육과정 설계, PBL기반 교육 실시, 프로젝트 진행, 산출물, 그리고 성과에 걸쳐 운영의 전 과정을 보고하고 있다. 성과는 학부과정에서 교과목 차원에서 화학적 융합교육을 시행한 점, 학내에 융합교육에 관심과 경험을 가진 교수자 집단이 생겨난 점, 학부과정에 적합한 융합교육 모델을 제시한 점을 꼽을 수 있다. 본 연구는 융합교육 시도의 가치를 가질 수 있을 것이다. This research is on interdisciplinary course which was run in second semester, 2013 in the university that the researchers are affiliated to. The interdisciplinary course was led by 6 professors affiliated to the university, for 44 junior undergraduate students. Major of professors and undergraduate students varied from design, computer engineering, human factor, medical engineering, electronic engineering to writing and literary arts. This study reveals overall progress of interdisciplinary class for undergraduate students including advanced research, implications, preparation process, specific curriculum, implementation of Problem-Based Learning, progress of project, results and outcomes. The outcomes of this interdisciplinary course are as follows: it is designed for undergraduate studies, it created group of professors who are inter-ested and experienced in interdisciplinary education, and it proposed an interdisciplinary education model suitable for undergraduate. This re-search will be valued as a case study of interdisciplinary course.

안구 길이와 전방 깊이에 따른 Haigis 공식의 정확성

이찬희,최성호,정의상,정태영,Chan-Hui Yi,Sung-Ho Choi,Eui-Sang Chung,Tae-Young Chung 대한안과학회 2011 대한안과학회지 Vol.52 No.2

Purpose: To evaluate the effect of axial length (AXL) and anterior chamber depth (ACD) on the accuracy of the Haigis formula in comparison to its effect on other 3rd generation IOL power calculations. The possibility of measurement error in ACD using either method was also investigated. Methods: A study was performed on 137 eyes of 98 patients who underwent cataract surgery in our hospital. AXL and ACD were measured using IOL Master, and IOL power was calculated using the Haigis, SRK/T, Hoffer Q, and Holladay 1 formulas. ACD was also measured using Pentacam. Patients were divided into 3 groups based on ACD and AXL. Mean numeric error and mean absolute error were analyzed 1 month after surgery. Results: Five formulae showed no significant difference in refractive error in the 3 groups based on AXL. In contrast, the Haigis formula showed statistically significant differences in the group with shallow ACD, in which hyperopic shift was also demonstrated. The difference in ACD between using IOL Master and using Pentacam was significant in the shallow ACD group, with IOL Master showing more shallow measurement. However, the other groups based on ACD showed no significant difference in the refractive error from the Haigis formula, and in the difference in ACD between measurements. Conclusions: Errors in ACD measurement should be taken into consideration for discrepancy between the Haigis formula measurement and other formula measurements. The authors of the present study suggest that ACD-driven refractive error should be considered in determination of IOL. J Korean Ophthalmol Soc 2011;52(2):175-181

인간 단핵구 THP-1 세포에서 β-glucan으로 인한 TNF-α 분비 증가 효과

금보람(Bo Ram Keum),현진이(Jin Yi Hyeon),최소희(So Hui Choe),진지영(Ji Young Jin),정지우(Ji Woo Jeong),임종민(Jong Min Lim),박동찬(Dong Chan Park),조광근(Kwang Keun Cho),최은영(Eun Young Choi),최인순(In Soon Choi) 한국생명과학회 2017 생명과학회지 Vol.27 No.11

β-glucan은 균류의 세포벽, 귀리, 효모, 식물의 구성물질로, 면역 세포의 활성, 전염증성 사이토카인 분비, 항암효능과 같은 면역 체계에 중요한 역할을 한다. 면역계는 건강한 몸 상태의 항상성을 유지한다. 하지만, 병원성 물질이 신체 내로 들어오게 되면 면역 항상성이 무너지게 되고, 질병이 유발될 수 있다. 따라서, 본 연구는 β-glucan이 인간 단핵구 THP-1 세포에서 면역 조절 효과에 이용될 수 있는지를 확인하였다. β-glucan은 THP-1 세포에 다양한 농도를 처리하여 배양하였으며, TNF-α mRNA 발현과 단백질 수준을 Real-time PCR와 ELISA을 이용하여 분석하였다. 또한 전사 인자 NF-κB p50와 MAPKs 신호 기작 활성을 western blot을 이용하여 분석하였다. β-glucan으로 유도된 MAPKs와 NF-κB p50 활성이 증가하였다. β-glucan이 인간 단핵구 THP-1 세포에서 TNF-α 생성에 의해 면역 증강 효과를 나타내며, 이는 MAPKs와 NF-κB p50 신호 전달을 통해 나타내는 것을 제시한다. 종합적으로, 본 연구는 β-glucan이 인간 단핵구 THP-1 세포를 통해 면역 체계를 향상시킬 것이라고 사료된다. β-glucan is a constituent of the cell wall of fungi, yeast and plants. It plays an important role in the immune system such as activation of immunocyte, release of pro-inflammatory and anti-cancer effect. The immune system maintains a healthy immune homeostasis. However, when pathogenic substances enter the body, immune homeostasis can break down and disease can be triggered. Therefore, we studied a substance that regulates immune homeostasis. The purpose of the study we demonstrated whether the β-glucan can be applied to the immune-modulation effects in human monocytic THP-1 cells. β-glucan was incubated in THP-1 cells at various concentrations. The TNF-α mRNA expression and protein levels were analyzed by ELISA and Real-time PCR. Additionally, the expression of MAPKs (p38 and JNK), IκB-α and NF-κB p50 were analyzed by western blot. β-glucan enhanced the production of TNF-α mRNA expression and protein levels in human monocytic THP-1 cells. In addition, activation of MAPKs (p38 and JNK) and NF-κB p50 induced by β-glucan were increased. The study suggests that β-glucan contributes to immune-stimulation effect by production TNF-α in human monocytic THP-1 cells, and that MAPKs and NF-κB p50 are involved in the process. Synthetically, we have suggested β-glucan may be improved to immune system effect in human monocytic THP-1 cells.